Dissecting the Fidelity of Bacteriophage RB69 DNA Polymerase: Site-Specific Modulation of Fidelity by Polymerase Accessory Proteins

The Complete Genome Sequence of Escherichia coli K-12

1997 • 7,325 citations

Frameshift Mutations and the Genetic Code

1966 • 1,400 citations

A constant rate of spontaneous mutation in DNA-based microbes.

1991 • 1,194 citations

Crystal structure of a bacteriophage T7 DNA replication complex at 2.2 Å resolution

1998 • 1,164 citations

DNA Replication Fidelity

2000 • 980 citations

Molecular Biology of Bacteriophage T4

1994 • 881 citations

Crystal Structure of a Y-Family DNA Polymerase in Action

2001 • 602 citations

Compilation, alignment, and phylogenetic relationships of DNA polymerases

1993 • 590 citations

CONFORMATIONAL COUPLING IN DNA POLYMERASE FIDELITY

1993 • 558 citations

Structure of the Replicating Complex of a Pol α Family DNA Polymerase

2001 • 536 citations

Crystal Structure of a pol α Family Replication DNA Polymerase from Bacteriophage RB69

1997 • 431 citations

Building a Replisome from Interacting Pieces

1999 • 368 citations

The mutational specificity of DNA polymerase-beta during in vitro DNA synthesis. Production of frameshift, base substitution, and deletion mutations.

1985 • 317 citations

A thymidine triphosphate shape analog lacking Watson–Crick pairing ability is replicated with high sequence selectivity

1997 • 309 citations

Spectra of spontaneous mutations in Escherichia coli strains defective in mismatch correction: the nature of in vivo DNA replication errors.

1987 • 291 citations

Mutagenesis by transient misalignment.

1988 • 265 citations

Structural intermediates of deletion mutagenesis: a role for palindromic DNA.

1984 • 251 citations

The Fidelity of Human DNA Polymerase γ with and without Exonucleolytic Proofreading and the p55 Accessory Subunit

2001 • 248 citations

Hydrogen bonding revisited: Geometric selection as a principal determinant of DNA replication fidelity

1997 • 214 citations

Crystal structure of a thermostable type B DNA polymerase from Thermococcus gorgonarius

1999 • 208 citations

[18] Analyzing fidelity of DNA polymerases

1995 • 201 citations

Frameshift mutagenesis by eucaryotic DNA polymerases in vitro.

1986 • 177 citations

The fidelity of DNA synthesis catalyzed by derivatives of Escherichia coli DNA polymerase I.

1990 • 169 citations

Error induction and correction by mutant and wild type T4 DNA polymerases. Kinetic error discrimination mechanisms.

1979 • 167 citations

Fidelity of replication of phage phi X174 DNA by DNA polymerase III holoenzyme: spontaneous mutation by misincorporation.

1979 • 165 citations

Abasic Translesion Synthesis by DNA Polymerase β Violates the “A-rule”

1997 • 163 citations

Crystal structure of DNA polymerase from hyperthermophilic archaeon Pyrococcus kodakaraensis KOD111Edited by R. Huber

2001 • 157 citations

Crystal structure of a pol α family DNA polymerase from the hyperthermophilic archaeon Thermococcus sp . 9°N-7 1 1Edited by D. Rees

2000 • 139 citations

Frameshift errors initiated by nucleotide misincorporation.

1990 • 136 citations

Fidelity of Nucleotide Incorporation by Human Mitochondrial DNA Polymerase

2001 • 123 citations

Error-prone replication of repeated DNA sequences by T7 DNA polymerase in the absence of its processivity subunit.

1994 • 108 citations

On the fidelity of DNA replication. Effect of the next nucleotide on proofreading.

1981 • 107 citations

Functional Hydrogen-Bonding Map of the Minor Groove Binding Tracks of Six DNA Polymerases

2000 • 100 citations

Structure and function of the bacteriophage T4 DNA polymerase holoenzyme

1992 • 96 citations

Modular Organization of T4 DNA Polymerase

1995 • 93 citations

DNA Replication Errors Produced by the Replicative Apparatus of Escherichia coli

1999 • 85 citations

Processiveness of DNA polymerases. A comparative study using a simple procedure.

1979 • 77 citations

Kinetic Analysis of Base Substitution Mutagenesis by Transient Misalignment of DNA and by Miscoding

1989 • 70 citations

Streisinger Revisited: DNA Synthesis Errors Mediated by Substrate Misalignments

2000 • 67 citations

Statistical approaches for analyzing mutational spectra: some recommendations for categorical data.

1994 • 62 citations

The Base Substitution and Frameshift Fidelity of Escherichia coli DNA Polymerase III Holoenzyme in Vitro

1998 • 59 citations

Interacting Fidelity Defects in the Replicative DNA Polymerase of Bacteriophage RB69

2001 • 54 citations

Proliferating Cell Nuclear Antigen Promotes Misincorporation Catalyzed by Calf Thymus DNA Polymerase δ

1996 • 52 citations

Are DNA precursors concentrated at replication sites?

1982 • 51 citations

Fidelity and Error Specificity of the α Catalytic Subunit of Escherichia coli DNA Polymerase III

1996 • 44 citations

DNA polymerase of the T4-related bacteriophages

2000 • 43 citations

Replication of Template-Primers Containing Propanodeoxyguanosine by DNA Polymerase β

1997 • 42 citations

Divergence of a DNA Replication Gene Cluster in the T4-Related Bacteriophage RB69

1998 • 41 citations

Effect of accessory proteins on T4 DNA polymerase replication fidelity

1998 • 39 citations

Functional Consequences and Exonuclease Kinetic Parameters of Point Mutations in Bacteriophage T₄ DNA Polymerase

1996 • 39 citations

Products of bacteriophage T4 genes 32 and 45 improve the accuracy of DNA replication in vitro.

1983 • 39 citations

Conditional Coupling of Leading-strand and Lagging-strand DNA Synthesis at Bacteriophage T4 Replication Forks

2001 • 35 citations

Specificity and efficiency of editing of mismatches involved in the formation of base-substitution mutations by the 3'----5' exonuclease activity of phage T4 DNA polymerase.

1987 • 23 citations

Error induction and correction by mutant and wild type T4 DNA polymerases

1979 • 23 citations

Retention of replication fidelity by a DNA polymerase functioning in a distantly related environment

1997 • 23 citations

Resolving a Fidelity Paradox

2002 • 20 citations

MOLECULAR ASPECTS OF THE INTERACTIONS OF T4-CODED GENE 32-PROTEIN AND DNA POLYMERASE (GENE 43-PROTEIN) WITH NUCLEIC ACIDS

1980 • 13 citations