Emerging paradigms of T-cell co-stimulation

Interleukin-10 and the Interleukin-10 Receptor

2001 • 6,422 citations

Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4

1995 • 2,842 citations

Development of Lupus-like Autoimmune Diseases by Disruption of the PD-1 Gene Encoding an ITIM Motif-Carrying Immunoreceptor

1999 • 2,574 citations

Autoimmune Dilated Cardiomyopathy in PD-1 Receptor-Deficient Mice

2001 • 1,761 citations

The B7–CD28 superfamily

2002 • 1,646 citations

ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28

1999 • 1,418 citations

Differential T Cell Costimulatory Requirements in CD28-Deficient Mice

1993 • 1,271 citations

Complexities of CD28/B7: CTLA-4 Costimulatory Pathways in Autoimmunity and Transplantation

2001 • 1,032 citations

ICOS co-stimulatory receptor is essential for T-cell activation and function

2001 • 902 citations

The B7 Family of Ligands and Its Receptors: New Pathways for Costimulation and Inhibition of Immune Responses

2002 • 884 citations

Co-stimulatory members of the TNFR family: keys to effective T-cell immunity?

2003 • 848 citations

T-cell co-stimulation through B7RP-1 and ICOS

1999 • 758 citations

Homozygous loss of ICOS is associated with adult-onset common variable immunodeficiency

2003 • 734 citations

ICOS is essential for effective T-helper-cell responses

2001 • 666 citations

ICOS is critical for CD40-mediated antibody class switching

2001 • 646 citations

The Interaction Properties of Costimulatory Molecules Revisited

2002 • 640 citations

Endothelial expression of PD‐L1 and PD‐L2 down‐regulates CD8⁺ T cell activation and cytolysis

2003 • 436 citations

Mouse Inducible Costimulatory Molecule (ICOS) Expression Is Enhanced by CD28 Costimulation and Regulates Differentiation of CD4+ T Cells

2000 • 423 citations

The expanding B7 superfamily: Increasing complexity in costimulatory signals regulating T cell function

2001 • 413 citations

Unifying concepts in CD28, ICOS and CTLA4 co-receptor signalling

2003 • 368 citations

4-1BB Ligand Induces Cell Division, Sustains Survival, and Enhances Effector Function of CD4 and CD8 T Cells with Similar Efficacy

2001 • 352 citations

Regulation of surface and intracellular expression of CTLA4 on mouse T cells.

1996 • 340 citations

Genomic expression programs and the integration of the CD28 costimulatory signal in T cell activation

2002 • 334 citations

Activation and inhibition of lymphocytes by costimulation

2002 • 332 citations

B7-H1 Is Expressed by Human Endothelial Cells and Suppresses T Cell Cytokine Synthesis

2002 • 313 citations

Modulation of TCR-induced transcriptional profiles by ligation of CD28, ICOS, and CTLA-4 receptors

2002 • 300 citations

Compromised Ox40 Function in Cd28-Deficient Mice Is Linked with Failure to Develop Cxc Chemokine Receptor 5–Positive Cd4 Cells and Germinal Centers

1999 • 275 citations

Activation and inhibition of lymphocytes by costimulation

2002 • 264 citations

Expression of ICOS In Vivo Defines CD4+ Effector T Cells with High Inflammatory Potential and a Strong Bias for Secretion of Interleukin 10

2003 • 247 citations

Costimulation of T cells by OX40, 4-1BB, and CD27

2003 • 229 citations

New regulatory co-receptors: inducible co-stimulator and PD-1

2002 • 227 citations

ICOS-ligand, expressed on human endothelial cells, costimulates Th1 and Th2 cytokine secretion by memory CD4⁺T cells

2002 • 221 citations

Induction, binding specificity and function of human ICOS

2000 • 175 citations

Costimulation in antiviral immunity: differential requirements for CD4+ and CD8+ T cell responses

2000 • 148 citations

Structural mechanisms of costimulation

2002 • 129 citations

ICOS Costimulation Requires IL-2 and Can Be Prevented by CTLA-4 Engagement

2001 • 127 citations

Inducible Costimulator Regulates Th2-Mediated Inflammation, but Not Th2 Differentiation, in a Model of Allergic Airway Disease

2001 • 127 citations

LIGHT–HVEM signaling and the regulation of T cell-mediated immunity

2003 • 125 citations

ICOS and CD28 reversely regulate IL-10 on re-activation of human effector T cells with mature dendritic cells

2002 • 121 citations

The SLAM family of immune-cell receptors

2003 • 119 citations

The right place at the right time: novel B7 family members regulate effector T cell responses

2002 • 113 citations

Amelioration of Experimental Autoimmune Encephalomyelitis with Anti-OX40 Ligand Monoclonal Antibody: A Critical Role for OX40 Ligand in Migration, But Not Development, of Pathogenic T Cells

2001 • 110 citations

Immunobiology of human vascular endothelium

1999 • 106 citations

BTLA: a new inhibitory receptor with a B7-like ligand

2003 • 89 citations

Constitutive Expression of the B7h Ligand for Inducible Costimulator on Naive B Cells Is Extinguished after Activation by Distinct B Cell Receptor and Interleukin 4 Receptor–mediated Pathways and Can Be Rescued by CD40 Signaling

2002 • 83 citations

Expression and a role of CD30 in regulation of T-cell activity

2003 • 68 citations

A Role for Inducible Costimulator Protein in the CD28- Independent Mechanism of Resistance to Toxoplasma gondii

2002 • 58 citations

ICOS⁺ Th cells produce distinct cytokines in different mucosal immune responses

2003 • 48 citations

Vascular endothelial cells provide T cells with costimulatory signals via the OX40/gp34 system

2000 • 45 citations