Cellular interpretation of multiple TGF-β signals: intracellular antagonism between activin/BVg1 and BMP-2/4 signaling mediated by Smads

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Firefly luciferase gene: structure and expression in mammalian cells.

1987 • 3,088 citations

Normal table of Xenopus laevis (Daudin)

1995 • 2,955 citations

Mechanism of activation of the TGF-β receptor

1994 • 2,298 citations

Bone morphogenetic proteins: multifunctional regulators of vertebrate development.

1996 • 1,959 citations

The Spemann Organizer Signal noggin Binds and Inactivates Bone Morphogenetic Protein 4

1996 • 1,604 citations

Functional messenger RNAs are produced by SP6in vitrotranscription of cloned cDNAs

1984 • 1,533 citations

Dorsoventral Patterning in Xenopus: Inhibition of Ventral Signals by Direct Binding of Chordin to BMP-4

1996 • 1,126 citations

Firefly Luciferase Gene: Structure and Expression in Mammalian Cells

1987 • 924 citations

Partnership between DPC4 and SMAD proteins in TGF-β signalling pathways

1996 • 899 citations

Direct and Long-Range Action of a DPP Morphogen Gradient

1996 • 896 citations

Receptor-associated Mad homologues synergize as effectors of the TGF-β response

1996 • 874 citations

MADR2 Maps to 18q21 and Encodes a TGFβ–Regulated MAD–Related Protein That Is Functionally Mutated in Colorectal Carcinoma

1996 • 855 citations

TGFβ Signaling: Receptors, Transducers, and Mad Proteins

1996 • 840 citations

Molecular nature of Spemann's organizer: the role of the Xenopus homeobox gene goosecoid

1991 • 799 citations

MADR2 Is a Substrate of the TGFβ Receptor and Its Phosphorylation Is Required for Nuclear Accumulation and Signaling

1996 • 740 citations

Identification of type I receptors for osteogenic protein-1 and bone morphogenetic protein-4.

1994 • 737 citations

MADR1, a MAD-Related Protein That Functions in BMP2 Signaling Pathways

1996 • 710 citations

A transcriptional partner for MAD proteins in TGF-β signalling

1996 • 699 citations

GS domain mutations that constitutively activate T beta R-I, the downstream signaling component in the TGF-beta receptor complex.

1995 • 682 citations

A human Mad protein acting as a BMP-regulated transcriptional activator

1996 • 674 citations

Genetic characterization and cloning of mothers against dpp, a gene required for decapentaplegic function in Drosophila melanogaster.

1995 • 672 citations

Activins are expressed early in Xenopus embryogenesis and can induce axial mesoderm and anterior structures

1990 • 600 citations

Bone morphogenetic protein 4: a ventralizing factor in early Xenopus development

1992 • 573 citations

Cloning and characterization of a human type II receptor for bone morphogenetic proteins.

1995 • 551 citations

Caenorhabditis elegans genes sma-2, sma-3, and sma-4 define a conserved family of transforming growth factor beta pathway components.

1996 • 528 citations

Drosophila Mad binds to DNA and directly mediates activation of vestigial by Decapentaplegic

1997 • 524 citations

Osteogenic protein-1 binds to activin type II receptors and induces certain activin-like effects.

1995 • 510 citations

Graded changes in dose of a Xenopus activin A homologue elicit stepwise transitions in embryonic cell fate

1990 • 508 citations

DVR-4 (Bone Morphogenetic Protein-4) as a posterior-ventralizing factor in Xenopus mesoderm induction

1992 • 488 citations

Studies with a Xenopus BMP receptor suggest that ventral mesoderm-inducing signals override dorsal signals in vivo

1994 • 463 citations

A structural basis for mutational inactivation of the tumour suppressor Smad4

1997 • 459 citations

A truncated bone morphogenetic protein receptor affects dorsal-ventral patterning in the early Xenopus embryo.

1994 • 449 citations

Xenopus Mad Proteins Transduce Distinct Subsets of Signals for the TGFβ Superfamily

1996 • 432 citations

Processed Vg1 protein is an axial mesoderm inducer in xenopus

1993 • 417 citations

Nodal-related signals induce axial mesoderm and dorsalize mesoderm during gastrulation

1995 • 415 citations

On the function of BMP-4 in patterning the marginal zone of the Xenopus embryo.

1994 • 396 citations

Disruption of BMP signals in embryonic Xenopus ectoderm leads to direct neural induction.

1995 • 368 citations

A novel mesoderm inducer, Madr2, functions in the activin signal transduction pathway.

1996 • 351 citations

A nodal-related gene defines a physical and functional domain within the Spemann organizer

1995 • 332 citations

Antagonizing the Spemann organizer: role of the homeobox gene Xvent-1.

1995 • 331 citations

Anterior neurectoderm is progressively induced during gastrulation: the role of the Xenopus homeobox gene orthodenticle

1995 • 317 citations

Characterization and relationship of dpp receptors encoded by the saxophone and thick veins genes in Drosophila

1994 • 317 citations

The tumor suppressor Smad4/DPC 4 as a central mediator of Smad function

1997 • 317 citations

Genetic screens to identify elements of the decapentaplegic signaling pathway in Drosophila.

1995 • 306 citations

Drosophila Dpp signaling is mediated by the punt gene product: A dual ligand-binding type II receptor of the TGFβ receptor family

1995 • 275 citations

The Xvent-2 homeobox gene is part of the BMP-4 signalling pathway controling dorsoventral patterning of Xenopus mesoderm

1996 • 275 citations

Localized BMP-4 Mediates Dorsal/Ventral Patterning in the Early Xenopus Embryo

1995 • 229 citations

Molecular mechanisms of Spemann's organizer formation: conserved growth factor synergy between Xenopus and mouse.

1995 • 225 citations

Heteromeric and Homomeric Interactions Correlate with Signaling Activity and Functional Cooperativity of Smad3 and Smad4/DPC4

1997 • 207 citations

Secretion and mesoderm-inducing activity of the TGF-beta-related domain of Xenopus Vg1.

1993 • 177 citations

Mothers against dpp encodes a conserved cytoplasmic protein required in DPP/TGF-β responsive cells

1996 • 174 citations

Xenopus mothers against decapentaplegic is an embryonic ventralizing agent that acts downstream of the BMP-2/4 receptor

1996 • 172 citations

Intracellular signalling: The Mad way to do it

1996 • 162 citations

Induction of dorsal mesoderm by soluble, mature Vg1 protein

1995 • 150 citations

Mammalian dwarfins are phosphorylated in response to transforming growth factor beta and are implicated in control of cell growth.

1996 • 146 citations

Bone morphogenetic protein-4 (BMP-4) acts during gastrula stages to cause ventralization of Xenopus embryos

1996 • 143 citations

The role of gsc and BMP-4 in dorsal-ventral patterning of the marginal zone in Xenopus: a loss-of-function study using antisense RNA.

1995 • 137 citations

Genes for bone morphogenetic proteins are differentially transcribed in early amphibian embryos

1992 • 132 citations

Identification of a Drosophila activin receptor.

1993 • 114 citations

Mesodern-inducing factors and mesodermal patterning

1995 • 113 citations

TGF-β related genes in development

1994 • 96 citations

Differential expression of Xenopus BMPs in early embryos and tissues.

1993 • 30 citations

Biosynthesis of protease nexin-I.

1986 • 16 citations