Myofibroblasts. I. Paracrine cells important in health and disease

Rho GTPases and the Actin Cytoskeleton

1998 • 6,129 citations

Gain-of-Function Mutations of c- kit in Human Gastrointestinal Stromal Tumors

1998 • 4,380 citations

Biologic basis for interleukin-1 in disease

1996 • 4,324 citations

Transforming Growth Factor β in Tissue Fibrosis

1994 • 3,055 citations

Pericyte Loss and Microaneurysm Formation in PDGF-B-Deficient Mice

1997 • 2,136 citations

IL-6 is an antiinflammatory cytokine required for controlling local or systemic acute inflammatory responses.

1998 • 1,463 citations

Presence of modified fibroblasts in granulation tissue and their possible role in wound contraction

1971 • 1,458 citations

The Cellular Basis of Hepatic Fibrosis -- Mechanisms and Treatment Strategies

1993 • 1,444 citations

W/kit gene required for interstitial cells of Cajal and for intestinal pacemaker activity

1995 • 1,398 citations

Pathophysiology of Progressive Nephropathies

1998 • 1,250 citations

Alpha-smooth muscle actin is transiently expressed by myofibroblasts during experimental wound healing.

1990 • 1,176 citations

Apoptosis mediates the decrease in cellularity during the transition between granulation tissue and scar.

1995 • 1,167 citations

The Pathophysiologic Roles of Interleukin-6 in Human Disease

1998 • 1,132 citations

Mice deficient for PDGF B show renal, cardiovascular, and hematological abnormalities.

1994 • 1,123 citations

Mechanisms of spontaneous resolution of rat liver fibrosis. Hepatic stellate cell apoptosis and reduced hepatic expression of metalloproteinase inhibitors.

1998 • 1,032 citations

A Structural Scaffolding of Intermediate Filaments in Health and Disease

1998 • 1,003 citations

Abnormal kidney development and hematological disorders in PDGF beta-receptor mutant mice.

1994 • 984 citations

A case for interstitial cells of Cajal as pacemakers and mediators of neurotransmission in the gastrointestinal tract

1996 • 970 citations

Identification, culture, and characterization of pancreatic stellate cells in rats and humans

1998 • 961 citations

Insulin-Like Growth Factors

1997 • 897 citations

Duration of exposure to gluten and risk for autoimmune disorders in patients with celiac disease

1999 • 892 citations

Periacinar stellate shaped cells in rat pancreas: identification, isolation, and culture

1998 • 884 citations

Connective tissue growth factor: a cysteine-rich mitogen secreted by human vascular endothelial cells is related to the SRC-induced immediate early gene product CEF-10.

1991 • 878 citations

PDGF-A Signaling Is a Critical Event in Lung Alveolar Myofibroblast Development and Alveogenesis

1996 • 867 citations

Differentiation repertoire of fibroblastic cells: expression of cytoskeletal proteins as marker of phenotypic modulations.

1990 • 838 citations

Regulation of cell number in the mammalian gastrointestinal tract: the importance of apoptosis

1994 • 820 citations

The Fibronectin Domain ED-A Is Crucial for Myofibroblastic Phenotype Induction by Transforming Growth Factor-β1

1998 • 801 citations

Expression and function of c-kit in hemopoietic progenitor cells.

1991 • 756 citations

Connective tissue growth factor: a mediator of TGF-β action on fibroblasts

1997 • 743 citations

Regulation of connective tissue growth factor gene expression in human skin fibroblasts and during wound repair.

1993 • 706 citations

PDGF and FGF stimulate wound healing in the genetically diabetic mouse.

1990 • 689 citations

Expressional control of the ‘constitutive’ isoforms of nitric oxide synthase (NOS I and NOS III)

1998 • 651 citations

Unconventional Myosins in Cell Movement, Membrane Traffic, and Signal Transduction

1998 • 649 citations

The fibronexus: a transmembrane association of fibronectin-containing fibers and bundles of 5 nm microfilaments in hamster and human fibroblasts

1979 • 536 citations

Induction of alpha-smooth muscle actin by transforming growth factor-beta 1 in quiescent human breast gland fibroblasts. Implications for myofibroblast generation in breast neoplasia.

1993 • 511 citations

Insulin-like growth factor binding proteins and their role in controlling IGF actions

1997 • 510 citations

The rat canalicular conjugate export pump (Mrp2) is down-regulated in intrahepatic and obstructive cholestasis

1997 • 502 citations

Gastric Mucosa Abnormalities and Tumorigenesis in Mice Lacking the pS2 Trefoil Protein

1996 • 498 citations

Myofibroblasts differentiate from fibroblasts when plated at low density.

1996 • 482 citations

Induction of a novel epidermal growth factor-secreting cell lineage by mucosal ulceration in human gastrointestinal stem cells

1990 • 465 citations

Cytokine modulation of intestinal epithelial cell restitution: Central role of transforming growth factor β

1993 • 446 citations

Expression of variant fibronectins in wound healing: cellular source and biological activity of the EIIIA segment in rat hepatic fibrogenesis.

1994 • 444 citations

Heterogeneity of myofibroblast phenotypic features: an example of fibroblastic cell plasticity

1994 • 431 citations

The origin of the myofibroblasts in breast cancer. Recapitulation of tumor environment in culture unravels diversity and implicates converted fibroblasts and recruited smooth muscle cells.

1995 • 425 citations

Fibrogenic cytokines and connective tissue production

1994 • 425 citations

High glucose-induced transforming growth factor beta1 production is mediated by the hexosamine pathway in porcine glomerular mesangial cells.

1998 • 418 citations

Cell-specific expression of transforming growth factor-beta in rat liver. Evidence for autocrine regulation of hepatocyte proliferation.

1995 • 414 citations

Tubular epithelial-myofibroblast transdifferentiation in progressive tubulointerstitial fibrosis in 5/6 nephrectomized rats

1998 • 402 citations

Role of insulin-like growth factor binding proteins in controlling IGF actions

1998 • 401 citations

Cultured lung fibroblasts isolated from patients with idiopathic pulmonary fibrosis have a diminished capacity to synthesize prostaglandin E2 and to express cyclooxygenase-2.

1995 • 385 citations

Interleukin (IL) 4 and IL-13 act on human lung fibroblasts. Implication in asthma.

1998 • 353 citations

Angiotensin II Stimulated Expression of Transforming Growth Factor-β1in Cardiac Fibroblasts and Myofibroblasts

1997 • 350 citations

Expression of tissue inhibitor of metalloproteinases 1 and 2 is increased in fibrotic human liver

1996 • 349 citations

The cellular and molecular basis of gastric mucosal defense

1996 • 346 citations

Desmoid tumours in familial adenomatous polyposis.

1994 • 345 citations

Evidence of Fibroblast Heterogeneity and the Role of Fibroblast Subpopulations in Fibrosis

1994 • 343 citations

Trefoil peptide protection of intestinal epithelial barrier function: Cooperative interaction with mucin glycoprotein

1995 • 342 citations

Epidermal growth factor-related peptides and their relevance to gastrointestinal pathophysiology

1995 • 329 citations

The extracellular matrix in hepatic regeneration

1995 • 325 citations

Keratinocyte growth factor

1995 • 321 citations

Nitric oxide in excitable tissues: physiological roles and disease.

1997 • 312 citations

A Transforming Growth Factor β (TGFβ) Control Element Drives TGFβ-induced Stimulation of Smooth Muscle α-Actin Gene Expression in Concert with Two CArG Elements

1997 • 297 citations

Regulation of Fibroplasia in Cutaneous Wound Repair

1993 • 295 citations

Interstitial cells of Cajal in human colon and in Hirschsprung's disease

1996 • 292 citations

Hepatic fibrosis, glomerulosclerosis, and a lipodystrophy-like syndrome in PEPCK-TGF-beta1 transgenic mice.

1997 • 281 citations

Keratinocyte growth factor induces proliferation of hepatocytes and epithelial cells throughout the rat gastrointestinal tract.

1994 • 276 citations

Intestinal subepithelial myofibroblasts

1999 • 269 citations

Fibroblast growth factors modulate intestinal epithelial cell growth and migration

1994 • 266 citations

Epithelial-neutrophil activating peptide (ENA-78) is an important angiogenic factor in non-small cell lung cancer.

1998 • 259 citations

Oral trefoil peptides protect against ethanol- and indomethacin-induced gastric injury in rats

1996 • 257 citations

Inducible nitric oxide synthase plays a critical role in resolving intestinal inflammation

1997 • 252 citations

Fibroblast contraction occurs on release of tension in attached collagen lattices: Dependency on an organized actin cytoskeleton and serum

1992 • 249 citations

Spatial and temporal patterns of c-kit-expressing cells in WlacZ/+ and WlacZ/WlacZ mouse embryos

1996 • 247 citations

Interstitial cells of Cajal direct normal propulsive contractile activity in the mouse small intestine

1998 • 246 citations

Intestinal epithelial cells both express and respond to interleukin 15

1996 • 244 citations

Impaired development of interstitial cells and intestinal electrical rhythmicity in steel mutants

1995 • 243 citations

Study of the interstitial cells of Cajal in infantile hypertrophic pyloric stenosis

1996 • 241 citations

Transdifferentiation of hepatic stellate cells (Ito cells) to myofibroblasts: a key event in hepatic fibrogenesis.

1996 • 237 citations

Molecular Aspects of Mesenchymal-Epithelial Interactions

1993 • 232 citations

Development of c-Kit-positive cells and the onset of electrical rhythmicity in murine small intestine

1997 • 232 citations

Regulation of signal transduction during liver regeneration

1996 • 228 citations

Platelet-derived growth factor-BB induces renal tubulointerstitial myofibroblast formation and tubulointerstitial fibrosis.

1996 • 224 citations

Crypt stem cell survival in the mouse intestinal epithelium is regulated by prostaglandins synthesized through cyclooxygenase-1.

1997 • 219 citations

Intestinal inflammation: a complex interplay of immune and nonimmune cell interactions

1997 • 218 citations

Astrocytes in infectious and immune‐mediated diseases of the central nervous system

1993 • 217 citations

Regulation of keratinocyte growth factor gene expression by interleukin 1.

1994 • 217 citations

Colonic pericryptal fibroblast sheath: replication, migration, and cytodifferentiation of a mesenchymal cell system in adult tissue. I. Autoradiographic studies of normal rabbit colon.

1968 • 211 citations

Hepatocyte growth factor/scatter factor effects on epithelia. Regulation of intercellular junctions in transformed and nontransformed cell lines, basolateral polarization of c-met receptor in transformed and natural intestinal epithelia, and induction of rapid wound repair in a transformed model epithelium.

1994 • 209 citations

α-Smooth muscle actin is expressed in a subpopulation of cultured and cloned fibroblasts and is modulated by γ-interferon

1992 • 209 citations

Stromal–epithelial interactions in the normal and neoplastic prostate

1997 • 208 citations

Cross-talk between cyclooxygenase and nitric oxide pathways: prostaglandin E2 negatively modulates induction of nitric oxide synthase by interleukin 1.

1994 • 207 citations

Basic fibroblast growth factor-induced activation of latent transforming growth factor beta in endothelial cells: regulation of plasminogen activator activity.

1992 • 205 citations

Mechanisms for Rapid Re-Epithelialization of the Gastric Mucosal Surface

1985 • 204 citations

Phosphatidylinositol 3-kinase is required for platelet-derived growth factor's actions on hepatic stellate cells

1997 • 202 citations

Targeted overexpression of IGF-I evokes distinct patterns of organ remodeling in smooth muscle cell tissue beds of transgenic mice.

1997 • 201 citations

Localization of intestinal interleukin 1 activity and protein and gene expression to lamina propria cells

1993 • 196 citations

Interleukin-11 prevents apoptosis and accelerates recovery of small intestinal mucosa in mice treated with combined chemotherapy and radiation.

1996 • 186 citations

Deficiency of c-kit+ cells in patients with a myopathic form of chronic idiopathic intestinal pseudo-obstruction.

1997 • 183 citations

Selective upregulation of platelet-derived growth factor alpha receptors by transforming growth factor beta in scleroderma fibroblasts.

1992 • 181 citations

Interleukin-10 modulates type I collagen and matrix metalloprotease gene expression in cultured human skin fibroblasts.

1994 • 181 citations

TR1, a new member of the tumor necrosis factor receptor superfamily, induces fibroblast proliferation and inhibits osteoclastogenesis and bone resorption

1998 • 179 citations

Extracellular matrix components in intestinal development

1995 • 178 citations

The Role of α1β1 Integrin in Wound Contraction

1997 • 177 citations

Expression pattern of heme oxygenase isoenzymes 1 and 2 in normal and stress-exposed rat liver

1998 • 176 citations

Platelet-derived Growth Factor and Fibronectin-stimulated Migration Are Differentially Regulated by the Rac and Extracellular Signal-regulated Kinase Pathways

1997 • 173 citations

Inducible nitric oxide synthase in rat hepatic lipocytes and the effect of nitric oxide on lipocyte contractility.

1995 • 172 citations

Genomic instability in the type II TGF-beta1 receptor gene in atherosclerotic and restenotic vascular cells.

1997 • 171 citations

The role of cytoskeletal and cytocontractile elements in pathologic processes.

1983 • 170 citations

IL-1 stimulates intestinal myofibroblast COX gene expression and augments activation of Cl- secretion in T84 cells

1996 • 170 citations

Healing the epithelium: Solving the problem from two sides

1997 • 167 citations

Idiopathic Pulmonary Fibrosis: Current Concepts

1998 • 166 citations

Human orbital fibroblasts are activated through CD40 to induce proinflammatory cytokine production

1998 • 160 citations

A transmembrane relationship between fibronectin and vinculin (130 kd protein): Serum modulation in normal and transformed hamster fibroblasts

1981 • 157 citations

Collagens in the liver extracellular matrix bind hepatocyte growth factor

1998 • 157 citations

Expression of intracellular adhesion molecule 1 by activated hepatic stellate cells

1996 • 154 citations

The Cellular Derivation and the Life Span of the Myofibroblast

1996 • 153 citations

Regulation of Astrocyte Morphology by RhoA and Lysophosphatidic Acid

1998 • 153 citations

Prostaglandins I2 and E2 have a synergistic role in rescuing epithelial barrier function in porcine ileum.

1997 • 152 citations

GM-CSF, IL-1α, IL-β, IL-6, IL-8, IL-10, ICAM-1 and VCAM-1 gene expression and cytokine production in human duodenal fibroblasts stimulated with lipopolysaccharide, IL-1α and TNF-α

1994 • 150 citations

Regulated overexpression of interleukin 11 in the lung. Use to dissociate development-dependent and -independent phenotypes.

1997 • 147 citations

Mast Cell and Myofibroblast in Wound Healing

1993 • 143 citations

Colonic Pericryptal Fibroblast Sheath: Replication, Migration, and Cytodifferentiation of a Mesenchymal Cell System in Adult Tissue

1968 • 141 citations

Extracellular matrix composition and gene expression in collagenous colitis

1997 • 141 citations

Cell-type-specific expression of neural cell adhesion molecule (N-CAM) in Ito cells of rat liver. Up-regulation during in vitro activation and in hepatic tissue repair.

1996 • 140 citations

Re-evaluation of fibroblasts and fibroblast-like cells

1990 • 138 citations

Temporal differences in fibroblast proliferation and phenotype expression in response to chronic administration of angiotensin II or aldosterone

1995 • 137 citations

Transforming Growth Factor-β1 Expression and Myofibroblast Formation During Arterial Repair

1996 • 136 citations

Apc1638N: A mouse model for familial adenomatous polyposis–associated desmoid tumors and cutaneous cysts

1998 • 133 citations

Tumor necrosis factor alpha regulates proliferation in a mouse intestinal cell line

1997 • 132 citations

Antioxidants Inhibit Interleukin-1-induced Cyclooxygenase and Nitric-oxide Synthase Expression in Rat Mesangial Cells

1996 • 130 citations

Expression of connective tissue growth factor mRNA in the fibrous stroma of mammary tumors

1997 • 129 citations

The Rho GTPases Have Multiple Effects on the Actin Cytoskeleton

1999 • 129 citations

Increased expression of keratinocyte growth factor messenger RNA associated with inflammatory bowel disease

1996 • 129 citations

Placental villous stroma as a model system for myofibroblast differentiation

1996 • 128 citations

Morphologic and biochemical evidence for a contractile cell network within the rat intestinal mucosa

1987 • 128 citations

Induction of Smooth Muscle Cell Phenotype in Cultured Human Prostatic Stromal Cells

1997 • 127 citations

Intestinal fibroblasts regulate intestinal epithelial cell proliferation via hepatocyte growth factor

1998 • 125 citations

Villus contraction aids repair of intestinal epithelium after injury

1989 • 124 citations

Hemeoxygenase-1 inhibits human myometrial contractility via carbon monoxide and is upregulated by progesterone during pregnancy.

1998 • 120 citations

Fibroblasts modulate intestinal secretory responses to inflammatory mediators.

1992 • 120 citations

Paracrine interactions between fibroblasts and endothelial cells in a serum-free coculture model. Modulation of angiogenesis and collagen gel contraction.

1994 • 119 citations

Role of Stromal Myofibroblasts Infiltrating Colon Cancer in Tumor Invasion

1996 • 118 citations

Epidermal growth factor receptor–stimulated intestinal epithelial cell migration requires phospholipase C activity

1998 • 114 citations

Appearance of alpha-smooth muscle actin in human eye lens cells of anterior capsular cataract and in cultured bovine lens-forming cells

1990 • 114 citations

Myofibroblast phenotypes expression in experimental renal scarring

1997 • 113 citations

Thrombin stimulates proliferation of liver fat-storing cells and expression of monocyte chemotactic protein-1: Potential role in liver injury*1

1995 • 112 citations

Modulation of actin isoform expression in alveolar myofibroblasts (contractile interstitial cells) during pulmonary hypertension.

1990 • 107 citations

Why is epidermal growth factor present in the gut lumen?

1996 • 107 citations

Expression of interleukin-4 in scleroderma skin specimens and scleroderma fibroblast cultures. Potential role in fibrosis.

1996 • 106 citations

Stromal cells of the human prostate: Initial isolation and characterization

1996 • 105 citations

Phenotypic characterization of an intestinal subepithelial myofibroblast cell line

1997 • 105 citations

Various mechanisms cause RET-mediated signaling defects in Hirschsprung's disease.

1998 • 104 citations

Brief Review of the Fibronexus and Its Significance for Myofibroblastic Differentiation and Tumor Diagnosis

1993 • 104 citations

Transforming Growth Factor-β1 Induces α-Smooth Muscle-Actin Expression in Cultured Human and Monkey Trabecular Meshwork

1996 • 104 citations

Morphology and Cell Proliferation of Subepithelial Fibroblasts in Adult Mouse Jejunum

1974 • 103 citations

Inhibition of TGF‐β‐stimulated CTGF gene expression and anchorage‐independent growth by cAMP identifies a CTGF‐dependent restriction point in the cell cycle

1998 • 103 citations

Platelet-derived Growth Factor-BB and Thrombin Generate Positive and Negative Signals for Human Hepatic Stellate Cell Proliferation

1998 • 103 citations

Growth inhibitory properties of endothelin-1 in activated human hepatic stellate cells: a cyclic adenosine monophosphate-mediated pathway. Inhibition of both extracellular signal-regulated kinase and c-Jun kinase and upregulation of endothelin B receptors.

1996 • 103 citations

Endothelin-1-induced vasoconstriction causes a significant increase in portal pressure of rat liver: Localized constrictive effect on the distal segment of preterminal portal venules as revealed by light and electron microscopy and serial reconstruction

1998 • 102 citations

Smooth muscle differentiation in scleroderma fibroblastic cells.

1990 • 101 citations

Collagen XVIII is localized in sinusoids and basement membrane zones and expressed by hepatocytes and activated stellate cells in fibrotic human liver

1998 • 100 citations

Proinflammatory cytokines differentially modulate their own expression in human intestinal mucosal mesenchymal cells

1998 • 100 citations

Expression of Interleukin-4 in Scleroderma Skin Specimens and Scleroderma Fibroblast Cultures

1996 • 98 citations

Glomerulonephritis

1998 • 97 citations

Peptides and gastrointestinal mucosal integrity.

1995 • 95 citations

Rat hepatic lipocytes synthesize and secrete transin (Stromelysin) in early primary culture

1995 • 93 citations

Induction of neutrophil-attracting chemokines in transforming rat hepatic stellate cells

1997 • 92 citations

Thrombin receptor peptides induce shape change in neonatal murine astrocytes in culture

1994 • 90 citations

Myofibroblast differentiation during fibrosis.

1995 • 87 citations

Nonmitogenic actions of growth factors: an integrated view of their role in intestinal physiology and pathophysiology.

1997 • 87 citations

Cytokines modulate fibroblast phenotype and epithelial-stroma interactions in rat intestine

1997 • 85 citations

Capillary growth: a two-cell system.

1992 • 85 citations

Myofibroblast-like cells in human anterior capsular cataract

1984 • 85 citations

Colonic pericrypt sheath cells: characterisation of cell type with new monoclonal antibody.

1987 • 83 citations

Myofibroblasts in the Lamina Propria of Human Seminiferous Tubules are Dynamic Structures of Heterogeneous Phenotype.

1996 • 82 citations

Morphology and Cell Proliferation of Subepithelial Fibroblasts in Adult Mouse Jejunum

1974 • 82 citations

Amplification of nitric oxide synthase expression by nitric oxide in interleukin 1 beta-stimulated rat mesangial cells.

1995 • 82 citations

Myofibroblast Accumulation Induced by Transforming Growth Factor‐β Is Involved in the Pathogenesis of Nasal Polyps

1997 • 82 citations

Liver stellate cells in chronic viral hepatitis: the effect of interferon therapy

1996 • 80 citations

Rho directs activation-associated changes in rat hepatic stellate cell morphology via regulation of the actin cytoskeleton

1998 • 79 citations

Autocrine and paracrine actions of intestinal fibroblast-derived insulin-like growth factors

1999 • 79 citations

Myofibroblasts and local angiotensin II in rat cardiac tissue repair

1997 • 79 citations

Interactions between stromal cell--derived keratinocyte growth factor and epithelial transforming growth factor in immune-mediated crypt cell hyperplasia.

1998 • 78 citations

Heme oxygenase 2 is present in interstitial cell networks of the mouse small intestine

1998 • 78 citations

TGF beta and bFGF synthesis and localization in Dupuytren's disease (nodular palmar fibromatosis) relative to cellular activity, myofibroblast phenotype and oncofetal variants of fibronectin.

1995 • 77 citations

Expression of alpha-smooth muscle actin in murine bone marrow stromal cells

1991 • 76 citations

The colonic pericryptal fibroblast sheath: replication, migration, and cytodifferentiation of a mesenchymal cell system in adult tissue. 3. Replication and differentiation in human hyperplastic and adenomatous polyps.

1971 • 75 citations

Fibroblast growth factor 2 and transforming growth factor β1 interactions in human liver myofibroblasts

1995 • 74 citations

The Colonic Pericryptal Fibroblast Sheath: Replication, Migration, and Cytodifferentiation of a Mesenchymal Cell System in Adult Tissue

1971 • 73 citations

α-Smooth muscle actin is expressed in a subset of bone marrow stromal cells in normal and pathological conditions

1989 • 72 citations

Vascular Pericytes Not Only Regulate Growth, but Also Preserve Prostacyclin-Producing Ability and Protect Against Lipid Peroxide-Induced Injury of Cocultured Endothelial Cells

1993 • 71 citations

Alpha smooth muscle actin (α-SM actin) in normal human ovaries, in ovarian stromal hyperplasia and in ovarian neoplasms

1989 • 70 citations

Regulation of proliferation of human colonic subepithelial myofibroblasts by mediators important in intestinal inflammation.

1998 • 68 citations

Expression of α‐sooth‐muscle actin in stromal cells of the uterine cervix during epithlial neoplastic changes

1991 • 68 citations

Desmoplastic breast carcinoma as a source of human myofibroblasts.

1984 • 68 citations

Mesangial Cells Orchestrate Inflammation in the Renal Glomerulus

1994 • 66 citations

Trophic effects of interleukin-11 in rats with experimental short bowel syndrome

1996 • 65 citations

Pathogenesis of intestinal strictures in Crohn's disease—an update

1995 • 65 citations

Tumor necrosis factor alpha inhibits collagen alpha 1(I) gene expression in rat hepatic stellate cells through a G protein

1997 • 64 citations

Proliferative retinal diseases: myofibroblasts cause chronic vitreoretinal traction.

1992 • 64 citations

IGF-I induces collagen and IGFBP-5 mRNA in rat intestinal smooth muscle

1997 • 63 citations

TGFβ and bFGF synthesis and localization in Dupuytren's disease (nodular palmar fibromatosis) relative to cellular activity, myofibroblast phenotype and oncofetal variants of fibronectin

1995 • 63 citations

In Vitro System for Differentiating Pluripotent Neural Crest Cells into Smooth Muscle Cells

1998 • 61 citations

Epidermal growth factor promotes rapid response to epithelial injury in rabbit duodenum in vitro

1996 • 61 citations

A cellular reticulum of fibroblast-like cells in the rat intestine: Scanning and transmission electron microscopy.

1984 • 59 citations

Myofibroblasts in diffuse alveolar damage of the lung.

1998 • 59 citations

Immunodetection of connexins and cadherins in corneal fibroblasts and myofibroblasts.

1996 • 58 citations

Identification and classification of interstitial cells in the canine proximal colon by ultrastructure and immunocytochemistry

1994 • 57 citations

Glial fibrillary acidic protein as a marker of perisinusoidal stellate cells that can distinguish between the normal and myofibroblast‐like phenotypes

1996 • 55 citations

CXC chemokines and angiogenesis/angiostasis.

1998 • 55 citations

Rheumatoid synovial cell morphologic changes induced by a mononuclear cell factor in culture

1983 • 53 citations

An in vitro model for cell-cell interactions

1992 • 52 citations

Sequential changes in human Ito cells and their relation to postnecrotic liver fibrosis in massive and submassive hepatic necrosis

1995 • 50 citations

Trefoil Peptides in the Defense of the Gastrointestinal Tract

1997 • 48 citations

A role for stem cell factor (SCF): c-kit interaction(s) in the intestinal tract response to Salmonella typhimurium infection.

1996 • 48 citations

Cell Shape Determination: A Pivotal Role for Rho

1996 • 46 citations

Assessment of Rapid Morphological Changes Associated with Elevated cAMP Levels in Human Orbital Fibroblasts

1998 • 45 citations

Modifications of Insulin-Like Growth Factor Binding Proteins and Their Role in Controlling IGF Actions

1998 • 44 citations

Localization of the fibronexus at the surface of granulation tissue myofibroblasts using double-label immunogold electron microscopy on ultrathin frozen sections.

1985 • 44 citations

The renal tubule in the progression of chronic renal failure.

1997 • 44 citations

Intestinal subepithelial myofibroblasts and mucosal immunophysiology

1994 • 42 citations

Gastric mucosal smooth muscles may explain oscillations in glandular pressure: Role of vasoactive intestinal peptide

1998 • 41 citations

Myofibroblasts in the rat testicular capsule

1974 • 41 citations

Gastric inflammatory myofibroblastic proliferation in children

1998 • 40 citations

Differential responses of scirrhous and well-differentiated gastric cancer cells to orthotopic fibroblasts

1996 • 39 citations

Pathogenesis of Intestinal Strictures in Crohnʼs Disease—An Update

1995 • 39 citations

Chemotactic factors stimulate CD18-dependent canine neutrophil adherence and motility on lung fibroblasts.

1996 • 38 citations

Insulin-like growth factors and inflammatory bowel disease

1996 • 38 citations

Closing in on the signals of hepatic fibrosis

1997 • 37 citations

Mesenchymal cells stimulate human intestinal intraepithelial lymphocytes

1997 • 34 citations

Histogenesis of Dupuytren's disease: An immunohistochemical study of 30 cases

1988 • 33 citations

Basic fibroblast growth factor treatment for non-steroidal anti-inflammatory drug associated gastric ulceration.

1995 • 33 citations

Dynamic interactions between lung fibroblasts and leukocytes: implications for fibrotic lung disease.

1998 • 33 citations

Different Effects of Basic Fibroblast Growth Factor and Transforming Growth Factor-β on the Two Platelet-Derived Growth Factor Receptors' Expression in Scleroderma and Healthy Human Dermal Fibroblasts

1995 • 32 citations

Ovarian Steroids Regulate the Expression of Basic Fibroblast Growth Factor and its mRNA in Fibroblasts Derived from Uterine Endometrium

1997 • 32 citations

Expression of trefoil peptides pS2 and human spasmolytic polypeptide in gastric metaplasia at the margin of duodenal ulcers.

1995 • 32 citations

Intracellular calcium responses and shape conversions induced by endothelin in cultured subepithelial fibroblasts of rat duodenal villi

1994 • 31 citations

Opposing Actions of Hepatocyte Growth Factor and Basic Fibroblast Growth Factor on Cell Contact, Intracellular Free Calcium Levels, and Rat Ovarian Surface Epithelial Cell Viability

1997 • 31 citations

A new source of cells contributing to the developing gastrointestinal tract demonstrated in chick embryos☆☆☆

1998 • 31 citations

Prostaglandin E2 alters human orbital fibroblast shape through a mechanism involving the generation of cyclic adenosine monophosphate.

1995 • 30 citations

Intermediate Filaments of Myofibroblasts

1987 • 29 citations

T-Lymphocyte-fibroblast interactions

1997 • 29 citations

Thrombin stimulates proliferation of liver fat-storing cells and expression of monocyte chemotactic protein-1: Potential role in liver injury

1995 • 28 citations

Fibronexus formation is an early event during fibronectin-induced restoration of more normal morphology and substrate adhesion patterns in transformed hamster fibroblasts

1982 • 28 citations

Molecular Aspects of Epithelial-Mesenchymal Interactions

1993 • 27 citations

Extracellular Matrix: The Cellular Environment

1994 • 26 citations

Characterization of newly established testicular peritubular and prostatic stromal cell lines: potential use in the study of mesenchymal-epithelial interactions.

1995 • 26 citations

Hepatic stellate cells reversibly express α-smooth muscle actin during acute hepatic ischemia

1997 • 26 citations

The Fibroblast Is the Target Cell in the Connective Tissue Manifestations of Graves' Disease

1995 • 26 citations

Proteolytic enzymes in inflammatory bowel disease

1998 • 24 citations

Insights Into the Pathogenesis of Psoriasis and Psoriatic Arthritis

1998 • 24 citations

Characteristics of cultured subepithelial fibroblasts of rat duodenal villi

1993 • 20 citations

Proteolytic Enzymes in Inflammatory Bowel Disease

1998 • 20 citations

<sup>125</sup>I-Endothelin binds to Fibroblasts beneath the Epithelium of Rat Small Intestine

1990 • 19 citations

Role of multipotent fibroblasts in the healing colonic mucosa of rabbits. Ultrastructural and immunocytochemical study.

1992 • 18 citations

The origin of Ia antigen-expressing cells in the rat kidney.

1987 • 16 citations

A two-pronged approach to the clinical use of HGF

1998 • 14 citations

Extracellular matrix‐cytoskeletal interactions in rheumatoid arthritis. I. Immunoelectron microscopic analysis of the fibronexus at the adhesive surface of normal porcine type B synoviocytes in vitro

1985 • 13 citations

Myofibroblasts in Human Palatal Mucosa

1988 • 12 citations

Eicosanoids, Mesangial Contraction, and Intracellular Signal Transduction.

1992 • 11 citations

A monoclonal antibody to astrocytes, subepithelial fibroblasts of small intestinal villi and interstitial cells of the myenteric plexus layer

1997 • 8 citations

Interleukin-4 induces myofibroblast differentiation in synovial fibroblasts

1997 • 7 citations

Fluorescent Histochemical Study on the Localization of Myofibroblasts in the Healing of Acetic Acid-Induced Gastric Ulcers in the Rat

1989 • 7 citations

Modulation of Morphology, Proliferation and Collagen Synthesis in Fibroblasts by the Exudate from Hypersensitive Granulomatous Inflammation in Rats

1994 • 6 citations

Immunoelectron Microscopical Characterization of the Epithelioid Type of Smooth Muscle Cells in Human Glomus Organs

1997 • 6 citations

Immunohistochemical localization of the actin in the healing stage of gastric ulcers.

1987 • 4 citations

Characterisation of a myofibroblast-like cell line from an angiosarcoma

1996 • 2 citations

Myofibroblasts and ECL are altered in the aged rat stomach

1998 • 1 citations