The Molecular Basis of X‐Linked Severe Combined Immunodeficiency: The Role of the Interleukin‐2 Receptor γ Chain as a Common γ Chain, γc

Rapid and sensitive detection of point mutations and DNA polymorphisms using the polymerase chain reaction

1989 • 3,557 citations

Human Growth Hormone and Extracellular Domain of Its Receptor: Crystal Structure of the Complex

1992 • 2,236 citations

Structural design and molecular evolution of a cytokine receptor superfamily.

1990 • 2,104 citations

Interleukin-2 receptor γ chain mutation results in X-linked severe combined immunodeficiency in humans

1993 • 1,317 citations

Attachment of a 40-base-pair G + C-rich sequence (GC-clamp) to genomic DNA fragments by the polymerase chain reaction results in improved detection of single-base changes.

1989 • 1,295 citations

Structure and expression of a cloned cDNA for human interleukin-2

1983 • 1,176 citations

Interleukin-2 Receptor γ Chain: a Functional Component of the Interleukin-7 Receptor

1993 • 1,128 citations

The IL-6 Signal Transducer, gp130: an Pncostatin M Receptor and Affinity Converter for the LIF Receptor

1992 • 897 citations

Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting

1991 • 892 citations

A monoclonal antibody that appears to recognize the receptor for human T-cell growth factor; partial characterization of the receptor

1982 • 877 citations

Mutation of Unique Region of Bruton's Tyrosine Kinase in Immunodeficient XID Mice

1993 • 868 citations

Molecular cloning and expression of cDNAs for the human interleukin-2 receptor

1984 • 858 citations

Cloning of the γ Chain of the Human IL-2 Receptor

1992 • 835 citations

Complementation cloning of an MHC class II transactivator mutated in hereditary MHC class II deficiency (or bare lymphocyte syndrome)

1993 • 828 citations

Stimulation of B-cell progenitors by cloned murine interleukin-7

1988 • 826 citations

The IL-2/IL-2 receptor system: A current overview

1993 • 778 citations

Sharing of the Interleukin-2 (IL-2) Receptor γ Chain Between Receptors for IL-2 and IL-4

1993 • 734 citations

Crystal structure of the phosphotyrosine recognition domain SH2 of v-src complexed with tyrosine-phosphorylated peptides

1992 • 684 citations

Interleukin-2 Receptor β Chain Gene: Generation of Three Receptor Forms by Cloned Human α and β Chain cDNA's

1989 • 680 citations

Colocalization of X-Linked Agammaglobulinemia and X-Linked Immunodeficiency Genes

1993 • 631 citations

Expression cloning of the human IL-3 receptor cDNA reveals a shared β subunit for the human IL-3 and GM-CSF receptors

1991 • 617 citations

Cloning of the human and murine interleukin-7 receptors: Demonstration of a soluble form and homology to a new receptor superfamily

1990 • 614 citations

Expression of interleukin-2 receptors as a differentiation marker on intrathymic stem cells

1985 • 613 citations

Fundamental Immunology

1990 • 607 citations

A human high affinity interleukin-5 receptor (IL5R) is composed of an IL5-specific α chain and a β chain shared with the receptor for GM-CSF

1991 • 598 citations

Centre d'Etude du polymorphisme humain (CEPH): Collaborative genetic mapping of the human genome

1990 • 595 citations

Interleukin-2 Receptor γ Chain: a Functional Component of the Interleukin-4 Receptor

1993 • 593 citations

Novel Interleukin-2 Receptor Subunit Detected by Cross-Linking Under High-Affinity Conditions

1986 • 585 citations

Molecular cloning of cDNA encoding human interleukin-2 receptor

1984 • 567 citations

Interleukin 2 high-affinity receptor expression requires two distinct binding proteins.

1987 • 565 citations

Recognition of a high-affinity phosphotyrosyl peptide by the Src homology-2 domain of p56lck

1993 • 497 citations

Demonstration of a non-Tac peptide that binds interleukin 2: a potential participant in a multichain interleukin 2 receptor complex.

1986 • 477 citations

Receptors for interleukin-13 and interleukin-4 are complex and share a novel component that functions in signal transduction.

1993 • 457 citations

The IL-2 Receptor β Chain (p70): Role in Mediating Signals for LAK, NK, and Proliferative Activities

1987 • 444 citations

Human interleukin 4 receptor confers biological responsiveness and defines a novel receptor superfamily.

1990 • 430 citations

Lymphospecific toxicity in adenosine deaminase deficiency and purine nucleoside phosphorylase deficiency: Possible role of nucleoside kinase(s)

1977 • 416 citations

IL-4 induces allergic-like inflammatory disease and alters T cell development in transgenic mice

1990 • 410 citations

The interleukin 2 receptor. Functional consequences of its bimolecular structure.

1987 • 409 citations

IRS-1: Essential for Insulin- and IL-4-Stimulated Mitogenesis in Hematopoietic Cells

1993 • 401 citations

Deoxyadenosine triphosphate as a potentially toxic metabolite in adenosine deaminase deficiency.

1978 • 399 citations

Laser-Focused Atomic Deposition

1993 • 387 citations

B cell precursor growth-promoting activity. Purification and characterization of a growth factor active on lymphocyte precursors.

1988 • 379 citations

A restricted cytoplasmic region of IL-2 receptor β chain is essential for growth signal transduction but not for ligand binding and internalization

1989 • 370 citations

Detecting single base substitutions as heteroduplex polymorphisms

1992 • 365 citations

Inhibition of murine B and T lymphopoiesis in vivo by an anti-interleukin 7 monoclonal antibody.

1993 • 345 citations

THE MULTI-SUBUNIT INTERLEUKIN-2 RECEPTOR

1989 • 323 citations

A second human interleukin-2 binding protein that may be a component of high-affinity interleukin-2 receptors

1987 • 306 citations

The interleukin-2 receptor γ chain maps to Xq13.1 and is mutated in X-linked severe combined immunodeficiency, SCIDX1

1993 • 306 citations

Cloning, sequence and expression of human interleukin-2 receptor

1984 • 272 citations

Involvement of IL-6 signal transducer gp130 in IL-11-mediated signal transduction.

1993 • 267 citations

HUMAN GENE THERAPY

1993 • 262 citations

The Interleukin 2 Receptor

1989 • 244 citations

Characterization of the human receptor for T-cell growth factor.

1983 • 240 citations

Recombinant interleukin 7, pre-B cell growth factor, has costimulatory activity on purified mature T cells.

1989 • 230 citations

Structure of the Human Interleukin-2 Receptor Gene

1985 • 219 citations

Expression and function of interleukin-2 receptors on immature thymocytes

1985 • 217 citations

Deoxyguanosine Triphosphate as a Possible Toxic Metabolite in the Immunodeficiency Associated with Purine Nucleoside Phosphorylase Deficiency

1978 • 215 citations

Novel Fold and Putative Receptor Binding Site of Granulocyte-Macrophage Colony-Stimulating Factor

1991 • 206 citations

Functional inhibition of hematopoietic and neurotrophic cytokines by blocking the interleukin 6 signal transducer gp130.

1992 • 206 citations

Interleukin 7 is a T-cell growth factor.

1989 • 206 citations

Epstein–Barr Virus–Associated B-Cell Proliferations of Diverse Clonal Origins after Bone Marrow Transplantation in a 12-Year-Old Patient with Severe Combined Immunodeficiency

1985 • 198 citations

Structure of the human interleukin 2 gene.

1983 • 197 citations

IL-7 is a growth and maintenance factor for mature and immature thymocyte subsets

1989 • 180 citations

Effect of IL-7 on the growth of fetal thymocytes in culture.

1989 • 179 citations

Common elements in interleukin 4 and insulin signaling pathways in factor-dependent hematopoietic cells.

1993 • 173 citations

Carrier detection in X-linked severe combined immunodeficiency based on patterns of X chromosome inactivation.

1987 • 154 citations

Contrasting interleukin 2 binding properties of the alpha (p55) and beta (p70) protein subunits of the human high-affinity interleukin 2 receptor.

1987 • 147 citations

Severe Combined Immunodeficiency Due to a Specific Defect in the Production of Interleukin-2

1990 • 146 citations

Molecular Approaches to Analysis of X-Linked Immunodeficiencies

1992 • 139 citations

Characterization of the interleukin 2 receptors (IL-2R) expressed on human natural killer cells activated in vivo by IL-2: association of the p64 IL-2R gamma chain with the IL-2R beta chain in functional intermediate-affinity IL-2R.

1992 • 135 citations

An associated molecule, p64, with IL-2 receptor beta chain. Its possible involvement in the formation of the functional intermediate-affinity IL-2 receptor complex.

1992 • 128 citations

Nonrandom X chromosome inactivation in B cells from carriers of X chromosome-linked severe combined immunodeficiency.

1988 • 125 citations

Class II-antigen-negative patient and mutant B-cell lines represent at least three, and probably four, distinct genetic defects defined by complementation analysis.

1991 • 125 citations

Importance of IL-2 receptors in intra-thymic generation of cells expressing T-cell receptors

1987 • 124 citations

Molecular cloning of a cDNA encoding the human interleukin 4 receptor

1990 • 119 citations

Reconstitution of functional interleukin 2 receptor complexes on fibroblastoid cells: involvement of the cytoplasmic domain of the gamma chain in two distinct signaling pathways.

1993 • 114 citations

T-cell growth factor: complete nucleotide sequence and organization of the gene in normal and malignant cells.

1984 • 113 citations

Close linkage of the locus for X chromosome-linked severe combined immunodeficiency to polymorphic DNA markers in Xq11-q13.

1987 • 108 citations

Absence of growth by most receptor-expressing fetal thymocytes in the presence of interleukin-2

1985 • 108 citations

Promotion of human T lymphocyte proliferation by IL-4.

1989 • 104 citations

Familial Defect in the Surface Expression of the T-Cell Receptor–CD3 Complex

1988 • 103 citations

Localization of human variable and constant region immunoglobulin heavy chain genes on subtelomeric band q32 of chromosome 14

1982 • 101 citations

Recombinant interleukin 2 therapy in severe combined immunodeficiency disease.

1989 • 100 citations

Assignment of Nucleoside Phosphorylase to D-14 and Localization of X-linked Loci in Man by Somatic Cell Genetics

1973 • 99 citations

Tyrosine kinase(s) regulate apoptosis and bcl-2 expression in a growth factor-dependent cell line.

1993 • 98 citations

Gene for T-Cell Growth Factor: Location on Human Chromosome 4q and Feline Chromosome B1

1984 • 97 citations

Essential role of the interleukin 2-interleukin 2 receptor pathway in thymocyte maturation in vivo.

1988 • 95 citations

Pseudo-high affinity interleukin 2 (IL-2) receptor lacks the third component that is essential for functional IL-2 binding and signaling.

1992 • 93 citations

Characterization of the human interleukin-2 receptor gamma chain gene

1993 • 88 citations

Interleukin 4 expressed in situ selectively alters thymocyte development.

1991 • 86 citations

IL-4 and IL-2 upregulate the expression of antigen B7, the B cell counterstructure to T cell CD28: an amplification mechanism for T-B cell interactions

1991 • 85 citations

Report of the committee on the genetic constitution of the X chromosome (Part 1 of 3)

1989 • 85 citations

The human interleukin-2 receptor β-chain gene: genomic organization, promoter analysis and chromosomal assignment

1990 • 85 citations

Assignment of a Gene for Adenosine Deaminase to Human Chromosome 20

1974 • 83 citations

Localization of the Gene Encoding the Human Interleukin-2 Receptor on Chromosome 10

1985 • 75 citations

Interleukin 7 is a growth factor for mature human T cells

1990 • 75 citations

The interleukin-4-related lymphokines and their binding to hematopoietin receptors.

1992 • 70 citations

The human interleukin 2 receptor beta chain (p70). Direct identification, partial purification, and patterns of expression on peripheral blood mononuclear cells.

1988 • 68 citations

Characterization of cDNAs encoding the murine interleukin 2 receptor (IL-2R) gamma chain: chromosomal mapping and tissue specificity of IL-2R gamma chain expression.

1993 • 65 citations

Interleukin 7 receptor engagement stimulates tyrosine phosphorylation, inositol phospholipid turnover, proliferation, and selective differentiation to the CD4 lineage by human fetal thymocytes.

1991 • 65 citations

Interleukin-4 and Cancer Therapy

1993 • 65 citations

An associated molecule, p64, eith high-affinity interleukin 2 receptor

1990 • 64 citations

GENETIC ANALYSIS USING THE POLYMERASE CHAIN REACTION

1992 • 64 citations

Human interleukin 2 receptor beta-chain gene: chromosomal localization and identification of 5' regulatory sequences.

1990 • 63 citations

Hematopoietin sub-family classification based on size, gene organization and sequence homology

1993 • 60 citations

Molecular cloning and structure of the human interleukin 2 receptor gene

1985 • 59 citations

Interleukin (IL)-2 and IL-3 induce distinct but overlapping responses in murine IL-3-dependent 32D cells transduced with human IL-2 receptor beta chain: involvement of tyrosine kinase(s) other than p56lck.

1992 • 58 citations

Interleukin 4 strongly augments or inhibits DNA synthesis and differentiation of B‐type chronic lymphocytic leukemia cells depending on the costimulatory activation and progression signals

1989 • 58 citations

Primary combined immunodeficiency resulting from defective transcription of multiple T-cell lymphokine genes.

1990 • 55 citations

Comparison between Mice Chimaeric and Heterozygous for the X-linked Gene tabby

1973 • 55 citations

Development of immature thymocytes: initiation of CD3, CD4, and CD8 acquisition parallels down‐regulation of the interleukin 2 receptor α chain

1990 • 53 citations

Cloning of the Mouse Interleukin 2 Receptor γ Chain: Demonstration of Functional Differences Between the Mouse and Human Receptors

1993 • 52 citations

X-linked severe combined immunodeficiency: localization within the region Xq13.1-q21.1 by linkage and deletion analysis.

1989 • 51 citations

Independent regulation of interleukin 4 (IL-4)-induced expression of human B cell surface CD23 and IgM: functional evidence for two IL-4 receptors

1991 • 46 citations

The IL-4 receptor: biochemical characterization of IL-4-binding molecules in a T cell line expressing large numbers of receptors.

1991 • 39 citations

A new source of polymorphic DNA markers for sperm typing: analysis of microsatellite repeats in single cells.

1992 • 39 citations

Inhibitory effect of murine recombinant IL-4 on thymocyte development in fetal thymus organ cultures.

1990 • 37 citations

X-chromosome inactivation in mammals.

1966 • 34 citations

Pathology of the Thymus in Immunodeficiency States

1986 • 19 citations

X-Linked Immunodeficiencies

1993 • 18 citations

IV. Immunologic Studies

1977 • 15 citations

Cloning and sequencing of the cDNA encoding a mouse IL-2 receptor γ

1993 • 15 citations