An unusually large multifunctional polypeptide in the erythromycin-producing polyketide synthase of Saccharopolyspora erythraea

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

A comprehensive set of sequence analysis programs for the VAX

1984 • 14,824 citations

Fatty acid synthase, a proficient multifunctional enzyme

1989 • 801 citations

Graphic methods to determine the function of nucleic acid sequences

1984 • 367 citations

Analysis of the nucleotide sequence of the Streptomyces glaucescens tcmI genes provides key information about the enzymology of polyketide antibiotic biosynthesis.

1989 • 250 citations

Structure and deduced function of the granaticin-producing polyketide synthase gene cluster of Streptomyces violaceoruber Tü22.

1989 • 226 citations

A subcloning strategy for DNA sequence analysis

1980 • 161 citations

β-ketoacyl-ACP synthase I of Escherichia coli: Nucleotide sequence of thefabB gene and identification of the cerulenin binding residue

1988 • 151 citations

Cyclosporin synthetase. The most complex peptide synthesizing multienzyme polypeptide so far described.

1990 • 136 citations

Cloning and Expression in Streptomyces lividans of Clustered Erythromycin Biosynthesis Genes from Streptomyces erythreus

1986 • 127 citations

The pentafunctional FAS1 gene of yeast: its nucleotide sequence and order of the catalytic domains

1986 • 126 citations

Primary structure of the multifunctional alpha subunit protein of yeast fatty acid synthase derived from FAS2 gene sequence.

1988 • 121 citations

Genetic analysis of erythromycin production in Streptomyces erythreus

1985 • 110 citations

Organization of a cluster of erythromycin genes in Saccharopolyspora erythraea

1990 • 101 citations

Actinomycete Antibiotics

1962 • 85 citations

Molecular characterization of a gene from Saccharopolyspora erythraea (Streptomyces erythraeus) which is involved in erythromycin biosynthesis

1989 • 82 citations

Rat mammary gland fatty acid synthase: localization of the constituent domains and two functional polyadenylation/termination signals in the cDNA

1989 • 75 citations

Cloning of genes involved in erythromycin biosynthesis from Saccharopolyspora erythraea using a novel actinomycete-Escherichia coli cosmid

1990 • 68 citations

Macrolide biosynthesis. 3. Stereochemistry of the chain-elongation steps of erythromycin biosynthesis

1986 • 51 citations

The use of a chromosome integration vector to map erythromycin resistance and production genes in Saccharopolyspora erythraea (Streptomyces erythraeus)

1988 • 47 citations

A Novel cDNA Extension Procedure

1989 • 35 citations

Macrolide biosynthesis. Origin of the oxygen atoms in the erythromycins

1981 • 33 citations

On the domain construction of the multienzyme gramicidin S synthetase 2

1990 • 23 citations