DNA Damage Control by Novel DNA Polymerases: Translesion Replication and Mutagenesis

DNA Repair and Mutagenesis

2006 • 4,725 citations

DNA repair and mutagenesis

1996 • 2,289 citations

Inactivation of Antibiotics and the Dissemination of Resistance Genes

1994 • 1,766 citations

The XPV (xeroderma pigmentosum variant) gene encodes human DNA polymerase η

1999 • 1,273 citations

Biochemistry of homologous recombination in Escherichia coli

1994 • 1,195 citations

Detection of carcinogens as mutagens: bacterial tester strains with R factor plasmids.

1975 • 1,030 citations

hRAD30 Mutations in the Variant Form of Xeroderma Pigmentosum

1999 • 724 citations

Efficient Bypass of a Thymine-Thymine Dimer by Yeast DNA Polymerase, Polη

1999 • 719 citations

FIDELITY MECHANISMS IN DNA REPLICATION

1991 • 709 citations

Molecular Mechanisms for Repair of DNA

1975 • 676 citations

Thymine-Thymine Dimer Bypass by Yeast DNA Polymerase ζ

1996 • 655 citations

Eukaryotic polymerases ι and ζ act sequentially to bypass DNA lesions

2000 • 621 citations

ESCHERICHIA COLI SINGLE-STRANDED DNA-BINDING PROTEIN: Multiple DNA-Binding Modes and Cooperativities

1994 • 604 citations

Deoxycytidyl transferase activity of yeast REV1 protein

1996 • 566 citations

UmuD′ ₂ C is an error-prone DNA polymerase, Escherichia coli pol V

1999 • 524 citations

Mechanisms of accurate translesion synthesis by human DNA polymerase eta

2000 • 496 citations

The dinB Gene Encodes a Novel E. coli DNA Polymerase, DNA Pol IV, Involved in Mutagenesis

1999 • 469 citations

Roles of E. coli DNA polymerases IV and V in lesion-targeted and untargeted SOS mutagenesis

2000 • 444 citations

A model for replication repair in mammalian cells

1976 • 443 citations

The RecA Protein: Structure and Functio

1990 • 409 citations

All three SOS-inducible DNA polymerases (Pol II, Pol IV and Pol V) are involved in induced mutagenesis

2000 • 399 citations

Fidelity of Human DNA Polymerase η

2000 • 395 citations

Developmental Control of Cell Cycle Regulators: A Fly's Perspective

1996 • 383 citations

The Mutagenesis Protein UmuC Is a DNA Polymerase Activated by UmuD′, RecA, and SSB and Is Specialized for Translesion Replication

1999 • 371 citations

Low fidelity DNA synthesis by human DNA polymerase-η

2000 • 362 citations

Efficient and accurate replication in the presence of 7,8-dihydro-8-oxoguanine by DNA polymerase η

2000 • 340 citations

Multiple pathways for SOS-induced mutagenesis in Escherichia coli : An overexpression of dinB / dinP results in strongly enhancing mutagenesis in the absence of any exogenous treatment to damage DNA

1997 • 328 citations

polι, a remarkably error-prone human DNA polymerase

2000 • 309 citations

A human homolog of the Saccharomyces cerevisiae REV3 gene, which encodes the catalytic subunit of DNA polymerase ζ

1998 • 300 citations

Error-free and error-prone lesion bypass by human DNA polymerase kappa in vitro

2000 • 294 citations

Error-prone bypass of certain DNA lesions by the human DNA polymerase κ

2000 • 274 citations

DNA polymerase mu (Pol micro), homologous to TdT, could act as a DNA mutator in eukaryotic cells

2000 • 263 citations

DNA polymerase lambda (Pol λ), a novel eukaryotic DNA polymerase with a potential role in meiosis 1 1Edited by M. Yaniv

2000 • 260 citations

Homologous and non-homologous recombination differentially affect DNA damage repair in mice

2000 • 245 citations

A plethora of lesion-replicating DNA polymerases

1999 • 244 citations

MSH2 and MSH6 Are Required for Removal of Adenine Misincorporated Opposite 8-Oxo-Guanine in S. cerevisiae

1999 • 230 citations

UmuC mutagenesis protein of Escherichia coli: purification and interaction with UmuD and UmuD'.

1989 • 222 citations

Fidelity and Processivity of DNA Synthesis by DNA Polymerase κ, the Product of the Human DINB1 Gene

2000 • 222 citations

Eukaryotic DNA polymerases, a growing family

2000 • 220 citations

Recombinational DNA Repair in Bacteria and the RecA Protein

1999 • 213 citations

Efficient Translesion Replication Past Oxaliplatin and Cisplatin GpG Adducts by Human DNA Polymerase η

2000 • 207 citations

Mutagenic potency of exocyclic DNA adducts: marked differences between Escherichia coli and simian kidney cells.

1994 • 202 citations

Biochemical basis of SOS-induced mutagenesis in Escherichia coli : Reconstitution of in vitro lesion bypass dependent on the UmuD′ ₂ C mutagenic complex and RecA protein

1998 • 202 citations

Activity of the purified mutagenesis proteins UmuC, UmuD', and RecA in replicative bypass of an abasic DNA lesion by DNA polymerase III.

1992 • 199 citations

Preferential Incorporation of G Opposite Template T by the Low-Fidelity Human DNA Polymerase ι

2000 • 195 citations

Pol κ: A DNA Polymerase Required for Sister Chromatid Cohesion

2000 • 188 citations

Error-prone lesion bypass by human DNA polymerase eta

2000 • 188 citations

5'-Deoxyribose Phosphate Lyase Activity of Human DNA Polymerase ɩ in Vitro

2001 • 186 citations

The human DINB1 gene encodes the DNA polymerase Polθ

2000 • 182 citations

A Human REV7 Homolog That Interacts with the Polymerase ζ Catalytic Subunit hREV3 and the Spindle Assembly Checkpoint Protein hMAD2

2000 • 178 citations

The human REV1 gene codes for a DNA template-dependent dCMP transferase

1999 • 176 citations

Disruption of the developmentally regulated Rev3l gene causes embryonic lethality

2000 • 175 citations

The function of the human homolog of Saccharomyces cerevisiae REV1 is required for mutagenesis induced by UV light

2000 • 172 citations

DNA polymerase zeta and the control of DNA damage induced mutagenesis in eukaryotes.

1996 • 169 citations

Disruption of the Rev3l-encoded catalytic subunit of polymerase ζ in mice results in early embryonic lethality

2000 • 165 citations

Two novel human and mouse DNA polymerases of the polX family

2000 • 164 citations

Escherichia coli DNA Polymerase IV Mutator Activity: Genetic Requirements and Mutational Specificity

2000 • 161 citations

Disruption of mouse polymerase ζ (Rev3) leads to embryonic lethality and impairs blastocyst development in vitro

2000 • 154 citations

SOS functions, cancer and inducible evolution

1981 • 147 citations

Specificity of DNA Lesion Bypass by the Yeast DNA Polymerase η

2000 • 145 citations

Bridging the gap: A family of novel DNA polymerases that replicate faulty DNA

1999 • 135 citations

The contribution of homologous recombination in preserving genome integrity in mammalian cells

1999 • 132 citations

The Mutagenesis Proteins UmuD′ and UmuC Prevent Lethal Frameshifts While Increasing Base Substitution Mutations

1998 • 132 citations

Role of RecA protein in untargeted UV mutagenesis of bacteriophage lambda: evidence for the requirement for the dinB gene.

1986 • 128 citations

A model for SOS-lesion-targeted mutations in Escherichia coli

2001 • 128 citations

Replication of Damaged DNA and the Molecular Mechanism of Ultraviolet Light Mutagenesis

1993 • 124 citations

Purification and Characterization of polκ, a DNA Polymerase Encoded by the Human DINB1 Gene

2001 • 117 citations

Cloning and Chromosomal Mapping of the Human DNA Polymerase θ (POLQ), the Eighth Human DNA Polymerase

1999 • 117 citations

Highly mutagenic replication by DNA polymerase V (UmuC) provides a mechanistic basis for SOS untargeted mutagenesis

2000 • 115 citations

Genetic requirements and mutational specificity of the Escherichia coli SOS mutator activity

1997 • 113 citations

Replication of damaged DNA: molecular defect in Xeroderma pigmentosum variant cells

1999 • 112 citations

Targeting of the UmuD, UmuD', and MucA' mutagenesis proteins to DNA by RecA protein.

1993 • 110 citations

Human DNA polymerase kappa synthesizes DNA with extraordinarily low fidelity

2000 • 108 citations

Purification of a Soluble UmuD′C Complex from Escherichia coli

1996 • 105 citations

Coping with replication ‘train wrecks’ in Escherichia coli using Pol V, Pol II and RecA proteins

2000 • 105 citations

Mutagenesis induced by bacterial UmuDC proteins and their plasmid homologues

1992 • 104 citations

SOS-regulated proteins in translesion DNA synthesis and mutagenesis

1995 • 101 citations

Role of thedinBGene Product in Spontaneous Mutation inEscherichia coliwith an Impaired Replicative Polymerase

2000 • 93 citations

Targeted and Untargeted Mutagenesis by Various Inducers of SOS Functions in Escherichia coli

1979 • 88 citations

Non-targeted mutagenesis of unirradiated lambda phage in Escherichia coli host cells irradiated with ultraviolet light

1984 • 79 citations

Coding Properties of a Unique Apurinic/Apyrimidinic Site Replicated in Mammalian Cells

1994 • 63 citations

Cellular strategies for accommodating replication-hindering adducts in DNA: control by the SOS response in Escherichia coli.

1996 • 57 citations

Plasmid-encoded MucB protein is a DNA polymerase (pol RI) specialized for lesion bypass in the presence of MucA′, RecA, and SSB

2000 • 55 citations

SOS mutator effect in E. coli mutants deficient in mismatch correction.

1984 • 52 citations

Lesion Bypass by the Escherichia coli DNA Polymerase V Requires Assembly of a RecA Nucleoprotein Filament

2001 • 47 citations

The Mutagenesis Protein MucB Interacts with Single Strand DNA Binding Protein and Induces a Major Conformational Change in Its Complex with Single-stranded DNA

1998 • 32 citations

Translesion DNA synthesis: polymerase response to altered nucleotides.

1985 • 26 citations

Discrimination between Translesion Synthesis and Template Switching during Bypass Replication of Thymine Dimers in Duplex DNA

2000 • 10 citations