CTLA-4 (CD152) and its involvement in autoimmune disease

Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease

2001 • 5,526 citations

A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease

2001 • 4,997 citations

T-cell antigen receptor genes and T-cell recognition

1988 • 3,099 citations

Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory disease

1992 • 2,969 citations

Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4

1995 • 2,842 citations

CD28/B7 SYSTEM OF T CELL COSTIMULATION

1996 • 2,726 citations

Cytotoxic T Lymphocyte–Associated Antigen 4 Plays an Essential Role in the Function of Cd25+Cd4+ Regulatory Cells That Control Intestinal Inflammation

2000 • 2,211 citations

Immunologic Self-Tolerance Maintained by Cd25+Cd4+Regulatory T Cells Constitutively Expressing Cytotoxic T Lymphocyte–Associated Antigen 4

2000 • 2,207 citations

Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease

2003 • 2,181 citations

CTLA-4 can function as a negative regulator of T cell activation

1994 • 2,107 citations

CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation.

1995 • 2,090 citations

B7/CD28 Costimulation Is Essential for the Homeostasis of the CD4+CD25+ Immunoregulatory T Cells that Control Autoimmune Diabetes

2000 • 2,090 citations

Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death.

1993 • 1,941 citations

The B7–CD28 superfamily

2002 • 1,646 citations

Modulation of tryptophan catabolism by regulatory T cells

2003 • 1,323 citations

The Role of the CD28 Receptor During T Cell Responses to Antigen

1993 • 1,320 citations

A genome-wide search for human type 1 diabetes susceptibility genes

1994 • 1,294 citations

A new member of the immunoglobulin superfamily—CTLA-4

1987 • 1,214 citations

CD28 costimulation can promote T cell survival by enhancing the expression of Bcl-xL

1995 • 1,212 citations

CTLA-4–Ig regulates tryptophan catabolism in vivo

2002 • 1,150 citations

Binding of the B cell activation antigen B7 to CD28 costimulates T cell proliferation and interleukin 2 mRNA accumulation.

1991 • 1,132 citations

The Autoimmune Diseases

2006 • 986 citations

Human B7-1 (CD80) and B7-2 (CD86) bind with similar avidities but distinct kinetics to CD28 and CTLA-4 receptors

1994 • 950 citations

Regulation of Lymphokine Messenger RNA Stability by a Surface-Mediated T Cell Activation Pathway

1989 • 910 citations

The B7 Family of Ligands and Its Receptors: New Pathways for Costimulation and Inhibition of Immune Responses

2002 • 884 citations

T-cell regulation by CD28 and CTLA-4

2001 • 857 citations

The CTLA-4 gene region of chromosome 2q33 is linked to, and associated with, type 1 diabetes. Belgian Diabetes Registry

1996 • 794 citations

The effect of antigen dose on CD4+ T helper cell phenotype development in a T cell receptor-alpha beta-transgenic model.

1995 • 768 citations

A regulatory polymorphism in PDCD1 is associated with susceptibility to systemic lupus erythematosus in humans

2002 • 756 citations

A Polymorphic Locus Near the Human Insulin Gene Is Associated with Insulin-dependent Diabetes Melliitus

1984 • 744 citations

Genetic Analysis of Autoimmune Disease

1996 • 739 citations

Treatment of Murine Lupus with CTLA4Ig

1994 • 683 citations

Molecular Basis of T Cell Inactivation by CTLA-4

1998 • 678 citations

Cutting Edge: CD28 Controls Peripheral Homeostasis of CD4+CD25+ Regulatory T Cells

2003 • 674 citations

A full genome search in multiple sclerosis

1996 • 666 citations

CD28 activation pathway regulates the production of multiple T-cell-derived lymphokines/cytokines.

1989 • 662 citations

The Interaction Properties of Costimulatory Molecules Revisited

2002 • 640 citations

The Emerging Role of CTLA-4 as an Immune Attenuator

1997 • 637 citations

Differential effects of anti-B7-1 and anti-B7-2 monoclonal antibody treatment on the development of diabetes in the nonobese diabetic mouse.

1995 • 595 citations

Coexpression and functional cooperation of CTLA-4 and CD28 on activated T lymphocytes.

1992 • 592 citations

Genetic Control of Autoimmune Diabetes in the Nod Mouse

1995 • 586 citations

Intracellular Trafficking of CTLA-4 and Focal Localization Towards Sites of TCR Engagement

1996 • 583 citations

Cytotoxic T Lymphocyte Antigen-4 Accumulation in the Immunological Synapse Is Regulated by TCR Signal Strength

2002 • 497 citations

Genome scan of human systemic lupus erythematosus: Evidence for linkage on chromosome 1q in African-American pedigrees

1998 • 458 citations

The expanding B7 superfamily: Increasing complexity in costimulatory signals regulating T cell function

2001 • 413 citations

Insulin-dependent diabetes mellitus (IDDM) is associated with CTLA4 polymorphisms in multiple ethnic groups

1997 • 408 citations

Genetic mapping of a susceptibility locus for insulin-dependent diabetes mellitus on chromosome llq

1994 • 397 citations

The genetics of complex autoimmune diseases: non-MHC susceptibility genes

2001 • 394 citations

C1q and Systemic Lupus Erythematosus

1998 • 383 citations

CTLA-4: a negative regulator of autoimmune disease.

1996 • 382 citations

CD28/B7 Regulation of Th1 and Th2 Subsets in the Development of Autoimmune Diabetes

1996 • 379 citations

Regulation of immunostimulatory function and costimulatory molecule (B7-1 and B7-2) expression on murine dendritic cells.

1994 • 379 citations

A genome-wide search for susceptibility genes in human systemic lupus erythematosus sib-pair families

1998 • 362 citations

Engagement of Cytotoxic T Lymphocyte–associated Antigen 4 (CTLA-4) Induces Transforming Growth Factor β (TGF-β) Production by Murine CD4+ T Cells

1998 • 359 citations

A search for type 1 diabetes susceptibility genes in families from the United Kingdom

1998 • 329 citations

Genome-Wide Screen for Systemic Lupus Erythematosus Susceptibility Genes in Multiplex Families

1999 • 319 citations

The role of B7 co‐stimulation in activation and differentiation ofCD4⁺and CD8⁺T cells

1998 • 306 citations

CD28 costimulation promotes the production of Th2 cytokines.

1997 • 299 citations

Polygenic control of autoimmune diabetes in nonobese diabetic mice

1993 • 298 citations

Cytotoxic T Lymphocyte–associated Antigen 4 (CTLA-4) Regulates the Unfolding of Autoimmune Diabetes

1998 • 295 citations

Is CTLA-4 a master switch for peripheral T cell tolerance?

1997 • 284 citations

What's the difference between CD80 and CD86?

2003 • 271 citations

A soluble form of CTLA-4 generated by alternative splicing is expressed by nonstimulated human T cells

1999 • 257 citations

Prevention and amelioration of collagen‐induced arthritis by blockade of the CD28 co‐stimulatory pathway: requirement for both B7‐1 and B7‐2

1996 • 244 citations

Codon 17 Polymorphism of the Cytotoxic T Lymphocyte Antigen 4 Gene in Hashimoto’s Thyroiditis and Addison’s Disease1

1997 • 242 citations

Structure and Dimerization of a Soluble Form of B7-1

2000 • 240 citations

Cutting Edge: Lymphoproliferative Disease in the Absence of CTLA-4 Is Not T Cell Autonomous

1999 • 236 citations

CTLA-4 blockade enhances clinical disease and cytokine production during experimental allergic encephalomyelitis.

1996 • 232 citations

Cutting Edge: A Soluble Form of CTLA-4 in Patients with Autoimmune Thyroid Disease

2000 • 227 citations

CTLA-4 gene polymorphism is associated with predisposition to coeliac disease

1998 • 220 citations

Long-term inhibition of murine lupus by brief simultaneous blockade of the B7/CD28 and CD40/gp39 costimulation pathways.

1997 • 219 citations

T‐cell costimulatory pathways in allograft rejection and tolerance

2003 • 218 citations

The cytotoxic T lymphocyte antigen-4 is a major Graves' disease locus

1999 • 216 citations

An Autoimmune Disease-Associated CTLA-4 Splice Variant Lacking the B7 Binding Domain Signals Negatively in T Cells

2004 • 212 citations

CTLA-4 and T cell activation

1999 • 209 citations

The Roles of the New Negative T Cell Costimulatory Pathways in Regulating Autoimmunity

2004 • 208 citations

CD28-B7 costimulatory blockade by CTLA4Ig prevents actively induced experimental autoimmune encephalomyelitis and inhibits Th1 but spares Th2 cytokines in the central nervous system.

1995 • 204 citations

A Susceptibility Locus for Human Systemic Lupus Erythematosus (hSLE1) on Chromosome 2q

2000 • 201 citations

Studies using antigen-presenting cells lacking expression of both B7-1 (CD80) and B7-2 (CD86) show distinct requirements for B7 molecules during priming versus restimulation of Th2 but not Th1 cytokine production.

1998 • 198 citations

The genetically isolated populations of Finland and Sardinia may not be a panacea for linkage disequilibrium mapping of common disease genes

2000 • 195 citations

Insulin VNTR allele-specific effect in type 1 diabetes depends on identity of untransmitted paternal allele

1997 • 189 citations

Lymphoproliferative Disorder in CTLA-4 Knockout Mice Is Characterized by CD28-Regulated Activation of Th2 Responses

1999 • 182 citations

Identification of murine loci associated with susceptibility to chronic experimental autoimmune encephalomyelitis

1995 • 181 citations

Production of congenic mouse strains carrying genomic intervals containing SLE-susceptibility genes derived from the SLE-prone NZM2410 strain

1996 • 180 citations

CTLA-4 gene polymorphism confers susceptibility to primary biliary cirrhosis

2000 • 179 citations

Studies Using Antigen-Presenting Cells Lacking Expression of Both B7-1 (CD80) and B7-2 (CD86) Show Distinct Requirements for B7 Molecules During Priming Versus Restimulation of Th2 But Not Th1 Cytokine Production

1998 • 175 citations

Genetic analysis of the NZB contribution to lupus-like autoimmune disease in (NZB x NZW)F1 mice.

1994 • 174 citations

Role of costimulators in T cell differentiation: studies using antigen-presenting cells lacking expression of CD80 or CD86.

1997 • 174 citations

Type 1 diabetes in mice is linked to the interleukin-1 receptor and Lsh/lty/Bcg genes on chromosome 1

1991 • 171 citations

Collagen-induced arthritis in the BB rat. Prevention of disease by treatment with CTLA-4-Ig.

1995 • 166 citations

CTLA4 promoter and exon 1 dimorphisms in multiple sclerosiso

1999 • 164 citations

NOD Idd5 locus controls insulitis and diabetes and overlaps the orthologous CTLA4/IDDM12 and NRAMP1 loci in humans.

2000 • 157 citations

Association of CTLA‐4 but not CD28 gene polymorphisms with systemic lupus erythematosus in the Japanese population

2001 • 154 citations

Cytotoxic T Lymphocyte Antigen 4 (CTLA-4) Interferes with Extracellular Signal-regulated Kinase (ERK) and Jun NH2-terminal Kinase (JNK) Activation, but Does Not Affect Phosphorylation of T Cell Receptor ζ and ZAP70

1997 • 153 citations

An Mse I RFLP in the Human CTLA4 Promotor

1996 • 150 citations

Thymocyte development is normal in CTLA-4-deficient mice

1997 • 147 citations

Cytolytic T lymphocyte-associated antigen-4 and the TCR zeta/CD3 complex, but not CD28, interact with clathrin adaptor complexes AP-1 and AP-2.

1999 • 138 citations

Emerging paradigms of T-cell co-stimulation

2004 • 137 citations

Evidence for CTLA4 as a susceptibility gene for systemic lupus erythematosus

2004 • 131 citations

Codon 17 Polymorphism of the Cytotoxic T Lymphocyte Antigen 4 Gene in Hashimoto's Thyroiditis and Addison's Disease

1997 • 130 citations

Congenic mapping of the insulin-dependent diabetes (Idd) gene, Idd10, localizes two genes mediating the Idd10 effect and eliminates the candidate Fcgr1.

1997 • 129 citations

Identification and mapping to chromosome 1 of a susceptibility locus for periinsulitis in non-obese diabetic mice

1991 • 129 citations

Confirmation of three susceptibility genes to insulin-dependent diabetes mellitus: IDDM4, IDDM5 and IDDM8

1996 • 129 citations

A Major Susceptibility Gene for Asthma Maps to Chromosome 14q24

2002 • 127 citations

CTLA4 codon 17 dimorphism in patients with rheumatoid arthritis

1998 • 125 citations

The emerging role of the CTLA-4 gene in autoimmune endocrinopathies

2004 • 124 citations

Activated Self-MHC-Reactive T Cells Have the Cytokine Phenotype of Th3/T Regulatory Cell 1 T Cells

2000 • 124 citations

Resistance alleles at two non-major histocompatibility complex-linked insulin-dependent diabetes loci on chromosome 3, Idd3 and Idd10, protect nonobese diabetic mice from diabetes.

1994 • 123 citations

Human primary immunodeficiency diseases: a perspective

2003 • 123 citations

B7 expression on thymic medullary epithelium correlates with epithelium-mediated deletion of V beta 5+ thymocytes.

1994 • 118 citations

Apoptosis resistance of nonobese diabetic peripheral lymphocytes linked to theIdd5diabetes susceptibility region

1997 • 115 citations

Cytolytic T Lymphocyte-Associated Antigen-4 and the TCRζ/CD3 Complex, But Not CD28, Interact with Clathrin Adaptor Complexes AP-1 and AP-2

1999 • 113 citations

Genetic and physical mapping of a type 1 diabetes susceptibility gene (IDDM12) to a 100-kb phagemid artificial chromosome clone containing D2S72-CTLA4-D2S105 on chromosome 2q33.

2000 • 113 citations

Fine Mapping, Gene Content, Comparative Sequencing, and Expression Analyses Support Ctla4 and Nramp1 as Candidates for Idd5.1 and Idd5.2 in the Nonobese Diabetic Mouse

2004 • 111 citations

Establishment of tissue‐specific tolerance is driven by regulatory T cells selected by thymic epithelium

1996 • 110 citations

A cytotoxic T lymphocyte antigen‐4 (CTLA‐4) gene polymorphism is associated with autoimmune Addison's disease in English patients

1998 • 109 citations

Lymphocytes selected in allogeneic thymic epithelium mediate dominant tolerance toward tissue grafts of the thymic epithelium haplotype.

1995 • 109 citations

TGF-β Mediates CTLA-4 Suppression of Cellular Immunity in Murine Kalaazar

2000 • 104 citations

Dinucleotide repeat polymorphism at the human CTLA4 gene

1991 • 103 citations

Genetic analysis of immune dysfunction in non‐obese diabetic (NOD) mice: Mapping of a susceptibility locus close to the Bcl‐2 gene correlates with increased resistance of NOD T cells to apoptosis induction

1994 • 92 citations

CTLA-4 regulates the requirement for cytokine-induced signals in TH2 lineage commitment

2003 • 90 citations

BTLA: a new inhibitory receptor with a B7-like ligand

2003 • 89 citations

Mapping autoimmunity genes

1999 • 83 citations

A Role for the B7-1/B7-2:CD28/CTLA-4 Pathway During Negative Selection

2003 • 83 citations

CTLA-4 Ligation Suppresses CD28-induced NF-κB and AP-1 Activity in Mouse T Cell Blasts

1999 • 78 citations

Three Loci on Mouse Chromosome 6 Influence Onset and Final Incidence of Type I Diabetes in NOD.C3H Congenic Strains

2001 • 78 citations

Normal Responsiveness of CTLA-4-Deficient Anti-Viral Cytotoxic T Cells

1998 • 75 citations

Normal thymic selection, normal viability and decreased lymphoproliferation in T cell receptor‐transgenic CTLA‐4‐deficient mice

1997 • 74 citations

DIFFERENTIAL GLYCOSYLATION OF INTERLEUKIN 2, THE MOLECULAR BASIS FOR THE NOD Idd3 TYPE 1 DIABETES GENE?

2000 • 71 citations

Polarization of Naive CD4+ T Cells Toward the Th1 Subset by CTLA-4 Costimulation

2000 • 70 citations

Genetic analysis of chromosome 2 in type 1 diabetes: analysis of putative loci IDDM7, IDDM12, and IDDM13 and candidate genes NRAMP1 and IA-2 and the interleukin-1 gene cluster. IMDIAB Group.

1998 • 66 citations

Medullary thymic epithelium expresses a ligand for CTLA4 in situ and in vitro.

1993 • 64 citations

Rescue of thymocytes from glucocorticoid-induced cell death mediated by CD28/CTLA-4 costimulatory interactions with B7-1/B7-2.

1996 • 63 citations

The Diabetes Susceptibility Locus Idd5.1 on Mouse Chromosome 1 Regulates ICOS Expression and Modulates Murine Experimental Autoimmune Encephalomyelitis

2004 • 62 citations

Cytotoxic T Lymphocyte Antigen 4 Is Induced in the Thymus upon In Vivo Activation and Its Blockade Prevents Anti-CD3–mediated Depletion of Thymocytes

1998 • 57 citations

Cytotoxic T lymphocyte antigen 4 (CTLA-4) dimorphism in patients with systemic lupus erythematosus.

1999 • 57 citations

Lack of a role for transforming growth factor-β in cytotoxic T lymphocyte antigen-4-mediated inhibition of T cell activation

2001 • 57 citations

Type 1 Diabetes and the Control of Dexamethazone-Induced Apoptosis in Mice Maps to the Same Region on Chromosome 6

1995 • 55 citations

CTLA4 polymorphism in spanish patients with systemic lupus erythematosus

2003 • 53 citations

Linkage and association between insulin–dependent diabetes mellitus (IDDM) susceptibility and markers near the glucokinase gene on chromosome 7

1995 • 49 citations

Inheritance of susceptibility to experimental autoimmune encephalomyelitis

1996 • 47 citations

Fine mapping of a multiple sclerosis locus to 2.5 Mb on chromosome 17q22-q24

2002 • 46 citations

Further Mapping of the Idd5.1 Locus for Autoimmune Diabetes in NOD Mice

2001 • 43 citations

Interval mapping of quantitative trait loci controlling humoral immunity to exogenous antigens: evidence that non-MHC immune response genes may also influence susceptibility to autoimmunity.

1996 • 32 citations

Diabetes Protection and Restoration of Thymocyte Apoptosis in NODIdd6Congenic Strains

2003 • 32 citations

Autoimmune Disease

2013 • 24 citations

CTLA-4: Acting at the Synapse

2002 • 15 citations