Crystal Structure of an Hsp90–Geldanamycin Complex: Targeting of a Protein Chaperone by an Antitumor Agent

The CCP4 suite: programs for protein crystallography

1994 • 17,203 citations

MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

1991 • 14,222 citations

Protein folding and association: Insights from the interfacial and thermodynamic properties of hydrocarbons

1991 • 5,267 citations

Raster3D Version 2.0. A program for photorealistic molecular graphics

1994 • 2,515 citations

Cyclins and cancer II: Cyclin D and CDK inhibitors come of age

1994 • 2,122 citations

Protein Folding

1992 • 1,601 citations

Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformation.

1994 • 1,426 citations

Structural Analysis of Substrate Binding by the Molecular Chaperone DnaK

1996 • 1,247 citations

The Biology of heat shock proteins and molecular chaperones.

1994 • 1,226 citations

Helix geometry in proteins

1988 • 1,042 citations

Reduced levels of hsp90 compromise steroid receptor action in vivo

1990 • 794 citations

Peptide-binding specificity of the molecular chaperone BiP

1991 • 763 citations

The value of estrogen and progesterone receptors in the treatment of breast cancer

1980 • 735 citations

hsp82 is an essential protein that is required in higher concentrations for growth of cells at higher temperatures.

1989 • 624 citations

Inhibition of tyrosine phosphorylation prevents T-cell receptor-mediated signal transduction.

1990 • 526 citations

Preclinical pharmacologic evaluation of geldanamycin as an antitumor agent

1995 • 496 citations

Mammalian p50Cdc37 is a protein kinase-targeting subunit of Hsp90 that binds and stabilizes Cdk4.

1996 • 475 citations

GELDANAMYCIN, A NEW ANTIBIOTIC

1970 • 460 citations

Disruption of the Raf-1-Hsp90 Molecular Complex Results in Destabilization of Raf-1 and Loss of Raf-1-Ras Association

1995 • 454 citations

Mutational Analysis of Hsp90 Function: Interactions with a Steroid Receptor and a Protein Kinase

1995 • 425 citations

The human cytosolic molecular chaperones hsp90, hsp70 (hsc70) and hdj-1 have distinct roles in recognition of a non-native protein and protein refolding.

1996 • 424 citations

Heat-shock protein hsp90 governs the activity of pp60v-src kinase.

1993 • 420 citations

Pharmacologic shifting of a balance between protein refolding and degradation mediated by Hsp90

1996 • 406 citations

Stochastic appearance of mammary tumors in transgenic mice carrying the MMTV/c-neu oncogene

1989 • 395 citations

Evidence That the 90-kDa Heat Shock Protein Is Necessary for the Steroid Binding Conformation of the L Cell Glucocorticoid Receptor

1989 • 394 citations

Assisting spontaneity: the role of Hsp90 and small Hsps as molecular chaperones

1994 • 382 citations

Chaperone Function of Hsp90-Associated Proteins

1996 • 376 citations

Molecular Chaperone Machines: Chaperone Activities of the Cyclophilin Cyp-40 and the Steroid Aporeceptor-Associated Protein p23

1996 • 371 citations

Two mammalian heat shock proteins, HSP90 and HSP100, are actin-binding proteins.

1986 • 338 citations

Raf exists in a native heterocomplex with hsp90 and p50 that can be reconstituted in a cell-free system.

1993 • 302 citations

Mutations in Hsp83 and cdc37 impair signaling by the sevenless receptor tyrosine kinase in Drosophila

1994 • 294 citations

Progesterone Receptor Structure and Function Altered by Geldanamycin, an hsp90-Binding Agent

1995 • 291 citations

Dynamics of heat shock protein 90-progesterone receptor binding and the disactivation loop model for steroid receptor complexes.

1993 • 287 citations

Stable and specific binding of heat shock protein 90 by geldanamycin disrupts glucocorticoid receptor function in intact cells.

1996 • 259 citations

p185erbB2 Binds to GRP94 in Vivo

1996 • 259 citations

A role for Hsp90 in cell cycle control: Wee1 tyrosine kinase activity requires interaction with Hsp90.

1994 • 257 citations

hsp82 Is an Essential Protein That Is Required in Higher Concentrations for Growth of Cells at Higher Temperatures

1989 • 244 citations

A pathway of multi-chaperone interactions common to diverse regulatory proteins: estrogen receptor, Fes tyrosine kinase, heat shock transcription factor Hsf1, and the aryl hydrocarbon receptor

1996 • 240 citations

A Cyclophilin Function in Hsp90-Dependent Signal Transduction

1996 • 233 citations

Isolation of an immunodominant viral peptide that is endogenously bound to the stress protein GP96/GRP94.

1996 • 222 citations

Isolation of Hsp90 mutants by screening for decreased steroid receptor function.

1993 • 201 citations

Inhibition of the oncogene product p185erbB-2 in vitro and in vivo by geldanamycin and dihydrogeldanamycin derivatives

1995 • 198 citations

Herbimycin, a new antibiotic produced by a strain of Streptomyces.

1979 • 175 citations

Reconstitution of the Steroid Receptor·hsp90 Heterocomplex Assembly System of Rabbit Reticulocyte Lysate

1996 • 160 citations

ATP-dependent chaperoning activity of reticulocyte lysate

1994 • 143 citations

erbB-2 oncogene inhibition by geldanamycin derivatives: synthesis, mechanism of action, and structure-activity relationships

1995 • 138 citations

Depletion of the erbB-2 gene product p185 by benzoquinoid ansamycins.

1994 • 115 citations

Chaperone functions of the heat shock proteins associated with steroid receptors

1994 • 108 citations

A 50-kDa cytosolic protein complexed with the 90-kDa heat shock protein (hsp90) is the same protein complexed with pp60v-src hsp90 in cells transformed by the Rous sarcoma virus.

1991 • 101 citations

Association of Hsp90 with Cellular Src-Family Kinases in a Cell-Free System Correlates with Altered Kinase Structure and Function

1994 • 93 citations

Chemistry of the Ansamycin Antibiotics

1976 • 90 citations

The involvement of p23, hsp90, and immunophilins in the assembly of progesterone receptor complexes

1996 • 79 citations

Endoplasmic Reticulum Chaperone GRP94 Subunit Assembly Is Regulated through a Defined Oligomerization Domain

1996 • 74 citations

Growth inhibition of virus transformed cells in vitro and antitumor activity in vivo of geldanamycin and its derivatives.

1979 • 67 citations

Mutational analysis of hsp90 binding to the progesterone receptor.

1993 • 65 citations

Temperature-sensitive mutants of hsp82 of the budding yeast Saccharomyces cerevisiae

1994 • 52 citations

Herbimycin A: An ansamycin antibiotic; X-ray crystal structure.

1980 • 40 citations

Accelerated degradation of 160 kDa epidermal growth factor (EGF) receptor precursor by the tyrosine kinase inhibitor herbimycin A in the endoplasmic reticulum of A431 human epidermoid carcinoma cells

1994 • 39 citations

Antitumor and cytocidal activities of a newly isolated benzenoid ansamycin, macbecin I.

1982 • 11 citations

Deleted Work

1955 • 0 citations