The ATP hydrolysis-dependent reaction cycle of the Escherichia coli Hsp70 system DnaK, DnaJ, and GrpE.

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

Protein folding in the cell

1992 • 4,138 citations

MOLECULAR CHAPERONE FUNCTIONS OF HEAT-SHOCK PROTEINS

1993 • 1,591 citations

Speculations on the functions of the major heat shock and glucose-regulated proteins

1986 • 1,574 citations

An hsp70-like protein in the ER: Identity with the 78 kd glucose-regulated protein and immunoglobulin heavy chain binding protein

1986 • 1,457 citations

Successive action of DnaK, DnaJ and GroEL along the pathway of chaperone-mediated protein folding

1992 • 965 citations

Escherichia coli DnaJ and GrpE heat shock proteins jointly stimulate ATPase activity of DnaK.

1991 • 835 citations

Peptide-binding specificity of the molecular chaperone BiP

1991 • 763 citations

Affinity panning of a library of peptides displayed on bacteriophages reveals the binding specificity of BiP

1993 • 650 citations

DnaK, DnaJ and GrpE form a cellular chaperone machinery capable of repairing heat-induced protein damage.

1993 • 593 citations

Kinetics of Molecular Chaperone Action

1994 • 440 citations

Function in protein folding of TRiC, a cytosolic ring complex containing TCP-1 and structurally related subunits.

1992 • 414 citations

The E. coli dnaK gene product, the hsp70 homolog, can reactivate heat-inactivated RNA polymerase in an ATP hydrolysis-dependent manner

1990 • 407 citations

ATP-induced protein Hsp70 complex dissociation requires K+ but not ATP hydrolysis

1993 • 366 citations

Guanylyl cyclase receptors and their endocrine, paracrine, and autocrine ligands

1992 • 346 citations

Interaction of hsp70 with unfolded proteins: effects of temperature and nucleotides on the kinetics of binding.

1991 • 332 citations

Physical interaction between heat shock proteins DnaK, DnaJ, and GrpE and the bacterial heat shock transcription factor σ32

1992 • 314 citations

Regulation of Hsp70 function by a eukaryotic DnaJ homolog.

1992 • 262 citations

The emergence of the chaperone machines

1992 • 249 citations

The Escherichia coli DnaK chaperone, the 70-kDa heat shock protein eukaryotic equivalent, changes conformation upon ATP hydrolysis, thus triggering its dissociation from a bound target protein

1991 • 245 citations

Specificity of DnaK-peptide Binding

1994 • 244 citations

Cooperation of GroEL/GroES and DnaK/DnaJ heat shock proteins in preventing protein misfolding in Escherichia coli.

1992 • 214 citations

Function of DnaJ and DnaK as chaperones in origin-specific DNA binding by RepA

1991 • 204 citations

Monomerization of RepA dimers by heat shock proteins activates binding to DNA replication origin.

1991 • 183 citations

Purification and properties of the dnaJ replication protein of Escherichia coli.

1985 • 178 citations

The DnaK chaperone modulates the heat shock response of Escherichia coli by binding to the sigma 32 transcription factor.

1992 • 178 citations

A role for a eukaryotic GrpE-related protein, Mge1p, in protein translocation.

1994 • 167 citations

Control of folding and membrane translocation by binding of the chaperone DnaJ to nascent polypeptides.

1993 • 163 citations

The grpE protein of Escherichia coli. Purification and properties.

1987 • 160 citations

Unfolded proteins stimulate molecular chaperone Hsc70 ATPase by accelerating ADP/ATP exchange

1992 • 132 citations

A conserved loop in the ATPase domain of the DnaK chaperone is essential for stable binding of GrpE

1994 • 123 citations

DnaK, hsp73, and their molten globules. Two different ways heat shock proteins respond to heat.

1992 • 118 citations

YGE1 is a yeast homologue of Escherichia coli grpE and is required for maintenance of mitochondrial functions

1994 • 92 citations

Activity of the Hsp70 chaperone complex--DnaK, DnaJ, and GrpE--in initiating phage lambda DNA replication by sequestering and releasing lambda P protein.

1992 • 69 citations