Platelet-Derived Growth Factor–Stimulated Superoxide Anion Production Modulates Activation of Transcription Factor NF-κB and Expression of Monocyte Chemoattractant Protein 1 in Human Aortic Smooth Muscle Cells

The pathogenesis of atherosclerosis: a perspective for the 1990s

1993 • 10,730 citations

Rapid detection of octamer binding proteins with ‘mini extracts’, prepared from a small number of cells

1989 • 4,279 citations

Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1.

1991 • 3,819 citations

Angiotensin II stimulates NADH and NADPH oxidase activity in cultured vascular smooth muscle cells.

1994 • 2,753 citations

Requirement for Generation of H ₂ O ₂ for Platelet-Derived Growth Factor Signal Transduction

1995 • 2,505 citations

Angiotensin II-mediated hypertension in the rat increases vascular superoxide production via membrane NADH/NADPH oxidase activation. Contribution to alterations of vasomotor tone.

1996 • 2,456 citations

Superoxide anion is involved in the breakdown of endothelium-derived vascular relaxing factor

1986 • 2,416 citations

Role of transcription factor NF-kappa B/Rel in induction of nitric oxide synthase.

1994 • 2,216 citations

Antioxidant and redox regulation of gene transcription

1996 • 1,999 citations

Hypercholesterolemia increases endothelial superoxide anion production.

1993 • 1,799 citations

Monocyte chemoattractant protein 1 acts as a T-lymphocyte chemoattractant.

1994 • 1,190 citations

Minimally modified low density lipoprotein induces monocyte chemotactic protein 1 in human endothelial cells and smooth muscle cells.

1990 • 1,147 citations

Inhibition of Neointimal Smooth Muscle Accumulation After Angioplasty by an Antibody to PDGF

1991 • 1,081 citations

Expression of monocyte chemoattractant protein 1 in macrophage-rich areas of human and rabbit atherosclerotic lesions.

1991 • 879 citations

Activated transcription factor nuclear factor-kappa B is present in the atherosclerotic lesion.

1996 • 795 citations

Inhibition of histamine secretion by wortmannin through the blockade of phosphatidylinositol 3-kinase in RBL-2H3 cells.

1993 • 738 citations

The extinction coefficient of cytochrome c

1962 • 693 citations

Platelet-derived growth factor receptor signals.

1994 • 561 citations

Phosphoinositide kinases

1996 • 529 citations

NF-kappa B and Sp1 regulate transcription of the human monocyte chemoattractant protein-1 gene.

1994 • 527 citations

Reaction of superoxide with nitric oxide to form peroxonitrite in alkaline aqueous solution

1985 • 512 citations

Purification and amino acid analysis of two human glioma-derived monocyte chemoattractants.

1989 • 497 citations

Potent selective inhibitors of protein kinase C

1989 • 482 citations

Native Low-Density Lipoprotein Increases Endothelial Cell Nitric Oxide Synthase Generation of Superoxide Anion

1995 • 479 citations

Nitric Oxide Modulates the Expression of Monocyte Chemoattractant Protein 1 in Cultured Human Endothelial Cells

1995 • 475 citations

Enzymic mechanisms of superoxide production

1991 • 475 citations

Differential Activation of Mitogen-Activated Protein Kinases by H ₂ O ₂ and O ₂ ⁻ in Vascular Smooth Muscle Cells

1995 • 416 citations

Superoxide anion is an endothelium-derived contracting factor

1989 • 398 citations

Permeation of the erythrocyte stroma by superoxide radical

1978 • 367 citations

Role of Superoxide in the Depressed Nitric Oxide Production by the Endothelium of Genetically Hypertensive Rats

1995 • 304 citations

Oxygen radicals as second messengers for expression of the monocyte chemoattractant protein, JE/MCP-1, and the monocyte colony-stimulating factor, CSF-1, in response to tumor necrosis factor-alpha and immunoglobulin G. Evidence for involvement of reduced nicotinamide adenine dinucleotide phosphate (NADPH)-dependent oxidase.

1993 • 275 citations

Activation and attenuation of transcription factor NF-kB in mouse glomerular mesangial cells in response to tumor necrosis factor-alpha, immunoglobulin G, and adenosine 3':5'-cyclic monophosphate. Evidence for involvement of reactive oxygen species.

1994 • 179 citations

Two transduction sequences are necessary for neutrophil activation by receptor agonists.

1988 • 172 citations

Platelet-derived growth factor suppresses and fibroblast growth factor enhances cytokine-induced production of nitric oxide by cultured smooth muscle cells. Effects on cell proliferation.

1992 • 172 citations

Sites of superoxide anion production detected by lucigenin in calf pulmonary artery smooth muscle

1994 • 165 citations

Regulation of spontaneous EDRF release in diabetic rat aorta by oxygen free radicals

1992 • 161 citations

Role of Nitric Oxide and Its Interaction With Superoxide in the Suppression of Cardiac Muscle Mitochondrial Respiration

1996 • 153 citations

JE mRNA accumulates rapidly in aortic injury and in platelet-derived growth factor-stimulated vascular smooth muscle cells.

1992 • 147 citations

Ca2+-channel blockers inhibit the action of recombinant platelet-derived growth factor in vascular smooth muscle cells.

1989 • 138 citations

Involvement of phenyl radicals in iodonium inhibition of flavoenzymes.

1994 • 137 citations

Antisense Oligonucleotides to the P65 Subunit of NF-κb Inhibit Human Vascular Smooth Muscle Cell Adherence and Proliferation and Prevent Neointima Formation in Rat Carotid Arteries

1995 • 136 citations

High <scp>D</scp>-Glucose–Induced Changes in Endothelial Ca2+/EDRF Signaling are Due to Generation of Superoxide Anions

1996 • 136 citations

Platelet-derived growth factor promotes polymorphonuclear leukocyte activation

1984 • 132 citations

Evidence for superoxide radical-dependent coronary vasospasm after angioplasty in intact dogs.

1991 • 120 citations

Platelet-derived growth factor promotes human peripheral monocyte activation

1985 • 116 citations

Diverse prostaglandin receptors activate distinct signal transduction pathways in rat myometrium

1992 • 115 citations

Platelet-derived Growth Factor Stimulates Protein Kinase A through a Mitogen-activated Protein Kinase-dependent Pathway in Human Arterial Smooth Muscle Cells

1996 • 102 citations

Mechanism of action of platelet-derived growth factor

1996 • 99 citations

Platelet-derived Growth Factor Induction of the Immediate-early gene Is Mediated by NF-κB and a 90-kDa Phosphoprotein Coactivator

1996 • 88 citations

Superoxide as a signal for increase in intracellular pH

1988 • 87 citations

NF-κB Is Induced in the Nuclei of Cultured Rat Aortic Smooth Muscle Cells by Stimulation of Various Growth Factors

1996 • 84 citations

Suppression of Interleukin-1β-induced Nitric-oxide Synthase Promoter/Enhancer Activity by Transforming Growth Factor-β1 in Vascular Smooth Muscle Cells

1996 • 78 citations

Hypoxia-reoxygenation increases O2-. efflux which injures endothelial cells by an extracellular mechanism

1996 • 45 citations

Lack of effect of recombinant platelet-derived growth factor on human neutrophil function.

1995 • 33 citations

Pyrrolidine dithiocarbamate selectively prevents the expression of the inducible nitric oxide synthase in the rat aorta

1994 • 30 citations

Dexamethasone Inhibits Nitric Oxide Synthase mRNA Induction by Interleukin-la and Tumor Necrosis Factor-α in Vascular Smooth Muscle Cells

1993 • 17 citations