Role for NADPH/NADH Oxidase in the Modulation of Vascular Tone^a

The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine

1980 • 12,033 citations

Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor

1987 • 10,774 citations

Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide.

1990 • 7,068 citations

Vascular endothelial cells synthesize nitric oxide from L-arginine

1988 • 4,800 citations

Angiotensin II stimulates NADH and NADPH oxidase activity in cultured vascular smooth muscle cells.

1994 • 2,753 citations

Peroxynitrite oxidation of sulfhydryls.

1991 • 2,479 citations

Angiotensin II-mediated hypertension in the rat increases vascular superoxide production via membrane NADH/NADPH oxidase activation. Contribution to alterations of vasomotor tone.

1996 • 2,456 citations

Superoxide anion is involved in the breakdown of endothelium-derived vascular relaxing factor

1986 • 2,416 citations

Peroxynitrite-induced membrane lipid peroxidation: The cytotoxic potential of superoxide and nitric oxide

1991 • 2,215 citations

Nitric oxide-generating vasodilators and 8-bromo-cyclic guanosine monophosphate inhibit mitogenesis and proliferation of cultured rat vascular smooth muscle cells.

1989 • 2,183 citations

Endothelial-Leukocyte Adhesion Molecules

1993 • 1,324 citations

The anti‐aggregating properties of vascular endothelium: interactions between prostacyclin and nitric oxide

1987 • 1,171 citations

Vasorelaxant properties of the endothelium-derived relaxing factor more closely resemble S-nitrosocysteine than nitric oxide

1990 • 996 citations

Role of Superoxide in Angiotensin II–Induced but Not Catecholamine-Induced Hypertension

1997 • 831 citations

p22 Is a Critical Component of the Superoxide-generating NADH/NADPH Oxidase System and Regulates Angiotensin IIinduced Hypertrophy in Vascular Smooth Muscle Cells

1996 • 768 citations

p22phox mRNA Expression and NADPH Oxidase Activity Are Increased in Aortas From Hypertensive Rats

1997 • 555 citations

NADH oxidoreductase is a major source of superoxide anion in bovine coronary artery endothelium

1994 • 546 citations

Localization of a constitutively active, phagocyte-like NADPH oxidase in rabbit aortic adventitia: Enhancement by angiotensin II

1997 • 463 citations

Expression of phagocyte NADPH oxidase components in human endothelial cells

1996 • 432 citations

Superoxide Anion From the Adventitia of the Rat Thoracic Aorta Inactivates Nitric Oxide

1998 • 387 citations

Circulating plasma xanthine oxidase contributes to vascular dysfunction in hypercholesterolemic rabbits.

1996 • 375 citations

Hydralazine prevents nitroglycerin tolerance by inhibiting activation of a membrane-bound NADH oxidase. A new action for an old drug.

1996 • 312 citations

An NADPH oxidase superoxide-generating system in the rabbit aorta

1995 • 295 citations

Increased NAD(P)H oxidase-mediated superoxide production in renovascular hypertension: Evidence for an involvement of protein kinase C

1999 • 249 citations

Nitric Oxide Regulation of Superoxide and Peroxynitrite-dependent Lipid Peroxidation

1994 • 244 citations

Polymorphism of the NADH/NADPH Oxidase p22 phox Gene in Patients With Coronary Artery Disease

1998 • 240 citations

Peroxynitrite, a product of superoxide and nitric oxide, produces coronary vasorelaxation in dogs.

1994 • 232 citations

Evidence for a role of endothelin 1 and protein kinase C in nitroglycerin tolerance.

1995 • 179 citations

Cyclic strain induces an oxidative stress in endothelial cells

1997 • 179 citations

Dietary supplement with vitamin C prevents nitrate tolerance.

1998 • 140 citations

Protein kinase C isotypes and signal-transduction in human neutrophils: Selective substrate specificity of calcium-dependent β-PKC and novel calcium-independent nPKC

1993 • 126 citations

Relationship between phosphorylation and translocation to the plasma membrane of p47phox and p67phox and activation of the NADPH oxidase in normal and Ca2+-depleted human neutrophils

1993 • 125 citations

Assembly and regulation of NADPH oxidase and nitric oxide synthase

1994 • 123 citations

Cytochrome b-558 α-subunit cloning and expression in rat aortic smooth muscle cells

1995 • 110 citations

Randomized, Double-Blind, Placebo-Controlled Study of Supplemental Vitamin E on Attenuation of the Development of Nitrate Tolerance

1997 • 95 citations

Effect of Sympathoinhibition on Exercise Performance in Patients With Heart Failure

1997 • 76 citations

Anti-free-radical and neutrophil-modulating properties of the nitrovasodilator, nicorandil

1992 • 70 citations

Dissociation of coronary vascular tolerance and neurohormonal adjustments during long-term nitroglycerin therapy in patients with stable coronary artery disease

1996 • 68 citations

A Reappraisal of Nitrate Therapy

1988 • 57 citations

Early tolerance to hemodynamic effects of high dose transdermal nitroglycerin in responders with severe chronic heart failure

1987 • 46 citations

Prevention of vascular nitroglycerin tolerance by inhibition of protein kinase C

1996 • 32 citations

EMD 52692 (bimakalim), a new potassium channel opener, attenuates luminol-enhanced chemiluminescence and superoxide anion radical formation by zymosan-activated polymorphonuclear leukocytes

1992 • 21 citations

A reappraisal of nitrate therapy

1988 • 10 citations

Herzvergrößerung bei einem Sportler - Eine diagnostische Herausforderung

1998 • 7 citations