p53 gene mutations and protein accumulation in human ovarian cancer.

p53 Mutations in Human Cancers

1991 • 8,133 citations

The p53 tumour suppressor gene

1991 • 3,871 citations

Germ Line p53 Mutations in a Familial Syndrome of Breast Cancer, Sarcomas, and Other Neoplasms

1990 • 3,720 citations

Mutations in the p53 gene occur in diverse human tumour types

1989 • 2,765 citations

The p53 proto-oncogene can act as a suppressor of transformation

1989 • 2,019 citations

A role for sunlight in skin cancer: UV-induced p53 mutations in squamous cell carcinoma.

1991 • 1,946 citations

Mutational hot spot in the p53 gene in human hepatocellular carcinomas

1991 • 1,525 citations

Selective G to T mutations of p53 gene in hepatocellular carcinoma from southern Africa

1991 • 1,418 citations

A cancer family syndrome in twenty-four kindreds.

1988 • 1,274 citations

Germ-line transmission of a mutated p53 gene in a cancer-prone family with Li–Fraumeni syndrome

1990 • 1,228 citations

Molecular basis of base substitution hotspots in Escherichia coli

1978 • 1,185 citations

Activating mutations for transformation by p53 produce a gene product that forms an hsc70-p53 complex with an altered half-life.

1988 • 1,140 citations

The CpG dinucleotide and human genetic disease

1988 • 946 citations

Tumor suppressor genes

1991 • 775 citations

Accumulation of p53 Tumor Suppressor Gene Protein: An Independent Marker of Prognosis in Breast Cancers

1992 • 757 citations

5-Methylcytosine as an Endogenous Mutagen in the Human LDL Receptor and p53 Genes

1990 • 643 citations

Structural aspects of the p53 protein in relation to gene evolution.

1990 • 618 citations

Mutation is required to activate the p53 gene for cooperation with the ras oncogene and transformation

1989 • 599 citations

Isolation of human‐p53‐specific monoclonal antibodies and their use in the studies of human p53 expression

1986 • 508 citations

Overexpression and mutation of p53 in epithelial ovarian cancer.

1991 • 464 citations

Borderline and malignant mucinous tumors of the ovary.Histologic criteria and clinical behavior

1973 • 337 citations

Mutation spectrum of the p53 gene in bone and soft tissue sarcomas.

1992 • 305 citations

Prevalence and Spectrum of Germline Mutations of the p53 Gene among Patients with Sarcoma

1992 • 304 citations

Activating Mutations for Transformation by p53 Produce a Gene Product That Forms an hsc70-p53 Complex with an Altered Half-Life

1988 • 298 citations

p53 point mutation in HPV negative human cervical carcinoma cell lines.

1991 • 271 citations

Activation of ras Oncogenes Preceding the Onset of Neoplasia

1990 • 261 citations

Tumor suppressor p53: analysis of wild-type and mutant p53 complexes.

1991 • 242 citations

The p53 gene is very frequently mutated in small-cell lung cancer with a distinct nucleotide substitution pattern

1992 • 199 citations

Tumor suppressor genes: the p53 and retinoblastoma sensitivity genes and gene products

1990 • 175 citations

Detection of DNA sequence polymorphisms by enzymatic amplification and direct genomic sequencing.

1989 • 166 citations

p53 mutations in ovarian cancer: a late event?

1991 • 151 citations

Polymorphism at codon 213 within the p53 gene.

1991 • 137 citations

Overexpression of the p53 protein and allele loss at 17p13 in ovarian carcinoma

1992 • 94 citations

Are germ cell tumors part of the Li-Fraumeni cancer family syndrome?

1989 • 72 citations

Tumor Suppressor p53: Analysis of Wild-Type and Mutant p53 Complexes

1991 • 66 citations

Correlation of metabolic stability and altered quaternary structure of oncoprotein p53 with cell transformation

1991 • 60 citations

Frequent p53 mutations in chemically induced murine fibrosarcoma.

1991 • 44 citations

Neoplastic Transformation of Rat 3Y1 Cells by a Transcriptionally Activated Human c-myc Gene and Stabilization of p53 Cellular Tumor Antigen in the Transformed Cells

1986 • 23 citations

The effects of estrogen on prolactin gene methylation in normal and neoplastic rat pituitary tissues.

1992 • 16 citations