Structural Insights into the Origins of DNA Polymerase Fidelity

Molecular Structure of Nucleic Acids: A Structure for Deoxyribose Nucleic Acid

1953 • 12,496 citations

DNA Repair and Mutagenesis

2006 • 4,725 citations

DNA repair and mutagenesis

1996 • 2,289 citations

Structure of a Covalently Trapped Catalytic Complex of HIV-1 Reverse Transcriptase: Implications for Drug Resistance

1998 • 1,420 citations

The XPV (xeroderma pigmentosum variant) gene encodes human DNA polymerase η

1999 • 1,273 citations

Crystal structure of a bacteriophage T7 DNA replication complex at 2.2 Å resolution

1998 • 1,164 citations

Structure of large fragment of Escherichia coli DNA polymerase I complexed with dTMP

1985 • 855 citations

DNA Polymerases: Structural Diversity and Common Mechanisms

1999 • 814 citations

Error-Prone Repair DNA Polymerases in Prokaryotes and Eukaryotes

2002 • 730 citations

hRAD30 Mutations in the Variant Form of Xeroderma Pigmentosum

1999 • 724 citations

FIDELITY MECHANISMS IN DNA REPLICATION

1991 • 709 citations

Structures of ternary complexes of rat DNA polymerase beta, a DNA template-primer, and ddCTP.

1994 • 694 citations

Crystal structures of open and closed forms of binary and ternary complexes of the large fragment of Thermus aquaticus DNA polymerase I: structural basis for nucleotide incorporation

1998 • 682 citations

Eukaryotic polymerases ι and ζ act sequentially to bypass DNA lesions

2000 • 621 citations

Crystal Structure of a Y-Family DNA Polymerase in Action

2001 • 602 citations

Crystal Structures of Human DNA Polymerase β Complexed with Gapped and Nicked DNA: Evidence for an Induced Fit Mechanism^,

1997 • 601 citations

Structures of Ternary Complexes of Rat DNA Polymerase β, a DNA Template-Primer, and ddCTP

1994 • 587 citations

Deoxycytidyl transferase activity of yeast REV1 protein

1996 • 566 citations

CONFORMATIONAL COUPLING IN DNA POLYMERASE FIDELITY

1993 • 558 citations

Structure of the Replicating Complex of a Pol α Family DNA Polymerase

2001 • 536 citations

The dinB Gene Encodes a Novel E. coli DNA Polymerase, DNA Pol IV, Involved in Mutagenesis

1999 • 469 citations

Roles of E. coli DNA polymerases IV and V in lesion-targeted and untargeted SOS mutagenesis

2000 • 444 citations

Structure of the Catalytic Core of S. cerevisiae DNA Polymerase η

2001 • 341 citations

DNA Polymerase II

1970 • 330 citations

A-form Conformational Motifs in Ligand-bound DNA Structures

2000 • 325 citations

An open and closed case for all polymerases

1999 • 310 citations

polι, a remarkably error-prone human DNA polymerase

2000 • 309 citations

Structure of an adenine˙cytosine base pair in DNA and its implications for mismatch repair

1986 • 279 citations

Sulfolobus solfataricus P2 DNA polymerase IV (Dpo4): an archaeal DinB-like DNA polymerase with lesion-bypass properties akin to eukaryotic poleta

2001 • 227 citations

Crystal Structure of a DinB Lesion Bypass DNA Polymerase Catalytic Fragment Reveals a Classic Polymerase Catalytic Domain

2001 • 199 citations

Preferential Incorporation of G Opposite Template T by the Low-Fidelity Human DNA Polymerase ι

2000 • 195 citations

Interaction with PCNA Is Essential for Yeast DNA Polymerase η Function

2001 • 195 citations

Targeting of human DNA polymerase ι to the replication machinery via interaction with PCNA

2001 • 184 citations

Crystal structure of a DinB family error-prone DNA polymerase from Sulfolobus solfataricus.

2001 • 176 citations

Stimulation of DNA Synthesis Activity of Human DNA Polymerase κ by PCNA

2002 • 173 citations

The β clamp targets DNA polymerase IV to DNA and strongly increases its processivity

2000 • 170 citations

DNA Structure and Aspartate 276 Influence Nucleotide Binding to Human DNA Polymerase β

2001 • 151 citations

Structural design of a eukaryotic DNA repair polymerase: DNA polymerase β

2000 • 144 citations

Efficiency of Correct Nucleotide Insertion Governs DNA Polymerase Fidelity

2002 • 128 citations

Error-Prone DNA Polymerases

2001 • 127 citations

Insight into the Catalytic Mechanism of DNA Polymerase β: Structures of Intermediate Complexes^,

2001 • 118 citations

Deoxynucleoside Triphosphate and Pyrophosphate Binding Sites in the Catalytically Competent Ternary Complex for the Polymerase Reaction Catalyzed by DNA Polymerase I (Klenow Fragment)

1995 • 114 citations

Low Fidelity DNA Synthesis by a Y Family DNA Polymerase Due to Misalignment in the Active Site

2002 • 107 citations

The Escherichia coli SOS mutagenesis proteins UmuD and UmuD′ interact physically with the replicative DNA polymerase

1999 • 103 citations

Polymerase β simulations suggest that Arg258 rotation is a slow step rather than large subdomain motions per se 1 1Edited by B. Honig

2002 • 89 citations

Structural insights into DNA polymerase β fidelity: hold tight if you want it right

1998 • 88 citations

Reexamination of induced fit as a determinant of substrate specificity in enzymic reactions

1995 • 79 citations

Misincorporation and mispaired primer extension by human immunodeficiency virus reverse transcriptase.

1994 • 75 citations

Correlation of the Kinetics of Finger Domain Mutants in RB69 DNA Polymerase with Its Structure

2002 • 50 citations

Uniquely Altered DNA Replication Fidelity Conferred by an Amino Acid Change in the Nucleotide Binding Pocket of Human Immunodeficiency Virus Type 1 Reverse Transcriptase

1999 • 49 citations

Slow Rate of Phosphodiester Bond Formation Accounts for the Strong Bias that Taq DNA Polymerase Shows against 2‘,3‘-Dideoxynucleotide Terminators

1996 • 46 citations

Significance of the O-Helix Residues of Escherichia coli DNA Polymerase I in DNA Synthesis: Dynamics of the dNTP Binding Pocket

1996 • 43 citations

Mutants Affecting Nucleotide Recognition by T7 DNA Polymerase

1994 • 37 citations

DNA Lesion Bypass Polymerases Open Up

2001 • 25 citations