In vivo functions of the Saccharomyces cerevisiae Hsp90 chaperone

Enzymatic Amplification of β-Globin Genomic Sequences and Restriction Site Analysis for Diagnosis of Sickle Cell Anemia

1985 • 9,128 citations

A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae.

1989 • 8,705 citations

Principles that Govern the Folding of Protein Chains

1973 • 6,771 citations

Molecular chaperones in cellular protein folding

1996 • 3,540 citations

Crystal Structure of an Hsp90–Geldanamycin Complex: Targeting of a Protein Chaperone by an Antitumor Agent

1997 • 1,345 citations

Successive action of DnaK, DnaJ and GroEL along the pathway of chaperone-mediated protein folding

1992 • 965 citations

Sequences That Regulate the Divergent GAL1-GAL10 Promoter in Saccharomyces cerevisiae

1984 • 955 citations

Protein disaggregation mediated by heat-shock protein Hspl04

1994 • 861 citations

hsp82 is an essential protein that is required in higher concentrations for growth of cells at higher temperatures.

1989 • 624 citations

Three-dimensional structure of β-galactosidase from E. coli.

1994 • 589 citations

A GAL10-CYC1 hybrid yeast promoter identifies the GAL4 regulatory region as an upstream site.

1982 • 575 citations

Hsp90 chaperones protein folding in vitro

1992 • 514 citations

Mutational Analysis of Hsp90 Function: Interactions with a Steroid Receptor and a Protein Kinase

1995 • 425 citations

The human cytosolic molecular chaperones hsp90, hsp70 (hsc70) and hdj-1 have distinct roles in recognition of a non-native protein and protein refolding.

1996 • 424 citations

Heat-shock protein hsp90 governs the activity of pp60v-src kinase.

1993 • 420 citations

Supervising the fold: functional principles of molecular chaperones

1996 • 420 citations

Pharmacologic shifting of a balance between protein refolding and degradation mediated by Hsp90

1996 • 406 citations

Recombination of protein domains facilitated by co-translational folding in eukaryotes

1997 • 400 citations

Chaperone Function of Hsp90-Associated Proteins

1996 • 376 citations

Molecular Chaperone Machines: Chaperone Activities of the Cyclophilin Cyp-40 and the Steroid Aporeceptor-Associated Protein p23

1996 • 371 citations

Folding in vivo of bacterial cytoplasmic proteins: Role of GroEL

1993 • 345 citations

THE ROLE OF THEhsp90-BASED CHAPERONE SYSTEM IN SIGNAL TRANSDUCTION BY NUCLEAR RECEPTORS AND RECEPTORS SIGNALING VIA MAP KINASE

1997 • 329 citations

The 90-kDa heat shock protein, HSP90, binds and protects casein kinase II from self-aggregation and enhances its kinase activity.

1992 • 308 citations

Mutations in Hsp83 and cdc37 impair signaling by the sevenless receptor tyrosine kinase in Drosophila

1994 • 294 citations

Progesterone Receptor Structure and Function Altered by Geldanamycin, an hsp90-Binding Agent

1995 • 291 citations

Dynamics of heat shock protein 90-progesterone receptor binding and the disactivation loop model for steroid receptor complexes.

1993 • 287 citations

hsp82 Is an Essential Protein That Is Required in Higher Concentrations for Growth of Cells at Higher Temperatures

1989 • 244 citations

A Cyclophilin Function in Hsp90-Dependent Signal Transduction

1996 • 233 citations

A molecular clamp in the crystal structure of the N-terminal domain of the yeast Hsp90 chaperone

1997 • 229 citations

Cdc37 is a molecular chaperone with specific functions in signal transduction.

1997 • 205 citations

Heat-induced Chaperone Activity of HSP90

1996 • 194 citations

Ancient heat shock gene is dispensable

1988 • 173 citations

Protein Folding In Vivo: Unraveling Complex Pathways

1997 • 170 citations

Cooperative Action of Hsp70, Hsp90, and DnaJ Proteins in Protein Renaturation

1996 • 157 citations

Substrate Shuttling Between the DnaK and GroEL Systems Indicates a Chaperone Network Promoting Protein Folding

1996 • 145 citations

ATP-dependent chaperoning activity of reticulocyte lysate

1994 • 143 citations

Suppression of c-Src activity by C-terminal Src kinase involves the c-Src SH2 and SH3 domains: analysis with Saccharomyces cerevisiae.

1993 • 132 citations

Bacterial luciferase alpha beta fusion protein is fully active as a monomer and highly sensitive in vivo to elevated temperature.

1989 • 89 citations

Hsp90 Is Obligatory for the Heme-regulated eIF-2α Kinase to Acquire and Maintain an Activable Conformation

1997 • 85 citations

Effect of Geldanamycin on the Kinetics of Chaperone-Mediated Renaturation of Firefly Luciferase in Rabbit Reticulocyte Lysate

1996 • 77 citations

Temperature-sensitive mutations and second-site suppressor substitutions affect folding of the P22 tailspike protein in vitro.

1993 • 70 citations

Temperature-sensitive mutants of hsp82 of the budding yeast Saccharomyces cerevisiae

1994 • 52 citations

The carboxyl-terminal tripeptide serine-lysine-leucine of firefly luciferase is necessary but not sufficient for peroxisomal import in yeast.

1992 • 45 citations

Suppression of c-Src Activity by C-Terminal Src Kinase Involves the c-Src SH2 and SH3 Domains: Analysis with Saccharomyces cerevisiae

1993 • 26 citations

GroE-mediated folding of bacterial luciferases in vivo

1993 • 20 citations

Nopaline causes a conformational change in the NocR regulatory protein-nocR promoter complex of Agrobacterium tumefaciens Ti plasmid pTiT37

1993 • 20 citations