IL-2 and IL-7 but not IL-12 protect natural killer cells from death by apoptosis and up-regulate bcl-2 expression.

Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation

1980 • 4,591 citations

Biology of Natural Killer Cells

1989 • 2,970 citations

The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis

1991 • 2,815 citations

Induction by Antigen of Intrathymic Apoptosis of CD4 ⁺ CD8 ⁺ TCR ^lo Thymocytes in Vivo

1990 • 1,781 citations

Interleukin-2 Receptor γ Chain: a Functional Component of the Interleukin-7 Receptor

1993 • 1,128 citations

Mechanism of antigen-driven selection in germinal centres

1989 • 1,097 citations

Haemopoietic colony stimulating factors promote cell survival by suppressing apoptosis

1990 • 945 citations

Biology and clinical relevance of human natural killer cells

1990 • 930 citations

Gene induction by gamma-irradiation leads to DNA fragmentation in lymphocytes.

1987 • 923 citations

Sharing of the Interleukin-2 (IL-2) Receptor γ Chain Between Receptors for IL-2 and IL-4

1993 • 734 citations

Response of resting human peripheral blood natural killer cells to interleukin 2.

1984 • 616 citations

Natural killer cells are a source of interferon gamma that drives differentiation of CD4+ T cell subsets and induces early resistance to Leishmania major in mice.

1993 • 612 citations

Programmed Cell Death in the Immune System

1991 • 575 citations

Cell Death Mechanisms and the Immune System

1991 • 459 citations

Combination IL-2 and IL-4 reduces glucocorticoid receptor-binding affinity and T cell response to glucocorticoids.

1993 • 457 citations

The IL-2 Receptor β Chain (p70): Role in Mediating Signals for LAK, NK, and Proliferative Activities

1987 • 444 citations

IL-2 addiction: withdrawal of growth factor activates a suicide program in dependent T cells.

1986 • 380 citations

Interleukin 4 protects chronic lymphocytic leukemic B cells from death by apoptosis and upregulates Bcl-2 expression.

1992 • 366 citations

Interleukin-10 prevents spontaneous death of germinal center B cells by induction of the bcl-2 protein.

1994 • 344 citations

The role of natural killer cells in innate resistance to infection

1993 • 330 citations

A comparative study of IL-12 (cytotoxic lymphocyte maturation factor)-, IL-2-, and IL-7-induced effects on immunomagnetically purified CD56+ NK cells.

1992 • 245 citations

IL-12 induces the production of IFN-gamma by neonatal human CD4 T cells.

1993 • 232 citations

The p75 peptide is the receptor for interleukin 2 expressed on large granular lymphocytes and is responsible for the interleukin 2 activation of these cells.

1987 • 226 citations

Selective long-term elimination of natural killer cells in vivo by an anti-interleukin 2 receptor beta chain monoclonal antibody in mice.

1993 • 178 citations

T-Cell Effector Functions: Mechanisms for Delivery of Cytotoxicity and Help

1991 • 103 citations

Glucocorticoid-induced apoptosis of natural killer cells and cytotoxic T lymphocytes

1992 • 15 citations

Apoptosis in cytotoxic T lymphocytes and their targets.

1992 • 7 citations