Expression of heme oxygenase-1 in atherosclerotic lesions.

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

The pathogenesis of atherosclerosis: a perspective for the 1990s

1993 • 10,730 citations

Bilirubin Is an Antioxidant of Possible Physiological Importance

1987 • 3,406 citations

Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells

1992 • 2,216 citations

Spontaneous Hypercholesterolemia and Arterial Lesions in Mice Lacking Apolipoprotein E

1992 • 2,189 citations

Atherosclerosis: Basic Mechanisms

1995 • 1,697 citations

Carbon Monoxide: a Putative Neural Messenger

1993 • 1,519 citations

The oxidation hypothesis of atherosclerosis

1994 • 1,418 citations

Ferritin: a cytoprotective antioxidant strategem of endothelium.

1992 • 1,100 citations

Autoxidation of human low density lipoprotein: loss of polyunsaturated fatty acids and vitamin E and generation of aldehydes

1987 • 773 citations

Smooth muscle cell-derived carbon monoxide is a regulator of vascular cGMP.

1995 • 709 citations

Induction of heme oxygenase is a rapid, protective response in rhabdomyolysis in the rat.

1992 • 691 citations

Heme oxygenase 1 mediates an adaptive response to oxidative stress in human skin fibroblasts.

1994 • 520 citations

Free and albumin-bound bilirubin are efficient co-antioxidants for alpha-tocopherol, inhibiting plasma and low density lipoprotein lipid peroxidation

1994 • 512 citations

Endothelium-Dependent and -Independent Vasodilation Involving Cyclic GMP: Relaxation Induced by Nitric Oxide, Carbon Monoxide and Light

1991 • 476 citations

Heme oxygenase-1 is associated with the neurofibrillary pathology of Alzheimer's disease.

1994 • 420 citations

Identification of binding sites for transcription factors NF-kappa B and AP-2 in the promoter region of the human heme oxygenase 1 gene.

1994 • 401 citations

Oxidative stress resulting from ultraviolet A irradiation of human skin fibroblasts leads to a heme oxygenase-dependent increase in ferritin

1993 • 394 citations

Endothelial cell expression of vasoconstrictors and growth factors is regulated by smooth muscle cell-derived carbon monoxide.

1995 • 355 citations

Transfection of the human heme oxygenase gene into rabbit coronary microvessel endothelial cells: protective effect against heme and hemoglobin toxicity.

1995 • 343 citations

Induction of Haem Oxygenase as a Defence Against Oxidative Stress

1990 • 322 citations

Human heme oxygenase cDNA and induction of its mRNA by hemin

1988 • 320 citations

Heme oxygenase and oxidative stress. Evidence of involvement of bilirubin as physiological protector against oxidative damage

1994 • 302 citations

Induction of heme oxygenase-1 inhibits the monocyte transmigration induced by mildly oxidized LDL.

1997 • 294 citations

Evidence suggesting that the two forms of heme oxygenase are products of different genes.

1988 • 288 citations

Pathology of atheromatous lesions in inbred and genetically engineered mice. Genetic determination of arterial calcification.

1994 • 244 citations

Transcriptional Activation of the Heme Oxygenase Gene by Heme and Cadmium in Mouse Hepatoma Cells

1989 • 230 citations

Oxidant stress leads to transcriptional activation of the human heme oxygenase gene in cultured skin fibroblasts.

1990 • 226 citations

Antioxidation of human low density lipoprotein by unconjugated and conjugated bilirubins

1996 • 211 citations

Lysophosphatidylcholine plays an essential role in the mitogenic effect of oxidized low density lipoprotein on murine macrophages.

1994 • 196 citations

NO^•, CO and ^•OH Endogenous soluble guanylyl cyclase‐activating factors

1992 • 192 citations

Zinc · protoporphyrin is a selective inhibitor of heme oxygenase activity in the neonatal rat

1981 • 186 citations

Contrary Effects of Lightly and Strongly Oxidized LDL With Potent Promotion of Growth Versus Apoptosis on Arterial Smooth Muscle Cells, Macrophages, and Fibroblasts

1996 • 178 citations

Bilirubin attenuates radical‐mediated damage to serum albumin

1993 • 176 citations

Increased ferritin gene expression in atherosclerotic lesions.

1996 • 161 citations

Role of Bilirubin as an Antioxidant in an Ischemia–Reperfusion of Rat Liver and Induction of Heme Oxygenase

1996 • 160 citations

Lipid hydroperoxy and hydroxy derivatives in copper-catalyzed oxidation of low density lipoprotein.

1990 • 153 citations

Interleukin-1 and tumour necrosis factor induce hepatic haem oxygenase. Feedback regulation by glucocorticoids

1991 • 153 citations

Cytokine induction of haem oxygenase mRNA in mouse liver. Interleukin 1 transcriptionally activates the haem oxygenase gene

1993 • 145 citations

Oxidized Low Density Lipoprotein and Lysophosphatidylcholine Stimulate Cell Cycle Entry in Vascular Smooth Muscle Cells

1996 • 142 citations

Lysophosphatidylcholine upregulates the level of heparin-binding epidermal growth factor-like growth factor mRNA in human monocytes.

1994 • 138 citations

Heme Oxygenase-mediated Resistance to Oxygen Toxicity in Hamster Fibroblasts

1997 • 135 citations

Multiple elements within the 5' distal enhancer of the mouse heme oxygenase-1 gene mediate induction by heavy metals.

1994 • 130 citations

Nitric oxide and carbon monoxide as possible retrograde messengers in hgippocampal long‐term potentiation

1994 • 130 citations

Induction of the heme oxygenase gene in human skin fibroblasts by hydrogen peroxide and UVA (365 nm) radiation: evidence for the involvement of the hydroxyl radical

1990 • 125 citations

Endothelial cell heme oxygenase and ferritin induction in rat lung by hemoglobin in vivo

1995 • 115 citations

Preischemic But Not Postischemic Zinc Protoporphyrin Treatment Reduces Infarct Size and Edema Accumulation After Temporary Focal Cerebral Ischemia in Rats

1995 • 112 citations

Induction of the antioxidant stress proteins heme oxygenase‐1 and MSP23 by stress agents and oxidised LDL in cultured vascular smooth muscle cells

1995 • 99 citations

Renal tubular epithelial cells mimic endothelial cells upon exposure to oxidized LDL

1996 • 86 citations

Bilirubin Is Oxidized in Rats Treated with Endotoxin and Acts as a Physiological Antioxidant Synergistically with Ascorbic Acid in Vivo

1995 • 76 citations

High macrophage lipoprotein lipase expression and secretion are associated in inbred murine strains with susceptibility to atherosclerosis.

1993 • 73 citations

Neuroprotection against CA1 injury with metalloporphyrins

1996 • 60 citations

Oxidant Stress Leads to Transcriptional Activation of the Human Heme Oxygenase Gene in Cultured Skin Fibroblasts

1990 • 53 citations

Heme oxygenase does not protect human cells against oxidant stress.

1994 • 32 citations