Thymocyte development is normal in CTLA-4-deficient mice

Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4

1995 • 2,842 citations

CD28/B7 SYSTEM OF T CELL COSTIMULATION

1996 • 2,726 citations

CTLA-4 can function as a negative regulator of T cell activation

1994 • 2,107 citations

CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation.

1995 • 2,090 citations

Selected methods in cellular immunology

1981 • 1,915 citations

Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene

1991 • 1,317 citations

Differential T Cell Costimulatory Requirements in CD28-Deficient Mice

1993 • 1,271 citations

A new member of the immunoglobulin superfamily—CTLA-4

1987 • 1,214 citations

Antibodies to CD3/T-cell receptor complex induce death by apoptosis in immature T cells in thymic cultures

1989 • 1,159 citations

CTLA-4 engagement inhibits IL-2 accumulation and cell cycle progression upon activation of resting T cells.

1996 • 917 citations

Turnover of naive- and memory-phenotype T cells.

1994 • 900 citations

CTLA-4 ligation blocks CD28-dependent T cell activation.

1996 • 787 citations

Characterization of a monoclonal antibody which detects all murine alpha beta T cell receptors.

1989 • 778 citations

Mammalian Membrane-bound Adenylyl Cyclases

1995 • 722 citations

The tissue distribution of the B7-2 costimulator in mice: abundant expression on dendritic cells in situ and during maturation in vitro.

1994 • 607 citations

Intracellular Trafficking of CTLA-4 and Focal Localization Towards Sites of TCR Engagement

1996 • 583 citations

Developmentally ordered appearance of thymocytes expressing different T-cell antigen receptors

1988 • 540 citations

A Role for CD5 in TCR-Mediated Signal Transduction and Thymocyte Selection

1995 • 437 citations

Lymphocyte life-span and memory

1994 • 405 citations

Kinetics and efficacy of positive selection in the thymus of normal and T cell receptor transgenic mice

1991 • 368 citations

Cloning and expression of the mouse pgk-1 gene and the nucleotide sequence of its promoter

1987 • 361 citations

Kinetics of mature T-cell development in the thymus.

1990 • 331 citations

Identification and distribution of the costimulatory receptor CD28 in the mouse.

1992 • 316 citations

Reentry of T cells to the adult thymus is restricted to activated T cells.

1991 • 263 citations

Negative selection of CD4+CD8+ thymocytes by T cell receptor-induced apoptosis requires a costimulatory signal that can be provided by CD28.

1994 • 257 citations

CD 69 expression during selection and maturation of CD4⁺8⁺ thymocytes

1993 • 242 citations

The Role of CTLA‐4 in the Regulation and Initiation of T‐Cell Responses

1996 • 208 citations

Cytotoxic T Lymphocyte-associated Molecule-4, a High Avidity Receptor for CD80 and CD86, Contains an Intracellular Localization Motif in Its Cytoplasmic Tail

1995 • 189 citations

Lymphocyte Development from Stem Cells

1992 • 170 citations

T Cell Reactivity to MHC Molecules: Immunity Versus Tolerance

1990 • 148 citations

Two signals are required for negative selection of CD4+CD8+ thymocytes.

1993 • 143 citations

Murine B7 antigen provides an efficient costimulatory signal for activation of murine T lymphocytes via the T-cell receptor/CD3 complex.

1992 • 138 citations

Unusual phenotype of B cells in the thymus of normal mice.

1988 • 127 citations

B7 expression on thymic medullary epithelium correlates with epithelium-mediated deletion of V beta 5+ thymocytes.

1994 • 118 citations

CD28 expression is not essential for positive and negative selection of thymocytes or peripheral T cell tolerance.

1996 • 105 citations

Both immature and mature T cells mobilize Ca2+ in response to antigen receptor crosslinking

1987 • 89 citations

Differing roles for B7 and intercellular adhesion molecule-1 in negative selection of thymocytes.

1996 • 84 citations

Analysis of lymphocyte costimulation in vivo using transgenic and 'knockout' mice

1995 • 84 citations

Seeding of neonatal lymph nodes by T cells and identification of a novel population of CD3⁻CD4⁺ cells

1992 • 83 citations

Analysis of recent thymic emigrants with subse- and maturity-related markers

1990 • 83 citations

Events that regulate differentiation of αβ TCR+and γδ TCR+T cells from a common precursor

1997 • 73 citations

Thymocytes expressing CD8 differentiate into CD4+ cells following intrathymic injection.

1988 • 72 citations

Medullary thymic epithelium expresses a ligand for CTLA4 in situ and in vitro.

1993 • 64 citations

Rescue of thymocytes from glucocorticoid-induced cell death mediated by CD28/CTLA-4 costimulatory interactions with B7-1/B7-2.

1996 • 63 citations

CD28-B7 interactions are not required for intrathymic clonal deletion

1993 • 53 citations

CD28-mediated signaling in vivo prevents activation-induced apoptosis in the thymus and alters peripheral lymphocyte homeostasis.

1995 • 46 citations

Regulation of T cell production in T cell receptor transgenic mice

1993 • 36 citations

Positive Selection by Purified MHC Class II / Thymic Epithelial CellsIn Vitro: Costimulatory Signals Mediated by B7 Are Not Involved

1993 • 24 citations

A positively selecting thymic epithelial cell line lacks costimulatory activity.

1994 • 20 citations

A positively selecting thymic epithelial cell line lacks costimulatory activity.

1994 • 14 citations

The balance between deletion and activation of CD4⁺8⁺ thymocytes is controlled by T cell receptor‐antigen interactions and is affected by cyclosporin A

1994 • 11 citations

Pillars Article: Characterization of a Monoclonal Antibody Which Detects All Murine αβ T Cell Receptors. J. Immunol. 1989. 142: 2736-2742.

2016 • 11 citations

Exogenous Mtv-7 superantigen transgene expression in major histocompatibility complex class II I-E- mice reconstituted with embryonic stem cell-derived hematopoietic stem cells.

1994 • 8 citations

Developmental regulation of TCR-CD3-dependent [Ca2+]i responses of individual normal and pp59fyn-deficient T lymphocytes.

1995 • 7 citations