Regulation of cell number in the mammalian gastrointestinal tract: the importance of apoptosis

Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

1972 • 15,349 citations

Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.

1992 • 9,540 citations

“Gray's Anatomy”

1985 • 4,681 citations

Disruption of epithelial cell-matrix interactions induces apoptosis

1994 • 3,167 citations

Cell Death During Development of the Nervous System

1991 • 3,033 citations

Social controls on cell survival and cell death

1992 • 2,641 citations

Mechanisms and Functions of Cell Death

1991 • 2,061 citations

Stem cells: attributes, cycles, spirals, pitfalls and uncertainties. Lessons for and from the crypt

1990 • 1,793 citations

Origin, differentiation and renewal of the four main epithelial cell types in the mouse small intestine V. Unitarian theory of the origin of the four epithelial cell types

1974 • 1,697 citations

Cell death and control of cell survival in the oligodendrocyte lineage

1992 • 1,331 citations

Association of the APC Gene Product with β-Catenin

1993 • 1,215 citations

Association of the APC Tumor Suppressor Protein with Catenins

1993 • 1,202 citations

CELL DEATHS IN NORMAL VERTEBRATE ONTOGENY

1951 • 1,194 citations

Death in Embryonic Systems

1966 • 943 citations

Histology for Pathologists

1992 • 820 citations

Cell proliferation and migration as revealed by radioautography after injection of thymidine-H3 into male rats and mice

1960 • 811 citations

Physiology of the Digestive Tract.

1961 • 587 citations

In situ end‐labelling detects DNA strand breaks in apoptosis and other physiological and pathological states

1993 • 584 citations

The role of p53 in spontaneous and radiation-induced apoptosis in the gastrointestinal tract of normal and p53-deficient mice.

1994 • 564 citations

The cell biology of transforming growth factor β

1990 • 537 citations

Apoptotic cell death and tissue remodelling during mouse mammary gland involution

1992 • 536 citations

Large-scale normal cell death in the developing rat kidney and its reduction by epidermal growth factor

1993 • 433 citations

Histology for Pathologists

1993 • 426 citations

Extreme sensitivity of some intestinal crypt cells to X and γ irradiation

1977 • 417 citations

Molecular biology of the cell (3rd edn)

1995 • 346 citations

The biology of epithelial cell populations

1984 • 339 citations

Gastro-intestinal Pathology

1980 • 314 citations

The turnover and shedding of epithelial cells: Part I The turnover in the gastro-intestinal tract

1961 • 285 citations

The streaming liver

1985 • 271 citations

The Biology of Epithelial Cell Populations

1985 • 246 citations

Signal transduction events underlying neurite outgrowth stimulated by cell adhesion molecules

1994 • 242 citations

Colonic pericryptal fibroblast sheath: replication, migration, and cytodifferentiation of a mesenchymal cell system in adult tissue. I. Autoradiographic studies of normal rabbit colon.

1968 • 211 citations

Importance of apoptosis in the histopathology of drug related lesions in the large intestine.

1993 • 206 citations

CLASSIFICATION OF CELL POPULATIONS ON THE BASIS OF THEIR PROLIFERATIVE BEHAVIOR.

1964 • 198 citations

Atrophy and apoptosis in the cyclical human endometrium

1976 • 192 citations

Differential expression of the VLA family of integrins along the crypt-villus axis in the human small intestine

1992 • 176 citations

Colonic pericryptal fibroblast sheath: replication, migration, and cytodifferentiation of a mesenchymal cell system in adult tissue. II. Fine structural aspects of normal rabbit and human colon.

1968 • 155 citations

A possible explanation for the differential cancer incidence in the intestine, based on distribution of the cytotoxic effects of carcinogens in the murine large bowel

1992 • 152 citations

Colonic Pericryptal Fibroblast Sheath: Replication, Migration, and Cytodifferentiation of a Mesenchymal Cell System in Adult Tissue

1968 • 141 citations

The streaming adrenal cortex: direct evidence of centripetal migration of adrenocytes by estimation of cell turnover rate

1986 • 133 citations

Melanosis coli. A consequence of anthraquinone-induced apoptosis of colonic epithelial cells.

1988 • 130 citations

Reduction in apoptosis relative to mitosis in histologically normal epithelium accompanies fibrocystic change and carcinoma of the premenopausal human breast

1992 • 126 citations

The Temporal and Spatial Changes in Cell Proliferation within the Irradiated Crypts of the Murine Small Intestine

1990 • 125 citations

Ultrastructure of the rat pancreas after experimental duct ligation. I. The role of apoptosis and intraepithelial macrophages in acinar cell deletion.

1987 • 114 citations

TGF-β expression in the human colon: differential immunostaining along crypt epithelium

1993 • 113 citations

The streaming submandibular gland

1985 • 106 citations

Morphology and Cell Proliferation of Subepithelial Fibroblasts in Adult Mouse Jejunum

1974 • 103 citations

Migration and turnover of entero‐endocrine and caveolated cells in the epithelium of the descending colon, as shown by radioautography after continuous infusion of ³H‐thymidine into mice

1979 • 102 citations

The Pericryptal Fibroblast Sheath

1974 • 92 citations

Morphology and Cell Proliferation of Subepithelial Fibroblasts in Adult Mouse Jejunum

1974 • 82 citations

Expression of J1 / ten asci n in the crypt-villus unit of adult mouse small intestine: implications for its role in epithelial cell shedding

1990 • 80 citations

Distribution of deoxyribonuclease I in rat tissues and its correlation to cellular turnover and apoptosis (programmed cell death).

1994 • 77 citations

Stem cells: Their identification and characterisation

1984 • 68 citations

Expression of SV-40 T antigen in the small intestinal epithelium of transgenic mice results in proliferative changes in the crypt and reentry of villus-associated enterocytes into the cell cycle but has no apparent effect on cellular differentiation programs and does not cause neoplastic transformation

1992 • 66 citations

A quantitative evaluation of apoptotic bodies in rat liver

1988 • 61 citations

The streaming liver III. Littoral cells accompany the streaming hepatocyte

1988 • 57 citations

Gastro-Intestinal Cell Loss in Man

1973 • 54 citations

Regional variability of colonocyte growth and differentiation in the rat

1992 • 52 citations

Automatic Counting of Microscopic Particles

1952 • 43 citations

Argentaffin and other “endocrine” cells of the small intestine in the adult mouse. II. Renewal

1971 • 41 citations

Epithelial cell proliferation and migration in the developing rat gastric mucosa

1976 • 41 citations

Cell loss from small intestinal mucosa: a morphological study

1970 • 40 citations

A nude mouse xenograft model of fetal intestine development and differentiation

1992 • 36 citations

Quantitative study of apoptosis in normal rat gastroduodenal mucosa

1990 • 29 citations

D.N.A. AND CELL LOSS FROM NORMAL SMALL-INTESTINAL MUCOSA

1968 • 26 citations

Assessment of Cell Proliferation in Clinical Practice

1992 • 20 citations

Zum Mechanismus der Zellabsto�ung im Bereich der D�nndarmzotten

1967 • 17 citations

The Kinetic Organisation of Tissues

1992 • 11 citations

Streaming kidney

1991 • 8 citations