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Luteinizing Hormone-Releasing Hormone Agonists Interfere with the Mitogenic Activity of the Insulin-Like Growth Factor System in Androgen-Independent Prostate Cancer Cells**This work was supported by Associazione Italiana per la Ricerca sul Cancro, Consiglio Nazionale delle Ricerche through the special project ACRO (Contract 96.00594.PF39), and Ministero dell’Università e della Ricerca Scentifica e Tecnologica.

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Ovarian Surface Epithelium: Autonomous Production of Connective Tissue-Type Extracellular Matrix1

1991 • 55 citations

Regulation of Proliferation and Apoptosis by Epidermal Growth Factor and Protein Kinase C in Human Ovarian Surface Epithelial Cells

1999 • 55 citations

Epidermal Growth Factor Receptor Expression in Gynecological Malignancies

1989 • 54 citations

Tumour necrosis factor and cancer

1992 • 54 citations

Lupron Retards Proliferation of Ovarian Epithelial Tumor Cells Cultured in Serum-Free Medium

1991 • 54 citations

Increased insulin-like growth factor binding protein-2 (IGFBP-2) gene expression and protein production lead to high IGFBP-2 content in malignant ovarian cyst fluid

1996 • 54 citations

Mutations of theBRCA1gene in human cancer

1996 • 54 citations

Cytosol and nuclear estrogen and progestin receptors and 17 beta‐hydroxysteroid dehydrogenase activity in non‐diseased tissue and in benign and malignant tumors of the human ovary

1983 • 53 citations

Epidermal growth factor antagonizes ovarian theca-interstitial cytodifferentiation

1983 • 53 citations

Expression of two mucin antigens in cultured human ovarian surface epithelium: Influence of a family hostory of ovarian cancer

1995 • 53 citations

Importance of steroid receptors and aromatase activity in the prognosis of ovarian cancer: High tumor progesterone receptor levels correlate with longer survival

1989 • 53 citations

Steroid receptor content in human ovarian tumors: Survival of patients with ovarian carcinoma related to steroid receptor content

1986 • 52 citations

Peritoneum and Tissues of the Female Reproductive Tract as Physiological Sources of CA-125

1998 • 52 citations

Presence of Activin, Inhibin, and Follistatin in Epithelial Ovarian Carcinoma

1997 • 51 citations

Growth factors interact with estradiol and gonadotropins in the regulation of ovarian cancer cell growth and growth factor receptors.

1993 • 51 citations

Human chorionic gonadotropin (hCG) inhibits cisplatin-induced apoptosis in ovarian cancer cells: Possible role of up-regulation of insulin-like growth factor-1 by hCG

1998 • 50 citations

Human ovarian surface epithelial cells are capable of physically restructuring extracellular matrix

1992 • 50 citations

Androgen and Estrogen Secretion by Normal and Neoplastic Ovaries in Premenopausal Women

1986 • 50 citations

Fas Antigen-Mediated Apoptosis of Ovarian Surface Epithelial Cells*

1997 • 50 citations

Ovarian surface epithelium during ovulatory and anovulatory ovine estrous cycles

1994 • 49 citations

Maternal Hemoglobin Concentration is Closely Related to Birth Weight in Normal Pregnancies

1984 • 49 citations

Ovarian carcinoma: Histologic and clinical correlation of cytoplasmic estrogen and progesterone binding

1981 • 49 citations

c‐erbb growth‐factor‐receptor proteins in ovarian tumours

1995 • 49 citations

Zoladex: Endocrine and therapeutic effects in post-menopausal breast cancer

1989 • 48 citations

Transforming Growth Factor-β1 Induces a Mesenchyme-Like Cell Shape without Epithelial Polarization in Thyrocytes and Inhibits Thyroid Folliculogenesis in Collagen Gel Culture

1997 • 48 citations

Histopathologic Features of Ovaries at Increased Risk for Carcinoma

1999 • 47 citations

Transforming growth factor-β isoform expression in human ovarian tumours

1997 • 47 citations

The insulin-like growth factor 1 receptor induces transformation and tumorigenicity of ovarian mesothelial cells and down-regulates their Fas-receptor expression.

1999 • 47 citations

Different effects of interferons, interleukin-1β and tumor necrosis factor-α in normal (OSE) and malignant human ovarian epithelial cells

1996 • 47 citations

Surface Morphology of Ovarian Mesothelium (Surface Epithelium) and of Other Pelvic and Extrapelvic Mesothelial Sites in the Rabbit

1984 • 47 citations

An in vitro model of ovarian epithelial carcinogenesis: Changes in cell‐cell communication and adhesion occurring during neoplastic progression

1993 • 46 citations

Expression of the hepatocyte growth factor/scatter factor receptor tyrosine kinase is localized to epithelia in the adult mouse.

1995 • 46 citations

Targeted cytotoxic analog of luteinizing hormone‐releasing hormone AN‐207 inhibits the growth of PC‐82 human prostate cancer in nude mice

1999 • 45 citations

Tumor markers in inclusion cysts of the ovary

1982 • 45 citations

Identification of Insulin and Insulin-like Growth Factor I (IGF I) Receptors in Ovarian Cancer Tissue

1994 • 45 citations

Multiple Immunoreactive Inhibin Proteins in Serum from Postmenopausal Women with Epithelial Ovarian Cancer

1997 • 45 citations

Autocrine Interactions of Keratinocyte Growth Factor, Hepatocyte Growth Factor, and Kit-Ligand in the Regulation of Normal Ovarian Surface Epithelial Cells*

2000 • 44 citations

Marker profile of different phases in the transition of normal human ovarian epithelium to ovarian carcinomas.

1991 • 44 citations

Hepatocyte growth factor modulates motility and invasiveness of ovarian carcinomas via Ras-mediated pathway

2000 • 44 citations

Primary Ovarian Cancer Cultures are Resistant to Fas-Mediated Apoptosis

1999 • 44 citations

Targeted cytotoxic analog of luteinizing hormone-releasing hormone AN-207 inhibits the growth of PC-82 human prostate cancer in nude mice

1999 • 44 citations

A phase II study of tamoxifen in ovarian cancer

1986 • 43 citations

Transforming growth factor-beta and ovarian carcinoma cells: regulation of proliferation and surface antigen expression

1990 • 43 citations

Characterization of Bovine Ovarian Surface Epithelium and Stromal Cells: Identification of Secreted Proteins1

1994 • 43 citations

Insulinlike Growth Factors in Human Malignancy

1991 • 42 citations

Growth Inhibition of Ovarian Cancer Cells Induced by Antisense IL-6 Oligonucleotides

1993 • 42 citations

Human epithelial ovarian cancer cell steroid secretion and its control by gonadotropins

1991 • 42 citations

Long-term LHRH-agonist treatment in metastatic breast cancer as a single treatment and in combination with other additive endocrine treatments

1984 • 41 citations

αvβ3 and Vitronectin Expression by Normal Ovarian Surface Epithelial Cells: Role in Cell Adhesion and Cell Proliferation

1999 • 40 citations

Oncogene expression in vivo by ovarian adenocarcinomas and mixed-mullerian tumors.

1989 • 40 citations

Inhibin and ovarian cancer

1998 • 39 citations

Cytoplasmic steroid receptors in ovarian tumours

1982 • 39 citations

Telomeric Instability and Reduced Proliferative Potential in Ovarian Surface Epithelial Cells from Women with a Family History of Ovarian Cancer

1999 • 39 citations

Differential regulation of inhibin/activin α- and βA-subunit and follistatin mRNAs by cyclic AMP and phorbol ester in cultured human granulosa-luteal cells

1996 • 39 citations

Gene structure and expression analysis of the epidermal growth factor receptor, transforming growth factor-alpha,myc, jun, and metallothionein in human ovarian carcinomas classification of malignant phenotypes

1993 • 39 citations

Expression and Action of Hepatocyte Growth Factor in Human and Bovine Normal Ovarian Surface Epithelium and Ovarian Cancer1

2000 • 39 citations

Coupling of gonadotropin-releasing hormone receptor to Gi protein in human reproductive tract tumors

1996 • 39 citations

Differential expression of activin/inhibin subunit and activin receptor mRNAs in normal and neoplastic ovarian surface epithelium (OSE)

2001 • 38 citations

Transforming Growth Factor α Localization and Role in Surface Epithelium of Normal Human Ovaries and in Ovarian Carcinoma Cells

1994 • 38 citations

Response to inhibition of androgen action of human ovarian cancer cells in vitro

1989 • 37 citations

Estradiol and Progesterone Receptors in Normal Ovary and Ovarian Tumors

1984 • 37 citations

Mitogenic effects of epidermal growth factor and transforming growth factor-α on EGF-receptor positive human ovarian carcinoma cell lines

1992 • 36 citations

A Cell Line, ROSE 199, Derived from Normal Rat Ovarian Surface Epithelium

1985 • 36 citations

Estrogen regulation of transforming growth factor-α in ovarian cancer

1998 • 36 citations

Secretion of androgens and estrogens by normal and neoplastic ovaries in postmenopausal women

1987 • 36 citations

Influence of intratumoral basic fibroblast growth factor concentration on survival in ovarian cancer patients

1998 • 36 citations

Diagnostic value of serum VEGF in women with ovarian tumors.

1999 • 36 citations

Growth regulation of ovarian cancer cells by epidermal growth factor and tranforming growth factors α and β1

1992 • 36 citations

A novel in vitro experimental model for ovarian endometriosis: the three-dimensional culture of human ovarian surface epithelial cells in collagen gels

1999 • 35 citations

Age at Onset of Ovarian Cancer in Women with a Strong Family History of Ovarian Cancer

1997 • 35 citations

The prognostic value of epidermal growth factor receptors, determined by both immunohistochemistry and ligand binding assays, in primary epithelial ovarian cancer: a pilot study

1993 • 35 citations

Insulin-like growth factor-I (IGF-I) and IGF-binding protein-2 are increased in cyst fluids of epithelial ovarian cancer

1994 • 35 citations

Monoallelic expression of the insulin-like growth factor-2 gene in ovarian cancer.

1996 • 35 citations

Prolactin-Dependent Up-Regulation ofBRCA1Expression in Human Breast Cancer Cell Lines

1999 • 35 citations

Targeted cytotoxic analog of luteinizing hormone–releasing hormone AN-207 inhibits growth of OV-1063 human epithelial ovarian cancers in nude mice

1999 • 34 citations

Estrogen and progesterone receptors in ovarian neoplasms

1983 • 34 citations

The development of the sexually indifferent gonad in the prosimian, Galago crassicaudatus crassicaudatus

1988 • 34 citations

Progesterone as a possible tumor marker for “nonendocrine” ovarian malignant tumors

1983 • 34 citations

Antisense phosphorothioate oligodeoxynucleotide down-regulation of the insulin-like growth factor I receptor in ovarian cancer cells

1998 • 34 citations

Epidermal growth factor receptor and transforming growth factor alpha expression in human ovarian carcinomas

1992 • 34 citations

Marker profile of mesothelial cells versus ovarian carcinoma cells

1989 • 33 citations

Serum Human Hepatocyte Growth Factor in Human Menstrual Cycle and Pregnancy: A Novel Serum Marker of Regeneration and Reconstruction of Human Endometrium

1995 • 33 citations

Expression of basic fibroblast growth factor and its mRNA in advanced ovarian cancers.

1997 • 33 citations

P-Cadherin Expression in Human Endometrium and Endometriosis

1994 • 32 citations

Epidermal growth factor receptors (EGFR) in human ovarian cancer

1991 • 32 citations

c‐erbB‐2 anti‐sense phosphorothioate oligodeoxynucleotides inhibit growth and serum‐induced cell spreading of p185^c‐erbB‐2‐overexpressing ovarian carcinoma cells

1995 • 32 citations

Progesterone Receptor Status Is a Significant Prognostic Variable of Progression-Free Survival in Advanced Epithelial Ovarian Cancer

1998 • 32 citations

Estrogen and progesterone receptors in human ovarian tumors

1983 • 32 citations

Complete regression of MX-1 human breast carcinoma xenografts after targeted chemotherapy with a cytotoxic analog of luteinizing hormone-releasing hormone, AN-207

1999 • 31 citations

Peripheral and ovarian venous concentrations of steroid and gonadotropin hormones in postmenopausal women with epithelial ovarian tumors

1986 • 31 citations

Opposing Actions of Hepatocyte Growth Factor and Basic Fibroblast Growth Factor on Cell Contact, Intracellular Free Calcium Levels, and Rat Ovarian Surface Epithelial Cell Viability

1997 • 31 citations

A scanning electron microscopic study of the human ovarian surface epithelium: characterization of two cell types

1991 • 31 citations

Expression of Epithelial Cadherin in the Developing and Adult Pig Ovary1

1996 • 30 citations

Plasma level of estradiol in patients with ovarian malignant tumors

1988 • 30 citations

Induction of apoptosis by a gonadotropin-releasing hormone agonist during early pregnancy in the rat

1998 • 29 citations

Female sex steroid receptors in gynecological malignancies: Clinical correlates

1983 • 29 citations

Luteinizing hormone-releasing hormone antagonists interfere with autocrine and paracrine growth stimulation of MCF-7 mammary cancer cells by insulin-like growth factors

1993 • 29 citations

Transforming growth factor-β mRNA expression and growth control of human ovarian carcinoma cells

1992 • 29 citations

Regulation of insulin-like growth factor binding proteins in ovarian cancer cells by oestrogen

1993 • 29 citations

Steroid receptors in human ovarian malignancy. A review of four years tissue collection

1986 • 28 citations

A line of rat ovarian surface epithelium provides a continuous source of complex extracellular matrix

1994 • 28 citations

BRCA1, BRCA2 and their possible function in DNA damage response

1999 • 28 citations

GnRH Agonist Therapy in Human Ovarian Epithelial Carcinoma (OVCAR-3) Heterotransplanted in the Nude Mouse Is Characterized by Latency and Transience

1994 • 28 citations

Biopathology of Ovarian Mesothelium

1991 • 27 citations

Clinical correlation of hormone receptor status in epithelial ovarian cancer

1989 • 27 citations

Hepatocyte Growth Factor Induces Rat Ovarian Surface Epithelial Cell Mitosis or Apoptosis Depending on the Presence or Absence of an Extracellular Matrix*

1999 • 27 citations

Basic fibroblast growth factor and ovarian cancer

1995 • 27 citations

tHigh frequency of telomeric associations in human ovarian surface epithelial cells transformed by human papilloma viral oncogenes

1997 • 26 citations

Expression of platelet-derived endothelial cell growth factor (PD-ECGF) and its mRNA in ovarian cancers

1998 • 26 citations

mRNA phenotyping of the major ligands and receptors of the EGF supergene family in human ovarian epithelial cells

1995 • 26 citations

Immunopathologic Analysis of a Panel of Mouse Monoclonal Antibodies Reacting with Human Ovarian Carcinomas and Other Human Tumors

1985 • 26 citations

Correlation between Steroid Hormone Receptors, Histological and Clinical Parameters in Ovarian Carcinoma

1988 • 26 citations

Östrogen- und Progesteronrezeptoren in malignen Ovarialtumoren

1983 • 25 citations

Targeted cytotoxic luteinizing hormone releasing hormone (LH-RH) analogs inhibit growth of estrogen independent MXT mouse mammary cancers in vivo by decreasing cell proliferation and inducing apoptosis

1997 • 25 citations

Epidermal growth factor receptor in ovarian tumours: correlation of immunohistochemistry with ligand binding assay

1992 • 24 citations

Human ovarian surface epithelium: growth patterns and differentiation

1995 • 24 citations

Androstenedione production by malignant epithelial ovarian tumors

1986 • 24 citations

Molecular Basis of Reproductive Endocrinology

2011 • 24 citations

In vitro effects of gonadotropin-releasing hormone (GnRH) analogue on cancer cell sensitivity to cis-platinum

1998 • 24 citations

Influence of Human Luteinizing Hormone on Cell Growth and CA125 Secretion of Primary Epithelial Ovarian Carcinomas in vitro

1995 • 24 citations

Cyclic hormonal treatment in ovarian cancer. A phase-II trial

1987 • 23 citations

Growth of normal human ovarian surface epithelial cells in reduced-serum and serum-free media

1993 • 23 citations

Ethinyl estradiol and medroxyprogesterone acetate in patients with epithelial ovarian carcinoma: a phase II study.

1986 • 23 citations

Effect of luteinizing hormone-releasing hormone analogs containing cytotoxic radicals on growth of estrogen-independent MXT mouse mammary carcinoma in vivo

1992 • 23 citations

A qualitative and quantitative study of rete ovarii development in the fetal rat: Correlation with the onset of meiosis and follicle cell appearance

1979 • 23 citations

Isolation, growth and characteristics of human ovarian surface epithelium

1994 • 23 citations

Inhibitory effect of GnRH superagonist on the growth of human ovarian carcinoma NIH: OVCAR 3 in the nude mouse

1986 • 22 citations

Influence of Growth Factors on Proliferation and Morphogenesis of Rabbit Ovarian Mesothelial Cells in Vitro1

1996 • 21 citations

Intermediate filaments in rat ovarian surface epithelial cells: changes with neoplastic progression in culture

1992 • 21 citations

Clinical and pathophysiological aspects of inhibin

1993 • 21 citations

Neuroendocrine Control of the Postpartum Period

1983 • 18 citations

Effects of interferon ? on the proliferation and modulation of cell-surface structures of human ovarian carcinoma cell lines

1993 • 18 citations

Spatiotemporal changes in cytokeratin expression in the neonatal rat ovary

1998 • 18 citations

Testosterone, Shbg and Albumin in Patients with Ovarian Carcinoma

1986 • 18 citations

Transforming growth factor-β regulates Kit ligand expression in rat ovarian surface epithelial cells

1999 • 18 citations

Induction of Apoptosis in Ovarian Carcinoma Cell Line by Gonadotropin-releasing Hormone Agonist.

1998 • 17 citations

Correlation of Multiple Steroid Receptors with Histological Type and Grade in Human Ovarian Cancer

1987 • 17 citations

Autoradiographic investigation of estrogen binding in cultured rat ovarian surface epithelial cells.

1983 • 16 citations

PLASMA 20α‐OH‐PROGESTERONE IN WOMEN WITH MALIGNANT EPITHELIAL ‘NON‐ENDOCRINE’ OVARIAN TUMORS

1985 • 16 citations

Inhibition of transforming growth factor α (TGF-α)-mediated growth effects in ovarian cancer cell lines by a tyrosine kinase inhibitor ZM 252868

1999 • 15 citations

Human Granulocyte-Macrophage Colony-stimulating Factor Is a Growth Factor Active on Human Ovarian Cancer Cells

1991 • 15 citations

Detection of Serum Transforming Growth Factor-α in Patients of Primary Epithelial Ovarian Cancers by Enzyme Immunoassay

1997 • 14 citations

Growth factor content in normal and benign ovarian tumours

1992 • 13 citations

Triptorelin (D-Trp-6-LHRH) in combination with carboplatin-containing polychemotherapy for advanced ovarian cancer: a pilot study.

1993 • 13 citations

Steroidogenic Factor-1 Regulates the Rate of Proliferation of Normal and Neoplastic Rat Ovarian Surface Epithelial Cellsin Vitro1

1998 • 12 citations

Regulation and temporal sequence of surface epithelium morphogenesis in the postovulatory rabbit ovary.

1989 • 11 citations

Cell survival effect of activin against heat shock stress on OVCAR3

1998 • 11 citations

Antisense oligonucleotide to insulin-like growth factor II induces apoptosis in human ovarian cancer AO cell line

1998 • 10 citations

LH-RH Agonists in the Treatment of Ovarian Cancer

1992 • 10 citations

GnRH and Its Mechanism of Action

1993 • 10 citations

mRNA phenotyping of the major ligands and receptors of the EGF supergene family in human ovarian epithelial cells

1995 • 10 citations

Involvement of the c‐ erb B‐2 oncogene product in the egf‐induced cell motility of sk‐ov‐3 ovarian cancer cells

1999 • 9 citations

Immunohistochemical profile of ovarian inclusion cysts in patients with and without ovarian carcinoma

1995 • 8 citations

Peripheral and Ovarian Venous Concentrations of Estradiol and Progesterone in Postmenopausal Women with “Non‐Endocrine” Ovarian Tumors

1990 • 8 citations

c-myc overexpression in human primary ovarian tumours : its relevance to tumour progression

1992 • 8 citations

Unusual antiproliferative effects of transforming growth factors-β 1 andβ 2 against primary cells from human tumors

1989 • 8 citations

Ovarian cancer and gonadotropins in vitro: new evidence in favor of independence.

2000 • 8 citations

Interferon gamma‐induced reduction in erbB‐2 tyrosyl phosphorylation in human ovarian carcinoma cells

1994 • 7 citations

[Effect of antisense c-erbB2 on biologic behaviour and chemotherapeutic drug sensitivity in human ovarian cancer cells].

1996 • 6 citations

Vascular endothelial growth factor serum concentrations in ovarian cancer

1998 • 4 citations

Involvement of the c-erbB-2 oncogene product in the egf-induced cell motility of sk-ov-3 ovarian cancer cells

1999 • 4 citations

Effects of a Gonadotropin‐releasing Hormone Agonist on Rat Ovarian Adenocarcinoma Cell Lines in vitro and in vivo

1998 • 3 citations

EPIDERMAL GROWTH-FACTOR RECEPTOR EXPRESSION IN MALIGNANT OVARY, BENIGN OVARIAN-TUMORS AND NORMAL OVARY - A COMPARISON

1993 • 3 citations

Correlation of hormone receptors with histologic differentiation in ovarian carcinoma.

1988 • 2 citations

Deleted Work

1955 • 0 citations