The IL-2 Receptor Promotes Proliferation,bcl-2andbcl-xInduction, But Not Cell Viability Through the Adapter Molecule Shc

Site-directed mutagenesis by overlap extension using the polymerase chain reaction

1989 • 7,496 citations

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death

1993 • 6,009 citations

bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death

1993 • 3,111 citations

Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes

1983 • 2,871 citations

Serine Phosphorylation of Death Agonist BAD in Response to Survival Factor Results in Binding to 14-3-3 Not BCL-XL

1996 • 2,627 citations

Protein modules and signalling networks

1995 • 2,447 citations

Interleukin-3-Induced Phosphorylation of BAD Through the Protein Kinase Akt

1997 • 2,245 citations

Interleukin-2: Inception, Impact, and Implications

1988 • 2,166 citations

Bad, a heterodimeric partner for Bcl-xL and Bcl-2, displaces bax and promotes cell death

1995 • 2,114 citations

Transcriptional Regulation by Extracellular signals: Mechanisms and Specificity

1995 • 1,287 citations

Deregulated Bcl-2 gene expression selectively prolongs survival of growth factor-deprived hemopoietic cell lines.

1990 • 926 citations

The IL-2/IL-2 receptor system: A current overview

1993 • 778 citations

A c-myc antisense oligodeoxynucleotide inhibits entry into S phase but not progress from G0 to G1

1987 • 696 citations

Two Signals Are Necessary for Cell Proliferation Induced by a Cytokine Receptor gp130: Involvement of STAT3 in Anti-Apoptosis

1996 • 661 citations

The 145-kDa protein induced to associate with Shc by multiple cytokines is an inositol tetraphosphate and phosphatidylinositol 3,4,5-triphosphate 5-phosphatase.

1996 • 636 citations

Involvement of the Jak-3 Janus kinase in signalling by interleukins 2 and 4 in lymphoid and myeloid cells

1994 • 618 citations

Signaling Through the Hematopoietic Cytokine Receptors

1995 • 617 citations

Phosphorylation and activation of the Jak-3 Janus kinase in response to interleukin-2

1994 • 598 citations

Functional Activation of Jak1 and Jak3 by Selective Association with IL-2 Receptor Subunits

1994 • 581 citations

Interaction of the IL-2 Receptor with thesrc-Family Kinase p56^lck: Identification of Novel Intermolecular Association

1991 • 576 citations

Defects in B Lymphocyte Maturation and T Lymphocyte Activation in Mice Lacking Jak3

1995 • 551 citations

Transduction of interleukin-2 antiapoptotic and proliferative signals via Akt protein kinase

1997 • 534 citations

An Alternative to SH2 Domains for Binding Tyrosine-Phosphorylated Proteins

1994 • 501 citations

Developmental defects of lymphoid cells in Jak3 kinase-deficient mice

1995 • 493 citations

Suppression of interleukin-3-induced gene expression by a C-terminal truncated Stat5: role of Stat5 in proliferation.

1996 • 414 citations

Three distinct IL-2 signaling pathways mediated by bcl-2, c-myc, and lck cooperate in hematopoietic cell proliferation

1995 • 372 citations

Interleukin‐2 receptor common γ‐chain signaling cytokines regulate activated T cell apoptosis in response to growth factor withdrawal: Selective induction of anti‐apoptotic (bcl‐2, bcl‐x_L) but not pro‐apoptotic (bax, bcl‐x_S) gene expression

1996 • 367 citations

The Roles of Costimulation and Fas in T Cell Apoptosis and Peripheral Tolerance

1996 • 367 citations

Cytoplasmic domains of the interleukin-2 receptor β and γ chains mediate the signal for T-cell proliferation

1994 • 340 citations

Characterization of A1, a novel hemopoietic-specific early-response gene with sequence similarity to bcl-2.

1993 • 336 citations

Suppression of apoptotic death in hematopoietic cells by signalling through the IL-3/GM-CSF receptors.

1995 • 321 citations

An IL-4 receptor region containing an insulin receptor motif is important for IL-4-mediated IRS-1 phosphorylation and cell growth

1994 • 306 citations

A kinase-independent function of Lck in potentiating antigen-specific T cell activation

1993 • 252 citations

Multiple Requirements for SHPTP2 in Epidermal Growth Factor-Mediated Cell Cycle Progression

1996 • 247 citations

Not all Shc's roads lead to Ras

1996 • 239 citations

PTB Domains of IRS-1 and Shc Have Distinct but Overlapping Binding Specificities

1995 • 220 citations

Different interleukin 2 receptor beta-chain tyrosines couple to at least two signaling pathways and synergistically mediate interleukin 2-induced proliferation.

1996 • 202 citations

Functional responses and apoptosis of CD25 (IL-2R alpha)-deficient T cells expressing a transgenic antigen receptor.

1997 • 192 citations

Activation of Stat5 by interleukin 2 requires a carboxyl-terminal region of the interleukin 2 receptor beta chain but is not essential for the proliferative signal transmission.

1995 • 190 citations

Suppression of apoptosis in a cytotoxic T-cell line by interleukin 2-mediated gene transcription and deregulated expression of the protooncogene bcl-2.

1993 • 177 citations

Expression of Bcl-2, Bcl-x, and Bax after T cell activation and IL-2 withdrawal.

1995 • 167 citations

Tyrosine Phosphorylation Sites at Amino Acids 239 and 240 of Shc Are Involved in Epidermal Growth Factor-Induced Mitogenic Signaling That Is Distinct from Ras/Mitogen-Activated Protein Kinase Activation

1997 • 156 citations

Regulation of Bcl-2 expression by oncogenic Ras protein in hematopoietic cells.

1995 • 151 citations

Ligand-Induced Assembly and Activation of the Gamma Interferon Receptor in Intact Cells

1996 • 149 citations

Interleukins 2, 4, 7, and 15 Stimulate Tyrosine Phosphorylation of Insulin Receptor Substrates 1 and 2 in T Cells POTENTIAL ROLE OF JAK KINASES

1995 • 133 citations

A novel pathway from phosphorylation of tyrosine residues 239/240 of Shc, contributing to suppress apoptosis by IL-3.

1996 • 131 citations

Critical role of the interleukin 2 (IL-2) receptor gamma-chain-associated Jak3 in the IL-2-induced c-fos and c-myc, but not bcl-2, gene induction.

1995 • 108 citations

Evidence for a role for the phosphotyrosine-binding domain of Shc in interleukin 2 signaling.

1996 • 108 citations

Shc Contains Two Grb2 Binding Sites Needed for Efficient Formation of Complexes with SOS in B Lymphocytes

1997 • 94 citations

Activation of Stat5 by interleukin 2 requires a carboxy-terminal region β chain but is not exxential for the proliferative signal transdution.

1995 • 87 citations

Analysis of Interleukin-2-dependent Signal Transduction through the Shc/Grb2 Adapter Pathway

1995 • 75 citations

Distinct Tyrosine Residues within the Interleukin-2 Receptor β Chain Drive Signal Transduction Specificity, Redundancy, and Diversity

1996 • 75 citations

A Membrane-Proximal Region of the Interleukin-2 Receptor γ_c Chain Sufficient for Jak Kinase Activation and Induction of Proliferation in T Cells

1996 • 69 citations

Physical association of JAK1 and JAK2 tyrosine kinases with the interleukin 2 receptor beta and gamma chains.

1994 • 68 citations

Intermediate Affinity Interleukin-2 Receptor Mediates Survival via a Phosphatidylinositol 3-Kinase-dependent Pathway

1997 • 67 citations

Growth Signal Transduction by the Human Interleukin-2 Receptor Requires Cytoplasmic Tyrosines of the β Chain and Non-tyrosine Residues of the γc Chain

1995 • 67 citations

Requirement for an initial signal from the membrane-proximal region of the interleukin 2 receptor γ _c chain for Janus kinase activation leading to T cell proliferation

1997 • 47 citations

Inhibition of p21ras activation blocks proliferation but not differentiation of interleukin-3-dependent myeloid cells.

1994 • 46 citations

Interleukin-2 induces tyrosine phosphorylation of SHP-2 through IL-2 receptor β chain

1997 • 45 citations

Dispensability of Jak1 tyrosine kinase for interleukin‐2‐induced cell growth signaling in a human T cell line

1996 • 45 citations

Three Distinct IL-2 Signaling Pathways Mediated by bcl-2, c-myc, and lck Cooperate in Hematopoietic Cell Proliferation.

1996 • 20 citations