Association of Hereditary Nonpolyposis Colorectal Cancer–Related Tumors Displaying Low Microsatellite Instability with MSH6 Germline Mutations

A National Cancer Institute Workshop on Microsatellite Instability for cancer detection and familial predisposition: development of international criteria for the determination of microsatellite instability in colorectal cancer.

1998 • 4,047 citations

de la Chapelle, A.

1997 • 3,184 citations

New clinical criteria for hereditary nonpolyposis colorectal cancer (HNPCC, Lynch syndrome) proposed by the International Collaborative Group on HNPCC☆

1999 • 2,460 citations

The International Collaborative Group on Hereditary Non-Polyposis Colorectal Cancer (ICG-HNPCC)

1991 • 2,142 citations

Patients Tested at a Laboratory for Hereditary Cancer Syndromes Show an Overlap for Multiple Syndromes in Their Personal and Familial Cancer Histories

2015 • 1,481 citations

Genetic variation at five trimeric and tetrameric tandem repeat loci in four human population groups

1992 • 1,468 citations

Incidence of Hereditary Nonpolyposis Colorectal Cancer and the Feasibility of Molecular Screening for the Disease

1998 • 1,173 citations

Analysis of mismatch repair genes in hereditary non–polyposis colorectal cancer patients

1996 • 957 citations

Purification of DNA from formaldehyde fixed and paraffin embedded human tissue

1985 • 821 citations

Diagnostic microsatellite instability: definition and correlation with mismatch repair protein expression.

1997 • 751 citations

Microsatellite instability and mutations of the transforming growth factor beta type II receptor gene in colorectal cancer.

1995 • 743 citations

Isolation of an hMSH2-p160 Heterodimer That Restores DNA Mismatch Repair to Tumor Cells

1995 • 599 citations

Microsatellite instability is associated with tumors that characterize the hereditary non-polyposis colorectal carcinoma syndrome.

1993 • 596 citations

GTBP, a 160-Kilodalton Protein Essential for Mismatch-binding Activity in Human Cells

1995 • 528 citations

Mutations of GTBP in Genetically Unstable Cells

1995 • 471 citations

Germ-line mutation of the hMSH6/GTBP gene in an atypical hereditary nonpolyposis colorectal cancer kindred.

1997 • 465 citations

Mutation in the Mismatch Repair Gene Msh6 Causes Cancer Susceptibility

1997 • 359 citations

DNA mismatch repair gene mutations in 55 kindreds with verified or putative hereditary non-polyposis colorectal cancer

1996 • 264 citations

Mutations Predisposing to Hereditary Nonpolyposis Colorectal Cancer

1997 • 198 citations

MSH2 andMLH1 mutations in sporadic replication error-positive colorectal carcinoma as assessed by two-dimensional DNA electrophoresis

1997 • 118 citations

Comprehensive and accurate mutation scanning of theCFTR gene by two-dimensional DNA electrophoresis

1996 • 34 citations

Presence and instability of repetitive elements in sequences the altered expression of which characterizes risk for colonic cancer.

1995 • 28 citations

Improved mutation detection in GC-rich DNA fragments by combined DGGE and CDGE

1999 • 26 citations

Improved mutation detection in GC-rich DNA fragments by combined DGGE and CDGE

1999 • 23 citations

cDNA Sequence, Map, and Expression of the Murine Homolog ofGTBP,a DNA Mismatch Repair Gene

1996 • 17 citations