Arachidonic acid induces the activation of the stress‐activated protein kinase, membrane ruffling and H₂O₂ production via a small GTPase Rac1

Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis

1995 • 5,334 citations

The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

1992 • 4,454 citations

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

1992 • 3,628 citations

The stress-activated protein kinase subfamily of c-Jun kinases

1994 • 2,616 citations

Rho GTPases and signaling networks

1997 • 2,380 citations

Selective activation of the JNK signaling cascadeand c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs

1995 • 1,499 citations

Protein kinase cascades activated by stress and inflammatory cytokines

1996 • 722 citations

Regulation of reactive-oxygen-species generation in fibroblasts by Rac 1

1996 • 488 citations

Production of hydrogen peroxide by transforming growth factor-beta 1 and its involvement in induction of egr-1 in mouse osteoblastic cells.

1994 • 478 citations

Arachidonate lipoxygenases as essential regulators of cell survival and apoptosis.

1996 • 341 citations

Translocation of Rac correlates with NADPH oxidase activation. Evidence for equimolar translocation of oxidase components.

1993 • 316 citations

Fas- or Ceramide-induced Apoptosis Is Mediated by a Rac1-regulated Activation of Jun N-terminal Kinase/p38 Kinases and GADD153

1997 • 302 citations

Arachidonic acid in cell signaling

1993 • 295 citations

Epidermal growth factor—induced actin remodeling is regulated by 5-lipoxygenase and cyclooxygenase products

1993 • 255 citations

Arachidonic acid inhibits myosin light chain phosphatase and sensitizes smooth muscle to calcium.

1992 • 232 citations

Activation of mitogen-activated protein kinases by arachidonic acid and its metabolites in vascular smooth muscle cells.

1994 • 230 citations

Rac mediates growth factor-induced arachidonic acid release

1995 • 207 citations

The effects of the Rho‐kinase inhibitor Y‐27632 on arachidonic acid‐, GTPγS‐, and phorbol ester‐induced Ca²⁺‐sensitization of smooth muscle

1998 • 199 citations

Arachidonic acid activates c-jun N-terminal kinase through NADPH oxidase in rabbit proximal tubular epithelial cells

1997 • 177 citations

Activation of Mitogen-activated Protein Kinase by Arachidonic Acid in Rat Liver Epithelial WB Cells by a Protein Kinase C-dependent Mechanism

1995 • 116 citations

Hydrogen Peroxide Enhances Signal‐Responsive Arachidonic Acid Release from Neurons: Role of Mitogen‐Activated Protein Kinase

1998 • 84 citations

Serum stimulation of NIH 3T3 cells induces the production of lipids able to inhibit GTPase-activating protein activity.

1990 • 66 citations

Arachidonic acid mediates interleukin-1 and tumor necrosis factor-alpha- induced activation of the c-jun amino-terminal kinases in stromal cells

1996 • 65 citations

Potential role of phospholipase A2 in HL-60 cell differentiation to macrophages induced by protein kinase C activation.

1993 • 55 citations

G Proteins and the Mechanism of Action of Hormones, Neuretransmitters, and Autocrine and Paracrine Regulatory Factors

1990 • 44 citations

Arachidonic acid activates Jun N-terminal kinase in vascular smooth muscle cells

1998 • 40 citations

Arachidonic acid, a principal product of Rac‐activated phospholipase A₂, stimulates c‐fos serum response element via Rho‐dependent mechanism

1997 • 27 citations

Role of Rac GTPase in the nuclear signaling by EGF

1997 • 22 citations

Essential role of Rac GTPase in hydrogen peroxide‐induced activation of c‐fos serum response element

1997 • 20 citations

Arachidonic acid, a growth signal in murine P815 mastocytoma cells.

1993 • 16 citations