Mechanisms of spontaneous resolution of rat liver fibrosis. Hepatic stellate cell apoptosis and reduced hepatic expression of metalloproteinase inhibitors.

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.

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Induction of apoptosis in fibroblasts by c-myc protein

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The molecular biology of apoptosis.

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Molecular cloning and expression of collagenase-3, a novel human matrix metalloproteinase produced by breast carcinomas

1994 • 769 citations

Cooperative interaction between c-myc and bcl-2 proto-oncogenes

1992 • 766 citations

A License to Kill

1996 • 649 citations

Mesangial cell apoptosis: the major mechanism for resolution of glomerular hypercellularity in experimental mesangial proliferative nephritis.

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Expression of tissue inhibitor of metalloproteinases 1 and 2 is increased in fibrotic human liver

1996 • 349 citations

Rat hepatic lipocytes express smooth muscle actin upon activation in vivo and in culture.

1992 • 340 citations

Apoptosis and the cell cycle

1995 • 334 citations

Tissue inhibitor of metalloproteinase-1 messenger RNA expression is enhanced relative to interstitial collagenase messenger RNA in experimental liver injury and fibrosis

1996 • 321 citations

Apoptosis and hepatobiliary disease

1995 • 268 citations

Human hepatic lipocytes synthesize tissue inhibitor of metalloproteinases-1. Implications for regulation of matrix degradation in liver.

1992 • 207 citations

CD95/CD95L-mediated apoptosis of the hepatic stellate cell. A mechanism terminating uncontrolled hepatic stellate cell proliferation during hepatic tissue repair.

1997 • 183 citations

Lipocytes from normal rat liver release a neutral metalloproteinase that degrades basement membrane (type IV) collagen.

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Reversibility of hepatic fibrosis in experimentally induced cholestasis in rat.

1990 • 122 citations

Polyunsaturated lecithin prevents acetaldehyde-mediated hepatic collagen accumulation by stimulating collagenase activity in cultured lipocytes

1992 • 119 citations

Tissue Inhibitor of Metalloproteinase-1 and Interstitial Collagenase Expression in Autoimmune Chronic Active Hepatitis and Activated Human Hepatic Lipocytes

1995 • 112 citations

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1982 • 111 citations

Apoptosis and hepatobiliary disease*1

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Localization and cellular sources of activins in normal and fibrotic rat liver

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Temporal and spatial patterns of transin/stromelysin RNA expression following toxic injury in rat liver

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Matrix Degradation in the Liver

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Lysyl Oxidase and Collagenase in Experimental Acute and Chronic Liver Injury

1982 • 64 citations

Serum tissue inhibitor of metalloproteinases in patients with chronic liver disease and with hepatocellular carcinoma

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Collagenolytic activity in experimental cirrhosis of the liver

1987 • 54 citations

Clinical evaluation of serum tissue inhibitor of metalloproteinases‐1 levels in patients with liver diseases

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Collagenase of hepatocytes and sinusoidal liver cells in the reversibility of experimental cirrhosis of the liver

1990 • 37 citations

Tissue inhibitor of metalloproteinase-1 messenger RNA expression is enhanced relative to interstitial collagenase messenger RNA in experimental liver injury and fibrosis

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Collagenase and Collagenolytic Cathepsin in Normal and Fibrotic Rat Liver

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Serum Collagenase Activity in Chronic Liver Diseases

1994 • 12 citations