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Hereditary ovarian carcinoma: Heterogeneity, molecular genetics, pathology, and management

Data up to Jan 2025

Published2009
Citations198
References331

Total Citations Per Year

Abstract

References (331)

Cancer Statistics, 2008

2008 • 10,165 citations

A Strong Candidate for the Breast and Ovarian Cancer Susceptibility Gene BRCA1

1994 • 5,994 citations

The phosphatidylinositol 3-Kinase–AKT pathway in human cancer

2002 • 5,914 citations

Tamoxifen for Prevention of Breast Cancer: Report of the National Surgical Adjuvant Breast and Bowel Project P-1 Study

1998 • 5,487 citations

PTEN , a Putative Protein Tyrosine Phosphatase Gene Mutated in Human Brain, Breast, and Prostate Cancer

1997 • 4,753 citations

A National Cancer Institute Workshop on Microsatellite Instability for cancer detection and familial predisposition: development of international criteria for the determination of microsatellite instability in colorectal cancer.

1998 • 4,047 citations

Identification of the breast cancer susceptibility gene BRCA2

1995 • 3,581 citations

Average Risks of Breast and Ovarian Cancer Associated with BRCA1 or BRCA2 Mutations Detected in Case Series Unselected for Family History: A Combined Analysis of 22 Studies

2003 • 3,497 citations

de la Chapelle, A.

1997 • 3,184 citations

Genetic Heterogeneity and Penetrance Analysis of the BRCA1 and BRCA2 Genes in Breast Cancer Families

1998 • 2,920 citations

The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer

1993 • 2,884 citations

Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis

1993 • 2,711 citations

Linkage of Early-Onset Familial Breast Cancer to Chromosome 17q21

1990 • 2,505 citations

New clinical criteria for hereditary nonpolyposis colorectal cancer (HNPCC, Lynch syndrome) proposed by the International Collaborative Group on HNPCC☆

1999 • 2,460 citations

Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer

1993 • 2,282 citations

The Risk of Cancer Associated with Specific Mutations ofBRCA1andBRCA2among Ashkenazi Jews

1997 • 2,255 citations

Breast and Ovarian Cancer Risks Due to Inherited Mutations in BRCA1 and BRCA2

2003 • 2,170 citations

The International Collaborative Group on Hereditary Non-Polyposis Colorectal Cancer (ICG-HNPCC)

1991 • 2,142 citations

Mutation in the DNA mismatch repair gene homologue hMLH 1 is associated with hereditary non-polyposis colon cancer

1994 • 2,071 citations

Localization of a Breast Cancer Susceptibility Gene, BRCA2 , to Chromosome 13q12-13

1994 • 1,884 citations

Risks of cancer in BRCA1-mutation carriers

1994 • 1,865 citations

Mutation of a mutL Homolog in Hereditary Colon Cancer

1994 • 1,834 citations

Effects of Tamoxifen vs Raloxifene on the Risk of Developing Invasive Breast Cancer and Other Disease Outcomes<SUBTITLE>The NSABP Study of Tamoxifen and Raloxifene (STAR) P-2 Trial</SUBTITLE>

2006 • 1,621 citations

Breast and ovarian cancer incidence in BRCA1-mutation carriers. Breast Cancer Linkage Consortium.

1995 • 1,602 citations

Mutations of two P/WS homologues in hereditary nonpolyposis colon cancer

1994 • 1,544 citations

Cancer Risks in BRCA2 Mutation Carriers

1999 • 1,477 citations

National Center for Biotechnology Information

2019 • 1,448 citations

Prophylactic Oophorectomy in Carriers ofBRCA1orBRCA2Mutations

2002 • 1,448 citations

Genetic linkage analysis in familial breast and ovarian cancer: results from 214 families. The Breast Cancer Linkage Consortium.

1993 • 1,269 citations

Risk-Reducing Salpingo-oophorectomy in Women with aBRCA1orBRCA2Mutation

2002 • 1,229 citations

Cancer risk in mutation carriers of DNA-mismatch-repair genes

1999 • 1,219 citations

Ovarian Tumorigenesis

2004 • 1,182 citations

Promoter Hypermethylation and BRCA1 Inactivation in Sporadic Breast and Ovarian Tumors

2000 • 1,182 citations

Incidence of Hereditary Nonpolyposis Colorectal Cancer and the Feasibility of Molecular Screening for the Disease

1998 • 1,173 citations

INCESSANT OVULATION—A FACTOR IN OVARIAN NEOPLASIA ?

1971 • 1,104 citations

Intraepithelial Carcinoma of the Fimbria and Pelvic Serous Carcinoma: Evidence for a Causal Relationship

2007 • 1,074 citations

Cancer Incidence in BRCA1 Mutation Carriers

2002 • 1,064 citations

Ovarian Surface Epithelium: Biology, Endocrinology, and Pathology*

2001 • 984 citations

Analysis of mismatch repair genes in hereditary non–polyposis colorectal cancer patients

1996 • 957 citations

Overview of the main outcomes in breast-cancer prevention trials

2003 • 941 citations

Principles and Practice of Gynecologic Oncology

1992 • 933 citations

The Tubal Fimbria Is a Preferred Site for Early Adenocarcinoma in Women With Familial Ovarian Cancer Syndrome

2006 • 871 citations

Prevalence of BRCA1 and BRCA2 Gene Mutations in Patients With Early-Onset Breast Cancer

1999 • 866 citations

A candidate precursor to serous carcinoma that originates in the distal fallopian tube

2006 • 864 citations

Molecular alterations of the AKT2 oncogene in ovarian and breast carcinomas

1995 • 831 citations

Mutations in BRAF and KRAS Characterize the Development of Low-Grade Ovarian Serous Carcinoma

2003 • 829 citations

Cancer risk in families with hereditary nonpolyposis colorectal cancer diagnosed by mutation analysis

1996 • 814 citations

Mutations predisposing to hereditary nonpolyposis colorectal cancer: Database and results of a collaborative study. The International Collaborative Group on Hereditary Nonpolyposis Colorectal Cancer

1997 • 756 citations

Prophylactic Surgery to Reduce the Risk of Gynecologic Cancers in the Lynch Syndrome

2006 • 751 citations

Tamoxifen and Breast Cancer Incidence Among Women With Inherited Mutations in BRCA1 and BRCA2

2001 • 750 citations

The genetic attributable risk of breast and ovarian cancer

1996 • 740 citations

AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas.

1992 • 732 citations

Cancer Risk Estimates for BRCA1 Mutation Carriers Identified in a Risk Evaluation Program

2002 • 715 citations

GENETIC SUSCEPTIBILITY TO NONPOLYPOSIS COLORECTAL CANCER

1999 • 695 citations

Cancer risk associated with germline DNA mismatch repair gene mutations

1997 • 693 citations

Mutations in PTEN are frequent in endometrial carcinoma but rare in other common gynecological malignancies.

1997 • 689 citations

BRCA1 and BRCA2 mutations account for a large proportion of ovarian carcinoma cases

2005 • 682 citations

Role of DNA Mismatch Repair Defects in the Pathogenesis of Human Cancer

2003 • 680 citations

Continued Breast Cancer Risk Reduction in Postmenopausal Women Treated with Raloxifene: 4-Year Results from the MORE Trial

2001 • 678 citations

Continuing Outcomes Relevant to Evista: Breast Cancer Incidence in Postmenopausal Osteoporotic Women in a Randomized Trial of Raloxifene

2004 • 676 citations

Grading Ovarian Serous Carcinoma Using a Two-Tier System

2004 • 644 citations

Isolation of an hMSH2-p160 Heterodimer That Restores DNA Mismatch Repair to Tumor Cells

1995 • 599 citations

Carcinoma of the corpus uteri

2003 • 585 citations

Redundancy of Saccharomyces cerevisiae MSH3 and MSH6 in MSH2-dependent mismatch repair.

1996 • 576 citations

Risk-Reducing Salpingo-Oophorectomy for the Prevention of BRCA1- and BRCA2-Associated Breast and Gynecologic Cancer: A Multicenter, Prospective Study

2008 • 567 citations

The risk of extra‐colonic, extra‐endometrial cancer in the Lynch syndrome

2008 • 564 citations

Prevalence and penetrance of BRCA1 and BRCA2 mutations in a population-based series of breast cancer cases

2000 • 559 citations

Estimates of the gene frequency of BRCA1 and its contribution to breast and ovarian cancer incidence.

1995 • 541 citations

hMSH2 forms specific mispair-binding complexes with hMSH3 and hMSH6

1996 • 541 citations

Clinicopathologic Features of <EMPH TYPE="ITAL">BRCA</EMPH>-Linked and Sporadic Ovarian Cancer

2000 • 537 citations

Tamoxifen and risk of contralateral breast cancer in BRCA1 and BRCA2 mutation carriers: a case-control study

2000 • 536 citations

GTBP, a 160-Kilodalton Protein Essential for Mismatch-binding Activity in Human Cells

1995 • 528 citations

Population-Based Molecular Detection of Hereditary Nonpolyposis Colorectal Cancer

2000 • 523 citations

Risk and prognosis of endometrial cancer after tamoxifen for breast cancer

2000 • 521 citations

PTEN/MMAC1 mutations in endometrial cancers.

1997 • 517 citations

Familial breast-ovarian cancer locus on chromosome 17q12-q23

1991 • 513 citations

Human chromosome 3 corrects mismatch repair deficiency and microsatellite instability and reduces N-methyl-N'-nitro-N-nitrosoguanidine tolerance in colon tumor cells with homozygous hMLH1 mutation.

1994 • 506 citations

Germline mutations of the BRCA1 gene in breast and ovarian cancer families provide evidence for a genotype–phenotype correlation

1995 • 497 citations

Variation in Cancer Risks, by Mutation Position, in BRCA2 Mutation Carriers

2001 • 482 citations

The distal fallopian tube: a new model for pelvic serous carcinogenesis

2007 • 482 citations

Primary Fallopian Tube Malignancies in BRCA-Positive Women Undergoing Surgery for Ovarian Cancer Risk Reduction

2007 • 472 citations

Germ-line mutation of the hMSH6/GTBP gene in an atypical hereditary nonpolyposis colorectal cancer kindred.

1997 • 465 citations

Pathogenesis of Ovarian Cancer

2008 • 455 citations

“BRCAness” Syndrome in Ovarian Cancer: A Case-Control Study Describing the Clinical Features and Outcome of Patients With Epithelial Ovarian Cancer Associated With BRCA1 and BRCA2 Mutations

2008 • 453 citations

Loss of heterozygosity on 10q23.3 and mutation of the tumor suppressor gene PTEN in benign endometrial cyst of the ovary: possible sequence progression from benign endometrial cyst to endometrioid carcinoma and clear cell carcinoma of the ovary.

2000 • 444 citations

Genetic instability in pancreatic cancer and poorly differentiated type of gastric cancer.

1993 • 443 citations

Ovarian Surface Epithelium: Biology, Endocrinology, and Pathology

2001 • 441 citations

Variation of risks of breast and ovarian cancer associated with different germline mutations of the BRCA2 gene

1997 • 437 citations

Mutations Associated with HNPCC Predisposition — Update of ICG-HNPCC/INSiGHT Mutation Database

2004 • 436 citations

Breast Cancer Risk Following Bilateral Oophorectomy in BRCA1 and BRCA2 Mutation Carriers: An International Case-Control Study

2005 • 435 citations

Genetic mapping of a second locus predisposing to hereditary non–polyposis colon cancer

1993 • 434 citations

Improved survival in women with BRCA‐associated ovarian carcinoma

2003 • 430 citations

Early Events in the Pathogenesis of Epithelial Ovarian Cancer

2008 • 429 citations

Clinical and Pathological Features of Ovarian Cancer in Women with Germ-Line Mutations ofBRCA1

1996 • 427 citations

Cancer risk in hereditary nonpolyposis colorectal cancer due to MSH6 mutations: impact on counseling and surveillance

2004 • 423 citations

Frequent PTEN/MMAC mutations in endometrioid but not serous or mucinous epithelial ovarian tumors.

1998 • 423 citations

Overexpression of AKT2/protein kinase Bbeta leads to up-regulation of beta1 integrins, increased invasion, and metastasis of human breast and ovarian cancer cells.

2003 • 416 citations

Outcome of Preventive Surgery and Screening for Breast and Ovarian Cancer in BRCA Mutation Carriers

2002 • 411 citations

New Insights Into the Pathogenesis of Serous Ovarian Cancer and Its Clinical Impact

2008 • 408 citations

Patterns of p53 Mutations Separate Ovarian Serous Borderline Tumors and Low- and High-grade Carcinomas and Provide Support for a New Model of Ovarian Carcinogenesis

2005 • 405 citations

Isolation of MutSβ from Human Cells and Comparison of the Mismatch Repair Specificities of MutSβ and MutSα

1998 • 405 citations

Effect of Short-Term Hormone Replacement Therapy on Breast Cancer Risk Reduction After Bilateral Prophylactic Oophorectomy in BRCA1 and BRCA2 Mutation Carriers: The PROSE Study Group

2005 • 399 citations

Cancer Risks in Two Large Breast Cancer Families Linked to BRCA2 on Chromosome 13q12‐13

1997 • 389 citations

MSH2 Mutation Carriers Are at Higher Risk of Cancer Than MLH1 Mutation Carriers: A Study of Hereditary Nonpolyposis Colorectal Cancer Families

2001 • 386 citations

Somatic mutations in the BRCA1 gene in sporadic ovarian tumours

1995 • 377 citations

Hereditary factors in cancer. Study of two large midwestern kindreds

1966 • 377 citations

THE SECONDARY MÜLLERIAN SYSTEM

1972 • 360 citations

Risk-Reducing Salpingo-Oophorectomy in BRCA Mutation Carriers: Role of Serial Sectioning in the Detection of Occult Malignancy

2004 • 358 citations

Origins and molecular pathology of ovarian cancer

2005 • 355 citations

The Efficacy of Transvaginal Sonographic Screening in Asymptomatic Women at Risk for Ovarian Cancer

2000 • 351 citations

Tamoxifen for Prevention of Breast Cancer

2003 • 351 citations

Tamoxifen Therapy for Breast Cancer and Endometrial Cancer Risk

1999 • 348 citations

Lessons from BRCA: The Tubal Fimbria Emerges as an Origin for Pelvic Serous Cancer

2007 • 343 citations

Common origins of BRCA1 mutations in Canadian breast and ovarian cancer families

1994 • 334 citations

Occult Carcinoma in Prophylactic Oophorectomy Specimens

2001 • 330 citations

BRCA1 promoter region hypermethylation in ovarian carcinoma: a population-based study.

2000 • 322 citations

Effect of BRCA1/2 Mutations on Long-Term Survival of Patients With Invasive Ovarian Cancer: The National Israeli Study of Ovarian Cancer

2007 • 316 citations

Hereditary Factors in Cancer

1966 • 313 citations

Association of Hereditary Nonpolyposis Colorectal Cancer–Related Tumors Displaying Low Microsatellite Instability with MSH6 Germline Mutations

1999 • 309 citations

Founding mutations and Alu-mediated recombination in hereditary colon cancer

1995 • 308 citations

Pathologic Findings in Prophylactic Oophorectomy Specimens in High-Risk Women

2002 • 297 citations

p53 gene mutations and protein accumulation in human ovarian cancer.

1993 • 294 citations

PTEN mutations and microsatellite instability in complex atypical hyperplasia, a precursor lesion to uterine endometrioid carcinoma.

1998 • 286 citations

A candidate precursor to pelvic serous cancer (p53 signature) and its prevalence in ovaries and fallopian tubes from women with BRCA mutations

2008 • 277 citations

Serous Carcinogenesis in the Fallopian Tube

2008 • 275 citations

Risk of colorectal and endometrial cancer for carriers of mutations of the hMLH1 and hMSH2 gene: correction for ascertainment

2005 • 270 citations

An evaluation of genetic heterogeneity in 145 breast-ovarian cancer families. Breast Cancer Linkage Consortium.

1995 • 268 citations

Microscopic Benign and Invasive Malignant Neoplasms and a Cancer-Prone Phenotype in Prophylactic Oophorectomies

1996 • 266 citations

DNA mismatch repair gene mutations in 55 kindreds with verified or putative hereditary non-polyposis colorectal cancer

1996 • 264 citations

A randomized study of screening for ovarian cancer: a multicenter study in Japan

2007 • 263 citations

Survival of BRCA1 breast and ovarian cancer patients: a population-based study from southern Sweden.

1998 • 259 citations

Diverse mechanisms of beta-catenin deregulation in ovarian endometrioid adenocarcinomas.

2001 • 252 citations

Pathology of Ovarian Cancers in BRCA1 and BRCA2 Carriers

2004 • 247 citations

Human MLH1 deficiency predisposes to hematological malignancy and neurofibromatosis type 1.

1999 • 245 citations

Screening for early familial ovarian cancer with transvaginal ultrasonography and colour blood flow imaging.

1993 • 240 citations

Increased mutation rate at the hprt locus accompanies microsatellite instability in colon cancer.

1995 • 239 citations

Colorectal carcinoma survival among hereditary nonpolyposis colorectal carcinoma family members

1998 • 239 citations

Mutation of K-ras protooncogene in human ovarian epithelial tumors of borderline malignancy.

1993 • 238 citations

Neurofibromatosis and early onset of cancers in hMLH1-deficient children.

1999 • 238 citations

High prevalence of the 999del5 mutation in icelandic breast and ovarian cancer patients.

1996 • 232 citations

Outcome of Preventive Surgery and Screening for Breast and Ovarian Cancer in BRCA Mutation Carriers

2002 • 229 citations

Mutation of the PTEN tumor suppressor gene in endometrial hyperplasias.

1998 • 228 citations

β-Catenin Expression Pattern in Stage I and II Ovarian Carcinomas

1999 • 225 citations

The outcome of endometrial carcinoma surveillance by ultrasound scan in women at risk of hereditary nonpolyposis colorectal carcinoma and familial colorectal carcinoma

2002 • 224 citations

A Genetic Epidemiological Study of Carcinoma of the Fallopian Tube

2001 • 220 citations

Inactivation of BRCA1 and BRCA2 in Ovarian Cancer

2002 • 216 citations

p53 and Ki-ras gene mutations in epithelial ovarian neoplasms.

1993 • 216 citations

Clinical implications of the ErbB/epidermal growth factor (EGF) receptor family and its ligands in ovarian cancer

2008 • 214 citations

Steady-state Regulation of the Human DNA Mismatch Repair System

2000 • 211 citations

Molecular Analysis of Hereditary Nonpolyposis Colorectal Cancer in the United States: High Mutation Detection Rate among Clinically Selected Families and Characterization of an American Founder Genomic Deletion of the MSH2 Gene

2003 • 209 citations

Effect of BRCA Mutations on the Length of Survival in Epithelial Ovarian Tumors

2002 • 204 citations

Hereditary colorectal cancer syndromes: molecular genetics, genetic counseling, diagnosis and management

2007 • 199 citations

Fallopian Tube and Primary Peritoneal Carcinomas Associated With BRCA Mutations

2003 • 199 citations

Occult Cancer of the Fallopian Tube in BRCA-1 Germline Mutation Carriers at Prophylactic Oophorectomy: A Case for Recommending Hysterectomy at Surgical Prophylaxis

2001 • 195 citations

Surveillance for endometrial cancer in hereditary nonpolyposis colorectal cancer syndrome

2006 • 193 citations

Molecular Evidence Linking Primary Cancer of the Fallopian Tube to BRCA1 Germline Mutations

2000 • 193 citations

Selective Estrogen Receptor Modulators: An Update on Recent Clinical Findings

2008 • 191 citations

Novel inherited mutations and variable expressivity of BRCA1 alleles, including the founder mutation 185delAG in Ashkenazi Jewish families.

1995 • 191 citations

The biochemical basis of microsatellite instability and abnormal immunohistochemistry and clinical behavior in Lynch Syndrome: from bench to bedside

2007 • 188 citations

Risk models for familial ovarian and breast cancer

2000 • 187 citations

Sequence mutations and amplification of PIK3CA and AKT2 genes in purified ovarian serous neoplasms

2006 • 185 citations

Second Cancers After Adjuvant Tamoxifen Therapy for Breast Cancer

1996 • 184 citations

Prophylactic oophorectomy in inherited breast/ovarian cancer families.

1995 • 183 citations

BRCA1, BRCA2, and hereditary nonpolyposis colorectal cancer gene mutations in an unselected ovarian cancer population: Relationship to family history and implications for genetic testing

1998 • 183 citations

Variation in BRCA1 cancer risks by mutation position.

2002 • 182 citations

Allelic loss of sequences from the long arm of chromosome 10 and replication errors in endometrial cancers.

1995 • 181 citations

Molecular genetic alterations in endometrioid carcinomas of the ovary: Similar frequency of beta-catenin abnormalities but lower rate of microsatellite instability and PTEN alterations than in uterine endometrioid carcinomas

2004 • 179 citations

The role of ultrasound evaluation in the detection of early-stage epithelial ovarian cancer

2005 • 174 citations

CA125 and transvaginal ultrasound monitoring in high-risk women cannot prevent the diagnosis of advanced ovarian cancer

2005 • 173 citations

hMSH2 and hMSH6 play distinct roles in mismatch binding and contribute differently to the ATPase activity of hMutSalpha

1998 • 173 citations

BRCA2 in American families with four or more cases of breast or ovarian cancer: recurrent and novel mutations, variable expression, penetrance, and the possibility of families whose cancer is not attributable to BRCA1 or BRCA2.

1997 • 168 citations

Mutation and overexpression of p53 in early-stage epithelial ovarian cancer.

1993 • 168 citations

Gynecologic screening in hereditary nonpolyposis colorectal cancer

2003 • 168 citations

BRCA-Mutation–Associated Fallopian Tube Carcinoma

2005 • 165 citations

Mismatch Repair Gene PMS2

2004 • 162 citations

Phenotypic and genotypic heterogeneity in the Lynch syndrome: diagnostic, surveillance and management implications

2006 • 160 citations

Ovarian cancer risk in Ashkenazi Jewish carriers of BRCA1 and BRCA2 mutations.

2002 • 156 citations

Surface Epithelial Tumors of the Ovary

2010 • 153 citations

Competency in mismatch repair prohibits clonal expansion of cancer cells treated with N-methyl-N'-nitro-N-nitrosoguanidine.

1996 • 148 citations

Microsatellite instability and alteration of the expression of hMLH1 and hMSH2 in ovarian clear cell carcinoma

2004 • 145 citations

Risk of Endometrial Carcinoma Associated with BRCA Mutation

2001 • 145 citations

Advances in the Recognition of Tubal Intraepithelial Carcinoma

2006 • 144 citations

A homozygous germ-line mutation in the human MSH2 gene predisposes to hematological malignancy and multiple café-au-lait spots.

2002 • 142 citations

Survival in familial, BRCA1-associated, and BRCA2-associated epithelial ovarian cancer. United Kingdom Coordinating Committee for Cancer Research (UKCCCR) Familial Ovarian Cancer Study Group.

1999 • 141 citations

Cancer risk in mismatch repair gene mutation carriers.

2001 • 135 citations

Possible involvement of hMLH1, p16INK4a and PTEN in the malignant transformation of endometriosis

2002 • 134 citations

?-Catenin mutation and expression analysis in ovarian cancer: Exon 3 mutations and nuclear translocation in 16% of endometrioid tumours

1999 • 133 citations

Systematic Review and Meta-analysis of Ovarian Cancers: Estimation of Microsatellite-High Frequency and Characterization of Mismatch Repair Deficient Tumor Histology

2008 • 133 citations

The risk of endometrial cancer in women with BRCA1 and BRCA2 mutations. A prospective study

2006 • 132 citations

The performance of screening tests for ovarian cancer: results of a systematic review

1998 • 131 citations

Clinical outcome of prophylactic oophorectomy in BRCA1/BRCA2 mutation carriers and events during follow-up

2004 • 130 citations

The ovarian mesothelioma

1974 • 129 citations

The Founder Mutation MSH2*1906G→C Is an Important Cause of Hereditary Nonpolyposis Colorectal Cancer in the Ashkenazi Jewish Population

2002 • 128 citations

The contribution of the hereditary nonpolyposis colorectal cancer syndrome to the development of ovarian cancer

2005 • 125 citations

Effect of BRCA Mutations on the Length of Survival in Epithelial Ovarian Tumors

2002 • 120 citations

Microsatellite instability and alterations in the HMSH2 gene in human ovarian cancer

1995 • 119 citations

Molecular characterization of the spectrum of genomic deletions in the mismatch repair genes MSH2, MLH1, MSH6, and PMS2 responsible for hereditary nonpolyposis colorectal cancer (HNPCC)

2005 • 119 citations

Histopathologic Features of Genetically Determined Ovarian Cancer

2002 • 118 citations

The effect of tamoxifen and hormone replacement therapy on serum cholesterol, bone mineral density and coagulation factors in healthy postmenopausal women participating in a randomised, controlled tamoxifen prevention study

1996 • 118 citations

Endometrial and Colorectal Tumors from Patients with Hereditary Nonpolyposis Colon Cancer Display Different Patterns of Microsatellite Instability

2002 • 117 citations

Hereditary Ovarian Cancer

1992 • 117 citations

Microsatellite instability, MLH-1 promoter hypermethylation, and frameshift mutations at coding mononucleotide repeat microsatellites in ovarian tumors

2001 • 117 citations

Annual surveillance by CA125 and transvaginal ultrasound for ovarian cancer in both high‐risk and population risk women is ineffective

2007 • 116 citations

Role of estrogens and progesterone in the etiology and prevention of endometrial cancer: Review

1983 • 115 citations

Intraperitoneal serous adenocarcinoma: A critical appraisal of three hypotheses on its cause

2004 • 115 citations

Mutational Analysis of K-ras Segregates Ovarian Serous Carcinomas into Two Types: Invasive MPSC (Low-grade Tumor) and Conventional Serous Carcinoma (High-grade Tumor)

2003 • 115 citations

Phenocopies in BRCA1 and BRCA2 families: evidence for modifier genes and implications for screening

2006 • 113 citations

Evidence for sequential action of two ATPase active sites in yeast Msh2–Msh6

2002 • 112 citations

EGF/ErbB Receptor Family in Ovarian Cancer

2002 • 112 citations

Tumor Variation in Families With Breast Cancer

1972 • 110 citations

Heredity and Adenocarcinoma of the Colon

1967 • 108 citations

Genetics and ovarian carcinoma.

1998 • 107 citations

Cancer risk estimates for family members of a population-based family registry for breast and ovarian cancer.

2000 • 105 citations

A review of the clinical relevance of mismatch‐repair deficiency in ovarian cancer

2008 • 104 citations

Unexpected Gynecologic Neoplasms in Patients With Proven or Suspected BRCA-1 or -2 Mutations

2002 • 104 citations

BRCA germline mutations in Jewish women with uterine serous papillary carcinoma

2004 • 103 citations

Predictors of occult neoplasia in women undergoing risk-reducing salpingo-oophorectomy

2006 • 103 citations

An abundance of p53 null mutations in ovarian carcinoma.

1996 • 102 citations

Cancer variation associated with the position of the mutation in the BRCA2 gene

2002 • 102 citations

Iatrogenic risks of endometrial carcinoma after treatment for breast cancer in a large French case-control study

1998 • 100 citations

BRCA1 and BRCA2 Mutation Prevalence and Clinical Characteristics of a Population-Based Series of Ovarian Cancer Cases from Denmark

2008 • 100 citations

Gynecologic Surgeries and Risk of Ovarian Cancer in Women With BRCA1 and BRCA2 Ashkenazi Founder Mutations: An Israeli Population-Based Case-Control Study

2003 • 98 citations

Clinical features of ovarian cancer in Japanese women with germ-line mutations of BRCA1.

1998 • 97 citations

Intra-abdominal carcinomatosis after prophylactic oophorectomy in women of hereditary breast ovarian cancer syndrome kindreds associated with BRCA1 and BRCA2 mutations

2005 • 96 citations

Close linkage to chromosome 3p and conservation of ancestral founding haplotype in hereditary nonpolyposis colorectal cancer families.

1994 • 96 citations

Age and origin of two common MLH1 mutations predisposing to hereditary colon cancer.

1996 • 96 citations

Significance of epidermal growth factor receptor in advanced ovarian cancer.

1992 • 96 citations

MSH6 and MSH3 are rarely involved in genetic predisposition to nonpolypotic colon cancer.

2001 • 95 citations

The Average Cumulative Risks of Breast and Ovarian Cancer for Carriers of Mutations in BRCA1 and BRCA2 Attending Genetic Counseling Units in Spain

2008 • 94 citations

Cancer Incidence in a Population of Jewish Women at Risk of Ovarian Cancer

2002 • 94 citations

Cost‐effectiveness analysis of prevention strategies for gynecologic cancers in Lynch syndrome

2008 • 92 citations

Surveillance of women at high risk for hereditary ovarian cancer is inefficient

2006 • 92 citations

Outcome of surveillance and prophylactic salpingo-oophorectomy in asymptomatic women at high risk for ovarian cancer

2005 • 91 citations

Chromosome 8q23.3 and 11q23.1 Variants Modify Colorectal Cancer Risk in Lynch Syndrome

2008 • 91 citations

The effect of a single BRCA2 mutation on cancer in Iceland

2002 • 90 citations

Endometrial Carcinoma Risks among Menopausal Estrogen plus Progestin and Unopposed Estrogen Users in a Cohort of Postmenopausal Women

2005 • 88 citations

Cancer Risk in Young Women at Risk of Hereditary Nonpolyposis Colorectal Cancer: Implications for Gynecologic Surveillance

2001 • 87 citations

Tubal and ovarian pathways to pelvic epithelial cancer: a pathological perspective

2008 • 87 citations

Polymerase chain reaction allelotyping of human ovarian cancer

1994 • 87 citations

Hereditary Non-Polyposis Colorectal Cancer: Clinical Features and Survival Results from the Danish HNPCC Register

1997 • 86 citations

Extensive somatic microsatellite mutations in normal human tissue.

2001 • 85 citations

Six families prone to ovarian cancer

1975 • 84 citations

Estrogens, Progesterone, and Endometrial Cancer

1993 • 84 citations

Recurrent germline mutation in MSH2 arises frequently de novo

2000 • 83 citations

A Founder Mutation of the <EMPH TYPE="ITAL">MSH2</EMPH> Gene and Hereditary Nonpolyposis Colorectal Cancer in the United States

2004 • 83 citations

Hormone replacement therapy and the endometrium

2001 • 82 citations

Application of the National Cancer Institute international criteria for determination of microsatellite instability in ovarian cancer.

2001 • 82 citations

Molecular genetics of hereditary ovarian cancer.

1998 • 80 citations

Expression of cadherins and catenins correlates with distinct histologic types of ovarian carcinomas

2006 • 76 citations

Is Uterine Serous Papillary Carcinoma a BRCA1-Related Disease? Case Report and Review of the Literature

1999 • 75 citations

Demographic and genetic characteristics of patients with borderline ovarian tumors as compared to early stage invasive ovarian cancer

2005 • 72 citations

Survival of Patients with Ovarian Cancer due to a Mismatch Repair Defect

2005 • 71 citations

Early detection of breast and ovarian cancer in families with BRCA mutations

2005 • 71 citations

Lack of MSH2 and MSH6 characterizes endometrial but not colon carcinomas in hereditary nonpolyposis colorectal cancer.

2001 • 70 citations

Intronic alterations inBRCA1andBRCA2: effect on mRNA splicing fidelity and expression

2006 • 69 citations

Patterns of Loss of Heterozygosity at 10q23.3 and Microsatellite Instability in Endometriosis, Atypical Endometriosis, and Ovarian Carcinoma Arising in Association With Endometriosis

2006 • 69 citations

Allelic imbalance in BRCA1 and BRCA2 gene expression is associated with an increased breast cancer risk

2008 • 68 citations

Novel dominant mutations in Saccharomyces cerevisiae MSH6

2000 • 67 citations

Histopathological characteristics of BRCA1- and BRCA2-associated intraperitoneal cancer: a clinic-based study.

2003 • 67 citations

Carcinoma of the breast and ovary in three families.

1971 • 66 citations

Second cancers after adjuvant tamoxifen therapy for breast cancer in Japan

2000 • 66 citations

Improved survival in BRCA2 carriers with ovarian cancer

2006 • 64 citations

A 10‐Mb paracentric inversion of chromosome arm 2p inactivates MSH2 and is responsible for hereditary nonpolyposis colorectal cancer in a North‐American kindred

2002 • 62 citations

High incidence of BRCA1–2 germline mutations, previous breast cancer and familial cancer history in Jewish patients with uterine serous papillary carcinoma

2006 • 62 citations

Efficacy of screening women at high risk of hereditary ovarian cancer: results of an 11-year cohort study

2006 • 62 citations

The cancer-family syndrome

1979 • 61 citations

Screening for ovarian cancer by transvaginal ultrasound and serum CA125 measurement in women with a familial predisposition: A prospective cohort study

2006 • 60 citations

Germline BRCA2 Mutation in a Patient with Fallopian Tube Carcinoma: A Case Report

2000 • 60 citations

Familial association of carcinoma of the breast and ovary.

1974 • 59 citations

BRCA2, but not BRCA1, mutations account for familial ovarian cancer in Iceland: a population-based study

2004 • 58 citations

Histology of Prophylactically Removed Ovaries from BRCA1 and BRCA2 Mutation Carriers Compared with Noncarriers in Hereditary Breast Ovarian Cancer Syndrome Kindreds

2000 • 57 citations

Microsatellite instability and expression of hMLH1 and hMSH2 proteins in ovarian endometrioid cancer

2003 • 55 citations

Loss of MSH3 Protein Expression Is Frequent in MLH1-Deficient Colorectal Cancer and Is Associated with Disease Progression

2004 • 54 citations

Lack of relationship between EGFR-1 immunohistochemical expression and prognosis in a multicentre clinical trial of 93 patients with advanced primary ovarian epithelial cancer (GINECO group)

2004 • 51 citations

Results from an ultrasound‐based familial ovarian cancer screening clinic: a 10‐year observational study

2003 • 51 citations

Tamoxifen and toremifene treatment of breast cancer and risk of subsequent endometrial cancer: A population‐based case‐control study

2002 • 50 citations

The pathogenesis of ovarian neoplasia.

1979 • 49 citations

Failure of BRCA1 dysfunction to alter ovarian cancer survival.

2002 • 49 citations

A population-based study of BRCA1 and BRCA2 mutations in jewish women with epithelial ovarian cancer

1999 • 48 citations

Immunohistochemical staining of hMLH1 and hMSH2 reflects microsatellite instability status in ovarian carcinoma

2006 • 47 citations

Ovarian cancer survival in Ashkenazi Jewish patients with BRCA1 and BRCA2 mutations

2001 • 47 citations

Expression of differentiation and proliferation related proteins in epithelium of prophylactically removed ovaries from women with a hereditary female adnexal cancer predisposition

2003 • 46 citations

Adenovirus-mediated delivery of the PTEN gene inhibits cell growth by induction of apoptosis in endometrial cancer.

1999 • 46 citations

Association between endometrial cancer and tamoxifen treatment of breast cancer

1999 • 45 citations

Prospectively detected cancer in familial breast/ovarian cancer screening

1999 • 43 citations

Use of CA-125 and ultrasound in high-risk women

2002 • 43 citations

Estrogens, progestogens and endometrial cancer.

1977 • 42 citations

FAMILIAL ASSOCIATION OF CARCINOMA OF THE BREAST AND OVARY

1975 • 41 citations

Patterns of postmenopausal progestin use with estrogen in relation to endometrial cancer (United States).

2003 • 40 citations

CARCINOMA OF THE BREAST AND OVARY IN THREE FAMILIES

1972 • 40 citations

Familial Breast-Ovarian Cancer Locus on Chromosome 17q12-q23

1992 • 38 citations

Origins and Prevalence of the American Founder Mutation of MSH2

2008 • 38 citations

Founder BRCA 1 and 2 Mutations among a Consecutive Series of Ashkenazi Jewish Ovarian Cancer Patients

2000 • 37 citations

Hereditary gynecologic cancers: differential diagnosis, surveillance, management and surgical prophylaxis

2007 • 37 citations

GermlineBRCA1 andHMLH1 mutations in a family with male and female breast carcinoma

2000 • 36 citations

Linkage analysis of 26 Canadian breast and breast-ovarian cancer families

1995 • 35 citations

Peritoneal carcinoma in women with genetic susceptibility: implications for Jewish populations

2004 • 35 citations

Molecular evidence for putative tumour suppressor genes on chromosome 13q specific to BRCA1 related ovarian and fallopian tube cancer

2002 • 35 citations

Clear Cell Carcinoma of the Fimbria of the Fallopian Tube in a BRCA1 Carrier Undergoing Prophylactic Surgery

2000 • 32 citations

A Critical Analysis of Laparoscopic Assisted Vaginal Hysterectomies Compared with Vaginal Hysterectomies Unassisted by Laparoscopy and Transabdominal Hysterectomies*

1994 • 31 citations

Epithelial Ovarian Cancer

2004 • 30 citations

Characteristics of familial ovarian cancer: a report of the first 1,000 families in the Gilda Radner Familial Ovarian Cancer Registry.

1996 • 30 citations

Ovarian carcinoma screening in women at intermediate risk

2005 • 30 citations

BRCA1 Gene Mutations in Sporadic Ovarian Carcinomas: Detection by PCR and Reverse Allele-specific Oligonucleotide Hybridization

1999 • 28 citations

Laparoscopic management of women with a family history of ovarian cancer

1999 • 26 citations

Gynecologic cancer clues to Lynch syndrome II diagnosis: A family report

1992 • 25 citations

Survival analysis in familial ovarian cancer, a case control study

2001 • 25 citations

Age-dependent morphological alterations of human ovaries from populations with and without BRCA mutations

2006 • 25 citations

Hereditary nonpolyposis colon cancer: analysis of linkage to 2p15-16 places the COCA1 locus telomeric to D2S123 and reveals genetic heterogeneity in seven Canadian families.

1994 • 24 citations

An Embryologically Derived Classification of Ovarian Tumors

1960 • 23 citations

Loss of DNA mismatch repair protein hMSH6 in ovarian cancer is histotype-specific.

2008 • 22 citations

Prophylactic surgery prevents endometrial and ovarian cancer in Lynch syndrome

2007 • 21 citations

The HNPCC associated MSH2*1906G->C founder mutation probably originated between 1440 CE and 1715 CE in the Ashkenazi Jewish population

2005 • 20 citations

TP53 mutations in ovarian carcinomas from sporadic cases and carriers of two distinct BRCA1 founder mutations; relation to age at diagnosis and survival

2005 • 20 citations

Cancer risk in families with hereditary nonpolyposis colorectal cancer diagnosed by mutation analysis (vol 110, pg 1020, 1996)

1996 • 19 citations

Familial peritoneal ovarian carcinomatosis: A new clinical entity?

1986 • 19 citations

Better Life Expectancy in Women with BRCA2 Compared with BRCA1 Mutations Is Attributable to Lower Frequency and Later Onset of Ovarian Cancer

2008 • 19 citations

High Risk for Ovarian Cancer in a Prospective Series Is Restricted to BRCA1/2 Mutation Carriers

2008 • 18 citations

Prolonged survival among women with BRCA germline mutations and advanced endometrial cancer: a case series

2007 • 17 citations

Fallopian tube cancer in a BRCA1 mutation carrier: Rapid development and failure of screening

2002 • 16 citations

American founder mutation for Lynch syndrome

2005 • 15 citations

Refined chromosomal localization of the mismatch repair and hereditary nonpolyposis colorectal cancer genes hMSH2 and hMSH6.

1998 • 15 citations

Sublocalization of a locus at 3p21.3?23 predisposing to hereditary nonpolyposis colon cancer

1994 • 13 citations

Laparoscopic prophylactic oophorectomy in women with inherited risk of ovarian cancer.

1999 • 11 citations

Endometrial and other primary cancers after tamoxifen treatment of breast cancer — results of retrospective cohort study

2001 • 10 citations

Carcinoma of the Ovary

1962 • 10 citations

Incidental diagnosis of primary fallopian tube carcinoma during prophylactic salpingo‐oophorectomy in BRCA2 mutation carrier

2002 • 9 citations

Early detection of endometrial cancer by combined use of vaginal ultrasound and endometrial vacuum sampling

2002 • 6 citations

BRCA2 germline mutations in primary cancer of the fallopian tube

2004 • 6 citations

BRCA2 GERMLINE MUTATIONS IN PRIMARY CANCER OF THE FALLOPIAN TUBE

2004 • 4 citations

Estrogens, menopause and cancer.

1977 • 3 citations

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Hereditary ovarian carcinoma: Heterogeneity, molecular genetics, pathology, and management (2009) – Molecular Oncology | Metascience Observatory Explorer