Platelet-derived Growth Factor and Fibronectin-stimulated Migration Are Differentially Regulated by the Rac and Extracellular Signal-regulated Kinase Pathways

Tight control of gene expression in mammalian cells by tetracycline-responsive promoters.

1992 • 4,885 citations

The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

1992 • 4,454 citations

Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia

1995 • 4,387 citations

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

1992 • 3,628 citations

THE CHEMOTACTIC EFFECT OF MIXTURES OF ANTIBODY AND ANTIGEN ON POLYMORPHONUCLEAR LEUCOCYTES

1962 • 2,726 citations

Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells

1994 • 1,999 citations

Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase

1994 • 1,590 citations

Selective activation of the JNK signaling cascadeand c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs

1995 • 1,499 citations

Regulation of Cell Motility by Mitogen-activated Protein Kinase

1997 • 1,238 citations

Role of Phosphoinositide 3-OH Kinase in Cell Transformation and Control of the Actin Cytoskeleton by Ras

1997 • 1,064 citations

The Ras-Related Protein Cdc42Hs and Bradykinin Promote Formation of Peripheral Actin Microspikes and Filopodia in Swiss 3T3 Fibroblasts

1995 • 1,033 citations

Inhibition of MAP Kinase Kinase Blocks the Differentiation of PC-12 Cells Induced by Nerve Growth Factor

1995 • 906 citations

An essential role for Rac in Ras transformation

1995 • 895 citations

Activation of Rac1, RhoA, and Mitogen-Activated Protein Kinases Is Required for Ras Transformation

1995 • 683 citations

Integrin-mediated cell adhesion activates mitogen-activated protein kinases.

1994 • 660 citations

Multiple ras functions can contribute to mammalian cell transformation

1995 • 658 citations

A role for Rac in Tiaml-induced membrane ruffling and invasion

1995 • 562 citations

Regulation of Scatter Factor/Hepatocyte Growth Factor Responses by Ras, Rac, and Rho in MDCK Cells

1995 • 547 citations

PDGF stimulates an increase in GTP–Rac via activation of phosphoinositide 3-kinase

1995 • 542 citations

Identification of an invasion-inducing gene, Tiam-1, that encodes a protein with homology to GDP-GTP exchangers for Rho-like proteins

1994 • 518 citations

Regulation of chemotaxis by the platelet-derived growth factor receptor-β

1994 • 441 citations

Integrin-dependent activation of MAP kinase: a link to shape-dependent cell proliferation.

1995 • 415 citations

Stimulation of Membrane Ruffling and MAP Kinase Activation by Distinct Effectors of RAS

1996 • 377 citations

RapV12 antagonizes Ras-dependent activation of ERK1 and ERK2 by LPA and EGF in Rat-1 fibroblasts.

1993 • 356 citations

Oncogenic Ras Activation of Raf/Mitogen-Activated Protein Kinase-Independent Pathways Is Sufficient To Cause Tumorigenic Transformation

1996 • 350 citations

The Cellular Basis of Site-Specific Tumor Metastasis

1990 • 349 citations

Ral-GTPases mediate a distinct downstream signaling pathway from Ras that facilitates cellular transformation.

1996 • 335 citations

Cdc42 Regulates Anchorage-Independent Growth and Is Necessary for Ras Transformation

1997 • 312 citations

Identification of Novel Graded Polarity Actin Filament Bundles in Locomoting Heart Fibroblasts: Implications for the Generation of Motile Force

1997 • 312 citations

Analysis of the roles of microvessel endothelial cell random motility and chemotaxis in angiogenesis

1991 • 312 citations

Membrane ruffling and chemotaxis transduced by the PDGF beta-receptor require the binding site for phosphatidylinositol 3' kinase.

1994 • 303 citations

A Role for the Ral Guanine Nucleotide Dissociation Stimulator in Mediating Ras-induced Transformation

1996 • 245 citations

Hepatocyte Growth Factor-induced Scatter of Madin-Darby Canine Kidney Cells Requires Phosphatidylinositol 3-Kinase

1995 • 239 citations

Lysophosphatidic acid signalling

1995 • 223 citations

Complexes of polyoma virus medium T antigen and cellular proteins.

1985 • 223 citations

Mechanisms Controlling the Transcription of Matrix Metalloproteinase Genes in Normal and Neoplastic Cells

1996 • 194 citations

Integrin-mediated Activation of MEK and Mitogen-activated Protein Kinase Is Independent of Ras

1996 • 187 citations

The motility signal of scatter factor/hepatocyte growth factor mediated through the receptor tyrosine kinase met requires intracellular action of Ras.

1994 • 175 citations

Ras Activation Is Necessary for Integrin-mediated Activation of Extracellular Signal-regulated Kinase 2 and Cytosolic Phospholipase A2 but Not for Cytoskeletal Organization

1996 • 167 citations

The activity of the Ets transcription factor PEA3 is regulated by two distinct MAPK cascades.

1996 • 143 citations

Regulation of Mitogen-activated Protein Kinase Phosphatase-1 Expression by Extracellular Signal-related Kinase-dependent and Ca2+-dependent Signal Pathways in Rat-1 Cells

1997 • 121 citations

The chemotactic response to PDGF-BB: evidence of a role for Ras.

1995 • 116 citations

Extracellular Calcium and Platelet-derived Growth Factor Promote Receptor-mediated Chemotaxis in Osteoblasts through Different Signaling Pathways

1997 • 114 citations

Intracellular Signaling in Arterial Smooth Muscle Migration versus Proliferation

1996 • 32 citations

[1] Chemotaxis: An overview

1988 • 31 citations

Hepatocyte growth factor/scatter factor (HGF/SF) in early development: evidence for a role in neural induction

1995 • 14 citations