The Fidelity of Human DNA Polymerase γ with and without Exonucleolytic Proofreading and the p55 Accessory Subunit

Sequence and organization of the human mitochondrial genome

1981 • 9,348 citations

Rapid evolution of animal mitochondrial DNA.

1979 • 3,420 citations

Mitochondrial Diseases in Man and Mouse

1999 • 3,008 citations

Mitochondrial DNA sequences of primates: Tempo and mode of evolution

1982 • 1,578 citations

Frameshift Mutations and the Genetic Code

1966 • 1,400 citations

DISEASES OF THE MITOCHONDRIAL DNA

1992 • 1,294 citations

Crystal structure of a bacteriophage T7 DNA replication complex at 2.2 Å resolution

1998 • 1,164 citations

DNA Replication Fidelity

2000 • 980 citations

Facile Detection of Mitochondrial DNA Mutations in Tumors and Bodily Fluids

2000 • 808 citations

A pattern of accumulation of a somatic deletion of mitochondrial DNA in aging human tissues.

1992 • 633 citations

DNA MISMATCH REPAIR AND GENETIC INSTABILITY

2000 • 601 citations

Repair of Oxidative Damage to Nuclear and Mitochondrial DNA in Mammalian Cells

1997 • 508 citations

MITOMAP: a human mitochondrial genome database

1996 • 458 citations

Mitochondrial DNA in human malignancy

2001 • 438 citations

Characterization of insertion mutations in the Saccharomyces cerevisiae MSH1 and MSH2 genes: evidence for separate mitochondrial and nuclear functions.

1992 • 353 citations

DNA polymerase insertion fidelity. Gel assay for site-specific kinetics.

1987 • 332 citations

The mutational specificity of DNA polymerase-beta during in vitro DNA synthesis. Production of frameshift, base substitution, and deletion mutations.

1985 • 317 citations

Misalignment-mediated DNA synthesis errors

1990 • 306 citations

The development of mitochondrial medicine.

1994 • 296 citations

Base mispair extension kinetics. Comparison of DNA polymerase alpha and reverse transcriptase.

1990 • 293 citations

Cloning and Characterization of the Human Mitochondrial DNA Polymerase, DNA Polymerase γ

1996 • 277 citations

Repair of mitochondrial DNA after various types of DNA damage in Chinese hamster ovary cells

1992 • 269 citations

Mutagenesis by transient misalignment.

1988 • 265 citations

Sliding Clamps of DNA Polymerases

1993 • 250 citations

Nearest Neighbor Influences on DNA Polymerase Insertion Fidelity

1989 • 247 citations

Mitochondrial DNA repair pathways

1999 • 241 citations

The Mitochondrial p55 Accessory Subunit of Human DNA Polymerase γ Enhances DNA Binding, Promotes Processive DNA Synthesis, and Confers N-Ethylmaleimide Resistance

1999 • 223 citations

Identification of 5′-deoxyribose phosphate lyase activity in human DNA polymerase γ and its role in mitochondrial base excision repair in vitro

1998 • 220 citations

Escherichia coli thioredoxin stabilizes complexes of bacteriophage T7 DNA polymerase and primed templates.

1987 • 207 citations

[18] Analyzing fidelity of DNA polymerases

1995 • 201 citations

Efficient Repair of Abasic Sites in DNA by Mitochondrial Enzymes

1998 • 191 citations

In Vivo Functional Analysis of the Human Mitochondrial DNA Polymerase POLG Expressed in Cultured Human Cells

2000 • 184 citations

Mitochondrial mutational spectra in human cells and tissues

1997 • 181 citations

Repair of oxidative damage within the mitochondrial DNA of RINr 38 cells.

1993 • 175 citations

Characterization of the Native and Recombinant Catalytic Subunit of Human DNA Polymerase γ: Identification of Residues Critical for Exonuclease Activity and Dideoxynucleotide Sensitivity

1998 • 173 citations

Exonucleolytic proofreading enhances the fidelity of DNA synthesis by chick embryo DNA polymerase-gamma.

1988 • 167 citations

Microsatellite instability in the mitochondrial DNA of colorectal carcinomas: Evidence for mismatch repair systems in mitochondrial genome

1998 • 156 citations

An Oxidative Damage-specific Endonuclease from Rat Liver Mitochondria

1997 • 152 citations

Crystal Structure and Deletion Analysis Show that the Accessory Subunit of Mammalian DNA Polymerase γ, PolγB, Functions as a Homodimer

2001 • 151 citations

Repair of DNA damage in mitochondria

1999 • 150 citations

Exonuclease Proofreading by Human Mitochondrial DNA Polymerase

2001 • 148 citations

Human Mitochondrial DNA Polymerase Holoenzyme: Reconstitution and Characterization

2000 • 141 citations

Purification and identification of subunit structure of the human mitochondrial DNA polymerase.

1992 • 140 citations

Yeast mitochondrial DNA mutators with deficient proofreading exonucleolytic activity.

1992 • 137 citations

The Fidelity of DNA Polymerase β during Distributive and Processive DNA Synthesis

1999 • 134 citations

Effect of DNA Polymerases and High Mobility Group Protein 1 on the Carrier Ligand Specificity for Translesion Synthesis past Platinum−DNA Adducts

1999 • 133 citations

Fidelity of Nucleotide Incorporation by Human Mitochondrial DNA Polymerase

2001 • 123 citations

Construction of Transgenic Mice with Tissue-Specific Acceleration of Mitochondrial DNA Mutagenesis

2000 • 122 citations

Mitochondrial mutagenesis in human cells and tissues

1999 • 118 citations

Repair of alkylation and oxidative damage in mitochondrial DNA

1999 • 113 citations

Exonucleolytic Proofreading during Replication of Repetitive DNA

1996 • 111 citations

Error-prone replication of repeated DNA sequences by T7 DNA polymerase in the absence of its processivity subunit.

1994 • 108 citations

Single-nucleotide patch base excision repair of uracil in DNA by mitochondrial protein extracts#

1999 • 90 citations

The Role of 3′-5′ Exonucleolytic Proofreading and Mismatch Repair in Yeast Mitochondrial DNA Error Avoidance

1998 • 87 citations

Purification of nuclear and mitochondrial uracil-DNA glycosylase from rat liver. Identification of two distinct subcellular forms

1985 • 87 citations

The accessory subunit of mtDNA polymerase shares structural homology with aminoacyl-tRNA synthetases: Implications for a dual role as a primer recognition factor and processivity clamp

1999 • 87 citations

Analysis of microsatellite mutations in the mitochondrial DNA of Saccharomyces cerevisiae

2000 • 87 citations

Expression, Purification, and Initial Kinetic Characterization of the Large Subunit of the Human Mitochondrial DNA Polymerase

1998 • 83 citations

DNA damage in brain mitochondria caused by aging and MPTP treatment

2000 • 78 citations

Efficient Incorporation of Anti-HIV Deoxynucleotides by Recombinant Yeast Mitochondrial DNA Polymerase

1995 • 73 citations

Exonucleolytic proofreading by a mammalian DNA polymerase .gamma.

1989 • 70 citations

Streisinger Revisited: DNA Synthesis Errors Mediated by Substrate Misalignments

2000 • 67 citations

Catalytic Subunit of Mitochondrial DNA Polymerase from Embryos

1996 • 52 citations

Proliferating Cell Nuclear Antigen Promotes Misincorporation Catalyzed by Calf Thymus DNA Polymerase δ

1996 • 52 citations

Oxidative stress is not an obligate mediator of disease provoked by mitochondrial DNA mutations

2001 • 51 citations

Protein sequences conserved in prokaryotic aminoacyl-tRNA synthetases are important for the activity of the processivity factor of human mitochondrial DNA polymerase

2000 • 51 citations

Properties of the 3‘ to 5‘ exonuclease associated with porcine liver DNA polymerase gamma. Substrate specificity, product analysis, inhibition, and kinetics of terminal excision.

1991 • 51 citations

The gamma subfamily of DNA polymerases: cloning of a developmentally regulated cDNA encoding Xenopus laevis mitochondrial DNA polymerase gamma

1996 • 50 citations

Mismatch-specific 3'----5' exonuclease associated with the mitochondrial DNA polymerase from Drosophila embryos.

1989 • 44 citations

3‘–>5‘ exonuclease in Drosophila mitochondrial DNA polymerase. Substrate specificity and functional coordination of nucleotide polymerization and mispair hydrolysis

1992 • 44 citations

DNA polymerase γ from Xenopus laevis

1989 • 43 citations

Eukaryotic DNA replication

1989 • 42 citations

Differential Regulation of the Catalytic and Accessory Subunit Genes of Drosophila Mitochondrial DNA Polymerase

2000 • 36 citations

Deletion errors generated during replication of CAG repeats

1999 • 31 citations

Characterization of a new DNA polymerase from Schizosaccharomyces pombe: a probable homologue of the Saccharomyces cerevisiae DNA polymerase gamma

1995 • 29 citations

Multiple Regions of Subunit Interaction in Drosophila Mitochondrial DNA Polymerase: Three Functional Domains in the Accessory Subunit

2001 • 26 citations