Hereditary colorectal cancer syndromes: molecular genetics, genetic counseling, diagnosis and management

New clinical criteria for hereditary nonpolyposis colorectal cancer (HNPCC, Lynch syndrome) proposed by the International Collaborative Group on HNPCC☆

1999 • 2,460 citations

Colorectal cancer screening and surveillance: Clinical guidelines and rationale?Update based on new evidence

2003 • 2,185 citations

Hereditary Colorectal Cancer

2003 • 2,142 citations

The International Collaborative Group on Hereditary Non-Polyposis Colorectal Cancer (ICG-HNPCC)

1991 • 2,142 citations

American Cancer Society Guidelines for the Early Detection of Cancer

2002 • 1,652 citations

Controlled 15-year trial on screening for colorectal cancer in families with hereditary nonpolyposis colorectal cancer

2000 • 1,304 citations

Peutz-Jeghers syndrome is caused by mutations in a novel serine threoninekinase

1998 • 1,176 citations

Increased Risk of Cancer in the Peutz–Jeghers Syndrome

1987 • 865 citations

Recommendations for follow-up care of individuals with an inherited predisposition to cancer. II. BRCA1 and BRCA2. Cancer Genetics Studies Consortium

1997 • 833 citations

Prophylactic Surgery to Reduce the Risk of Gynecologic Cancers in the Lynch Syndrome

2006 • 751 citations

Recommendations for Follow-up Care of Individuals With an Inherited Predisposition to Cancer

1997 • 714 citations

GENETIC SUSCEPTIBILITY TO NONPOLYPOSIS COLORECTAL CANCER

1999 • 695 citations

Generalized Intestinal Polyposis and Melanin Spots of the Oral Mucosa, Lips and Digits

1949 • 644 citations

American Cancer Society Guidelines for the Early Detection of Cancer, 2006

2006 • 641 citations

Recommendations for the Care of Individuals With an Inherited Predisposition to Lynch Syndrome

2006 • 619 citations

PTEN Mutation Spectrum and Genotype-Phenotype Correlations in Bannayan-Riley-Ruvalcaba Syndrome Suggest a Single Entity With Cowden Syndrome

1999 • 589 citations

Generalized Intestinal Polyposis and Melanin Spots of the Oral Mucosa, Lips and Digits

1949 • 542 citations

Lower Cancer Incidence in Amsterdam-I Criteria Families Without Mismatch Repair Deficiency

2005 • 537 citations

HEREDITY WITH REFERENCE TO CARCINOMA

1913 • 501 citations

The Family History — More Important Than Ever

2004 • 494 citations

Localization of a susceptibility locus for Peutz-Jeghers syndrome to 19p using comparative genomic hybridization and targeted linkage analysis

1997 • 487 citations

Use of 5-fluorouracil and survival in patients with microsatellite-unstable colorectal cancer

2004 • 462 citations

Juvenile polyposis–a precancerous condition

1988 • 456 citations

Prediction of Germline Mutations and Cancer Risk in the Lynch Syndrome

2006 • 380 citations

Cancer family “G” revisited: 1895-1970

1971 • 365 citations

Gynecologic Cancer as a “Sentinel Cancer” for Women With Hereditary Nonpolyposis Colorectal Cancer Syndrome

2005 • 364 citations

Cancer Risk in Hereditary Nonpolyposis Colorectal Cancer Syndrome: Later Age of Onset

2005 • 357 citations

The Concise Handbook of Family Cancer Syndromes

1998 • 334 citations

Novel PTEN mutations in patients with Cowden disease: absence of clear genotype–phenotype correlations

1999 • 319 citations

The risk of gastrointestinal carcinoma in familial juvenile polyposis

1998 • 300 citations

Hereditary with reference to carcinoma as shown by the study of the cases examined in a pathological laboratory of the University of Michigan, 1895-1913

1913 • 295 citations

Attenuated familial adenomatous polyposis (AFAP) a phenotypically and genotypically distinctive variant of FAP

1995 • 266 citations

Role of hMLH1 promoter hypermethylation in drug resistance to 5‐fluorouracil in colorectal cancer cell lines

2003 • 264 citations

Prediction of MLH1 and MSH2 Mutations in Lynch Syndrome

2006 • 190 citations

The biochemical basis of microsatellite instability and abnormal immunohistochemistry and clinical behavior in Lynch Syndrome: from bench to bedside

2007 • 188 citations

Juvenile polyposis: massive gastric polyposis is more common in MADH4 mutation carriers than in BMPR1A mutation carriers

2002 • 178 citations

GermlineSMAD4 orBMPRIA mutations and phenotype of juvenile polyposis

2002 • 177 citations

Genotype-phenotype correlations in Peutz-Jeghers syndrome

2004 • 174 citations

Phenotypic and genotypic heterogeneity in the Lynch syndrome: diagnostic, surveillance and management implications

2006 • 160 citations

Gastrointestinal cancers and neurofibromatosis type 1 features in children with a germline homozygous MLH1 mutation

2004 • 122 citations

Disease severity and genetic pathways in attenuated familial adenomatous polyposis vary greatly but depend on the site of the germline mutation

2006 • 104 citations

A Founder Mutation of the <EMPH TYPE="ITAL">MSH2</EMPH> Gene and Hereditary Nonpolyposis Colorectal Cancer in the United States

2004 • 83 citations

History and Molecular Genetics of Lynch Syndrome in Family G

2005 • 80 citations

Pathology of the hereditary colorectal carcinoma

2007 • 70 citations

Unusual tumors associated with the hereditary nonpolyposis colorectal cancer syndrome

2004 • 69 citations

Prostate cancer is part of the hereditary non‐polyposis colorectal cancer (HNPCC) tumor spectrum

2003 • 68 citations

Hereditary Nonpolyposis Colon Cancer

2007 • 68 citations

The Bannayan Syndrome: An Autosomal Dominant Disorder Consisting of Macrocephaly, Lipomas, Hemangiomas, and Risk for Intracranial Tumors

1982 • 67 citations

Family information service and hereditary cancer

2001 • 67 citations

Genetic alterations and epithelial dysplasia in juvenile polyposis syndrome and sporadic juvenile polyps.

1997 • 64 citations

Comprehensive Analysis of SMAD4 Mutations and Protein Expression in Juvenile Polyposis

2001 • 63 citations

Peutz-Jeghers Syndrome and Ureteral Polyposis

1970 • 63 citations

A 10‐Mb paracentric inversion of chromosome arm 2p inactivates MSH2 and is responsible for hereditary nonpolyposis colorectal cancer in a North‐American kindred

2002 • 62 citations

Vessels' morphology in SMAD4 and BMPR1A‐related juvenile polyposis

2005 • 51 citations

An economic viewpoint on alternative strategies for identifying persons with hereditary nonpolyposis colorectal cancer

2003 • 48 citations

Gastrointestinal Polyposis Syndromes

1989 • 46 citations

Loss of Phosphatase and Tensin Homologue Increases Transforming Growth Factor β–Mediated Invasion with Enhanced SMAD3 Transcriptional Activity

2005 • 45 citations

Inclusion of malignant fibrous histiocytoma in the tumour spectrum associated with hereditary non-polyposis colorectal cancer

2000 • 44 citations

Challenge in The Differentiation Between Attenuated Familial Adenomatous Polyposis and Hereditary Nonpolyposis Colorectal Cancer: Case Report With Review of The Literature

2002 • 37 citations

Hereditary gynecologic cancers: differential diagnosis, surveillance, management and surgical prophylaxis

2007 • 37 citations

Microsatellite instability in a pleomorphic rhabdomyosarcoma in a patient with hereditary non‐polyposis colorectal cancer

2003 • 35 citations

Carrier risk status changes resulting from mutation testing in hereditary non-polyposis colorectal cancer and hereditary breast-ovarian cancer

2003 • 31 citations

Familial cancer in an oncology clinic

1981 • 30 citations

Microsatellite instability and hMLH1 and hMSH2 expression analysis in soft tissue sarcomas.

2005 • 27 citations

Microsatellite alterations in various sarcomas in Japanese patients

1999 • 23 citations

Immunolocalization of beta catenin in intestinal polyps of Peutz- Jeghers and juvenile polyposis syndromes

1999 • 21 citations

American founder mutation for Lynch syndrome

2005 • 15 citations

Deleted Work

1955 • 0 citations

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