Mapping autoimmunity genes

Germline Mutations in the Extracellular Domains of the 55 kDa TNF Receptor, TNFR1, Define a Family of Dominantly Inherited Autoinflammatory Syndromes

1999 • 1,363 citations

Clustering of non-major histocompatibility complex susceptibility candidate loci in human autoimmune diseases

1998 • 601 citations

New susceptibility locus for rheumatoid arthritis suggested by a genome-wide linkage study

1998 • 480 citations

Differential susceptibility of inbred mouse strains to dextran sulfate sodium-induced colitis

1998 • 389 citations

A Genomewide Analysis Provides Evidence for Novel Linkages in Inflammatory Bowel Disease in a Large European Cohort

1999 • 386 citations

A genome-wide search for susceptibility genes in human systemic lupus erythematosus sib-pair families

1998 • 362 citations

A Genome-wide Search for Linkage to Asthma22See the Appendix.

1999 • 351 citations

GENETIC SUSCEPTIBILITY TO SYSTEMIC LUPUS ERYTHEMATOSUS

1998 • 313 citations

The genetics revolution and the assault on rheumatoid arthritis

1999 • 285 citations

Linkage of the MHC to familial multiple sclerosis suggests genetic heterogeneity. The Multiple Sclerosis Genetics Group

1998 • 284 citations

MHC haplotype-dependent regulation of MOG-induced EAE in rats.

1998 • 257 citations

A radiation hybrid map of the rat genome containing 5,255 markers

1999 • 240 citations

Loci predisposing to autoimmunity in MRL-Fas lpr and C57BL/6-Faslpr mice.

1998 • 221 citations

Genetic control of arthritis onset, severity and chronicity in a model for rheumatoid arthritis in rats

1998 • 215 citations

A genome scan localizes five non–MHC loci controlling collagen–induced arthritis in rats

1996 • 212 citations

B-cell-deficient mice develop experimental allergic encephalomyelitis with demyelination after myelin oligodendrocyte glycoprotein sensitization.

1998 • 208 citations

A High-Density Integrated Genetic Linkage and Radiation Hybrid Map of the Laboratory Rat

1999 • 199 citations

Peripheral-antigen-expressing cells in thymic medulla: factors in self-tolerance and autoimmunity

1998 • 188 citations

Cutting Edge: B Cell-Deficient Mice Develop Experimental Allergic Encephalomyelitis with Demyelination After Myelin Oligodendrocyte Glycoprotein Sensitization

1998 • 177 citations

The genetics of multiple sclerosis: principles, background and updated results of the United Kingdom systematic genome screen

1998 • 173 citations

A genome-wide screen for susceptibility loci in ankylosing spondylitis

2004 • 167 citations

Genetic dissection of lupus pathogenesis: a recipe for nephrophilic autoantibodies

1999 • 166 citations

New Genetic Loci That Control Susceptibility and Symptoms of Experimental Allergic Encephalomyelitis in Inbred Mice

1998 • 151 citations

The genetics of human systemic lupus erythematosus

1998 • 147 citations

Myelin Oligodendrocyte Glycoprotein Induces Experimental Autoimmune Encephalomyelitis in the “Resistant” Brown Norway Rat: Disease Susceptibility Is Determined by MHC and MHC-Linked Effects on the B Cell Response

1999 • 144 citations

From genome to aetiology in a multifactorial disease, type 1 diabetes

1999 • 143 citations

Familial clustering of rheumatoid arthritis with other autoimmune diseases

1998 • 136 citations

Genetic linkage analysis of collagen-induced arthritis in the mouse

1998 • 134 citations

Multiple Lupus Susceptibility Loci Map to Chromosome 1 in BXSB Mice

1998 • 134 citations

Comparative genetics of type 1 diabetes and autoimmune disease: common loci, common pathways?

1999 • 128 citations

Genetic Epidemiology in Inflammatory Bowel Disease

1998 • 124 citations

Identification of rat susceptibility loci for adjuvant-oil-induced arthritis

1998 • 121 citations

Identification of Quantitative Trait Loci Governing Arthritis Severity and Humoral Responses in the Murine Model of Lyme Disease

1999 • 119 citations

Genetic Analysis of Disease Subtypes and Sexual Dimorphisms in Mouse Experimental Allergic Encephalomyelitis (EAE): Relapsing/Remitting and Monophasic Remitting/Nonrelapsing EAE Are Immunogenetically Distinct

1999 • 111 citations

Localization of Quantitative Trait Loci Regulating Adjuvant-Induced Arthritis in Rats: Evidence for Genetic Factors Common to Multiple Autoimmune Diseases

1998 • 110 citations

Subcongenic analysis of the Idd13 locus in NOD/Lt mice: evidence for several susceptibility genes including a possible diabetogenic role for beta 2-microglobulin.

1998 • 104 citations

Genomic screen for QTLs underlying alcohol consumption in the P and NP rat lines

1998 • 103 citations

A New Graves Disease–Susceptibility Locus Maps To Chromosome 20q11.2

1998 • 102 citations

Genetics of susceptibility to chronic experimental encephalomyelitis and arthritis

1998 • 90 citations

Multiplex inheritance of component phenotypes in a murine model of lupus

1999 • 90 citations

Linkage of a major quantitative trait locus toYaa gene-induced lupus-like nephritis in (NZW × C57BL/6)F1 mice

1998 • 85 citations

Quantitative trait loci disposing for both experimental arthritis and encephalomyelitis in the DA rat; impact on severity of myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis and antibody isotype pattern

1998 • 80 citations

Identification of a new non‐major histocompatibility complex genetic locus on chromosome 2 that controls disease severity in collagen‐induced arthritis in rats

1998 • 79 citations

Subcongenic Analysis of theIdd13Locus in NOD/Lt Mice: Evidence for Several Susceptibility Genes Including a Possible Diabetogenic Role for β2-Microglobulin

1998 • 79 citations

Localization of non-Mhccollagen-induced arthritis susceptibility loci in DBA/1j mice

1999 • 76 citations

A genome‐wide screen for susceptibility loci in ankylosing spondylitis

1998 • 76 citations

Genetics of Multiple Sclerosis

1998 • 74 citations

Susceptibility to lupus nephritis in the NZB/W model system

1998 • 74 citations

Genetic susceptibility factors in type 1 diabetes: linkage, disequilibrium and functional analyses

1998 • 73 citations

Animal models of rheumatoid arthritis and related inflammation

1999 • 72 citations

Genome-Wide Linkage Analysis of Chronic Relapsing Experimental Autoimmune Encephalomyelitis in the Rat Identifies a Major Susceptibility Locus on Chromosome 9

1999 • 70 citations

Identification of a new non-major histocompatibility complex genetic locus on chromosome 2 that controls disease severity in collagen-induced arthritis in rats

1998 • 66 citations

HLA-DQ6/8 Double Transgenic Mice Develop Auricular Chondritis Following Type II Collagen Immunization: A Model for Human Relapsing Polychondritis

1998 • 64 citations

A Genome-Wide Search Identifies Two Susceptibility Loci for Experimental Autoimmune Encephalomyelitis on Rat Chromosomes 4 and 10

1999 • 64 citations

Genetic Determinants of Autoimmune Disease and Coronary Vasculitis in the MRL-lpr/lprMouse Model of Systemic Lupus Erythematosus

1998 • 62 citations

The Genes of Systemic Autoimmunity

1999 • 52 citations

Non-major histocompatibility complex-linked diabetes susceptibility loci on chromosomes 4 and 13 in a backcross of the DP-BB/Wor rat to the WF rat.

1999 • 50 citations

Contributions ofEazandEbzMHC Genes to Lupus Susceptibility in New Zealand Mice

1998 • 49 citations

GENES IN THE SPONDYLOARTHROPATHIES

1998 • 49 citations

A Major Linkage Region on Distal Chromosome 4 Confers Susceptibility to Mouse Autoimmune Gastritis

1999 • 48 citations

Multigenic control of lupus‐associated antiphospholipid syndrome in a model of (NZW × BXSB) F1 mice

1998 • 45 citations

Control of separate pathogenic autoantibody responses marks MHC gene contributions to murine lupus

1999 • 44 citations

Genetic control of susceptibility to collagen-induced arthritis in T cell receptor ?-chain transgenic mice

1998 • 44 citations

Analysis of MHC Class II Genes in the Susceptibility to Lupus in New Zealand Mice

1999 • 40 citations

Multigenic control of lupus-associated antiphospholipid syndrome in a model of (NZW × BXSB) F1 mice

1998 • 38 citations

Theiler’s Virus Infection of Genetically Susceptible Mice Induces Central Nervous System-Infiltrating CTLs with no Apparent Viral or Major Myelin Antigenic Specificity

1998 • 35 citations

Genetic Factors Regulating Experimental Arthritis in Mice and Rats

1999 • 34 citations

Identification of a new quantitative trait locus on Chromosome 7 controlling disease severity of collagen-induced arthritis in rats

1999 • 34 citations

Localising Quantitative Trait Loci in the NOD Mouse Model of Type 1 Diabetes

1999 • 34 citations

Identification of genomic regions controlling experimental autoimmune uveoretinitis in rats

1999 • 33 citations

Mapping of Novel Genes Predisposing or Protecting Diabetes Development in the BB/OK Rat

1998 • 32 citations

An HLA-DRB1∗0402 derived peptide (HV3 65-79) prevents collagen-induced arthritis in HLA-DQ8 transgenic mice

1999 • 31 citations

Localization in rats of genetic loci regulating susceptibility to experimental erosive arthritis and related autoimmune diseases

1999 • 29 citations

Genetics of autoimmune diabetes in animal models

1998 • 28 citations

A gene map of the rat derived from linkage analysis and related regions in the mouse and human genomes

1999 • 25 citations

Genes in two major histocompatibility complex class I regions control selection, phenotype, and function of a rat Ly-49 natural killer cell subset

1999 • 25 citations

Pristane-induced arthritis in mice: V. Susceptibility to pristane-induced arthritis is determined by the genetic regulation of the T cell repertoire

1998 • 22 citations

T-cell receptor Vbeta deletion and Valpha polymorphism are responsible for the resistance of SWR mouse to arthritis induction

1999 • 14 citations

Genetic Susceptibility to Spontaneous Lupus in Mice

1999 • 10 citations

An integrated rat genetic map: analysis of linkage conservation with the mouse and human maps

1999 • 8 citations

Genetics of Experimental Autoimmune Encephalomyelitis

1999 • 7 citations

Rat genetic map and a rat/mouse/human comparative gene map

1999 • 2 citations