Transforming Growth Factor-β: Latent Forms, Binding Proteins and Receptors

Signal transduction by receptors with tyrosine kinase activity

1990 • 5,528 citations

The Transforming Growth Factor-beta Family

1990 • 3,028 citations

Human transforming growth factor-β complementary DNA sequence and expression in normal and transformed cells

1985 • 1,687 citations

Negative regulation of transforming growth factor-β by the proteoglycan decorin

1990 • 1,490 citations

Molecular Cloning of the Interleukin-1β Converting Enzyme

1992 • 1,115 citations

Expression cloning of the TGF-β type II receptor, a functional transmembrane serine/threonine kinase

1992 • 1,071 citations

Suppression of experimental glomerulonephritis by antiserum against transforming growth factor β1

1990 • 1,002 citations

Evidence that transforming growth factor-β is a hormonally regulated negative growth factor in human breast cancer cells

1987 • 998 citations

Proteolytic activation of latent transforming growth factor-beta from fibroblast-conditioned medium.

1988 • 962 citations

Inhibition of endothelial cell movement by pericytes and smooth muscle cells: activation of a latent transforming growth factor-beta 1-like molecule by plasmin during co-culture.

1989 • 914 citations

Specific EGF repeats of Notch mediate interactions with Delta and serrate: Implications for notch as a multifunctional receptor

1991 • 770 citations

An activated form of transforming growth factor beta is produced by cocultures of endothelial cells and pericytes.

1989 • 767 citations

Expression cloning of an activin receptor, a predicted transmembrane serine kinase

1991 • 760 citations

The Transforming Growth Factor-βs

1990 • 741 citations

Mechanism of activation of latent recombinant transforming growth factor beta 1 by plasmin.

1990 • 740 citations

Transforming growth factor-beta and the initiation of chondrogenesis and osteogenesis in the rat femur.

1990 • 734 citations

Structure and expression of the membrane proteoglycan betaglycan, a component of the TGF-β receptor system

1991 • 661 citations

Transforming Growth Factors β1 and α in Chronic Liver Disease

1991 • 655 citations

Latent high molecular weight complex of transforming growth factor beta 1. Purification from human platelets and structural characterization.

1988 • 648 citations

Expression cloning and characterization of the TGF-β type III receptor

1991 • 638 citations

Control of scarring in adult wounds by neutralising antibody to transforming growth factor β

1992 • 624 citations

Distribution and modulation of the cellular receptor for transforming growth factor-beta.

1987 • 556 citations

Latent transforming growth factor-beta from human platelets. A high molecular weight complex containing precursor sequences.

1988 • 548 citations

The cell biology of transforming growth factor β

1990 • 537 citations

Cellular activation of latent transforming growth factor beta requires binding to the cation-independent mannose 6-phosphate/insulin-like growth factor type II receptor.

1991 • 521 citations

A role of the latent TGF-beta 1-binding protein in the assembly and secretion of TGF-beta 1.

1991 • 509 citations

Novel activin receptors: Distinct genes and alternative mRNA splicing generate a repertoire of serine/threonine kinase receptors

1992 • 495 citations

Primary structure of endoglin, an RGD-containing glycoprotein of human endothelial cells.

1990 • 450 citations

TGF-β1 binding protein: A component of the large latent complex of TGF-β1 with multiple repeat sequences

1990 • 447 citations

Latent transforming growth factor-beta in serum. A specific complex with alpha 2-macroglobulin.

1987 • 434 citations

Two forms of transforming growth factor-β distinguished by multipotential haematopoietic progenitor cells

1987 • 407 citations

A new type of transforming growth factor-beta, TGF-beta 3.

1988 • 396 citations

Immunosuppression and transforming growth factor-beta in glioblastoma. Preferential production of transforming growth factor-beta 2.

1989 • 391 citations

Partial sequence of a candidate gene for the Marfan syndrome

1991 • 370 citations

Transforming growth factor β type 1 binds to collagen IV of basement membrane matrix: Implications for development

1991 • 350 citations

Membrane-anchored and soluble forms of betaglycan, a polymorphic proteoglycan that binds transforming growth factor-beta.

1989 • 346 citations

Physicochemical Activation of Recombinant Latent Transforming Growth Factor-beta's 1, 2, and 3

1990 • 343 citations

Distinct transforming growth factor-beta (TGF-beta) receptor subsets as determinants of cellular responsiveness to three TGF-beta isoforms

1990 • 342 citations

Retinoic acid induces transforming growth factor-beta 2 in cultured keratinocytes and mouse epidermis.

1989 • 333 citations

Identification of another member of the transforming growth factor type beta gene family.

1988 • 326 citations

Concomitant loss of transforming growth factor (TGF)-beta receptor types I and II in TGF-beta-resistant cell mutants implicates both receptor types in signal transduction.

1990 • 319 citations

daf-1, a C. elegans gene controlling dauer larva development, encodes a novel receptor protein kinase

1990 • 293 citations

Activation of the bone-derived latent TGF beta complex by isolated osteoclasts

1989 • 281 citations

Molecular events in the processing of recombinant type 1 pre-pro-transforming growth factor beta to the mature polypeptide.

1988 • 273 citations

Role for carbohydrate structures inTGF-β1 latency

1989 • 270 citations

Requirement for Activin a and Transforming Growth Factor--β1 Pro-Regions in Homodimer Assembly

1990 • 266 citations

Transforming growth factor-beta complexes with thrombospondin.

1992 • 256 citations

Responsiveness to transforming growth factor-beta (TGF-beta) restored by genetic complementation between cells defective in TGF-beta receptors I and II

1991 • 252 citations

The transforming growth factor-beta receptor type III is a membrane proteoglycan. Domain structure of the receptor.

1988 • 240 citations

Cloning of a Second Type of Activin Receptor and Functional Characterization in Xenopus Embryos

1992 • 226 citations

Transforming growth factor-beta activity is potentiated by heparin via dissociation of the transforming growth factor-beta/alpha 2-macroglobulin inactive complex.

1989 • 225 citations

Type 1 Transforming Growth Factor Beta: Amplified Expression and Secretion of Mature and Precursor Polypeptides in Chinese Hamster Ovary Cells

1987 • 224 citations

Site-directed Mutagenesis of Cysteine Residues in the Pro Region of the Transforming Growth Factor β1 Precursor

1989 • 220 citations

Identification of mannose 6-phosphate in two asparagine-linked sugar chains of recombinant transforming growth factor-beta 1 precursor.

1988 • 211 citations

Human transforming growth factor beta.alpha 2-macroglobulin complex is a latent form of transforming growth factor beta.

1988 • 209 citations

The many faces of epidermal growth factor repeats.

1990 • 197 citations

The pro domain of pre-pro-transforming growth factor .beta.1 when independently expressed is a functional binding protein for the mature growth factor

1990 • 185 citations

Transforming growth factor-beta 1, -beta 2, and -beta 3 secreted by a human glioblastoma cell line. Identification of small and different forms of large latent complexes.

1992 • 181 citations

The high molecular weight receptor to transforming growth factor-beta contains glycosaminoglycan chains.

1988 • 178 citations

The autocrine production of transforming growth factor-beta 1 during lymphocyte activation. A study with a monoclonal antibody-based ELISA.

1990 • 169 citations

Molecular cloning of the large subunit of transforming growth factor type beta masking protein and expression of the mRNA in various rat tissues.

1990 • 162 citations

Involvement of transforming growth factor-beta in the formation of fibrotic lesions in carcinoid heart disease.

1993 • 160 citations

Binding of Transforming Growth Factor-β to Cell Surface Proteins Varies with Cell Type

1989 • 160 citations

Intron-exon structure of the human transforming growth factor-β precursor gene

1987 • 159 citations

Differential inhibition of transforming growth factor beta 1 and beta 2 activity by alpha 2-macroglobulin.

1990 • 148 citations

Fibronectin‐associated transforming growth factor

1987 • 148 citations

Type 1 transforming growth factor beta: amplified expression and secretion of mature and precursor polypeptides in Chinese hamster ovary cells.

1987 • 147 citations

Transforming growth factor-beta (TGF-beta) isoforms in rat liver regeneration: messenger RNA expression and activation of latent TGF-beta.

1991 • 145 citations

Transforming growth factors and control of neoplastic cell growth

1987 • 141 citations

Immunoregulatory role of transforming growth factor beta (TGF-beta) in development of killer cells: comparison of active and latent TGF-beta 1.

1990 • 139 citations

An alpha 2-macroglobulin receptor-dependent mechanism for the plasma clearance of transforming growth factor-beta 1 in mice.

1991 • 139 citations

The growth inhibition of human breast cancer cells by a novel synthetic progestin involves the induction of transforming growth factor beta.

1991 • 122 citations

Autocrine induction of tumor protease production and invasion by a metallothionein-regulated TGF-beta 1 (Ser223, 225).

1992 • 121 citations

A transforming growth factor beta 2 (TGF-beta 2)-like immunosuppressive factor in amniotic fluid and localization of TGF-beta 2 mRNA in the pregnant uterus.

1990 • 120 citations

Latent Forms of Transforming Growth Factor-β (TGFβ) Derived from Bone Cultures: Identification of a Naturally Occurring 100-kDa Complex with Similarity to Recombinant Latent TGFβ

1991 • 119 citations

Membrane binding characteristics of two forms of transforming growth factor-beta.

1987 • 118 citations

Growth stimulation of human breast cancer cells with anti-transforming growth factor beta antibodies: evidence for negative autocrine regulation by transforming growth factor beta.

1990 • 118 citations

Latent beta-transforming growth factor in nontransformed and Kirsten sarcoma virus-transformed normal rat kidney cells, clone 49F.

1984 • 112 citations

Immunoelectron microscopic localization of transforming growth factor beta 1 and latent transforming growth factor beta 1 binding protein in human gastrointestinal carcinomas: qualitative difference between cancer cells and stromal cells.

1993 • 105 citations

A surface component on GH3 pituitary cells that recognizes transforming growth factor-beta, activin, and inhibin.

1988 • 103 citations

Retention of the transforming growth factor-beta 1 precursor in the Golgi complex in a latent endoglycosidase H-sensitive form.

1992 • 92 citations

Isoform-specific transforming growth factor-beta binding proteins with membrane attachments sensitive to phosphatidylinositol-specific phospholipase C.

1991 • 80 citations

Interaction of transforming growth factor-beta 1 with alpha 2-macroglobulin. Role in transforming growth factor-beta 1 clearance.

1991 • 76 citations

Identification and analysis of discrete functional domains in the pro region of pre-pro-transforming growth factor beta 1.

1991 • 69 citations

Purification of a new type high molecular weight receptor (type V receptor) of transforming growth factor beta (TGF-beta) from bovine liver. Identification of the type V TGF-beta receptor in cultured cells

1991 • 68 citations

Transforming Growth Factor β1: Importance of Glycosylaytion and Acidic Proteases for Processing and Secretion

1989 • 64 citations

Purification of transforming growth factor-beta 1 binding proteins from porcine uterus membranes.

1991 • 62 citations

Transforming growth factor-beta bound to soluble derivatives of the beta amyloid precursor protein of Alzheimer's disease

1990 • 60 citations

Dominant Negative Mutants of Transforming Growth Factor-βl Inhibit the Secretion of Different Transforming Growth Factor-β Isoforms

1992 • 59 citations

Purification and Structural Analysis of a Latent Form of Transforming Growth Factor-β from Rat Platelets1

1989 • 50 citations

Subtypes of betaglycan and of type I and type II transforming growth factor‐β (TGF‐β) receptors with different affinities for TGF‐β1 and TGF‐β2 are exhibited by human placental trophoblast cells

1992 • 49 citations

Novel 150- and 180-kDa glycoproteins that bind transforming growth factor (TGF)-beta 1 but not TGF-beta 2 are present in several cell lines

1991 • 41 citations

Identification of disulfide-linked transforming growth factor-beta 1-specific binding proteins in rat glomeruli.

1990 • 41 citations

Dominant negative mutants of transforming growth factor-beta 1 inhibit the secretion of different transforming growth factor-beta isoforms.

1992 • 40 citations

Binding of transforming growth factor-β1 to methylamine-modified α2-macroglobulin and to binary and ternary α2-macroglobulin-proteinase complexes

1992 • 37 citations

Two novel patterns of transforming growth factor beta (TGF-beta) binding to cell surface proteins are dependent upon the binding of TGF-beta 1 and indicate a mechanism of positive cooperativity.

1992 • 35 citations

Characterization of the binding of transforming growth factor-beta 1, -beta 2, and -beta 3 to recombinant beta 1-latency-associated peptide.

1992 • 33 citations

High-Level Expression of TGF-β2 and the TGF-β2(414) Precursor in Chinese Hamster Ovary Cells

1990 • 26 citations

Ca²⁺ binding of latent transforming growth factor‐β1 binding protein

1993 • 24 citations

Latent form of transforming growth factor-β1 acts as a potent growth inhibitor on a human erythroleukemia cell line

1990 • 22 citations

Characterization of Latent Transforming Growth Factor-β2 from Monkey Kidney Cells

1991 • 16 citations

Phenotypic alterations in fibroblasts and fibrosarcoma cells that overexpress latent transforming growth factor-beta 1.

1992 • 16 citations

The 260-kDa transforming growth factor (TGF)-beta binding protein in rat glomeruli is a complex comprised of 170- and 85-kDa TGF-beta binding proteins.

1992 • 12 citations