Positive and negative regulation of TGF-β signaling

TGF-β SIGNAL TRANSDUCTION

1998 • 7,582 citations

TGF-β signalling from cell membrane to nucleus through SMAD proteins

1997 • 3,650 citations

DPC4 , A Candidate Tumor Suppressor Gene at Human Chromosome 18q21.1

1996 • 2,320 citations

Bone morphogenetic proteins: multifunctional regulators of vertebrate development.

1996 • 1,959 citations

The TGF-beta superfamily: new members, new receptors, and new genetic tests of function in different organisms.

1994 • 1,950 citations

Identification of Smad7, a TGFβ-inducible antagonist of TGF-β signalling

1997 • 1,774 citations

Direct binding of Smad3 and Smad4 to critical TGFbeta -inducible elements in the promoter of human plasminogen activator inhibitor-type 1gene

1998 • 1,763 citations

The Spemann Organizer Signal noggin Binds and Inactivates Bone Morphogenetic Protein 4

1996 • 1,604 citations

The MAD-Related Protein Smad7 Associates with the TGFβ Receptor and Functions as an Antagonist of TGFβ Signaling

1997 • 1,328 citations

Dorsoventral Patterning in Xenopus: Inhibition of Ventral Signals by Direct Binding of Chordin to BMP-4

1996 • 1,126 citations

Smad6 inhibits signalling by the TGF-β superfamily

1997 • 1,026 citations

Transcriptional Activators of TGF-β Responses: Smads

1998 • 1,024 citations

A mechanism of repression of TGFbeta / Smad signaling by oncogenic Ras

1999 • 1,004 citations

SARA, a FYVE Domain Protein that Recruits Smad2 to the TGFβ Receptor

1998 • 952 citations

Opposing BMP and EGF signalling pathways converge on the TGF-β family mediator Smad1

1997 • 867 citations

Noggin-mediated antagonism of BMP signaling is required for growth and patterning of the neural tube and somite

1998 • 838 citations

FORMATION AND FUNCTION OF SPEMANN'S ORGANIZER

1997 • 836 citations

A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation

1999 • 833 citations

The head inducer Cerberus is a multifunctional antagonist of Nodal, BMP and Wnt signals

1999 • 823 citations

Inhibition of transforming growth factor-β/SMAD signalling by the interferon-γ/STAT pathway

1999 • 800 citations

Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-β-induced transcription

1998 • 789 citations

The Transforming Growth Factor-βs

1990 • 741 citations

Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor

1998 • 714 citations

Silencing of TGF-β signalling by the pseudoreceptor BAMBI

1999 • 691 citations

TGF-beta induces fibronectin synthesis through a c-Jun N-terminal kinase-dependent, Smad4-independent pathway

1999 • 667 citations

The Xenopus Dorsalizing Factor Gremlin Identifies a Novel Family of Secreted Proteins that Antagonize BMP Activities

1998 • 649 citations

Autoinduction of transforming growth factor beta 1 is mediated by the AP-1 complex.

1990 • 647 citations

Smad2 role in mesoderm formation, left–right patterning and craniofacial development

1998 • 600 citations

A Smad Transcriptional Corepressor

1999 • 563 citations

lefty-1 Is Required for Left-Right Determination as a Regulator of lefty-2 and nodal

1998 • 539 citations

Signal transduction by bone morphogenetic proteins

1998 • 528 citations

The tumor suppressor Smad4/DPC4 and transcriptional adaptor CBP/p300 are coactivators for Smad3 in TGF-β-induced transcriptional activation

1998 • 527 citations

Osteogenic protein-1 binds to activin type II receptors and induces certain activin-like effects.

1995 • 510 citations

TGF-β-stimulated cooperation of Smad proteins with the coactivators CBP/p300

1998 • 503 citations

Negative Feedback Regulation of TGF-β Signaling by the SnoN Oncoprotein

1999 • 498 citations

The Ski oncoprotein interacts with the Smad proteins to repress TGFbeta signaling

1999 • 471 citations

Interaction and Functional Cooperation of PEBP2/CBF with Smads

1999 • 449 citations

Direct binding of follistatin to a complex of bone-morphogenetic protein and its receptor inhibits ventral and epidermal cell fates in early Xenopus embryo

1998 • 448 citations

Substrate Targeting in the Ubiquitin System

1999 • 447 citations

Higher frequency of Smad4 gene mutation in human colorectal cancer with distant metastasis

1999 • 430 citations

Daughters against dpp modulates dpp organizing activity in Drosophila wing development

1997 • 426 citations

Cardiac defects and altered ryanodine receptor function in mice lacking FKBP12

1998 • 422 citations

Noggin is a mesenchymally derived stimulator of hair-follicle induction

1999 • 411 citations

TGF-β signaling by Smad proteins

2000 • 406 citations

c-Ski Acts as a Transcriptional Co-repressor in Transforming Growth Factor-β Signaling through Interaction with Smads

1999 • 380 citations

Mouse Lefty2 and Zebrafish Antivin Are Feedback Inhibitors of Nodal Signaling during Vertebrate Gastrulation

1999 • 372 citations

The Immunophilin FKBP12 Functions as a Common Inhibitor of the TGFβ Family Type I Receptors

1996 • 370 citations

Induction of Inhibitory Smad6 and Smad7 mRNA by TGF-β Family Members

1998 • 355 citations

Physical and Functional Interaction of SMADs and p300/CBP

1998 • 351 citations

ATF-2 Is a Common Nuclear Target of Smad and TAK1 Pathways in Transforming Growth Factor-β Signaling

1999 • 347 citations

Ubiquitin-dependent degradation of TGF-β-activated Smad2

1999 • 343 citations

Mechanism of TGFβ receptor inhibition by FKBP12

1997 • 342 citations

Bone morphogenetic proteins induce the expression of noggin, which limits their activity in cultured rat osteoblasts.

1998 • 339 citations

The BMP antagonist Gremlin regulates outgrowth, chondrogenesis and programmed cell death in the developing limb

1999 • 337 citations

Vascular MAD s: Two novel MAD -related genes selectively inducible by flow in human vascular endothelium

1997 • 325 citations

Smads bind directly to the Jun family of AP-1 transcription factors

1999 • 324 citations

Specific Interaction of Type I Receptors of the TGF-β Family with the Immunophilin FKBP-12

1994 • 321 citations

Control of Vertebrate Limb Outgrowth by the Proximal Factor Meis2 and Distal Antagonism of BMPs by Gremlin

1999 • 317 citations

Antivin, a novel and divergent member of the TGFβ superfamily, negatively regulates mesoderm induction

1999 • 316 citations

Transforming Growth Factor β Activation of p44mapk in Proliferating Cultures of Epithelial Cells

1995 • 312 citations

Latent transforming growth factor-β binding proteins (LTBPs)—structural extracellular matrix proteins for targeting TGF-β action

1999 • 302 citations

Evidence for a Role of Rho-like GTPases and Stress-activated Protein Kinase/c-Jun N-terminal Kinase (SAPK/JNK) in Transforming Growth Factor β-mediated Signaling

1997 • 301 citations

Smad2 transduces common signals from receptor serine–threonine and tyrosine kinases

1998 • 291 citations

Synergistic cooperation of TFE3 and Smad proteins in TGF-β-induced transcription of the plasminogen activator inhibitor-1 gene

1998 • 288 citations

A Mouse Cerberus/Dan-Related Gene Family

1999 • 283 citations

Ski is a component of the histone deacetylase complex required for transcriptional repression by Mad and thyroid hormone receptor

1999 • 277 citations

Interaction of the Ski Oncoprotein with Smad3 Regulates TGF-β Signaling

1999 • 265 citations

Smad3-Smad4 and AP-1 Complexes Synergize in Transcriptional Activation of the c-Jun Promoter by Transforming Growth Factor β

1999 • 261 citations

Cellular interpretation of multiple TGF-β signals: intracellular antagonism between activin/BVg1 and BMP-2/4 signaling mediated by Smads

1997 • 260 citations

The TGF-β signaling inhibitor Smad7 enhances tumorigenicity in pancreatic cancer

1999 • 259 citations

SnoN and Ski protooncoproteins are rapidly degraded in response to transforming growth factor β signaling

1999 • 252 citations

Regulation of Smad7 Promoter by Direct Association with Smad3 and Smad4

1999 • 249 citations

Regulation of Smad signalling by protein associations and signalling crosstalk

1999 • 248 citations

The Xenopus Dorsalizing Factor noggin Ventralizes Drosophila Embryos by Preventing DPP from Activating Its Receptor

1996 • 242 citations

Left–Right Asymmetric Expression of lefty2 and nodal Is Induced by a Signaling Pathway that Includes the Transcription Factor FAST2

2000 • 236 citations

The novel Cer-like protein Caronte mediates the establishment of embryonic left–right asymmetry

1999 • 225 citations

Complex regulation of transforming growth factor beta 1, beta 2, and beta 3 mRNA expression in mouse fibroblasts and keratinocytes by transforming growth factors beta 1 and beta 2.

1989 • 221 citations

Transforming Growth Factor-β: Latent Forms, Binding Proteins and Receptors

1993 • 215 citations

TGF-β–induced Phosphorylation of Smad3 Regulates Its Interaction with Coactivator p300/CREB-binding Protein

1998 • 211 citations

The ski oncogene induces muscle differentiation in quail embryo cells

1989 • 188 citations

Receptors for Transforming Growth Factor-β

1993 • 181 citations

Antagonistic Signaling by Caronte , a Novel Cerberus -Related Gene, Establishes Left–Right Asymmetric Gene Expression

1999 • 179 citations

CREB binding protein is a required coactivator for Smad-dependent, transforming growth factor β transcriptional responses in endothelial cells

1998 • 179 citations

Activin and Inhibin Have Antagonistic Effects on Ligand-Dependent Heteromerization of the Type I and Type II Activin Receptors and Human Erythroid Differentiation

1997 • 172 citations

Isolation of human cDNA clones ofskiand the ski-related gene,sno

1989 • 169 citations

Induction of Smad6 mRNA by Bone Morphogenetic Proteins

1998 • 168 citations

p38 Mitogen-Activated Protein Kinase Can Be Involved in Transforming Growth Factor β Superfamily Signal Transduction in Drosophila Wing Morphogenesis

1999 • 164 citations

Role of p300, a transcriptional coactivator, in signalling of TGF‐β

1998 • 162 citations

Specificity in transforming growth factor β-induced transcription of the plasminogen activator inhibitor-1 gene: Interactions of promoter DNA, transcription factor μE3, and Smad proteins

1999 • 155 citations

Smad7 Is an Activin-inducible Inhibitor of Activin-induced Growth Arrest and Apoptosis in Mouse B Cells

1998 • 139 citations

Smad4/DPC4 and Smad3 Mediate Transforming Growth Factor-β (TGF-β) Signaling through Direct Binding to a Novel TGF-β-responsive Element in the Human Plasminogen Activator Inhibitor-1 Promoter

1998 • 138 citations

Inhibin Antagonizes Inhibition of Liver Cell Growth by Activin by a Dominant-negative Mechanism

1995 • 126 citations

Cooperative Binding of Smad Proteins to Two Adjacent DNA Elements in the Plasminogen Activator Inhibitor-1 Promoter Mediates Transforming Growth Factor β-induced Smad-dependent Transcriptional Activation

1999 • 120 citations

Smad6 Suppresses TGF-β-Induced Growth Inhibition in COLO-357 Pancreatic Cancer Cells and Is Overexpressed in Pancreatic Cancer

1999 • 109 citations

Transforming Growth Factor-β signalling in extraembryonic mesoderm is required for yolk sac vasculogenesis in mice

1999 • 108 citations

Expression of spacer tRNA genes in ribosomal RNA transcription units carried by hybrid col E1 plasmids in E. coli

1977 • 106 citations

CBF alpha3 (AML2) is induced by TGF-beta1 to bind and activate the mouse germline Ig alpha promoter.

1998 • 105 citations

Interplay of Signal Mediators of Decapentaplegic (Dpp): Molecular Characterization of Mothers against dpp, Medea, and Daughters against dpp

1998 • 100 citations

CBFα3 (AML2) Is Induced by TGF-β1 to Bind and Activate the Mouse Germline Ig α Promoter

1998 • 97 citations

Identification of Two Smad4 Proteins in Xenopus

1999 • 95 citations

Skeletal Growth Factors

2001 • 94 citations

Xenopus Smad4β Is the Co-Smad Component of Developmentally Regulated Transcription Factor Complexes Responsible for Induction of Early Mesodermal Genes

1999 • 92 citations

Xenopus GDF6, a new antagonist of noggin and a partner of BMPs

1999 • 91 citations

A quantitative analysis of signal transduction from activin receptor to nucleus and its relevance to morphogen gradient interpretation

1999 • 90 citations

Hematopoietic Progenitor Kinase 1 Is a Component of Transforming Growth Factor β-induced c-Jun N-terminal Kinase Signaling Cascade

1999 • 81 citations

Expression ofnma, a novel gene, inversely correlates with the metastatic potential of human melanoma cell lines and xenografts

1996 • 80 citations

Identification of an Inhibin Receptor in Gonadal Tumors from Inhibin α-Subunit Knockout Mice

1998 • 65 citations

Structure and expression of the promoter for the R4/ALK5 human type I transforming growth factor-β receptor: regulation by TGF-β

1996 • 62 citations

Induction of the c-ski proto-oncogene by phorbol ester correlates with induction of megakaryocyte differentiation.

1994 • 29 citations

Regulation of Expression of Transforming Growth Factor-β2 by Transforming Growth Factor-β Isoforms is Dependent upon Cell Type

1992 • 23 citations

Regulation of Expression of Transforming Growth Factor-β2 by Transforming Growth Factor-β Isoforms is Dependent upon Cell Type

1992 • 20 citations

Chromatin modification: How to put a HAT on the histones

1999 • 19 citations