Genetic Analysis of Autoimmune Disease

Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results

1995 • 5,291 citations

Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM).

1993 • 3,693 citations

Genetic Dissection of Complex Traits

1994 • 3,497 citations

Abundant class of human DNA polymorphisms which can be typed using the polymerase chain reaction.

1989 • 3,458 citations

The 1993–94 Généthon human genetic linkage map

1994 • 1,870 citations

Linkage strategies for genetically complex traits. I. Multilocus models.

1990 • 1,335 citations

A genome-wide search for human type 1 diabetes susceptibility genes

1994 • 1,294 citations

Insulin-Dependent Diabetes Mellitus

1996 • 1,171 citations

Complete multipoint sib-pair analysis of qualitative and quantitative traits.

1995 • 929 citations

Fas and Fas ligand: lpr and gld mutations

1995 • 906 citations

Multiple Sclerosis: A Coordinated Immunological Attack against Myelin in the Central Nervous System

1996 • 903 citations

Susceptibility to human type 1 diabetes at IDDM2 is determined by tandem repeat variation at the insulin gene minisatellite locus

1995 • 749 citations

Systemic Lupus Erythematosus

1996 • 677 citations

A genetic basis for familial aggregation in multiple sclerosis

1995 • 626 citations

The Ity/Lsh/Bcg locus: natural resistance to infection with intracellular parasites is abrogated by disruption of the Nramp1 gene.

1995 • 603 citations

Genetic Control of Autoimmune Diabetes in the Nod Mouse

1995 • 586 citations

Assessing the role of HLA-linked and unlinked determinants of disease.

1987 • 548 citations

A genetic map of the mouse with 4,006 simple sequence length polymorphisms

1994 • 543 citations

Polygenic control of susceptibility to murine systemic lupus erythematosus

1994 • 484 citations

Towards construction of a high resolution map of the mouse genome using PCR-analysed microsatellites

1990 • 475 citations

Genetic mapping of a susceptibility locus for insulin-dependent diabetes mellitus on chromosome llq

1994 • 397 citations

Contribution of genes of the major histocompatibility complex to susceptibility and disease phenotype in inflammatory bowel disease

1996 • 371 citations

Genetic Susceptibility to Leishmania : IL-12 Responsiveness in T _H 1 Cell Development

1996 • 367 citations

Lupus susceptibility loci in New Zealand mice.

1994 • 359 citations

Genetic analysis of MRL-lpr mice: relationship of the Fas apoptosis gene to disease manifestations and renal disease-modifying loci.

1992 • 339 citations

Chromosome–specific microsatellite sets for fluorescence–based, semi–automated genome mapping

1994 • 304 citations

Polygenic control of autoimmune diabetes in nonobese diabetic mice

1993 • 298 citations

DESIGN AND USE OF PLASTIC TENTS FOR ISOLATION OF PATIENTS PRONE TO INFECTION

1968 • 294 citations

Mapping Genes in Diabetes: Genetic Epidemiological Perspective

1990 • 290 citations

Susceptibility to insulin dependent diabetes mellitus maps to a 4.1 kb segment of DNA spanning the insulin gene and associated VNTR

1993 • 271 citations

Genetic analysis of type 1 diabetes using whole genome approaches.

1995 • 256 citations

The genetics of psoriasis.

1994 • 247 citations

Polygenic disease: methods for mapping complex disease traits

1995 • 239 citations

Linkage disequilibrium mapping of a type 1 diabetes susceptibility gene (IDDM7) to chromosome 2q31–q33

1995 • 211 citations

The basis of autoimmunity: part II genetic predisposition

1995 • 205 citations

The Th1/Th2 balance in autoimmunity

1995 • 198 citations

Identification of murine loci associated with susceptibility to chronic experimental autoimmune encephalomyelitis

1995 • 181 citations

A locus on chromosome 15q26 (IDDM3) produces susceptibility to insulin-dependent diabetes mellitus

1994 • 175 citations

Genetic analysis of the NZB contribution to lupus-like autoimmune disease in (NZB x NZW)F1 mice.

1994 • 174 citations

IDDM2-VNTR-encoded Susceptibility to Type 1 Diabetes: Dominant Protection and Parental Transmission of Alleles of the Insulin Gene-linked Minisatellite Locus

1996 • 165 citations

The Genetics of Psoriasis

1994 • 162 citations

Use of recombinant congenic and congenic strains of NOD mice to identify a new insulin-dependent diabetes resistance gene.

1994 • 147 citations

Two-locus maximum lod score analysis of a multifactorial trait: joint consideration of IDDM2 and IDDM4 with IDDM1 in type 1 diabetes.

1995 • 145 citations

Crosses of NOD Mice With the Related NON Strain: A Polygenic Model for IDDM

1995 • 140 citations

FAMILIAL PATTERNS OF NARCOLEPSY

1989 • 137 citations

Molecular dissection of quantitative traits: progress and prospects.

1995 • 128 citations

The application of genetic epidemiology to systemic lupus erythematosus.

1987 • 123 citations

Resistance alleles at two non-major histocompatibility complex-linked insulin-dependent diabetes loci on chromosome 3, Idd3 and Idd10, protect nonobese diabetic mice from diabetes.

1994 • 123 citations

Taking stock of complex trait genetics in mice

1995 • 119 citations

Statistical evaluation of multiple-locus linkage data in experimental species and its relevance to human studies: application to nonobese diabetic (NOD) mouse and human insulin-dependent diabetes mellitus (IDDM).

1993 • 118 citations

Affected-sib-pair mapping of a novel susceptibility gene to insulin-dependent diabetes mellitus (IDDM8) on chromosome 6q25-q27.

1995 • 115 citations

Association of Graves' disease with an allele of the interleukin-1 receptor antagonist gene.

1995 • 112 citations

Genetic analysis of experimental allergic encephalomyelitis in mice.

1995 • 111 citations

Identification of a new susceptibility locus for insulin-dependent diabetes mellitus by ancestral haplotype congenic mapping.

1995 • 98 citations

Genetic Analysis of NIDDM: The Study of Quantitative Traits

1996 • 97 citations

Genetic analysis of immune dysfunction in non‐obese diabetic (NOD) mice: Mapping of a susceptibility locus close to the Bcl‐2 gene correlates with increased resistance of NOD T cells to apoptosis induction

1994 • 92 citations

A note on multiple testing procedures in linkage analysis.

1991 • 86 citations

HLA Disease Associations: Models for the Study of Complex Human Genetic Disorders

1995 • 86 citations

Locus controlling Bordetella pertussis-induced histamine sensitization (Bphs), an autoimmune disease-susceptibility gene, maps distal to T-cell receptor beta-chain gene on mouse chromosome 6.

1993 • 85 citations

Genetic and physiological association of diabetes susceptibility with raised Na+/H+ exchange activity.

1994 • 80 citations

The HOXD8 Locus (2q31) is Linked to Type I Diabetes: Interaction with Chromosome 6 and 11 Disease Susceptibility Genes

1995 • 76 citations

Genetic dissection of complex traits

1996 • 74 citations

Genetic analysis of diabetes and insulitis in an interspecific cross of the nonobese diabetic mouse with Mus spretus.

1993 • 60 citations

Type 1 Diabetes and the Control of Dexamethazone-Induced Apoptosis in Mice Maps to the Same Region on Chromosome 6

1995 • 55 citations

Aod2, the locus controlling development of atrophy in neonatal thymectomy-induced autoimmune ovarian dysgenesis, co-localizes with Il2, Fgfb, and Idd3.

1996 • 52 citations

Multiple loci govern the bone marrow-derived immunoregulatory mechanism controlling dominant resistance to autoimmune orchitis.

1995 • 46 citations

Aod1, the immunoregulatory locus controlling abrogation of tolerance in neonatal thymectomy-induced autoimmune ovarian dysgenesis, maps to mouse chromosome 16.

1995 • 42 citations

Mapping the diabetes polygene Idd3 on mouse Chromosome 3 by use of novel congenic strains

1995 • 41 citations

Genes and arthritis

1995 • 40 citations

Locus conteolling Bordetella perussis-induced histamine sensitization(Bphs), an autoimmune disease-susceptibility gene, chromosome 6

1993 • 39 citations

Characterizations of candidate genes for IDD susceptibility from the diabetes-prone NOD mouse strain

1993 • 27 citations

Genetic Linkage of Thymic T-Cell Proliferative Unresponsiveness to Mouse Chromosome 11 in NOD Mice: A Possible Role for Chemokine Genes

1995 • 26 citations

Ela Disease Associations

1989 • 26 citations

Genetic factors in primary biliary cirrhosis

1994 • 21 citations

Mapping of the diabetes polygene Idd3 on mouse Chromosome 3 using novel congenic strains

1995 • 8 citations