NKT cells: facts, functions and fallacies

CD1d-Restricted and TCR-Mediated Activation of V _α 14 NKT Cells by Glycosylceramides

1997 • 2,370 citations

MOUSE CD1-SPECIFIC NK1 T CELLS: Development, Specificity, and Function

1997 • 1,326 citations

Requirement for V _α 14 NKT Cells in IL-12-Mediated Rejection of Tumors

1997 • 1,226 citations

Tracking the Response of Natural Killer T Cells to a Glycolipid Antigen Using Cd1d Tetramers

2000 • 891 citations

CD4pos, NK1.1pos T cells promptly produce interleukin 4 in response to in vivo challenge with anti-CD3.

1994 • 862 citations

Cutting Edge: Cross-Talk Between Cells of the Innate Immune System: NKT Cells Rapidly Activate NK Cells

1999 • 856 citations

Differential Tumor Surveillance by Natural Killer (Nk) and Nkt Cells

2000 • 812 citations

Extreme Th1 bias of invariant Vα24JαQ T cells in type 1 diabetes

1998 • 642 citations

The Natural Killer T (NKT) Cell Ligand α-Galactosylceramide Demonstrates Its Immunopotentiating Effect by Inducing Interleukin (IL)-12 Production by Dendritic Cells and IL-12 Receptor Expression on NKT Cells

1999 • 624 citations

In Vivo Identification of Glycolipid Antigen–Specific T Cells Using Fluorescent Cd1d Tetramers

1999 • 551 citations

Requirements for CD1d Recognition by Human Invariant Vα24+ CD4−CD8− T Cells

1997 • 527 citations

Natural killer-like nonspecific tumor cell lysis mediated by specific ligand-activated Vα14 NKT cells

1998 • 474 citations

α/β–T Cell Receptor (TCR)+CD4−CD8− (NKT) Thymocytes Prevent Insulin-dependent Diabetes Mellitus in Nonobese Diabetic (NOD)/Lt Mice by the Influence of Interleukin (IL)-4 and/or IL-10

1998 • 473 citations

Murine CD1d-Restricted T Cell Recognition of Cellular Lipids

2000 • 467 citations

A Subset of CD4 ⁺ Thymocytes Selected by MHC Class I Molecules

1994 • 464 citations

An invariant V alpha 24-J alpha Q/V beta 11 T cell receptor is expressed in all individuals by clonally expanded CD4-8- T cells.

1994 • 448 citations

T cell receptor alpha/beta expressing double-negative (CD4-/CD8-) and CD4+ T helper cells in humans augment the production of pathogenic anti-DNA autoantibodies associated with lupus nephritis.

1989 • 402 citations

Natural Ligand of Mouse CD1d1: Cellular Glycosylphosphatidylinositol

1998 • 399 citations

Overexpression of Natural Killer T Cells Protects Vα14-Jα281 Transgenic Nonobese Diabetic Mice against Diabetes

1998 • 390 citations

CD1d-Restricted Immunoglobulin G Formation to GPI-Anchored Antigens Mediated by NKT Cells

1999 • 386 citations

Selective ability of mouse CD1 to present glycolipids: alpha-galactosylceramide specifically stimulates V alpha 14+ NK T lymphocytes.

1998 • 383 citations

Susceptibility of Mice Deficient in CD1D or TAP1 to Infection with Mycobacterium tuberculosis

1999 • 361 citations

Cd1-Reactive Natural Killer T Cells Are Required for Development of Systemic Tolerance through an Immune-Privileged Site

1999 • 360 citations

Cutting edge: activation of NK T cells by CD1d and alpha-galactosylceramide directs conventional T cells to the acquisition of a Th2 phenotype.

1999 • 359 citations

Early quantitative and functional deficiency of NK1⁺‐like thymocytes in the NOD mouse

1996 • 359 citations

NK1.1+ T cell receptor-alpha/beta+ cells: new clues to their origin, specificity, and function.

1995 • 355 citations

Interferon gamma production by natural killer (NK) cells and NK1.1+ T cells upon NKR-P1 cross-linking.

1996 • 349 citations

The Human Liver Contains Multiple Populations of NK Cells, T Cells, and CD3+CD56+ Natural T Cells with Distinct Cytotoxic Activities and Th1, Th2, and Th0 Cytokine Secretion Patterns

1999 • 345 citations

Tissue-Specific Segregation of CD1d-Dependent and CD1d-Independent NK T Cells

1999 • 332 citations

Selective induction of NK cell proliferation and cytotoxicity by activated NKT cells

2000 • 330 citations

Selective Ability of Mouse CD1 to Present Glycolipids: α-Galactosylceramide Specifically Stimulates Vα14+ NK T Lymphocytes

1998 • 319 citations

Bone Marrow NK1.1− and NK1.1+ T Cells Reciprocally Regulate Acute Graft versus Host Disease

1999 • 312 citations

Selective reduction of T cells bearing invariant V alpha 24J alpha Q antigen receptor in patients with systemic sclerosis.

1995 • 310 citations

Immunization with α-galactosylceramide polarizes CD1-reactive NK T cells towards Th2 cytokine synthesis

1999 • 306 citations

The Anti-Tumor Activity of IL-12: Mechanisms of Innate Immunity That Are Model and Dose Dependent

2000 • 304 citations

Gene sequences suggest inactivation of alpha-1,3-galactosyltransferase in catarrhines after the divergence of apes from monkeys.

1991 • 304 citations

Cutting Edge: Activation of NK T Cells by CD1d and α-Galactosylceramide Directs Conventional T Cells to the Acquisition of a Th2 Phenotype

1999 • 296 citations

Mouse NK1+ T cells

1995 • 292 citations

Selective reduction of V alpha 14+ NK T cells associated with disease development in autoimmune-prone mice.

1996 • 290 citations

Frameshift and nonsense mutations in a human genomic sequence homologous to a murine UDP-Gal:beta-D-Gal(1,4)-D-GlcNAc alpha(1,3)-galactosyltransferase cDNA.

1990 • 277 citations

Increased interleukin 4 and immunoglobulin E production in transgenic mice overexpressing NK1 T cells.

1996 • 268 citations

α-Galactosylceramide-activated Vα14 natural killer T cells mediate protection against murine malaria

2000 • 261 citations

NKT cells are phenotypically and functionally diverse

1999 • 259 citations

Association Between αβTCR+CD4−CD8− T-Cell Deficiency and IDDM in NOD/Lt Mice

1997 • 258 citations

Differential Expression of NK T Cell Vα24JαQ Invariant TCR Chain in the Lesions of Multiple Sclerosis and Chronic Inflammatory Demyelinating Polyneuropathy

2000 • 256 citations

Activation of hepatic NKT cells and subsequent liver injury following administration of α-galactosylceramide

2000 • 256 citations

NK Markers Are Expressed on a High Percentage of Virus-Specific CD8+ and CD4+ T Cells

2000 • 250 citations

Rapid Death and Regeneration of NKT Cells in Anti-CD3ε- or IL-12-Treated Mice

1998 • 233 citations

The interface between innate and acquired immunity: glycolipid antigen presentation by CD1d-expressing dendritic cells to NKT cells induces the differentiation of antigen-specific cytotoxic T lymphocytes

2000 • 222 citations

Cytotoxic NK1.1 Ag+ alpha beta T cells with intermediate TCR induced in the liver of mice by IL-12.

1995 • 222 citations

The development of autoimmunity in C57BL/6 lpr mice correlates with the disappearance of natural killer type 1-positive cells: evidence for their suppressive action on bone marrow stem cell proliferation, B cell immunoglobulin secretion, and autoimmune symptoms.

1993 • 219 citations

NK1.1+ T Cells in the Liver Arise in the Thymus and Are Selected by Interactions with Class I Molecules on CD4+CD8+ Cells

2000 • 217 citations

A novel function of Valpha14+CD4+NKT cells: stimulation of IL-12 production by antigen-presenting cells in the innate immune system.

1999 • 209 citations

CD161 (NKR-P1A) Costimulation of CD1d-dependent Activation of Human T Cells Expressing Invariant Vα24JαQ T Cell Receptor α Chains

1998 • 200 citations

Murine natural killer cells contribute to the granulomatous reaction caused by mycobacterial cell walls

1999 • 196 citations

The Src Family Tyrosine Kinase Fyn Regulates Natural Killer T Cell Development

1999 • 186 citations

Critical role of NK1+ T cells in IL-12-induced immune responses in vivo.

1998 • 179 citations

Liver NK1.1+ CD4+ alpha beta T cells activated by IL-12 as a major effector in inhibition of experimental tumor metastasis.

1996 • 175 citations

Molecular Recognition of Lipid Antigens by T Cell Receptors

1999 • 171 citations

Cutting Edge: A Role for CD1 in the Pathogenesis of Lupus in NZB/NZW Mice

2000 • 169 citations

Cutting Edge: NKT Cell Development Is Selectively Impaired in Fyn- Deficient Mice

1999 • 167 citations

Cytokine production by mature and immature CD4-CD8- T cells. Alpha beta-T cell receptor+ CD4-CD8- T cells produce IL-4.

1992 • 167 citations

Treatment of hepatic metastasis of the colon26 adenocarcinoma with an alpha-galactosylceramide, KRN7000.

1998 • 164 citations

A Novel Function of Vα14+CD4+NKT Cells: Stimulation of IL-12 Production by Antigen-Presenting Cells in the Innate Immune System

1999 • 163 citations

TCR V alpha 24 and V beta 11 coexpression defines a human NK1 T cell analog containing a unique Th0 subpopulation.

1997 • 159 citations

Inhibition of T Helper Cell Type 2 Cell Differentiation and Immunoglobulin E Response by Ligand-Activated Vα14 Natural Killer T Cells

1999 • 158 citations

A role for CD4+ NK1.1+ T lymphocytes as major histocompatibility complex class II independent helper cells in the generation of CD8+ effector function against intracellular infection.

1996 • 154 citations

Role for IL-15/IL-15 receptor beta-chain in natural killer 1.1+ T cell receptor-alpha beta+ cell development.

1997 • 153 citations

Analysis of Human Vα24+ CD4+ NKT Cells Activated by α-Glycosylceramide-Pulsed Monocyte-Derived Dendritic Cells

2000 • 145 citations

Cytotoxicity of fresh NK1.1+ T cell receptor alpha/beta+ thymocytes against a CD4+8+ thymocyte population associated with intact Fas antigen expression on the target.

1994 • 144 citations

α-Galactosylceramide Induces Early B-Cell Activation through IL-4 Production by NKT Cells

2000 • 141 citations

Cutting Edge: The IgG Response to the Circumsporozoite Protein Is MHC Class II-Dependent and CD1d-Independent: Exploring the Role of GPIs in NK T Cell Activation and Antimalarial Responses

2000 • 138 citations

Requirement for membrane lymphotoxin in natural killer cell development

1999 • 137 citations

The Ly-49 Family: Regulation of Cytotoxicity and Cytokine Production in Murine CD3+ Cells

1998 • 137 citations

A Defect in Interleukin 12–Induced Activation and Interferon γ Secretion of Peripheral Natural Killer T Cells in Nonobese Diabetic Mice Suggests New Pathogenic Mechanisms for Insulin-Dependent Diabetes Mellitus

1999 • 136 citations

Cutting Edge: Critical Role of NK1+ T Cells in IL-12-Induced Immune Responses In Vivo

1998 • 136 citations

Close phenotypic and functional similarities between human and murine alphabeta T cells expressing invariant TCR alpha-chains.

1997 • 135 citations

LPS induces NK1.1+ alpha beta T cells with potent cytotoxicity in the liver of mice via production of IL-12 from Kupffer cells.

1996 • 132 citations

Induction of IFN-γ-producing CD4+ natural killer T cells byMycobacterium bovis bacillus Calmette Guérin

1999 • 126 citations

Lipid antigen presentation in the immune system; lessons learned from CD 1 d knockout mice

1999 • 121 citations

NK1.1+ CD4+ T cells lose NK1.1 expression upon in vitro activation.

1997 • 112 citations

CD1-mediated immune responses to glycolipids

1999 • 99 citations

Flow Cytometric Study of T Cell Development in NOD Mice Reveals a Deficiency in αβTCR+CD4−CD8−Thymocytes

1997 • 99 citations

Liver CD4−CD8− NK1.1+ TCRαβ Intermediate Cells Increase During Experimental Malaria Infection and Are Able to Exhibit Inhibitory Activity Against the Parasite Liver Stage In Vitro

2000 • 95 citations

IL-4-producing NK T cells are biased towards IFN-γ production by IL-12. Influence of the microenvironment on the functional capacities of NK T cells

1998 • 93 citations

Mouse NKR-P1B, a Novel NK1.1 Antigen with Inhibitory Function

1999 • 91 citations

Three day neonatal thymectomy selectively depletes NK1.1+ T cells

1998 • 90 citations

Relative contribution of NK and NKT cells to the anti-metastatic activities of IL-12

2000 • 88 citations

Critical Role of Leukocyte Function-Associated Antigen-1 in Liver Accumulation of CD4+NKT Cells

1999 • 83 citations

Heterogeneity of NK1.1+ T Cells in the Bone Marrow: Divergence from the Thymus

1999 • 78 citations

IL-4 secretion by CD4+ NK1+ T cells induces monocyte chemoattractant protein-1 in early listeriosis.

1997 • 76 citations

Interleukin‐4‐producing CD4⁺ NK1.1⁺ TCRα/β^intermediate liver lymphocytes are down‐regulated by Listeria monocytogenes

1995 • 70 citations

Lineage Relationships and Differentiation of Natural Killer (NK) T Cells: Intrathymic Selection and Interleukin (IL)-4 Production in the Absence of NKR-P1 and Ly49 Molecules

1997 • 70 citations

Direct thymic involvement in anterior chamber-associated immune deviation: evidence for a nondeletional mechanism of centrally induced tolerance to extrathymic antigens in adult mice.

1997 • 70 citations

Thymic dependence of invariant Vα14+ Natural Killer-T cell development

1999 • 69 citations

Membrane Lymphotoxin Is Required for the Development of Different Subpopulations of NK T Cells

2000 • 67 citations

Association between alphabetaTCR+CD4-CD8- T-cell deficiency and IDDM in NOD/Lt mice

1997 • 65 citations

Developmentally Regulated Extinction of Ly-49 Receptor Expression Permits Maturation and Selection of NK1.1+ T Cells

1998 • 64 citations

Induction of differentiation of pre-NKT cells to mature Vα14 NKT cells by granulocyte/macrophage colony-stimulating factor

1999 • 56 citations

Development of CD4-CD8- alpha beta TCR+NK1.1+ T lymphocytes: thymic selection by self antigen.

1996 • 54 citations

Cutting edge: LFA-1 is required for liver NK1.1+TCR alpha beta+ cell development: evidence that liver NK1.1+TCR alpha beta+ cells originate from multiple pathways.

1999 • 53 citations

Immunostimulatory and Antitumor Activities of Monoglycosylceramides Having Various Sugar Moieties.

1995 • 52 citations

Development of Valpha4+ NK T cells in the early stages of embryogenesis.

1996 • 52 citations

TCR αβ⁺ CD4⁻ CD8⁻ T cells differentiate extrathymically in an lck‐independent manner and participate in early response against Listeria monocytogenes infection through interferon‐γ production

1997 • 51 citations

IL-7 Up-Regulates IL-4 Production by Splenic NK1.1+ and NK1.1− MHC Class I-Like/CD1-Dependent CD4+ T Cells

1999 • 50 citations

Cutting Edge: LFA-1 Is Required for Liver NK1.1+TCRαβ+ Cell Development: Evidence That Liver NK1.1+TCRαβ+ Cells Originate from Multiple Pathways

1999 • 45 citations

NK1.1⁺ T cells from IL-7-deficient mice have a normal distribution and selection but exhibit impaired cytokine production

1996 • 44 citations

Absolute requirement for the pre-T cell receptor α chain during NK1.1+ TCRα β cell development

1999 • 43 citations

Bacille Calmette Guérin and interleukin‐12 down‐modulate interleukin‐4‐producing CD4⁺ NK1⁺ T lymphocytes

1997 • 42 citations

Regulatory role of peritoneal NK1.1+ alpha beta T cells in IL-12 production during Salmonella infection.

1999 • 42 citations

Evidence for Two Subgroups of CD4−CD8− NKT Cells with Distinct TCRαβ Repertoires and Differential Distribution in Lymphoid Tissues

2000 • 42 citations

Thymus-independent generation of NK1+ T cells in vitro from fetal liver precursors

1997 • 41 citations

Generation of NK1.1⁺T cell antigen receptor α/β⁺thymocytes associated with intact thymic structure

1997 • 38 citations

TCR-Associated ζ-FcϵRlγ heterodimers on CD4−CD8− NK1.1+ t cells selected by specific class I MHC antigen

1995 • 38 citations

Thymus-independent generation of NK1+ T cells in vitro from fetal liver precursors.

1997 • 38 citations

Regulatory Role of Peritoneal NK1.1+αβ T Cells in IL-12 Production DuringSalmonellaInfection

1999 • 37 citations

Diabetes Prone BB Rats are Severely Deficient in Natural Killer T Cells

1999 • 35 citations

MHC class I-selected CD4-CD8-TCR-alpha beta+ T cells are a potential source of IL-4 during primary immune response.

1995 • 34 citations

Increased Interleukin-4 Production by NK T Cells in Systemic Lupus Erythematosus

1999 • 33 citations

Selection of phenotypically distinct NK1.1+ T cells upon antigen expression in the thymus or in the liver

1999 • 32 citations

Predominant appearance of NK1.1+ T cells producing IL-4 may be involved in the increased susceptibility of mice with the beige mutation during Salmonella infection.

1997 • 30 citations

Cutting Edge: Contribution of NK Cells to the Homing of Thymic CD4+NKT Cells to the Liver

2000 • 30 citations

Splenic NK1.1-negative, TCR alpha beta intermediate CD4+ T cells exist in naive NK1.1 allelic positive and negative mice, with the capacity to rapidly secrete large amounts of IL-4 and IFN-gamma upon primary TCR stimulation.

1999 • 29 citations

A population of CD62Llow NK1.1− CD4+ T cells that resembles NK1.1+ CD4+ T cells

1998 • 25 citations

Early appearance of T cell receptor αβ⁺ CD4⁻ CD8⁻ T cells with a skewed variable region repertoire after infection with Listeria monocytogenes

1995 • 22 citations

Intrathymic selection of NK1.1⁺α/β T cell antigen receptor (TCR)⁺cells in transgenic mice bearing TCR specific for chicken ovalbumin and restricted to I-A^d

1998 • 21 citations

Splenic NK1.1-Negative, TCRαβ Intermediate CD4+ T Cells Exist in Naive NK1.1 Allelic Positive and Negative Mice, with the Capacity to Rapidly Secrete Large Amounts of IL-4 and IFN-γ Upon Primary TCR Stimulation

1999 • 20 citations

Involvement of NK1+ CD4- CD8- alphabeta T cells and endogenous IL-4 in non-MHC-restricted rejection of embryonal carcinoma in genetically resistant mice.

1997 • 18 citations

Establishment and characterization of cloned CD4− CD8−αβ-T cell receptor (TCR)-bearing autoreactive T cells from autoimmune NZB×NZW F1 mice

1997 • 12 citations