Xenopus Smad4β Is the Co-Smad Component of Developmentally Regulated Transcription Factor Complexes Responsible for Induction of Early Mesodermal Genes

TGF-β SIGNAL TRANSDUCTION

1998 • 7,582 citations

Normal Table of Xenopus Laevis (Daudin)

1958 • 4,561 citations

Normal table of Xenopus laevis (Daudin)

1995 • 2,955 citations

DPC4 , A Candidate Tumor Suppressor Gene at Human Chromosome 18q21.1

1996 • 2,320 citations

The Rho family GTPases RhoA, Racl , and CDC42Hsregulate transcriptional activation by SRF

1995 • 1,280 citations

Transcriptional Activators of TGF-β Responses: Smads

1998 • 1,024 citations

TGF-beta receptor-mediated signalling through Smad2, Smad3 and Smad4

1997 • 1,023 citations

A mechanism of repression of TGFbeta / Smad signaling by oncogenic Ras

1999 • 1,004 citations

Partnership between DPC4 and SMAD proteins in TGF-β signalling pathways

1996 • 899 citations

Opposing BMP and EGF signalling pathways converge on the TGF-β family mediator Smad1

1997 • 867 citations

FORMATION AND FUNCTION OF SPEMANN'S ORGANIZER

1997 • 836 citations

MADR1, a MAD-Related Protein That Functions in BMP2 Signaling Pathways

1996 • 710 citations

Crystal Structure of a Smad MH1 Domain Bound to DNA

1998 • 709 citations

A transcriptional partner for MAD proteins in TGF-β signalling

1996 • 699 citations

DPC4 gene in various tumor types.

1996 • 680 citations

Bone morphogenetic proteins in development

2004 • 678 citations

A human Mad protein acting as a BMP-regulated transcriptional activator

1996 • 674 citations

Bone morphogenetic protein 4: a ventralizing factor in early Xenopus development

1992 • 573 citations

Identification and Functional Characterization of a Smad Binding Element (SBE) in the JunB Promoter That Acts as a Transforming Growth Factor-β, Activin, and Bone Morphogenetic Protein-inducible Enhancer

1998 • 562 citations

Caenorhabditis elegans genes sma-2, sma-3, and sma-4 define a conserved family of transforming growth factor beta pathway components.

1996 • 528 citations

THE TUMOR SUPPRESSOR GENES

1993 • 509 citations

Graded changes in dose of a Xenopus activin A homologue elicit stepwise transitions in embryonic cell fate

1990 • 508 citations

The tumor suppressor gene Smad4/Dpc4 is required for gastrulation and later for anterior development of the mouse embryo

1998 • 494 citations

Smads and early developmental signaling by the TGFβ superfamily

1998 • 485 citations

The Role of Maternal VegT in Establishing the Primary Germ Layers in Xenopus Embryos

1998 • 477 citations

Specific Activation of Smad1 Signaling Pathways by the BMP7 Type I Receptor, ALK2

1998 • 472 citations

Dual role of the Smad4/DPC4 tumor suppressor in TGFβ-inducible transcriptional complexes

1997 • 439 citations

Xenopus Mad Proteins Transduce Distinct Subsets of Signals for the TGFβ Superfamily

1996 • 432 citations

Nodal-related signals induce axial mesoderm and dorsalize mesoderm during gastrulation

1995 • 415 citations

Mutations increasing autoinhibition inactivate tumour suppressors Smad2 and Smad4

1997 • 365 citations

Concentration-dependent patterning of the Xenopus ectoderm by BMP4 and its signal transducer Smad1

1997 • 354 citations

A nodal-related gene defines a physical and functional domain within the Spemann organizer

1995 • 332 citations

Activin signalling and response to a morphogen gradient

1994 • 328 citations

The tumor suppressor Smad4/DPC 4 as a central mediator of Smad function

1997 • 317 citations

The DAF-3 Smad protein antagonizes TGF-β-related receptor signaling in the Caenorhabditis elegansdauer pathway

1997 • 197 citations

TGF-β signals and a prepattern in Xenopus laevis endodermal development

1996 • 196 citations

derrière: a TGF-β family member required for posterior development in Xenopus

1999 • 178 citations

Modifications of Vectors pEF-BOS, pcDNA1 and pcDNA3 Result in Improved Convenience and Expression

1996 • 159 citations

Medea is a Drosophila Smad4 homolog that is differentially required to potentiate DPP responses

1998 • 153 citations

Characterization of Functional Domains within Smad4/DPC4

1997 • 151 citations

Transcriptional activating activity of Smad4: Roles of SMAD hetero-oligomerization and enhancement by an associating transactivator

1998 • 139 citations

Regulation of the fibroblast growth factor receptor in early Xenopus embryos.

1990 • 135 citations

Genes for bone morphogenetic proteins are differentially transcribed in early amphibian embryos

1992 • 132 citations

Activins are expressed in preimplantation mouse embryos and in ES and EC cells and are regulated on their differentiation

1993 • 125 citations

The Drosophila Medea gene is required downstream of dpp and encodes a functional homolog of human Smad4

1998 • 113 citations

The Drosophila gene Medea demonstrates the requirement for different classes of Smads in dpp signaling

1998 • 112 citations

Destruction of Xenopus cyclins A and B2, but not B1, requires binding to p34cdc2.

1994 • 111 citations

Chapter 2 Genetics of Xenopus laevis

1991 • 111 citations

Identification of a potential regulator of early transcriptional responses to mesoderm inducers in the frog embryo.

1995 • 110 citations

Identification of Two Smad4 Proteins in Xenopus

1999 • 95 citations

DNA Sequences Mediating the Transcriptional Response of theMix.2Homeobox Gene to Mesoderm Induction

1996 • 79 citations

The DAF-3 Smad binds DNA and represses gene expression in the Caenorhabditis elegans pharynx

1999 • 67 citations

XSmad2 directly activates the activin-inducible, dorsal mesoderm gene XFKH1 in Xenopus embryos

1997 • 67 citations

Cytoplasmic retention of Xenopus nuclear factor 7 before the mid blastula transition uses a unique anchoring mechanism involving a retention domain and several phosphorylation sites

1994 • 64 citations

Spemann organizer activity of Smad10

1999 • 49 citations

Smad4 (DPC4) - a potent tumour suppressor?

1998 • 42 citations

Finely Tuned Regulation of Cytoplasmic Retention of Xenopus Nuclear Factor 7 by Phosphorylation of Individual Threonine Residues

1996 • 24 citations

Signalling to the nucleus by members of the transforming growth factor-β (TGF-β) superfamily

1996 • 23 citations

Mitogen-activated Protein Kinase and Cyclin B/Cdc2 PhosphorylateXenopus Nuclear Factor 7 (xnf7) in Extracts from Mature Oocytes

1997 • 18 citations