Growing up in a dangerous environment: a network of multiple targeting and folding pathways for nascent polypeptides in the cytosol

Molecular chaperones in cellular protein folding

1996 • 3,540 citations

The complete general secretory pathway in gram-negative bacteria

1993 • 1,668 citations

Macromolecular Crowding: Biochemical, Biophysical, and Physiological Consequences

1993 • 1,474 citations

Interaction of Hsp 70 with Newly Synthesized Proteins: Implications for Protein Folding and Assembly

1990 • 1,293 citations

Common Principles of Protein Translocation Across Membranes

1996 • 1,081 citations

Successive action of DnaK, DnaJ and GroEL along the pathway of chaperone-mediated protein folding

1992 • 965 citations

Folding of nascent polypeptide chains in a high molecular mass assembly with molecular chaperones

1994 • 651 citations

The translation machinery and 70 kd heat shock protein cooperate in protein synthesis

1992 • 512 citations

Signal sequences specify the targeting route to the endoplasmic reticulum membrane.

1996 • 455 citations

Hip, a novel cochaperone involved in the eukaryotic hsc70/hsp40 reaction cycle

1995 • 436 citations

A protein complex required for signal-sequence-specific sorting and translocation

1994 • 404 citations

Transient association of newly synthesized unfolded proteins with the heat-shock GroEL protein

1988 • 388 citations

Folding in vivo of bacterial cytoplasmic proteins: Role of GroEL

1993 • 345 citations

The signal recognition particle in S. cerevisiae

1991 • 299 citations

A cycle of binding and release of the DnaK, DnaJ and GrpE chaperones regulates activity of the Escherichia coli heat shock transcription factor sigma32.

1996 • 281 citations

Early events in preprotein recognition in E. coli: interaction of SRP and trigger factor with nascent polypeptides.

1995 • 276 citations

A ribosome-associated peptidyl-prolyl cis/trans isomerase identified as the trigger factor.

1995 • 273 citations

An alternative protein targeting pathway in Escherichia coli: studies on the role of FtsY.

1994 • 252 citations

The Escherichia coli heat shock proteins GroEL and GroES modulate the folding of the beta-lactamase precursor.

1990 • 250 citations

Principles of Chaperone-Assisted Protein Folding: Differences Between in Vitro and in Vivo Mechanisms

1996 • 249 citations

Escherichia coli trigger factor is a prolyl isomerase that associates with nascent polypeptide chains.

1996 • 244 citations

The role of molecular chaperones in protein folding.

1995 • 237 citations

A quantitative assessment of the role of the chaperonin proteins in protein folding in vivo

1996 • 235 citations

Cellular defects caused by deletion of the Escherichia coli dnaK gene indicate roles for heat shock protein in normal metabolism

1989 • 234 citations

The 70S Escherichia coli ribosome at 23 å resolution: fitting the ribosomal RNA

1995 • 225 citations

DnaK and DnaJ heat shock proteins participate in protein export in Escherichia coli.

1992 • 214 citations

The efficiency of folding of some proteins is increased by controlled rates of translation in vivo

1987 • 174 citations

Signal Recognition Particle (SRP), a Ubiquitous Initiator of Protein Translocation

1995 • 161 citations

The Binding Protein for Globular Heads of Complement C1q, gC1qR

1996 • 154 citations

The yeast SIS1 protein, a DnaJ homolog, is required for the initiation of translation

1993 • 150 citations

Mutations in cognate genes of Saccharomyces cerevisiae hsp70 result in reduced growth rates at low temperatures.

1985 • 147 citations

Chaperonin-mediated folding of actin and tubulin.

1996 • 145 citations

Substrate Shuttling Between the DnaK and GroEL Systems Indicates a Chaperone Network Promoting Protein Folding

1996 • 145 citations

A kinetic model of protein synthesis. Application to hemoglobin synthesis and translational control.

1979 • 143 citations

Cytoplasmic chaperones in precursor targeting to mitochondria: the role of MSF and hsp 70

1996 • 109 citations

Highly selective binding of nascent polypeptides by an Escherichia coli chaperone protein in vivo

1993 • 107 citations

SRP samples nascent chains for the presenceof signal sequences by interacting with ribosomes at a discrete step during translation elongation

1995 • 98 citations

Enzymatic activity of the ribosome‐bound nascent polypeptide

1996 • 82 citations

The nascent polypeptide-associated complex modulates interactions between the signal recognition particle and the ribosome

1996 • 82 citations

Stabilization of protein synthesis in thermotolerant cells during heat shock. Association of heat shock protein-72 with ribosomal subunits of polysomes.

1994 • 77 citations

The Escherichia coli trigger factor

1996 • 69 citations

Macromolecular composition of bacteria

1982 • 66 citations

From the elephant to E. coli: SRP-dependent protein targeting

1994 • 65 citations

Diffusion-Limited Interaction between Unfolded Polypeptides and the Escherichia coli Chaperone SecB

1995 • 62 citations

Complex environment of nascent polypeptide chains.

1994 • 58 citations

Folding of an Enzyme into an Active Conformation While Bound as Peptidyl-tRNA to the Ribosome

1995 • 53 citations

Successive action of Escherichia coli chaperones in vivo

1994 • 49 citations

Activation and release of enzymatically inactive, full-length rhodanese that is bound to ribosomes as peptidyl-tRNA

1994 • 41 citations

Demonstration in vivo that interaction of maltose-binding protein with SecB is determined by a kinetic partitioning

1995 • 27 citations

GroEL Binds to and Unfolds Rhodanese Posttranslationally

1996 • 23 citations

The elongation rate of proteins of different molecular weight classes in yeast

1974 • 21 citations

Development of a Chaperone-Deficient System by Fractionation of a Prokaryotic Coupled Transcription/Translation System

1994 • 20 citations