Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor

DPC4 , A Candidate Tumor Suppressor Gene at Human Chromosome 18q21.1

1996 • 2,320 citations

Bone morphogenetic proteins: multifunctional regulators of vertebrate development.

1996 • 1,959 citations

Identification of Smad7, a TGFβ-inducible antagonist of TGF-β signalling

1997 • 1,774 citations

The Spemann Organizer Signal noggin Binds and Inactivates Bone Morphogenetic Protein 4

1996 • 1,604 citations

The MAD-Related Protein Smad7 Associates with the TGFβ Receptor and Functions as an Antagonist of TGFβ Signaling

1997 • 1,328 citations

Expression cloning of noggin, a new dorsalizing factor localized to the Spemann organizer in Xenopus embryos

1992 • 1,176 citations

Xenopus chordin: A novel dorsalizing factor activated by organizer-specific homeobox genes

1994 • 1,114 citations

Expression of achaete-scute homolog 3 in Xenopus embryos converts ectodermal cells to a neural fate.

1994 • 1,032 citations

Smad6 inhibits signalling by the TGF-β superfamily

1997 • 1,026 citations

Partnership between DPC4 and SMAD proteins in TGF-β signalling pathways

1996 • 899 citations

Receptor-associated Mad homologues synergize as effectors of the TGF-β response

1996 • 874 citations

MADR2 Maps to 18q21 and Encodes a TGFβ–Regulated MAD–Related Protein That Is Functionally Mutated in Colorectal Carcinoma

1996 • 855 citations

Induction of epidermis and inhibition of neural fate by Bmp-4

1995 • 782 citations

Follistatin, an antagonist of activin, is expressed in the Spemann organizer and displays direct neuralizing activity

1994 • 759 citations

MADR2 Is a Substrate of the TGFβ Receptor and Its Phosphorylation Is Required for Nuclear Accumulation and Signaling

1996 • 740 citations

Regulation of neural induction by the Chd and Bmp-4 antagonistic patterning signals in Xenopus

1995 • 731 citations

MADR1, a MAD-Related Protein That Functions in BMP2 Signaling Pathways

1996 • 710 citations

A transcriptional partner for MAD proteins in TGF-β signalling

1996 • 699 citations

GS domain mutations that constitutively activate T beta R-I, the downstream signaling component in the TGF-beta receptor complex.

1995 • 682 citations

A human Mad protein acting as a BMP-regulated transcriptional activator

1996 • 674 citations

Identification of a potent Xenopus mesoderm-inducing factor as a homologue of activin A

1990 • 660 citations

Injected Xwnt-8 RNA acts early in Xenopus embryos to promote formation of a vegetal dorsalizing center

1991 • 651 citations

Activins are expressed early in Xenopus embryogenesis and can induce axial mesoderm and anterior structures

1990 • 600 citations

The TGF-beta family mediator Smad1 is phosphorylated directly and activated functionally by the BMP receptor kinase.

1997 • 569 citations

A truncated activin receptor inhibits mesoderm induction and formation of axial structures in Xenopus embryos

1992 • 538 citations

Studies with a Xenopus BMP receptor suggest that ventral mesoderm-inducing signals override dorsal signals in vivo

1994 • 463 citations

A structural basis for mutational inactivation of the tumour suppressor Smad4

1997 • 459 citations

A truncated bone morphogenetic protein receptor affects dorsal-ventral patterning in the early Xenopus embryo.

1994 • 449 citations

Dual role of the Smad4/DPC4 tumor suppressor in TGFβ-inducible transcriptional complexes

1997 • 439 citations

Xenopus Mad Proteins Transduce Distinct Subsets of Signals for the TGFβ Superfamily

1996 • 432 citations

Daughters against dpp modulates dpp organizing activity in Drosophila wing development

1997 • 426 citations

Mutations increasing autoinhibition inactivate tumour suppressors Smad2 and Smad4

1997 • 365 citations

Mesodermal induction in early amphibian embryos by activin A (erythroid differentiation factor)

1990 • 357 citations

Concentration-dependent patterning of the Xenopus ectoderm by BMP4 and its signal transducer Smad1

1997 • 354 citations

A novel mesoderm inducer, Madr2, functions in the activin signal transduction pathway.

1996 • 351 citations

Vascular MAD s: Two novel MAD -related genes selectively inducible by flow in human vascular endothelium

1997 • 325 citations

The tumor suppressor Smad4/DPC 4 as a central mediator of Smad function

1997 • 317 citations

Activation of Signalling by the Activin Receptor Complex

1996 • 317 citations

Frequency of Smad gene mutations in human cancers.

1997 • 289 citations

Cephalic expression and molecular characterization of Xenopus En-2

1991 • 289 citations

TGF-β signalling through the Smad pathway

1997 • 265 citations

Signaling via hetero-oligomeric complexes of type I and type II serine/threonine kinase receptors

1996 • 250 citations

Activin-like factor from a Xenopus laevis cell line responsible for mesoderm induction

1990 • 235 citations

Embryonic Patterning: To BMP or Not to BMP, That Is the Question

1997 • 221 citations

Heteromeric and Homomeric Interactions Correlate with Signaling Activity and Functional Cooperativity of Smad3 and Smad4/DPC4

1997 • 207 citations

Serine/threonine kinase receptors: mediators of transforming growth factor beta family signals.

1996 • 197 citations

Mothers against dpp encodes a conserved cytoplasmic protein required in DPP/TGF-β responsive cells

1996 • 174 citations

Xenopus mothers against decapentaplegic is an embryonic ventralizing agent that acts downstream of the BMP-2/4 receptor

1996 • 172 citations

Smad5 Induces Ventral Fates inXenopusEmbryo

1997 • 157 citations

Mammalian dwarfins are phosphorylated in response to transforming growth factor beta and are implicated in control of cell growth.

1996 • 146 citations

Vertebrate Neural Induction: Inducers, Inhibitors, and a New Synthesis

1997 • 131 citations

A Dominant Negative Bone Morphogenetic Protein 4 Receptor Causes Neuralization in Xenopus Ectoderm

1995 • 127 citations

Serine Phosphorylation, Chromosomal Localization, and Transforming Growth Factor-β Signal Transduction by Human

1996 • 89 citations

Cloning and Characterization of a Novel Member of the Human Mad Gene Family (MADH6)

1997 • 53 citations