Folding of Newly Translated Proteins In Vivo: The Role of Molecular Chaperones

THE UBIQUITIN SYSTEM

1998 • 8,360 citations

Principles that Govern the Folding of Protein Chains

1973 • 6,771 citations

Molecular chaperones in cellular protein folding

1996 • 3,540 citations

The Complete Atomic Structure of the Large Ribosomal Subunit at 2.4 Å Resolution

2000 • 3,245 citations

The Hsp70 and Hsp60 Chaperone Machines

1998 • 2,793 citations

From Levinthal to pathways to funnels

1997 • 2,277 citations

Hsp90 as a capacitor for morphological evolution

1998 • 2,261 citations

The Structural Basis of Ribosome Activity in Peptide Bond Synthesis

2000 • 2,195 citations

Protein misfolding, evolution and disease

1999 • 1,948 citations

The 26S Proteasome: A Molecular Machine Designed for Controlled Proteolysis

1999 • 1,872 citations

Protein Folding

1992 • 1,601 citations

Macromolecular Crowding: Biochemical, Biophysical, and Physiological Consequences

1993 • 1,474 citations

Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformation.

1994 • 1,426 citations

Crystal Structure of an Hsp90–Geldanamycin Complex: Targeting of a Protein Chaperone by an Antitumor Agent

1997 • 1,345 citations

The crystal structure of the bacterial chaperonln GroEL at 2.8 Å

1994 • 1,322 citations

Interaction of Hsp 70 with Newly Synthesized Proteins: Implications for Protein Folding and Assembly

1990 • 1,293 citations

Estimation of macromolecule concentrations and excluded volume effects for the cytoplasm of Escherichia coli

1991 • 1,253 citations

The crystal structure of the asymmetric GroEL–GroES–(ADP)7 chaperonin complex

1997 • 1,250 citations

Structural Analysis of Substrate Binding by the Molecular Chaperone DnaK

1996 • 1,247 citations

Identification and Structural Characterization of the ATP/ADP-Binding Site in the Hsp90 Molecular Chaperone

1997 • 1,235 citations

Structure of TPR Domain–Peptide Complexes

2000 • 1,159 citations

MOLECULAR CHAPERONES

1991 • 1,089 citations

Posttranslational Quality Control: Folding, Refolding, and Degrading Proteins

1999 • 1,064 citations

Chaperone-Mediated Protein Folding

1999 • 1,043 citations

Three-dimensional structure of the ATPase fragment of a 70K heat-shock cognate protein

1990 • 1,035 citations

Dynamic activation of endothelial nitric oxide synthase by Hsp90

1998 • 1,016 citations

Successive action of DnaK, DnaJ and GroEL along the pathway of chaperone-mediated protein folding

1992 • 965 citations

Cloning and functional analysis of BAG-1: A novel Bcl-2-binding protein with anti-cell death activity

1995 • 863 citations

Chaperonin-mediated protein folding at the surface of groEL through a 'molten globule'-like intermediate

1991 • 853 citations

Protein Folding: A Perspective from Theory and Experiment

1998 • 840 citations

Ubiquitin-mediated proteolysis: biological regulation via destruction

2000 • 839 citations

Substrate specificity of the DnaK chaperone determined by screening cellulose-bound peptide libraries

1997 • 797 citations

Reduced levels of hsp90 compromise steroid receptor action in vivo

1990 • 794 citations

Peptide-binding specificity of the molecular chaperone BiP

1991 • 763 citations

ATP binding and hydrolysis are essential to the function of the Hsp90 molecular chaperone invivo

1998 • 709 citations

Protein folding in mitochondria requires complex formation with hsp60 and ATP hydrolysis

1989 • 676 citations

Folding of nascent polypeptide chains in a high molecular mass assembly with molecular chaperones

1994 • 651 citations

Affinity panning of a library of peptides displayed on bacteriophages reveals the binding specificity of BiP

1993 • 650 citations

Protein Glucosylation and Its Role in Protein Folding

2000 • 644 citations

Hsp90 & Co. – a holding for folding

1999 • 631 citations

In Vivo Function of Hsp90 Is Dependent on ATP Binding and ATP Hydrolysis

1998 • 584 citations

STRUCTURE AND FUNCTION IN GroEL-MEDIATED PROTEIN FOLDING

1998 • 576 citations

Prefoldin, a Chaperone that Delivers Unfolded Proteins to Cytosolic Chaperonin

1998 • 548 citations

Functional requirement of p23 and Hsp90 in telomerase complexes

1999 • 538 citations

The ATP hydrolysis-dependent reaction cycle of the Escherichia coli Hsp70 system DnaK, DnaJ, and GrpE.

1994 • 520 citations

The translation machinery and 70 kd heat shock protein cooperate in protein synthesis

1992 • 512 citations

BAG-1 modulates the chaperone activity of Hsp70/Hsc70

1997 • 511 citations

An Evolutionarily Conserved Family of Hsp70/Hsc70 Molecular Chaperone Regulators

1999 • 509 citations

Effects of macromolecular crowding on protein folding and aggregation

1999 • 506 citations

Protein folding

1990 • 502 citations

Identification of in vivo substrates of the chaperonin GroEL

1999 • 499 citations

A cytoplasmic chaperonin that catalyzes β-actin folding

1992 • 498 citations

Role of auxilin in uncoating clathrin-coated vesicles

1995 • 495 citations

Understanding protein folding via free-energy surfaces from theory and experiment

2000 • 494 citations

Trigger factor and DnaK cooperate in folding of newly synthesized proteins

1999 • 491 citations

Crystal Structure of the Nucleotide Exchange Factor GrpE Bound to the ATPase Domain of the Molecular Chaperone DnaK

1997 • 489 citations

Translational Diffusion of Macromolecule-sized Solutes in Cytoplasm and Nucleus

1997 • 479 citations

The Ubiquitin-related BAG-1 Provides a Link between the Molecular Chaperones Hsc70/Hsp70 and the Proteasome

2000 • 478 citations

Mammalian p50Cdc37 is a protein kinase-targeting subunit of Hsp90 that binds and stabilizes Cdk4.

1996 • 475 citations

DnaJ-like proteins: molecular chaperones and specific regulators of Hsp70

1994 • 473 citations

The hsp90-based Chaperone System: Involvement in Signal Transduction from a Variety of Hormone and Growth Factor Receptors

1998 • 444 citations

Hip, a novel cochaperone involved in the eukaryotic hsc70/hsp40 reaction cycle

1995 • 436 citations

The crystal structure of the GroES co-chaperonin at 2.8 Å resolution

1996 • 436 citations

Protein folding: local structures, domains, subunits, and assemblies

1991 • 432 citations

Sequential interaction of the chaperones BiP and GRP94 with immunoglobulin chains in the endoplasmic reticulum

1994 • 430 citations

Identification of a regulatory motif in Hsp70 that affects ATPase activity, substrate binding and interaction with HDJ-1.

1995 • 428 citations

Getting Newly Synthesized Proteins into Shape

2000 • 426 citations

The human cytosolic molecular chaperones hsp90, hsp70 (hsc70) and hdj-1 have distinct roles in recognition of a non-native protein and protein refolding.

1996 • 424 citations

Crystal Structure of the Thermosome, the Archaeal Chaperonin and Homolog of CCT

1998 • 423 citations

Polypeptide Flux through Bacterial Hsp70

1999 • 421 citations

Heat-shock protein hsp90 governs the activity of pp60v-src kinase.

1993 • 420 citations

Function in protein folding of TRiC, a cytosolic ring complex containing TCP-1 and structurally related subunits.

1992 • 414 citations

The major substrates for TAP in vivo are derived from newly synthesized proteins

2000 • 408 citations

Pharmacologic shifting of a balance between protein refolding and degradation mediated by Hsp90

1996 • 406 citations

Distinct actions of cis and trans ATP within the double ring of the chaperonin GroEL

1997 • 406 citations

Characterization of the Active Intermediate of a GroEL–GroES-Mediated Protein Folding Reaction

1996 • 403 citations

Recombination of protein domains facilitated by co-translational folding in eukaryotes

1997 • 400 citations

GrpE-like regulation of the Hsc70 chaperone by the anti-apoptotic protein BAG-1

1997 • 397 citations

The J-domain family and the recruitment of chaperone power

1998 • 396 citations

The Role of ATP in the Functional Cycle of the DnaK Chaperone System

1995 • 388 citations

Protein folding in the central cavity of the GroEL–GroES chaperonin complex

1996 • 373 citations

Perturbation of Hsp90 interaction with nascent CFTR prevents its maturation and accelerates its degradation by the proteasome

1998 • 367 citations

In vivo functions of the Saccharomyces cerevisiae Hsp90 chaperone

1997 • 367 citations

GroEL-mediated protein folding proceeds by multiple rounds of binding and release of nonnative forms

1994 • 359 citations

Hop Modulates hsp70/hsp90 Interactions in Protein Folding

1998 • 351 citations

Principles of protein folding in the cellular environment

1999 • 349 citations

Folding in vivo of bacterial cytoplasmic proteins: Role of GroEL

1993 • 345 citations

In Vivo Observation of Polypeptide Flux through the Bacterial Chaperonin System

1997 • 345 citations

The Hdj-2/Hsc70 chaperone pair facilitates early steps in CFTR biogenesis

1999 • 336 citations

In vivo newly translated polypeptides are sequestered in a protected folding environment

1999 • 333 citations

Hop as an Adaptor in the Heat Shock Protein 70 (Hsp70) and Hsp90 Chaperone Machinery

1998 • 329 citations

Structure and in vivo function of Hsp90

2000 • 317 citations

Folding of VSV G Protein: Sequential Interaction with BiP and Calnexin

1994 • 316 citations

Structure of the Molecular Chaperone Prefoldin

2000 • 312 citations

Hepadnavirus assembly and reverse transcription require a multi-component chaperone complex which is incorporated into nucleocapsids

1997 • 310 citations

TRANSLATIONAL ACCURACY AND THE FITNESS OF BACTERIA

1992 • 305 citations

T-complex polypeptide-1 is a subunit of a heteromeric particle in the eukaryotic cytosol

1992 • 305 citations

A zinc finger-like domain of the molecular chaperone DnaJ is involved in binding to denatured protein substrates.

1996 • 304 citations

Molecular chaperones in cellular protein folding

1995 • 301 citations

A novel protein complex promoting formation of functional alpha - and gamma -tubulin

1998 • 296 citations

Chaperonin Function: Folding by Forced Unfolding

1999 • 294 citations

A Sec63p-BiP complex from yeast is required for protein translocation in a reconstituted proteoliposome.

1993 • 290 citations

Chaperones get in touch: the Hip-Hop connection

1997 • 289 citations

Role of ATP and disulphide bonds during protein folding in the endoplasmic reticulum

1992 • 286 citations

A cycle of binding and release of the DnaK, DnaJ and GrpE chaperones regulates activity of the Escherichia coli heat shock transcription factor sigma32.

1996 • 281 citations

A ribosome-associated peptidyl-prolyl cis/trans isomerase identified as the trigger factor.

1995 • 273 citations

Macromolecular crowding perturbs protein refolding kinetics: implications for folding inside the cell

2000 • 265 citations

Eukaryotic type II chaperonin CCT interacts with actin through specific subunits

1999 • 258 citations

Trigger factor: a soluble protein that folds pro-OmpA into a membrane-assembly-competent form.

1987 • 257 citations

Principles of Chaperone-Assisted Protein Folding: Differences Between in Vitro and in Vivo Mechanisms

1996 • 249 citations

Cotranslational folding and calnexin binding during glycoprotein synthesis.

1995 • 248 citations

Detecting and Measuring Cotranslational Protein Degradation in Vivo

2000 • 247 citations

Escherichia coli trigger factor is a prolyl isomerase that associates with nascent polypeptide chains.

1996 • 244 citations

The Crystal Structure of a GroEL/Peptide Complex

1999 • 241 citations

Protein folding in the cell: competing models of chaperonin function

1996 • 238 citations

Role of the Protein Chaperone YDJ1 in Establishing Hsp90-Mediated Signal Transduction Pathways

1995 • 237 citations

A quantitative assessment of the role of the chaperonin proteins in protein folding in vivo

1996 • 235 citations

Formation of the VHL–Elongin BC Tumor Suppressor Complex Is Mediated by the Chaperonin TRiC

1999 • 234 citations

Lectins as chaperones in glycoprotein folding

1998 • 233 citations

Escherichia coli dnaK null mutants are inviable at high temperature

1987 • 231 citations

Polypeptide release by Hsp90 involves ATP hydrolysis and is enhanced by the co-chaperone p23

2000 • 230 citations

Specific Binding of Tetratricopeptide Repeat Proteins to the C-terminal 12-kDa Domain of hsp90

1998 • 228 citations

Evidence for a Protein Mutator in Yeast: Role of the Hsp70-Related Chaperone Ssb in Formation, Stability, and Toxicity of the [PSI] Prion

1999 • 227 citations

Protein folding in the cytosol: chaperonin-dependent and -independent mechanisms

1998 • 226 citations

The molecular chaperone Ssb from Saccharomyces cerevisiae is a component of the ribosome–nascent chain complex

1998 • 224 citations

The Importance of ATP Binding and Hydrolysis by Hsp90 in Formation and Function of Protein Heterocomplexes

1999 • 224 citations

Interaction of the protein import and folding machineries of the chloroplast.

1996 • 223 citations

Protein Folding Activity of Hsp70 Is Modified Differentially by the Hsp40 Co-chaperones Sis1 and Ydj1

1998 • 222 citations

Sequential action of mitochondrial chaperones in protein import into the matrix.

1991 • 221 citations

Cotranslational Protein Folding

1997 • 221 citations

Group II chaperonins: new TRiC(k)s and turns of a protein folding machine

1999 • 208 citations

Cdc37 is a molecular chaperone with specific functions in signal transduction.

1997 • 205 citations

Cystosolic chaperonin subunits have a conserved ATPase domain but diverged polypeptide-binding domains

1994 • 203 citations

Degradation Signal Masking by Heterodimerization of MATα2 and MATa1 Blocks Their Mutual Destruction by the Ubiquitin-Proteasome Pathway

1998 • 201 citations

Compartmentation of protein folding invivo: sequestration of non-native polypeptide by the chaperonin-GimC system

1999 • 199 citations

Protein folding in vivo: the importance of molecular chaperones

2000 • 197 citations

Heat-induced Chaperone Activity of HSP90

1996 • 194 citations

Prefoldin–Nascent Chain Complexes in the Folding of Cytoskeletal Proteins

1999 • 191 citations

Multivalent Binding of Nonnative Substrate Proteins by the Chaperonin GroEL

2000 • 191 citations

NMR Structure of the J-domain and the Gly/Phe-rich Region of theEscherichia coliDnaJ Chaperone

1996 • 186 citations

Co-translational domain folding as the structural basis for the rapid de novo folding of firefly luciferase.

1999 • 184 citations

Folding of the Glucocorticoid Receptor by the Reconstituted hsp90-based Chaperone Machinery

1997 • 183 citations

Hsp90's secrets unfold: new insights from structural and functional studies

1999 • 181 citations

Chaperonin-Mediated Folding in the Eukaryotic Cytosol Proceeds through Rounds of Release of Native and Nonnative Forms

1997 • 174 citations

Cyclophilin 40 (CyP-40), Mapping of Its hsp90 Binding Domain and Evidence That FKBP52 Competes with CyP-40 for hsp90 Binding

1996 • 174 citations

Protein folding in the ER

1999 • 171 citations

Zuotin, a ribosome-associated DnaJmolecular chaperone

1998 • 170 citations

Stepwise Assembly of a Glucocorticoid Receptor·hsp90 Heterocomplex Resolves Two Sequential ATP-dependent Events Involving First hsp70 and Then hsp90 in Opening of the Steroid Binding Pocket

2000 • 168 citations

The crystal structure of the peptide-binding fragment from the yeast Hsp40 protein Sis1

2000 • 164 citations

Structure of the Substrate Binding Domain of the Thermosome, an Archaeal Group II Chaperonin

1997 • 162 citations

Translational Diffusion of Globular Proteins in the Cytoplasm of Cultured Muscle Cells

2000 • 161 citations

Nuclear Magnetic Resonance Solution Structure of the Human Hsp40 (HDJ-1) J-domain

1996 • 155 citations

SBA1 Encodes a Yeast Hsp90 Cochaperone That Is Homologous to Vertebrate p23 Proteins

1998 • 154 citations

Sequential action of two hsp70 complexes during protein import into mitochondria

1997 • 152 citations

Maturation of Human Cyclin E Requires the Function of Eukaryotic Chaperonin CCT

1998 • 152 citations

The yeast SIS1 protein, a DnaJ homolog, is required for the initiation of translation

1993 • 150 citations

Co-translational folding of an alphavirus capsid protein in the cytosol of living cells

1999 • 147 citations

Conformational specificity of the chaperonin GroEL for the compact folding intermediates of alpha-lactalbumin.

1994 • 147 citations

MtGimC, a novel archaeal chaperone related to the eukaryotic chaperonin cofactor GimC/prefoldin

1999 • 146 citations

Chaperonin-mediated folding of actin and tubulin.

1996 • 145 citations

Substrate Shuttling Between the DnaK and GroEL Systems Indicates a Chaperone Network Promoting Protein Folding

1996 • 145 citations

Cotranslational Folding of Globin

1997 • 143 citations

The yeast nascent polypeptide-associated complex initiates protein targeting to mitochondria in vivo

1998 • 143 citations

ATP-dependent chaperoning activity of reticulocyte lysate

1994 • 143 citations

Hsp70 chaperone systems: diversity of cellular functions and mechanism of action.

1998 • 139 citations

Folding of firefly luciferase during translation in a cell-free system.

1994 • 137 citations

Genetic interactions between KAR2 and SEC63, encoding eukaryotic homologues of DnaK and DnaJ in the endoplasmic reticulum.

1993 • 135 citations

Specificity in chaperonin-mediated protein folding

1995 • 132 citations

Cotranslational Ubiquitination of Cystic Fibrosis Transmembrane Conductance Regulator in Vitro

1998 • 132 citations

Misfolding the Way to Disease

1996 • 132 citations

NAC covers ribosome-associated nascent chains thereby forming a protective environment for regions of nascent chains just emerging from the peptidyl transferase center.

1995 • 131 citations

Protein folding: Versatility of the cytosolic chaperonin TRiC/CCT

2000 • 130 citations

Structural Features Required for the Interaction of the Hsp70 Molecular Chaperone DnaK with Its Cochaperone DnaJ

1999 • 127 citations

Trigger factor depletion or overproduction causes defective cell division but does not block protein export

1990 • 125 citations

Human DnaJ Homologs dj2 and dj3, and bag-1 Are Positive Cochaperones of hsc70

2000 • 121 citations

Differential requirement for the mitochondrial Hsp70-Tim44 complex in unfolding and translocation of preproteins.

1996 • 118 citations

Role of the DnaK and HscA homologs of Hsp70 chaperones in protein folding in E.coli

1998 • 118 citations

Systematic circular permutation of an entire protein reveals essential folding elements.

2000 • 117 citations

The effect of macromolecular crowding on chaperonin-mediated protein folding

1997 • 117 citations

Hsp90 Is Required for Pheromone Signaling in Yeast

1998 • 116 citations

Molecular chaperones: containers and surfaces for folding, stabilising or unfolding proteins

2000 • 116 citations

Depletion of yeast ribosomal proteins L16 or rp59 disrupts ribosome assembly.

1990 • 112 citations

Phosphorylation by CK2 and MAPK enhances calnexin association with ribosomes

1999 • 112 citations

Review: The Cct eukaryotic chaperonin subunits of Saccharomyces cerevisiae and other yeasts

1996 • 110 citations

[PSI+]: An Epigenetic Modulator of Translation Termination Efficiency

1999 • 108 citations

Discontinuous Occurrence of the hsp70 ( dnaK ) Gene among Archaea and Sequence Features of HSP70 Suggest a Novel Outlook on Phylogenies Inferred from This Protein

1999 • 107 citations

Myosin II Folding Is Mediated by a Molecular Chaperonin

1999 • 106 citations

Regulation of the heat shock conjugate Hsc70 in the mammalian cell: the characterization of the anti-apoptotic protein BAG-1 provides novel insights.

1998 • 106 citations

Interaction of homologues of Hsp70 and Cpn60 with ferredoxin‐NADP⁺ reductase upon its import into chloroplasts

1993 • 105 citations

Genetic and Biochemical Analysis of p23 and Ansamycin Antibiotics in the Function of Hsp90-Dependent Signaling Proteins

1998 • 105 citations

Specific Interaction of the 70-kDa Heat Shock Cognate Protein with the Tetratricopeptide Repeats

1999 • 105 citations

The Amino-terminal 118 Amino Acids of Escherichia coli Trigger Factor Constitute a Domain That Is Necessary and Sufficient for Binding to Ribosomes

1997 • 104 citations

Characterization of Interactions between the Anti-apoptotic Protein BAG-1 and Hsc70 Molecular Chaperones

1998 • 103 citations

Identification of invivo substrates of the yeast mitochondrial chaperonins reveals overlapping but non-identical requirement for hsp60 and hsp10

1998 • 96 citations

The Interaction of the Chaperonin Tailless Complex Polypeptide 1 (Tcp1) Ring Complex (Tric) with Ribosome-Bound Nascent Chains Examined Using Photo-Cross-Linking

2000 • 94 citations

Random circular permutation of genes and expressed polypeptide chains: application of the method to the catalytic chains of aspartate transcarbamoylase.

1996 • 94 citations

Molecular Chaperones: Opening and closing the Anfinsen cage

1994 • 93 citations

Dynamics of singular vortices on a beta-plane

1992 • 88 citations

Contribution of cotranslational folding to the rate of formation of native protein structure.

1995 • 86 citations

Distinct Isoforms of the Cofactor BAG-1 Differentially Affect Hsc70 Chaperone Function

2000 • 85 citations

Hsp90 Is Obligatory for the Heme-regulated eIF-2α Kinase to Acquire and Maintain an Activable Conformation

1997 • 85 citations

The Dissociation of ATP from hsp70 of Saccharomyces cerevisiae Is Stimulated by Both Ydj1p and Peptide Substrates

1995 • 84 citations

Folding in vivo of a newly translated yeast cytosolic enzyme is mediated by the SSA class of cytosolic yeast Hsp70 proteins

1998 • 82 citations

Molecular chaperones: Avoiding the crowd

1997 • 80 citations

The oligomeric structure of GroEL/GroES is required for biologically significant chaperonin function in protein folding

1998 • 77 citations

Individual Subunits of the Eukaryotic Cytosolic Chaperonin Mediate Interactions with Binding Sites Located on Subdomains of β-Actin

2000 • 76 citations

Trigger Factor Associates with GroEL in Vivo and Promotes Its Binding to Certain Polypeptides

1997 • 74 citations

Mutational Analysis of the hsp70-Interacting Protein Hip

1996 • 74 citations

Divergent Functional Properties of the Ribosome-Associated Molecular Chaperone Ssb Compared with Other Hsp70s

2001 • 71 citations

Co-translational folding

1999 • 69 citations

ATP‐dependent protein refolding activity in reticulocyte lysate

1993 • 67 citations

The Ydj1 molecular chaperone facilitates formation of active p60v-src in yeast.

1996 • 66 citations

GroEL-GroES-mediated protein folding requires an intact central cavity

1998 • 66 citations

Protein folding: Thickening the broth

2000 • 66 citations

Tissue-specific Isoforms of Chicken Myomesin Are Generated by Alternative Splicing

1996 • 65 citations

Equilibrium Intermediates in the Reversible Unfolding of Firefly (Photinus pyralis) Luciferase

1997 • 65 citations

Molecular chaperones: Pathways and networks

1999 • 63 citations

The Cytosolic Class II Chaperonin CCT Recognizes Delineated Hydrophobic Sequences in Its Target Proteins

1999 • 63 citations

Complex environment of nascent polypeptide chains.

1994 • 58 citations

Mutation of Hip’s Carboxy-Terminal Region Inhibits a Transitional Stage of Progesterone Receptor Assembly

1998 • 56 citations

Review

1998 • 55 citations

Sequential folding of UmuC by the Hsp70 and Hsp60 chaperone complexes of Escherichia coli.

1994 • 55 citations

Purification and Characterization of a 66-kDa Protein from Rabbit Reticulocyte Lysate Which Promotes the Recycling of Hsp 70

1996 • 54 citations

A Role for the Hsp40 Ydj1 in Repression of Basal Steroid Receptor Activity in Yeast

2000 • 54 citations

Growing up in a dangerous environment: a network of multiple targeting and folding pathways for nascent polypeptides in the cytosol

1996 • 52 citations

Structure and Function of Chaperonins in Archaebacteria and Eukaryotic Cytosol

1996 • 52 citations

Subunits of the eukaryotic cytosolic chaperonin CCT do not always behave as components of a uniform hetero-oligomeric particle

1999 • 50 citations

Chaperones in progesterone receptor complexes

2000 • 48 citations

Newly-Synthesized β-Tubulin Demonstrates Domain-Specific Interactions with the Cytosolic Chaperonin

1996 • 46 citations

Co-translational trimerization of the reovirus cell attachment protein.

1996 • 45 citations

Recognition of protein substrates by the prolyl isomerase trigger factor is independent of proline residues 1 1Edited by P. E. Wright

1998 • 45 citations

Protein folding and unfolding by Escherichia coli chaperones and chaperonins

2000 • 44 citations

Epstein-Barr virus-encoded nuclear protein EBNA-3 interacts with the epsilon-subunit of the T-complex protein 1 chaperonin complex.

1999 • 44 citations

Circularly permuted DNA, RNA and proteins — a review

1993 • 41 citations

Protein Folding: A Perspective from Theory and Experiment

1998 • 35 citations

The Folding of the Bifunctional TRP3 Protein in Yeast is Influenced by a Translational Pause which Lies in a Region of Structural Divergence with Escherichia coli Indoleglycerol‐Phosphate Synthase

1994 • 30 citations

Hyperactive forms of the Pdr1p transcription factor fail to respond to positive regulation by the Hsp70 protein Pdr13p

2000 • 28 citations

Directionality of Polypeptide Transfer in the Mitochondrial Pathway of Chaperone-Mediated Protein Folding

1998 • 28 citations

Review: The Cct Eukaryotic Chaperonin Subunits of Saccharomyces cerevisiae and other Yeasts

1996 • 11 citations