The emerging role of the CTLA-4 gene in autoimmune endocrinopathies

Enhancement of Antitumor Immunity by CTLA-4 Blockade

1996 • 3,585 citations

Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease

2003 • 2,181 citations

CTLA-4 can function as a negative regulator of T cell activation

1994 • 2,107 citations

CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation.

1995 • 2,090 citations

X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy

2001 • 1,831 citations

Positional cloning of the APECED gene

1997 • 1,385 citations

A new member of the immunoglobulin superfamily—CTLA-4

1987 • 1,214 citations

Long-Term Survival of Xenogeneic Pancreatic Islet Grafts Induced by CTLA4lg

1992 • 1,156 citations

CTLA-4 engagement inhibits IL-2 accumulation and cell cycle progression upon activation of resting T cells.

1996 • 917 citations

BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1

2003 • 816 citations

The CTLA-4 gene region of chromosome 2q33 is linked to, and associated with, type 1 diabetes. Belgian Diabetes Registry

1996 • 794 citations

Treatment of Murine Lupus with CTLA4Ig

1994 • 683 citations

Molecular Basis of T Cell Inactivation by CTLA-4

1998 • 678 citations

The Emerging Role of CTLA-4 as an Immune Attenuator

1997 • 637 citations

Differential effects of anti-B7-1 and anti-B7-2 monoclonal antibody treatment on the development of diabetes in the nonobese diabetic mouse.

1995 • 595 citations

Regulation of T Cell Receptor Signaling by Tyrosine Phosphatase SYP Association with CTLA-4

1996 • 529 citations

CTLA-4 Gene Polymorphism at Position 49 in Exon 1 Reduces the Inhibitory Function of CTLA-4 and Contributes to the Pathogenesis of Graves’ Disease

2000 • 508 citations

CTLA-4 gene polymorphism associated with Graves' disease in a Caucasian population.

1995 • 426 citations

Insulin-dependent diabetes mellitus (IDDM) is associated with CTLA4 polymorphisms in multiple ethnic groups

1997 • 408 citations

CTLA4 Alanine-17 Confers Genetic Susceptibility to Graves’ Disease and to Type 1 Diabetes Mellitus¹

1997 • 408 citations

CTLA4 mediates antigen-specific apoptosis of human T cells.

1995 • 331 citations

Cytotoxic T Lymphocyte–associated Antigen 4 (CTLA-4) Regulates the Unfolding of Autoimmune Diabetes

1998 • 295 citations

A CTLA‐4 gene polymorphism is associated with both Graves' disease and autoimmune hypothyroidism

1997 • 261 citations

Codon 17 Polymorphism of the Cytotoxic T Lymphocyte Antigen 4 Gene in Hashimoto’s Thyroiditis and Addison’s Disease1

1997 • 242 citations

CTLA-4 blockade enhances clinical disease and cytokine production during experimental allergic encephalomyelitis.

1996 • 232 citations

Genetic Effects on Age-Dependent Onset and Islet Cell Autoantibody Markers in Type 1 Diabetes

2002 • 229 citations

New regulatory co-receptors: inducible co-stimulator and PD-1

2002 • 227 citations

Cutting Edge: A Soluble Form of CTLA-4 in Patients with Autoimmune Thyroid Disease

2000 • 227 citations

CTLA-4 gene polymorphism is associated with predisposition to coeliac disease

1998 • 220 citations

Common and Unique Susceptibility Loci in Graves and Hashimoto Diseases: Results of Whole-Genome Screening in a Data Set of 102 Multiplex Families

2003 • 218 citations

The cytotoxic T lymphocyte antigen-4 is a major Graves' disease locus

1999 • 216 citations

Identification of susceptibility loci for autoimmune thyroid disease to 5q31-q33 and Hashimoto's thyroiditis to 8q23-q24 by multipoint affected sib-pair linkage analysis in Japanese

2001 • 190 citations

CTLA-4 gene polymorphism confers susceptibility to primary biliary cirrhosis

2000 • 179 citations

Mapping the Major Susceptibility Loci for Familial Graves’ and Hashimoto’s Diseases: Evidence for Genetic Heterogeneity and Gene Interactions¹

1999 • 165 citations

CTLA4 promoter and exon 1 dimorphisms in multiple sclerosiso

1999 • 164 citations

The Genetics of Autoimmune Thyroid Disease

2002 • 161 citations

The Development of Graves’ Disease and theCTLA-4Gene on Chromosome 2q33¹

1999 • 154 citations

Association of CTLA-4 Gene A-G Polymorphism (IDDM12 Locus) With Acute-Onset and Insulin-Depleted IDDM as Well as Autoimmune Thyroid Disease (Graves' Disease and Hashimoto's Thyroiditis) in the Japanese Population

1998 • 147 citations

CTLA‐4 promoter variants in patients with Graves' disease and Hashimoto's thyroiditis

1998 • 140 citations

CTLA4 Gene Polymorphism Confers Susceptibility to Graves' Disease in Japanese

1997 • 139 citations

CTLA-4 and Not CD28 Is a Susceptibility Gene for Thyroid Autoantibody Production¹

2001 • 138 citations

Blockade of CTLA-4 Enhances Host Resistance to the Intracellular Pathogen,Leishmania donovani

1998 • 135 citations

An association between the CTLA4 exon 1 polymorphism and early rheumatoid arthritis with autoimmune endocrinopathies

2002 • 133 citations

CTLA4 codon 17 dimorphism in patients with rheumatoid arthritis

1998 • 125 citations

Limited Genetic Susceptibility to Severe Graves' Ophthalmopathy: No Role for CTLA-4 But Evidence for an Environmental Etiology

2000 • 118 citations

Genetic and physical mapping of a type 1 diabetes susceptibility gene (IDDM12) to a 100-kb phagemid artificial chromosome clone containing D2S72-CTLA4-D2S105 on chromosome 2q33.

2000 • 113 citations

Protective Immunity to Nematode Infection Is Induced by CTLA-4 Blockade

1997 • 113 citations

Fas-independent death of activated CD4⁺T lymphocytes induced by CTLA-4 crosslinking

1998 • 112 citations

A cytotoxic T lymphocyte antigen‐4 (CTLA‐4) gene polymorphism is associated with autoimmune Addison's disease in English patients

1998 • 109 citations

CTLA-4 gene polymorphism confers susceptibility to insulin-dependent diabetes mellitus (IDDM) independently from age and from other genetic or immune disease markers

1997 • 105 citations

Association Analysis of the Cytotoxic T Lymphocyte Antigen-4 (CTLA-4) and Autoimmune Regulator-1 (AIRE-1) Genes in Sporadic Autoimmune Addison’s Disease¹

2000 • 103 citations

Polymorphism in the Promoter and Exon 1 of the Cytotoxic T Lymphocyte Antigen-4 Gene Associated with Autoimmune Thyroid Disease in Koreans

2000 • 102 citations

Association of cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) gene polymorphism and non-genetic factors with Graves' ophthalmopathy in European and Japanese populations

2003 • 100 citations

Relation of three polymorphisms of the CTLA-4 gene in patients with Graves’ disease

2002 • 96 citations

Association of DRB1*04-DQB1*0301 Haplotype and Lack of Association of Two Polymorphic Sites at CTLA-4 Gene with Hashimoto's Thyroiditis in an Italian Population

2001 • 96 citations

Polymorphism of the CTLA-4 Gene Is Associated with Autoimmune Hypothyroidism in the United Kingdom

2002 • 82 citations

Association studies of CTLA-4 , CD28 , and ICOS gene polymorphisms with type 1 diabetes in the Japanese population

2001 • 79 citations

Association of Autoimmune Thyroid Disease with Microsatellite Markers for the Thyrotropin Receptor Gene and CTLA-4 in Japanese Patients

2000 • 69 citations

No evidence for allelic association of a human CTLA‐4 promoter polymorphism with autoimmune thyroid disease in either population‐based case–control or family‐based studies

1998 • 68 citations

Genetic analysis of chromosome 2 in type 1 diabetes: analysis of putative loci IDDM7, IDDM12, and IDDM13 and candidate genes NRAMP1 and IA-2 and the interleukin-1 gene cluster. IMDIAB Group.

1998 • 66 citations

CTLA-4 Blockade Enhances the Immune Response Induced by Mycobacterial Infection but Does Not Lead to Increased Protection

1999 • 66 citations

Complex Association Analysis of Graves Disease Using a Set of Polymorphic Markers

2000 • 63 citations

Association of CTLA-4 gene A/G polymorphism in Japanese type 1 diabetic patients with younger age of onset and autoimmune thyroid disease.

2000 • 62 citations

CTLA-4 Gene Polymorphisms in Tunisian Patients with Graves' Disease

2001 • 62 citations

Remission of Graves’ Hyperthyroidism and A/G Polymorphism at Position 49 in Exon 1 of Cytotoxic T Lymphocyte-Associated Molecule-4 Gene

2002 • 60 citations

Association of the CTLA-4 Gene 49 A/G Polymorphism With Type 1 Diabetes and Autoimmune Thyroid Disease in Japanese Children

2003 • 60 citations

The Influence of the Exon 1 Polymorphism of the Cytotoxic T Lymphocyte Antigen 4 Gene on Thyroid Antibody Production in Patients with Newly Diagnosed Graves' Disease

2002 • 59 citations

No Major Role for the CTLA-4 Gene in the Association of Autoimmune Thyroid Disease With IDDM

1998 • 58 citations

Genome-Wide Scan of Graves’ Disease: Evidence for Linkage on Chromosome 5q31 in Chinese Han Pedigrees

2003 • 55 citations

Association of CTLA4 gene A–G polymorphism with type 1 diabetes in Chinese children

2000 • 54 citations

Association of autoimmune thyroid disease with a microsatellite marker for the thyrotropin receptor gene and CTLA-4 in a Japanese population.

1997 • 50 citations

The Human Leukocyte Antigen HLA DRB3∗0202/DQA1∗0501 Haplotype Is Associated with Graves’ Disease in African Americans

2000 • 49 citations

CTLA4 gene polymorphism correlates with the mode of onset and presence of ICA512 Ab in Japanese Type 1 diabetes

1999 • 48 citations

CTLA‐4 gene A–G polymorphism and childhood Graves’ disease

2002 • 45 citations

Lack of Association between CTLA-4 Gene Polymorphism and IDDM in Japanese Subjects

1999 • 41 citations

Cytotoxic T-Lymphocyte Antigen-4 Gene Polymorphisms and Human T-Cell Lymphotrophic Virus-1 Infection: Their Associations with Hashimoto's Thyroiditis in Japanese Patients

2002 • 40 citations

CTLA-4 gene polymorphism is associated with predisposition to IDDM in a population from central Poland.

1998 • 34 citations

The CTLA4 +49 A/G dimorphism is not associated with type 1 diabetes in Czech children

2002 • 33 citations

Cytotoxic T lymphocyte antigen 4 gene polymorphism confers susceptibility to Type 1 diabetes in Japanese children: analysis of association with HLA genotypes and autoantibodies

2001 • 30 citations

The Promoter Region of the CTLA4 Gene is Associated with Type 1 Diabetes Mellitus

2001 • 28 citations

Exon-1 Polymorphism of ctla-4 Gene in Iranian Patients with Graves' Disease

2003 • 27 citations

The Length of the CTLA-4 Microsatellite (AT)_N-Repeat Affects the Risk for Type 1 Diabetes: For the Swedish Childhood Diabetes Study Group

2000 • 26 citations

CTLA‐4 49 A/G dimorphism and type 1 diabetes susceptibility: a French case–control study and segregation analysis. Evidence of a maternal effect

2002 • 25 citations

Association of CTLA‐4 polymorphism with positive anti‐GAD antibody in Japanese subjects with type 1 diabetes mellitus

1999 • 23 citations

CTLA-4 gene A/G polymorphism associated with diabetes mellitus in Han Chinese.

2002 • 20 citations

Association of CTLA-4 variation with type I diabetes in Filipinos

2002 • 19 citations

No Association of Type 1 Diabetes with a Microsatellite Marker for CTLA-4 in a Japanese Population

2001 • 16 citations

Markers for Risk of Type 1 Diabetes in Relatives of Alsacian Patients With Type 1 Diabetes

2001 • 13 citations