TP53 mutations in ovarian carcinomas from sporadic cases and carriers of two distinct BRCA1 founder mutations; relation to age at diagnosis and survival

A simple salting out procedure for extracting DNA from human nucleated cells

1988 • 20,341 citations

A Strong Candidate for the Breast and Ovarian Cancer Susceptibility Gene BRCA1

1994 • 5,994 citations

Identification of the breast cancer susceptibility gene BRCA2

1995 • 3,581 citations

Genetic Heterogeneity and Penetrance Analysis of the BRCA1 and BRCA2 Genes in Breast Cancer Families

1998 • 2,920 citations

The IARC TP53 database: New online mutation analysis and recommendations to users

2002 • 1,248 citations

Estimates of the gene frequency of BRCA1 and its contribution to breast and ovarian cancer incidence.

1995 • 541 citations

Targeted mutations of breast cancer susceptibility gene homologs in mice: lethal phenotypes of Brca1, Brca2, Brca1/Brca2, Brca1/p53, and Brca2/p53 nullizygous embryos.

1997 • 537 citations

Improved survival in women with BRCA‐associated ovarian carcinoma

2003 • 430 citations

Clinical and Pathological Features of Ovarian Cancer in Women with Germ-Line Mutations ofBRCA1

1996 • 427 citations

Survival of BRCA1 breast and ovarian cancer patients: a population-based study from southern Sweden.

1998 • 259 citations

Prediction of cancer incidence in the Nordic countries up to the year 2020.

2002 • 257 citations

Hereditary ovarian cancer

2005 • 211 citations

Effect of BRCA Mutations on the Length of Survival in Epithelial Ovarian Tumors

2002 • 204 citations

TP53 mutations and breast cancer prognosis: Particularly poor survival rates for cases with mutations in the zinc‐binding domains

1995 • 179 citations

Defective DNA mismatch repair in acute myeloid leukemia/myelodysplastic syndrome after organ transplantation

2004 • 160 citations

Association Between Nonrandom X-Chromosome Inactivation and BRCA1 Mutation in Germline DNA of Patients With Ovarian Cancer

1999 • 124 citations

Effect of BRCA Mutations on the Length of Survival in Epithelial Ovarian Tumors

2002 • 120 citations

Molecular genetic characterization of BRCA1- and BRCA2-linked hereditary ovarian cancers.

1998 • 96 citations

Prediction of cancer incidence in the Nordic countries up to the years 2000 and 2010. A collaborative study of the five Nordic Cancer Registries.

1993 • 90 citations

Molecular genetics of hereditary ovarian cancer.

1998 • 80 citations

Increased frequency ofTP53 mutations inBRCA1 andBRCA2 ovarian tumours

1999 • 77 citations

DecreasedBRCA1Expression Levels May Arrest the Cell Cycle through Activation ofp53Checkpoint in Human Sporadic Breast Tumors

1998 • 75 citations

p53 Gene Mutation in Human Borderline Epithelial Ovarian Tumors

1994 • 65 citations

TP53 mutations in early-stage ovarian carcinoma, relation to long-term survival

2004 • 65 citations

p53 mutation does not affect prognosis in ovarian epithelial malignancies

2001 • 62 citations

Prognosis of patients with ovarian cancer and borderline tumours diagnosed in Norway between 1954 and 1993

1998 • 62 citations

BRCA1-related papillary serous carcinoma of the peritoneum has a unique molecular pathogenesis.

2000 • 59 citations

Hereditary ovarian cancer: Heterogeneity in age at onset

2010 • 58 citations

Effect of the codon 72 polymorphism (c.215G>C, p.Arg72Pro) in combination with somatic sequence variants in theTP53gene on survival in patients with advanced ovarian carcinoma

2004 • 51 citations

Therapy effect of either paclitaxel or cyclophosphamide combination treatment in patients with epithelial ovarian cancer and relation to TP53 gene status

1998 • 51 citations

Failure of BRCA1 dysfunction to alter ovarian cancer survival.

2002 • 49 citations

Accumulation of p53 protein is frequent in ovarian cancers associated with BRCA1 and BRCA2 germline mutations

1999 • 45 citations

Three per cent of Norwegian Ovarian Cancers are caused by BRCA1 1675delA or 1135insA

1999 • 38 citations

Prognosis of 2,800 patients with epithelial ovarian cancer diagnosed during 1975-94 and treated at the Norwegian Radium Hospital

1998 • 36 citations

BRCA1 1675delA and 1135insA Account for One Third of Norwegian Familial Breast-Ovarian Cancer and Are Associated with Later Disease Onset than Less Frequent Mutations

1999 • 31 citations

The p53 mutational spectrum associated with BRCA1 mutant ovarian cancer.

2001 • 31 citations

A BRCA1 founder mutation, identified with haplotype analysis, allowing genotype/phenotype determination and predictive testing

1997 • 28 citations

Mutation Analysis of BRCA1, TP53, and KRAS2 in Ovarian and Related Pelvic Tumors

1999 • 28 citations

Penetrances of BRCA1 1675delA and 1135insA with Respect to Breast Cancer and Ovarian Cancer

1999 • 27 citations

Mutation Screening of the <I>TP53</I> Gene by Temporal Temperature Gradient Gel Electrophoresis

2004 • 26 citations

Survival analysis in familial ovarian cancer, a case control study

2001 • 25 citations

Differences between hereditary and sporadic ovarian cancer

1999 • 19 citations

Expression of p53 in epithelial ovarian cancer

2000 • 5 citations