Apoptosis resistance of nonobese diabetic peripheral lymphocytes linked to theIdd5diabetes susceptibility region

Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.

1992 • 9,540 citations

MAPMAKER: An interactive computer package for constructing primary genetic linkage maps of experimental and natural populations

1987 • 6,762 citations

Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results

1995 • 5,291 citations

Mapping mendelian factors underlying quantitative traits using RFLP linkage maps.

1989 • 5,285 citations

Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4

1995 • 2,842 citations

CTLA-4 can function as a negative regulator of T cell activation

1994 • 2,107 citations

Resolution of quantitative traits into Mendelian factors by using a complete linkage map of restriction fragment length polymorphisms

1988 • 1,513 citations

Binding of the B cell activation antigen B7 to CD28 costimulates T cell proliferation and interleukin 2 mRNA accumulation.

1991 • 1,132 citations

Apoptosis and Programmed Cell Death in Immunity

1992 • 1,105 citations

Genetic Analysis of Autoimmune Disease

1996 • 739 citations

Type-I Diabetes: A Chronic Autoimmune Disease of Human, Mouse, and Rat

1990 • 650 citations

Coexpression and functional cooperation of CTLA-4 and CD28 on activated T lymphocytes.

1992 • 592 citations

Genetic Control of Autoimmune Diabetes in the Nod Mouse

1995 • 586 citations

Genetic analysis of autoimmune type 1 diabetes mellitus in mice

1991 • 494 citations

Towards construction of a high resolution map of the mouse genome using PCR-analysed microsatellites

1990 • 475 citations

Development and Selection of T Cells: Facts and Puzzles

1995 • 450 citations

CTLA-4 and CD28 activated lymphocyte molecules are closely related in both mouse and human as to sequence, message expression, gene structure, and chromosomal location.

1991 • 422 citations

CD28/B7 Regulation of Th1 and Th2 Subsets in the Development of Autoimmune Diabetes

1996 • 379 citations

Characterization of CTLA-4 structure and expression on human T cells.

1993 • 319 citations

Polygenic control of autoimmune diabetes in nonobese diabetic mice

1993 • 298 citations

Promotion of spontaneous diabetes in non-obese diabetes-prone mice by cyclophosphamide

1984 • 220 citations

Type 1 diabetes in mice is linked to the interleukin-1 receptor and Lsh/lty/Bcg genes on chromosome 1

1991 • 171 citations

NOR/Lt Mice: MHC-Matched Diabetes-Resistant Control Strain for NOD Mice

1992 • 151 citations

Use of recombinant congenic and congenic strains of NOD mice to identify a new insulin-dependent diabetes resistance gene.

1994 • 147 citations

Defective thymic T cell activation by concanavalin A and anti-CD3 in autoimmune nonobese diabetic mice. Evidence for thymic T cell anergy that correlates with the onset of insulitis.

1991 • 101 citations

Genetic analysis of immune dysfunction in non‐obese diabetic (NOD) mice: Mapping of a susceptibility locus close to the Bcl‐2 gene correlates with increased resistance of NOD T cells to apoptosis induction

1994 • 92 citations

Non-obese diabetic (NOD) mice display enhanced immune responses and prolonged survival of lymphoid cells

1994 • 88 citations

Type 1 Diabetes and the Control of Dexamethazone-Induced Apoptosis in Mice Maps to the Same Region on Chromosome 6

1995 • 55 citations

Programmed Cell Death in the Pathogenesis of Murine IDDM: Resistance to Apoptosis Induced in Lymphocytes by Cyclophosphamide

1996 • 48 citations