EGF/ErbB Receptor Family in Ovarian Cancer

Studies of the HER-2/ neu Proto-Oncogene in Human Breast and Ovarian Cancer

1989 • 6,734 citations

Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells

1984 • 2,762 citations

Epidermal growth factor-related peptides and their receptors in human malignancies

1995 • 2,689 citations

NEW EMBO MEMBERS' REVIEW: The ErbB signaling network: receptor heterodimerization in development and cancer

2000 • 2,394 citations

Epidermal growth factor.

1990 • 1,645 citations

Peptide Growth Factors and Their Receptors

1991 • 1,221 citations

Soluble interleukin 2 receptors are released from activated human lymphoid cells in vitro.

1985 • 1,143 citations

Soluble Human Complement Receptor Type 1: In Vivo Inhibitor of Complement Suppressing Post-Ischemic Myocardial Inflammation and Necrosis

1990 • 989 citations

Molecular cloning and expression of a receptor for human tumor necrosis factor

1990 • 973 citations

Epidermal growth factor-receptor-protein kinase interactions. Co-purification of receptor and epidermal growth factor-enhanced phosphorylation activity.

1980 • 853 citations

Specificity within the EGF family/ErbB receptor family signaling network

1998 • 804 citations

Overexpression of the human EGF receptor confers an EGF-dependent transformed phenotype to NIH 3T3 cells

1987 • 657 citations

The murine interleukin-4 receptor: Molecular cloning and characterization of secreted and membrane bound forms

1989 • 645 citations

Epidermal growth factor induces rapid, reversible aggregation of the purified epidermal growth factor receptor

1987 • 624 citations

Cloning of the human and murine interleukin-7 receptors: Demonstration of a soluble form and homology to a new receptor superfamily

1990 • 614 citations

Cloning and Sequencing of Porcine LH-hCG Receptor cDNA: Variants Lacking Transmembrane Domain

1989 • 568 citations

Prevalence of aberrant expression of the epidermal growth factor receptor in human cancers

1991 • 452 citations

Epidermal-Growth-Factor-Dependent Transformation by a Human EGF Receptor Proto-Oncogene

1987 • 448 citations

HIV infection is blocked in vitro by recombinant soluble CD4

1988 • 446 citations

The ErbB-2/HER2 oncoprotein of human carcinomas may function solely as a shared coreceptor for multiple stroma-derived growth factors

1999 • 440 citations

Expression Cloning of Human EGF Receptor Complementary DNA: Gene Amplification and Three Related Messenger RNA Products in A431 Cells

1984 • 406 citations

The growth hormone-binding protein in rat serum is an alternatively spliced form of the rat growth hormone receptor.

1989 • 399 citations

Characterization and sequence of the promoter region of the human epidermal growth factor receptor gene.

1985 • 391 citations

Isolation of an mRNA encoding a soluble form of the human interleukin-6 receptor

1992 • 388 citations

The type 1 (EGFR-related) family of growth factor receptors and their ligands

1992 • 377 citations

Diverse forms of a receptor for acidic and basic fibroblast growth factors.

1990 • 352 citations

A soluble form of intercellular adhesion molecule-1 inhibits rhinovirus infection

1990 • 292 citations

Basic science of HER-2/neu: a review.

1999 • 267 citations

The Epidermal Growth Factor Family

1991 • 260 citations

Regulation of Alloreactivity in Vivo by a Soluble Form of the Interleukin-1 Receptor

1990 • 235 citations

Epidermal growth factor receptor expression in normal ovarian epithelium and ovarian cancer

1991 • 230 citations

Ligand and protein kinase C downmodulate the colony-stimulating factor 1 receptor by independent mechanisms.

1989 • 228 citations

A truncated, secreted form of the epidermal growth factor receptor is encoded by an alternatively spliced transcript in normal rat tissue.

1990 • 198 citations

Chicken epidermal growth factor (EGF) receptor: cDNA cloning, expression in mouse cells, and differential binding of EGF and transforming growth factor alpha.

1988 • 178 citations

Structure and localization of genes encoding aberrant and normal epidermal growth factor receptor RNAs from A431 human carcinoma cells.

1985 • 171 citations

Epidermal growth factor-receptor-protein kinase interactions.

1981 • 171 citations

The Epidermal Growth Factor Family

1990 • 170 citations

A truncated intracellular HER2/neu receptor produced by alternative RNA processing affects growth of human carcinoma cells.

1993 • 161 citations

Identification of a truncated form of the nerve growth factor receptor.

1988 • 145 citations

Ligand activation of overexpressed epidermal growth factor receptors transforms NIH 3T3 mouse fibroblasts.

1988 • 139 citations

Real-time measurements of kinetics of EGF binding to soluble EGF receptor monomers and dimers support the dimerization model for receptor activation

1993 • 129 citations

The HER-2/neu receptor tyrosine kinase gene encodes a secreted autoinhibitor

1999 • 128 citations

Inhibition of Tyrosine Kinase Activity of the Epidermal Growth Factor (EGF) Receptor by a Truncated Receptor Form That Binds to EGF: Role for Interreceptor Interaction in Kinase Regulation

1989 • 125 citations

The human EGF receptor gene: structure of the 110 kb locus and identification of sequences regulating its transcription.

1987 • 121 citations

A soluble recombinant polypeptide comprising the amino-terminal half of the extracellular region of the CD4 molecule contains an active binding site for human immunodeficiency virus.

1988 • 120 citations

Comparative Genomic Sequence Analysis and Isolation of Human and Mouse Alternative EGFR Transcripts Encoding Truncated Receptor Isoforms

2001 • 115 citations

Heterodimerization of c-erbB2 with different epidermal growth factor receptor mutants elicits stimulatory or inhibitory responses.

1992 • 104 citations

Growth factor control of epidermal growth factor receptor kinase activity via an intramolecular mechanism.

1988 • 98 citations

Antibody-induced dimerization activates the epidermal growth factor receptor tyrosine kinase

1991 • 96 citations

Intrapeptide autophosphorylation of the epidermal growth factor receptor: regulation of kinase catalytic function by receptor dimerization

1985 • 90 citations

A 1.8 kb alternative transcript from the human epidermal growth factor receptor gene encodes a truncated form of the receptor

1996 • 85 citations

Serum levels of HER-2neu (C-erbB-2) correlate with overexpression of p185neu in human ovarian cancer

1993 • 84 citations

Activation of the epidermal growth factor receptor tyrosine protein kinase in the absence of receptor oligomerization.

1988 • 84 citations

An alternatively processed mRNA from the avian c-erbB gene encodes a soluble, truncated form of the receptor that can block ligand-dependent transformation.

1992 • 74 citations

Inhibition of tyrosine kinase activity of the epidermal growth factor (EGF) receptor by a truncated receptor form that binds to EGF: role for interreceptor interaction in kinase regulation.

1989 • 72 citations

Serum Levels of C-erbB-2 (HER-2/neu) in Patients with Malignant and Non-Malignant Diseases

1997 • 70 citations

c-erbB3 Gene Encodes Secreted as Well as Transmembrane Receptor Tyrosine Kinase

1993 • 69 citations

Serum sErbB1 and epidermal growth factor levels as tumor biomarkers in women with stage III or IV epithelial ovarian cancer.

1999 • 69 citations

Isolation and characterization of four alternate c-erbB3 transcripts expressed in ovarian carcinoma-derived cell lines and normal human tissues

1998 • 61 citations

Soluble recombinant CR2 (CD21) inhibits Epstein-Barr virus infection

1990 • 54 citations

An evolutionarily conserved enzyme degrades transforming growth factor-alpha as well as insulin.

1989 • 53 citations

An Oncogenic Epidermal Growth Factor Receptor Signals via a p21-activated Kinase-Caldesmon-Myosin Phosphotyrosine Complex

2000 • 42 citations

Expression and Action of Transforming Growth Factor Alpha in Normal Ovarian Surface Epithelium and Ovarian Cancer1

2000 • 37 citations

Detection of the extracellular domain of c‐erbB‐2 oncoprotein in sera from patients with various carcinomas: Correlation with tumor markers

1993 • 34 citations

Inhibition of epidermal growth factor receptor aggregation by an antibody directed against the epidermal growth factor receptor extracellular domain.

1993 • 29 citations

Activation of Rho Is Required for Ligand-independent Oncogenic Signaling by a Mutant Epidermal Growth Factor Receptor

2001 • 28 citations

Native avian c-erbB gene expresses a secreted protein product corresponding to the ligand-binding domain of the receptor.

1991 • 28 citations

Expression of a Truncated Epidermal Growth Factor Receptor-like Protein (TEGFR) in Ovarian Cancer

1997 • 26 citations

A sandwich type Acridinium-Linked ImmunoSorbent Assay (ALISA) detects soluble ErbB1 (sErbB1) in normal human sera

1998 • 23 citations

Utility of c-crbB-2 Expression in Tissue and Sera of Ovarian Cancer Patients

2000 • 19 citations

Clinical Use of Serum c-erbB-2 in Patients with Ovarian Masses

1999 • 16 citations