CTLA-4: a negative regulator of autoimmune disease.

Enhancement of Antitumor Immunity by CTLA-4 Blockade

1996 • 3,585 citations

Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4

1995 • 2,842 citations

CTLA-4 can function as a negative regulator of T cell activation

1994 • 2,107 citations

CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation.

1995 • 2,090 citations

B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: Application to autoimmune disease therapy

1995 • 1,695 citations

CTLA-4 is a second receptor for the B cell activation antigen B7.

1991 • 1,662 citations

Clonal Expansion Versus Functional Clonal Inactivation: A Costimulatory Signalling Pathway Determines the Outcome of T Cell Antigen Receptor Occupancy

1989 • 1,512 citations

A new member of the immunoglobulin superfamily—CTLA-4

1987 • 1,214 citations

Long-Term Survival of Xenogeneic Pancreatic Islet Grafts Induced by CTLA4lg

1992 • 1,156 citations

Immunosuppression in Vivo by a Soluble Form of the CTLA-4 T Cell Activation Molecule

1992 • 820 citations

CTLA-4 ligation blocks CD28-dependent T cell activation.

1996 • 787 citations

Differential effects of anti-B7-1 and anti-B7-2 monoclonal antibody treatment on the development of diabetes in the nonobese diabetic mouse.

1995 • 595 citations

Coexpression and functional cooperation of CTLA-4 and CD28 on activated T lymphocytes.

1992 • 592 citations

Functional evidence for epitope spreading in the relapsing pathology of experimental autoimmune encephalomyelitis.

1995 • 522 citations

Determinant spreading and the dynamics of the autoimmune T-cell repertoire

1993 • 467 citations

Blockade of CD28/B7-1 interaction prevents epitope spreading and clinical relapses of murine EAE

1995 • 326 citations

Antigen-dependent clonal expansion of a trace population of antigen-specific CD4+ T cells in vivo is dependent on CD28 costimulation and inhibited by CTLA-4.

1995 • 323 citations

Human Ig superfamily CTLA‐4 gene: chromosomal localization and identity of protein sequence between murine and human CTLA‐4 cytoplasmic domains

1988 • 296 citations

Induction of active and adoptive relapsing experimental autoimmune encephalomyelitis (EAE) using an encephalitogenic epitope of proteolipid protein

1992 • 231 citations

The immunopathogenesis and regulation of T-cell-mediated demyelinating diseases

1994 • 165 citations

INHIBITION OF TRANSPLANT REJECTION FOLLOWING TREATMENT WITH ANTI-B7-2 AND ANTI-B7-1 ANTIBODIES

1995 • 165 citations

Role of B7:CD28/CTLA-4 in the induction of chronic relapsing experimental allergic encephalomyelitis.

1995 • 153 citations

Costimulation of T lymphocytes with integrin ligands intercellular adhesion molecule-1 or vascular cell adhesion molecule-1 induces functional expression of CTLA-4, a second receptor for B7.

1994 • 93 citations

T cell co-stimulation and in vivo tolerance

1993 • 77 citations

Immunopathogenesis of multiple sclerosis.

1991 • 58 citations