Yeast DNA Polymerase η Utilizes an Induced-Fit Mechanism of Nucleotide Incorporation

The XPV (xeroderma pigmentosum variant) gene encodes human DNA polymerase η

1999 • 1,273 citations

Crystal structure of a bacteriophage T7 DNA replication complex at 2.2 Å resolution

1998 • 1,164 citations

hRAD30 Mutations in the Variant Form of Xeroderma Pigmentosum

1999 • 724 citations

Efficient Bypass of a Thymine-Thymine Dimer by Yeast DNA Polymerase, Polη

1999 • 719 citations

Xeroderma pigmentosum cells with normal levels of excision repair have a defect in DNA synthesis after UV-irradiation.

1975 • 617 citations

Crystal Structure of a Y-Family DNA Polymerase in Action

2001 • 602 citations

Analysis of numerical methods for computer simulation of kinetic processes: Development of KINSIM—A flexible, portable system

1983 • 597 citations

Pre-steady-state kinetic analysis of processive DNA replication including complete characterization of an exonuclease-deficient mutant

1991 • 495 citations

Mechanism and fidelity of HIV reverse transcriptase.

1992 • 484 citations

Fidelity of Human DNA Polymerase η

2000 • 395 citations

An induced-fit kinetic mechanism for DNA replication fidelity: direct measurement by single-turnover kinetics

1991 • 364 citations

Low fidelity DNA synthesis by human DNA polymerase-η

2000 • 362 citations

Kinetic mechanism of DNA polymerase I (Klenow)

1987 • 352 citations

Structure of the Catalytic Core of S. cerevisiae DNA Polymerase η

2001 • 341 citations

Efficient and accurate replication in the presence of 7,8-dihydro-8-oxoguanine by DNA polymerase η

2000 • 340 citations

DNA Polymerase II

1970 • 330 citations

Comparison between DNA melting thermodynamics and DNA polymerase fidelity.

1988 • 319 citations

The Saccharomyces cerevisiae RAD30 Gene, a Homologue of Escherichia coli dinB and umuC, Is DNA Damage Inducible and Functions in a Novel Error-Free Postreplication Repair Mechanism

1997 • 313 citations

An open and closed case for all polymerases

1999 • 310 citations

NMR structural studies of the ionizing radiation adduct 7-hydro-8-oxodeoxyguanosine (8-oxo-7H-dG) opposite deoxyadenosine in a DNA duplex. 8-Oxo-7H-dG(syn).cntdot.dA(anti) alignment at lesion site

1991 • 295 citations

Kinetic mechanism whereby DNA polymerase I (Klenow) replicates DNA with high fidelity

1988 • 278 citations

Ribozyme-catalyzed and nonenzymic reactions of phosphate diesters: rate effects upon substitution of sulfur for a nonbridging phosphoryl oxygen atom

1991 • 230 citations

CONTRASTING STRUCTURAL IMPACTS INDUCED BY cis‐syn CYCLOBUTANE DIMER AND (6–4) ADDUCT IN DNA DUPLEX DECAMERS: IMPLICATION IN MUTAGENESIS AND REPAIR ACTIVITY

1995 • 229 citations

Crystal Structure of a DNA Duplex Containing 8-Hydroxydeoxyguanine-Adenine Base Pairs

1994 • 225 citations

Kinetic mechanism of DNA polymerase I(Klenow fragment): identification of a second conformational change and evaluation of the internal equilibrium constant

1991 • 218 citations

X-ray structure of a DNA decamer containing 7,8-dihydro-8-oxoguanine.

1995 • 212 citations

NMR studies of a DNA containing 8-hydroxydeoxyguanosine

1991 • 209 citations

Kinetic characterization of the polymerase and exonuclease activities of the gene 43 protein of bacteriophage T4

1992 • 207 citations

Crystal Structure of a DinB Lesion Bypass DNA Polymerase Catalytic Fragment Reveals a Classic Polymerase Catalytic Domain

2001 • 199 citations

Role of DNA Polymerase η in the Bypass of a (6-4) TT Photoproduct

2001 • 195 citations

The mechanism of action of T7 DNA polymerase

1998 • 193 citations

[2] Rapid quench kinetic analysis of polymerases, adenosinetriphosphatases, and enzyme intermediates

1995 • 184 citations

Fidelity and Processivity of Saccharomyces cerevisiae DNA Polymerase η

1999 • 179 citations

Thymine dimers bend DNA.

1988 • 172 citations

Accuracy of thymine-thymine dimer bypass by Saccharomyces cerevisiae DNA polymerase eta

2000 • 170 citations

Evidence from mutation spectra that the UV hypermutability of xeroderma pigmentosum variant cells reflects abnormal, error-prone replication on a template containing photoproducts.

1993 • 158 citations

DNA Structure and Aspartate 276 Influence Nucleotide Binding to Human DNA Polymerase β

2001 • 151 citations

Replication past O⁶-Methylguanine by Yeast and Human DNA Polymerase η

2000 • 136 citations

Rate-limiting steps in the DNA polymerase I reaction pathway

1985 • 133 citations

Requirement of DNA Polymerase η for Error-Free Bypass of UV-Induced CC and TC Photoproducts

2001 • 132 citations

A tetrahedral intermediate in the EPSP synthase reaction observed by rapid quench kinetics

1988 • 130 citations

The nucleotide analog 2-aminopurine as a spectroscopic probe of nucleotide incorporation by the Klenow fragment of Escherichia coli polymerase I and bacteriophage T4 DNA polymerase

1995 • 128 citations

Replication Fork Bypass of a Pyrimidine Dimer Blocking Leading Strand DNA Synthesis

1997 • 123 citations

DNA Polymerase β: Structure−Fidelity Relationship from Pre-Steady-State Kinetic Analyses of All Possible Correct and Incorrect Base Pairs for Wild Type and R283A Mutant

1997 • 119 citations

¹H NMR study of the exchangeable protons of the duplex d(GCGTTGCG).d(CGCAACGC) containing a thymine photodimer containing a thymine photodimer

1987 • 113 citations

Inefficient Bypass of an Abasic Site by DNA Polymerase η

2001 • 107 citations

Requirement of DNA Polymerase Activity of Yeast Rad30 Protein for Its Biological Function

1999 • 105 citations

Determination of pyrimidine dimer unwinding angle by measurement of DNA electrophoretic mobility

1982 • 96 citations

DNA Polymerase β: Multiple Conformational Changes in the Mechanism of Catalysis

1997 • 96 citations

Ultraviolet Hypermutablity of a Shuttle Vector Propagated in Xeroderma Pigmentosum Variant Cells

1993 • 68 citations

DNA polymerase β

2002 • 67 citations

Kinetic Analysis of Nucleotide Incorporation by Mammalian DNA Polymerase δ

2000 • 56 citations

Translesion DNA Synthesis by Yeast DNA Polymerase η on Templates Containing N 2-Guanine Adducts of 1,3-Butadiene Metabolites

2001 • 39 citations

Advances in transient-state kinetics

1998 • 38 citations