Fine Mapping, Gene Content, Comparative Sequencing, and Expression Analyses Support Ctla4 and Nramp1 as Candidates for Idd5.1 and Idd5.2 in the Nonobese Diabetic Mouse

Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4

1995 • 2,842 citations

Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease

2003 • 2,181 citations

ICOS is critical for CD40-mediated antibody class switching

2001 • 646 citations

QUANTIFICATION OF MURINE CYTOKINE mRNAs USING REAL TIME QUANTITATIVE REVERSE TRANSCRIPTASE PCR

1999 • 567 citations

Meiotic recombination hot spots and cold spots

2001 • 510 citations

The mosaic structure of variation in the laboratory mouse genome

2002 • 474 citations

Targeting of both mouse neuropilin-1 and neuropilin-2 genes severely impairs developmental yolk sac and embryonic angiogenesis

2002 • 371 citations

A neuronal receptor, neuropilin-1, is essential for the initiation of the primary immune response

2002 • 314 citations

Human Ig superfamily CTLA‐4 gene: chromosomal localization and identity of protein sequence between murine and human CTLA‐4 cytoplasmic domains

1988 • 296 citations

A soluble form of CTLA-4 generated by alternative splicing is expressed by nonstimulated human T cells

1999 • 257 citations

Functional and ontogenetic analysis of murine CD45Rhi and CD45Rlo CD4+ T cells.

1990 • 236 citations

Genome-wide single-nucleotide polymorphism analysis defines haplotype patterns in mouse

2003 • 234 citations

Cutting Edge: A Soluble Form of CTLA-4 in Patients with Autoimmune Thyroid Disease

2000 • 227 citations

Regulated protein–protein interaction between aPKC and PAR‐3 plays an essential role in the polarization of epithelial cells

2002 • 187 citations

Changes in CD45 isoform expression accompany antigen-induced murine T-cell activation.

1989 • 185 citations

Molecular cloning and characterization of murine ICOS and identification of B7h as ICOS ligand

2000 • 176 citations

Natural resistance to infection with intracellular parasites: molecular genetics identifies Nramp1 as the Bcg/Ity/Lsh locus

1995 • 158 citations

NOD Idd5 locus controls insulitis and diabetes and overlaps the orthologous CTLA4/IDDM12 and NRAMP1 loci in humans.

2000 • 157 citations

ICOS Costimulation Requires IL-2 and Can Be Prevented by CTLA-4 Engagement

2001 • 127 citations

IL-10 is necessary and sufficient for autoimmune diabetes in conjunction with NOD MHC homozygosity.

1996 • 105 citations

Production of congenic mouse strains carrying NOD-derived diabetogenic genetic intervals: An approach for the genetic dissection of complex traits

1996 • 97 citations

The Diabetes Susceptibility Locus Idd5.1 on Mouse Chromosome 1 Regulates ICOS Expression and Modulates Murine Experimental Autoimmune Encephalomyelitis

2004 • 62 citations

Insulin Autoantibodies Are Associated With Islet Inflammation But Not Always Related to Diabetes Progression in NOD Congenic Mice

2003 • 52 citations

The Derivation of Highly Germline-Competent Embryonic Stem Cells Containing NOD-Derived Genome

2003 • 49 citations

Iron chelators modulate the fusogenic properties of Salmonella -containing phagosomes

2003 • 46 citations

Further Mapping of the Idd5.1 Locus for Autoimmune Diabetes in NOD Mice

2001 • 43 citations

Localising Quantitative Trait Loci in the NOD Mouse Model of Type 1 Diabetes

1999 • 34 citations

A Gly15Arg Mutation in the Interleukin-10 Gene Reduces Secretion of Interleukin-10 in Crohn Disease

2003 • 27 citations

Genes and Genetics of Autoimmunity

1999 • 12 citations