Enforced Expression of Bcl-2 Restores the Number of NK Cells, But Does Not Rescue the Impaired Development of NKT Cells or Intraepithelial Lymphocytes, in IL-2/IL-15 Receptor β-Chain-Deficient Mice

CD1d-Restricted and TCR-Mediated Activation of V _α 14 NKT Cells by Glycosylceramides

1997 • 2,370 citations

JAKS AND STATS: Biological Implications

1998 • 1,788 citations

Reversible Defects in Natural Killer and Memory Cd8 T Cell Lineages in Interleukin 15–Deficient Mice

2000 • 1,578 citations

Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice.

1994 • 1,572 citations

Lymphopenia in interleukin (IL)-7 gene-deleted mice identifies IL-7 as a nonredundant cytokine.

1995 • 1,447 citations

IL-15 Receptor Maintains Lymphoid Homeostasis by Supporting Lymphocyte Homing and Proliferation

1998 • 1,293 citations

Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function

2000 • 1,191 citations

Interleukin-2 Receptor γ Chain: a Functional Component of the Interleukin-7 Receptor

1993 • 1,128 citations

Defective lymphoid development in mice lacking expression of the common cytokine receptor γ chain

1995 • 1,024 citations

Utilization of the beta and gamma chains of the IL-2 receptor by the novel cytokine IL-15.

1994 • 1,008 citations

Lymphoid development in mice with a targeted deletion of the interleukin 2 receptor gamma chain.

1995 • 881 citations

NKT cells: facts, functions and fallacies

2000 • 875 citations

Deregulated T Cell Activation and Autoimmunity in Mice Lacking Interleukin-2 Receptor β

1995 • 868 citations

Cloning of the γ Chain of the Human IL-2 Receptor

1992 • 835 citations

Disruption of the Jak1 Gene Demonstrates Obligatory and Nonredundant Roles of the Jaks in Cytokine-Induced Biologic Responses

1998 • 827 citations

Sharing of the Interleukin-2 (IL-2) Receptor γ Chain Between Receptors for IL-2 and IL-4

1993 • 734 citations

Cytokine Signaling Through Nonreceptor Protein Tyrosine Kinases

1995 • 713 citations

THE MULTIFACETED REGULATION OF INTERLEUKIN-15 EXPRESSION AND THE ROLE OF THIS CYTOKINE IN NK CELL DIFFERENTIATION AND HOST RESPONSE TO INTRACELLULAR PATHOGENS

1999 • 712 citations

Interleukin-2 Receptor β Chain Gene: Generation of Three Receptor Forms by Cloned Human α and β Chain cDNA's

1989 • 680 citations

Defective Lymphoid Development in Mice Lacking Jak3

1995 • 650 citations

Interaction of IL-2Rβ and γ _c Chains with Jak1 and Jak3: Implications for XSCID and XCID

1994 • 647 citations

Involvement of the Jak-3 Janus kinase in signalling by interleukins 2 and 4 in lymphoid and myeloid cells

1994 • 618 citations

Bcl-2 Rescues T Lymphopoiesis in Interleukin-7 Receptor–Deficient Mice

1997 • 603 citations

Interleukin-2 Receptor γ Chain: a Functional Component of the Interleukin-4 Receptor

1993 • 593 citations

In vivo developmental stages in murine natural killer cell maturation

2002 • 588 citations

Functional Activation of Jak1 and Jak3 by Selective Association with IL-2 Receptor Subunits

1994 • 581 citations

Stat5 Is Required for IL-2-Induced Cell Cycle Progression of Peripheral T Cells

1999 • 554 citations

Defects in B Lymphocyte Maturation and T Lymphocyte Activation in Mice Lacking Jak3

1995 • 551 citations

Cutting Edge: The Common γ-Chain Is an Indispensable Subunit of the IL-21 Receptor Complex

2001 • 535 citations

Transduction of interleukin-2 antiapoptotic and proliferative signals via Akt protein kinase

1997 • 534 citations

Bcl-2 Can Rescue T Lymphocyte Development in Interleukin-7 Receptor–Deficient Mice but Not in Mutant rag-1 −/− Mice

1997 • 503 citations

Role of interleukin-15 in the development of human CD56+ natural killer cells from CD34+ hematopoietic progenitor cells

1996 • 495 citations

Developmental defects of lymphoid cells in Jak3 kinase-deficient mice

1995 • 493 citations

Immune Responses in Interleukin-2-Deficient Mice

1993 • 476 citations

Detection of intracytoplasmic cytokine using flow cytometry and directly conjugated anti-cytokine antibodies

1995 • 473 citations

IL-21 Limits NK Cell Responses and Promotes Antigen-Specific T Cell Activation

2002 • 470 citations

RETRACTED: Uncoupling IL-2 Signals that Regulate T Cell Proliferation, Survival, and Fas-Mediated Activation-Induced Cell Death

1999 • 443 citations

A potential role for interleukin-15 in the regulation of human natural killer cell survival.

1997 • 413 citations

Three distinct IL-2 signaling pathways mediated by bcl-2, c-myc, and lck cooperate in hematopoietic cell proliferation

1995 • 372 citations

Abnormal Development of Intestinal Intraepithelial Lymphocytes and Peripheral Natural Killer Cells in Mice Lacking the IL-2 Receptor β Chain

1997 • 359 citations

Homeostatic regulation of intestinal epithelia by intraepithelial gamma delta T cells.

1995 • 357 citations

Requirement for IRF-1 in the microenvironment supporting development of natural killer cells

1998 • 352 citations

The Immunobiology of T Cells with Invariant gammadelta Antigen Receptors

1991 • 343 citations

Functional Participation of the IL-2 Receptor γ Chain in IL-7 Receptor Complexes

1994 • 342 citations

The Earliest T Lineage–Committed Cells Depend on IL-7 for Bcl-2 Expression and Normal Cell Cycle Progression

1997 • 338 citations

Impaired immunoglobulin gene rearrangement in mice lacking the IL-7 receptor

1998 • 331 citations

Stat5b Is Essential for Natural Killer Cell–mediated Proliferation and Cytolytic Activity

1998 • 323 citations

Cloning of a type I cytokine receptor most related to the IL-2 receptor β chain

2000 • 322 citations

Interleukin 7 receptor-deficient mice lack gammadelta T cells.

1996 • 316 citations

Prevention of T Cell Anergy by Signaling Through the γ _c Chain of the IL-2 Receptor

1994 • 311 citations

Inhibition of gamma delta T cell development and early thymocyte maturation in IL-7 -/- mice.

1996 • 301 citations

Systemic Overexpression of BCL-2 in the Hematopoietic System Protects Transgenic Mice From the Consequences of Lethal Irradiation

1998 • 299 citations

Activation of Fas by FasL induces apoptosis by a mechanism that cannot be blocked by Bcl-2 or Bcl-x_L

1999 • 295 citations

Modulation of hematopoiesis in mice with a truncated mutant of the interleukin-2 receptor gamma chain

1996 • 268 citations

The IL-2 Receptor Promotes Lymphocyte Proliferation and Induction of the c-myc, bcl-2, and bcl-x Genes Through the trans-Activation Domain of Stat5

2000 • 234 citations

Bcl-2 Rescues T Lymphopoiesis, but Not B or NK Cell Development, in Common γ Chain–Deficient Mice

1997 • 220 citations

Interleukin-7 receptor alpha is essential for the development of gamma delta + T cells, but not natural killer cells.

1996 • 211 citations

Different interleukin 2 receptor beta-chain tyrosines couple to at least two signaling pathways and synergistically mediate interleukin 2-induced proliferation.

1996 • 202 citations

Thymus Independent T Cell Development and Selection in the Intestinal Epithelium

1994 • 197 citations

Activation of Stat5 by interleukin 2 requires a carboxyl-terminal region of the interleukin 2 receptor beta chain but is not essential for the proliferative signal transmission.

1995 • 190 citations

Sharing of the IL-2 receptor γ chain with the functional IL-9 receptor complex

1995 • 189 citations

The Transcription Factor Interferon Regulatory Factor 1 (IRF-1) Is Important during the Maturation of Natural Killer 1.1+ T Cell Receptor–α/β+ (NK1+ T) Cells, Natural Killer Cells, and Intestinal Intraepithelial T Cells

1998 • 185 citations

The Molecular Basis of X‐Linked Severe Combined Immunodeficiency: The Role of the Interleukin‐2 Receptor γ Chain as a Common γ Chain, γc

1994 • 180 citations

Lymphoid Hyperplasia, Autoimmunity, and Compromised Intestinal Intraepithelial Lymphocyte Development in Colitis-Free Gnotobiotic IL-2-Deficient Mice

1998 • 180 citations

The Common Cytokine Receptor γ Chain Plays an Essential Role in Regulating Lymphoid Homeostasis

1997 • 168 citations

Role for IL-15/IL-15 receptor beta-chain in natural killer 1.1+ T cell receptor-alpha beta+ cell development.

1997 • 153 citations

IL-15 can substitute for the marrow microenvironment in the differentiation of natural killer cells.

1996 • 148 citations

Generation of Lytic Natural Killer 1.1+, Ly-49− Cells from Multipotential Murine Bone Marrow Progenitors in a Stroma-free Culture: Definition of Cytokine Requirements and Developmental Intermediates

1997 • 139 citations

A Critical Role for IL-18 in the Proliferation and Activation of NK1.1+CD3− Cells

1998 • 135 citations

The V–J Recombination of T Cell Receptor-γ Genes Is Blocked in Interleukin-7 Receptor–deficient Mice

1996 • 132 citations

Interleukin 7 Receptor Control of T Cell Receptor γ Gene Rearrangement: Role of Receptor-associated Chains and Locus Accessibility

1998 • 131 citations

Interleukin‐15 preferentially promotes the growth of intestinal intraepithelial lymphocytes bearing γδ T cell receptor in mice

1997 • 131 citations

Differentiation of NK1.1+, Ly49+ NK cells from flt3+ multipotent marrow progenitor cells.

1999 • 124 citations

c-kit+ stem cells and thymocyte precursors in the livers of adult mice.

1996 • 121 citations

Induction of Germline Transcription in the TCRγ Locus by Stat5

1999 • 120 citations

Interleukin 2 Receptor Signaling Regulates the Perforin Gene through Signal Transducer and Activator of Transcription (Stat)5 Activation of Two Enhancers

1999 • 113 citations

IL-7 Receptor and VDJ Recombination: Trophic Versus Mechanistic Actions

1997 • 108 citations

Differentiation of NK1.1+, Ly49+ NK Cells from flt3+ Multipotent Marrow Progenitor Cells

1999 • 106 citations

Aiolos transcription factor controls cell death in Tcells by regulating Bcl-2 expression and its cellular localization

1999 • 96 citations

SKIN ALLOGRAFT REJECTION IN CD28-DEFICIENT MICE1

1996 • 93 citations

Regulation of Cell Growth by IL-2: Role of STAT5 in Protection from Apoptosis But Not in Cell Cycle Progression

1998 • 90 citations

Activation of Stat5 by interleukin 2 requires a carboxy-terminal region β chain but is not exxential for the proliferative signal transdution.

1995 • 87 citations

The IL-2 Receptor Promotes Proliferation,bcl-2andbcl-xInduction, But Not Cell Viability Through the Adapter Molecule Shc

1998 • 85 citations

Developmental and Functional Defects of Thymic and Epidermal Vγ3 Cells in IL-15-Deficient and IFN Regulatory Factor-1-Deficient Mice

2002 • 77 citations

IL-2 and IL-7 but not IL-12 protect natural killer cells from death by apoptosis and up-regulate bcl-2 expression.

1995 • 74 citations

The role of IL-7 in thymic and extrathymic development of TCR gamma delta cells.

1998 • 71 citations

Overexpression of Bcl-2 does not rescue impaired B lymphopoiesis in IL- 7 receptor-deficient mice but can enhance survival of mature B cells

1998 • 70 citations

Defective T-cell receptor γ gene rearrangement in interleukin-7 receptor knockout mice

1997 • 70 citations

Physical association of JAK1 and JAK2 tyrosine kinases with the interleukin 2 receptor beta and gamma chains.

1994 • 68 citations

Membrane Lymphotoxin Is Required for the Development of Different Subpopulations of NK T Cells

2000 • 67 citations

The Common Cytokine Receptor γ Chain Controls Survival of γ/δ T Cells

1997 • 64 citations

The Role of IL-7 in Thymic and Extrathymic Development of TCRγδ Cells

1998 • 63 citations

Functional dissection of the cytoplasmic subregions of the IL-2 receptor beta c chain in primary lymphocyte populations

1998 • 61 citations

A transgenic T cell receptor restores thymocyte differentiation in interleukin-7 receptor α chain-deficient mice

1997 • 51 citations

IL-2Rbeta/IL-7Ralpha doubly deficient mice recapitulate the thymic and intraepithelial lymphocyte (IEL) developmental defects of gammac-/- mice: roles for both IL-2 and IL-15 in CD8alphaalpha IEL development.

1999 • 47 citations

The primary site of CD4- 8- B220+ alphabeta T cells in lpr mice: the appendix in normal mice.

1998 • 46 citations

Requirement of the IL-2 Receptor β Chain for the Development of Vγ3 Dendritic Epidermal T Cells

1998 • 45 citations

Role of Bcl-2 in alpha beta T cell development in mice deficient in the common cytokine receptor gamma-chain: the requirement for Bcl-2 differs depending on the TCR/MHC affinity.

1999 • 41 citations

IL-2Rβ/IL-7Rα Doubly Deficient Mice Recapitulate the Thymic and Intraepithelial Lymphocyte (IEL) Developmental Defects of γc−/− Mice: Roles for Both IL-2 and IL-15 in CD8αα IEL Development

1999 • 40 citations

Role of Bcl-2 in αβ T Cell Development in Mice Deficient in the Common Cytokine Receptor γ-Chain: The Requirement for Bcl-2 Differs Depending on the TCR/MHC Affinity

1999 • 40 citations

The Primary Site of CD4−8−B220+ αβ T Cells inlprMice: The Appendix in Normal Mice

1998 • 38 citations

Systemic Overexpression of BCL-2 in the Hematopoietic System Protects Transgenic Mice From the Consequences of Lethal Irradiation

1998 • 37 citations

Differential Roles of Cytokine Receptors in the Development of Epidermal γδ T Cells

2001 • 34 citations

Distinct effects of Jak3 signaling on alphabeta and gammadelta thymocyte development.

1999 • 22 citations

Clonal Proliferation and Cytokine Requirement of Murine Progenitors for Natural Killer Cells

1997 • 21 citations

Development and Function of the Immune System in Mice with Targeted Disruption of the Interleukin 2 Gene

1994 • 19 citations

An IL-2 receptor β subdomain that controls Bcl-XL expression and cell survival

1999 • 18 citations

Development of Intestinal Intraepithelial Lymphocytes, NK Cells, and NK 1.1+ T Cells in CD45-Deficient Mice

2001 • 17 citations

Distinct Effects of Jak3 Signaling on αβ and γδ Thymocyte Development

1999 • 15 citations

Sharing of the IL-2 receptor γ chain with the functional IL-9 receptor complex

1994 • 4 citations

Deleted Work

1955 • 0 citations