Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer

A genetic model for colorectal tumorigenesis

1990 • 11,800 citations

Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes

1986 • 4,785 citations

Rapid production of full-length cDNAs from rare transcripts: amplification using a single gene-specific oligonucleotide primer.

1988 • 4,669 citations

Abundant class of human DNA polymorphisms which can be typed using the polymerase chain reaction.

1989 • 3,458 citations

Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis

1993 • 2,711 citations

Strategies for multilocus linkage analysis in humans.

1984 • 2,600 citations

Identification of FAP Locus Genes from Chromosome 5q21

1991 • 2,358 citations

APC mutations occur early during colorectal tumorigenesis

1992 • 1,901 citations

A second-generation linkage map of the human genome

1992 • 1,721 citations

Type 1 Neurofibromatosis Gene: Identification of a Large Transcript Disrupted in Three NF1 Patients

1990 • 1,471 citations

Deletions and a translocation interrupt a cloned gene at the neurofibromatosis type 1 locus

1990 • 1,085 citations

Destabilization of tracts of simple repetitive DNA in yeast by mutations affecting DNA mismatch repair

1993 • 1,076 citations

Genetics, natural history, tumor spectrum, and pathology of hereditary nonpolyposis colorectal cancer: An updated review

1993 • 1,076 citations

Hypermutability and mismatch repair deficiency in RER+ tumor cells

1993 • 1,042 citations

A workbench for multiple alignment construction and analysis

1991 • 1,005 citations

Molecular cloning and characterization of the human double-stranded RNA-activated protein kinase induced by interferon

1990 • 1,003 citations

Identification of p53 Gene Mutations in Bladder Cancers and Urine Samples

1991 • 891 citations

MECHANISMS AND BIOLOGICAL EFFECTS OF MISMATCH REPAIR

1991 • 876 citations

Hypomethylation of DNA from Benign and Malignant Human Colon Neoplasms

1985 • 844 citations

Purification of DNA from formaldehyde fixed and paraffin embedded human tissue

1985 • 821 citations

Genomic instability in colorectal cancer: relationship to clinicopathological variables and family history.

1993 • 796 citations

Zur Frage der Entstehung maligner Tumoren

1914 • 796 citations

Identification of deletion mutations and three new genes at the familial polyposis locus

1991 • 769 citations

Extracolonic cancer in hereditary nonpolyposis colorectal cancer

1993 • 690 citations

Microsatellite instability is associated with tumors that characterize the hereditary non-polyposis colorectal carcinoma syndrome.

1993 • 596 citations

Extracolonic cancer in hereditary nonpolyposis colorectal cancer

1993 • 589 citations

The pathway to signal achievement

1993 • 563 citations

Genetic instability of microsatellites in endometrial carcinoma.

1993 • 523 citations

HEREDITY WITH REFERENCE TO CARCINOMA

1913 • 501 citations

Genetic instability in pancreatic cancer and poorly differentiated type of gastric cancer.

1993 • 443 citations

Clonal analysis using recombinant DNA probes from the X-chromosome.

1987 • 439 citations

Genetic mapping of a second locus predisposing to hereditary non–polyposis colon cancer

1993 • 434 citations

A simple and efficient method for direct cloning of PCR products using ddT-tailed vectors

1991 • 381 citations

Hereditary factors in cancer. Study of two large midwestern kindreds

1966 • 377 citations

High frequencies of short frameshifts in poly-CA/TG tandem repeats borne by bacteriophage M13 inEscherichia coliK-12

1987 • 362 citations

Lambda YES: a multifunctional cDNA expression vector for the isolation of genes by complementation of yeast and Escherichia coli mutations.

1991 • 353 citations

Hereditary Factors in Cancer

1966 • 313 citations

Hereditary with reference to carcinoma as shown by the study of the cases examined in a pathological laboratory of the University of Michigan, 1895-1913

1913 • 295 citations

EFFECTS OF HIGH LEVELS OF DNA ADENINE METHYLATION ON METHYL-DIRECTED MISMATCH REPAIR IN ESCHERICHIA COLI

1983 • 294 citations

HUMAN TUMOR SUPPRESSOR GENES

1990 • 266 citations

Rapid generation of region specific probes by chromosome microdissection and their application

1992 • 262 citations

Isolation and characterization of allelic losses and gains in colorectal tumors by arbitrarily primed polymerase chain reaction.

1992 • 253 citations

The proximity of DNA sequences in interphase cell nuclei is correlated to genomic distance and permits ordering of cosmids spanning 250 kilobase pairs

1989 • 230 citations

Microsatellite instability in endometrial carcinoma.

1994 • 228 citations

Isolation and characterization of two Saccharomyces cerevisiae genes encoding homologs of the bacterial HexA and MutS mismatch repair proteins.

1992 • 221 citations

Abnormal patterns of DNA methylation in human neoplasia: potential consequences for tumor progression.

1991 • 207 citations

Evolution of hereditary non-polyposis colorectal cancer.

1992 • 199 citations

Tumor-suppressor genes: news about the interferon connection.

1993 • 199 citations

Cloning and nucleotide sequence of DNA mismatch repair gene PMS1 from Saccharomyces cerevisiae: homology of PMS1 to procaryotic MutL and HexB

1989 • 193 citations

Placental mosaicism and intrauterine survival of trisomies 13 and 18.

1989 • 179 citations

Generation of band-specific painting probes from a single microdissected chromosome

1993 • 124 citations

All in the (cancer) family

1993 • 93 citations

Diploid predominance in hereditary nonpolyposis colorectal carcinoma evaluated by flow cytometry

1990 • 89 citations

Chromosome microdissection and cloning in human genome and genetic disease analysis.

1991 • 64 citations

Familial adenomatous polyposis

1991 • 27 citations

Regional Assignment of a Human DNA Repair Gene (XRCC5) to 2q35 by X-Ray Hybrid Mapping

1994 • 24 citations

Mammalian Homologues of the Drosophila Son of sevenless Gene Map to Murine Chromosomes 17 and 12 and to Human Chromosomes 2 and 14, Respectively

1993 • 20 citations

Assignment of a human DNA double-strand break repair gene (XRCC5) to chromosome 2

1992 • 18 citations

Mapping of the gene for interferon‐inducible dsRNA‐dependent protein kinase to chromosome region 2p21‐22: A site of rearrangements in myeloproliferative disorders

1993 • 17 citations

Report of the Second International Workshop on Human Chromosome 2 Mapping 1992

1993 • 15 citations