Structure-based interpretation of missense mutations in Y-family DNA polymerases and their implications for polymerase function and lesion bypass

Protein folding and association: Insights from the interfacial and thermodynamic properties of hydrocarbons

1991 • 5,267 citations

Structure of a Covalently Trapped Catalytic Complex of HIV-1 Reverse Transcriptase: Implications for Drug Resistance

1998 • 1,420 citations

The XPV (xeroderma pigmentosum variant) gene encodes human DNA polymerase η

1999 • 1,273 citations

Crystal structure of a bacteriophage T7 DNA replication complex at 2.2 Å resolution

1998 • 1,164 citations

Crystal structure of the eukaryotic DNA polymerase processivity factor PCNA

1994 • 899 citations

DNA Polymerases: Structural Diversity and Common Mechanisms

1999 • 814 citations

The complete genome of the crenarchaeon Sulfolobus solfataricus P2

2001 • 758 citations

Three-dimensional structure of the β subunit of E. coli DNA polymerase III holoenzyme: A sliding DNA clamp

1992 • 748 citations

hRAD30 Mutations in the Variant Form of Xeroderma Pigmentosum

1999 • 724 citations

Efficient Bypass of a Thymine-Thymine Dimer by Yeast DNA Polymerase, Polη

1999 • 719 citations

Crystal structures of open and closed forms of binary and ternary complexes of the large fragment of Thermus aquaticus DNA polymerase I: structural basis for nucleotide incorporation

1998 • 682 citations

Eukaryotic polymerases ι and ζ act sequentially to bypass DNA lesions

2000 • 621 citations

Crystal Structure of a Y-Family DNA Polymerase in Action

2001 • 602 citations

Compilation, alignment, and phylogenetic relationships of DNA polymerases

1993 • 590 citations

Isolation and characterization of mutants of Escherichia coli deficient in induction of mutations by ultraviolet light

1977 • 567 citations

Deoxycytidyl transferase activity of yeast REV1 protein

1996 • 566 citations

Structure of the Replicating Complex of a Pol α Family DNA Polymerase

2001 • 536 citations

Visualizing DNA replication in a catalytically active Bacillus DNA polymerase crystal

1998 • 520 citations

Roles of E. coli DNA polymerases IV and V in lesion-targeted and untargeted SOS mutagenesis

2000 • 444 citations

All three SOS-inducible DNA polymerases (Pol II, Pol IV and Pol V) are involved in induced mutagenesis

2000 • 399 citations

Fidelity of Human DNA Polymerase η

2000 • 395 citations

The Mutagenesis Protein UmuC Is a DNA Polymerase Activated by UmuD′, RecA, and SSB and Is Specialized for Translesion Replication

1999 • 371 citations

Low fidelity DNA synthesis by human DNA polymerase-η

2000 • 362 citations

Structure of the Catalytic Core of S. cerevisiae DNA Polymerase η

2001 • 341 citations

Compilation and alignment of DNA polymerase sequences

1991 • 339 citations

Complete Genome Sequence of an Aerobic Thermoacidophilic Crenarchaeon, Sulfolobus tokodaii strain7

2001 • 327 citations

A universal protein–protein interaction motif in the eubacterial DNA replication and repair systems

2001 • 325 citations

MUTANTS OF YEAST DEFECTIVE IN MUTATION INDUCED BY ULTRAVIOLET LIGHT

1971 • 321 citations

Crystal Structure of the Processivity Clamp Loader Gamma (γ) Complex of E. coli DNA Polymerase III

2001 • 313 citations

The Saccharomyces cerevisiae RAD30 Gene, a Homologue of Escherichia coli dinB and umuC, Is DNA Damage Inducible and Functions in a Novel Error-Free Postreplication Repair Mechanism

1997 • 313 citations

polι, a remarkably error-prone human DNA polymerase

2000 • 309 citations

SOS Mutator DNA Polymerase IV Functions in Adaptive Mutation and Not Adaptive Amplification

2001 • 300 citations

Error-free and error-prone lesion bypass by human DNA polymerase kappa in vitro

2000 • 294 citations

Domain structure, localization, and function of DNA polymerase η, defective in xeroderma pigmentosum variant cells

2001 • 275 citations

Error-prone bypass of certain DNA lesions by the human DNA polymerase κ

2000 • 274 citations

Uvm mutants of Escherichia coli K 12 deficient in UV mutagenesis

1978 • 233 citations

Physical and Functional Interactions of Human DNA Polymerase η with PCNA

2001 • 229 citations

Sulfolobus solfataricus P2 DNA polymerase IV (Dpo4): an archaeal DinB-like DNA polymerase with lesion-bypass properties akin to eukaryotic poleta

2001 • 227 citations

UmuC mutagenesis protein of Escherichia coli: purification and interaction with UmuD and UmuD'.

1989 • 222 citations

Fidelity and Processivity of DNA Synthesis by DNA Polymerase κ, the Product of the Human DINB1 Gene

2000 • 222 citations

umuDC and mucAB operons whose products are required for UV light- and chemical-induced mutagenesis: UmuD, MucA, and LexA proteins share homology.

1985 • 219 citations

Biochemical basis of SOS-induced mutagenesis in Escherichia coli : Reconstitution of in vitro lesion bypass dependent on the UmuD′ ₂ C mutagenic complex and RecA protein

1998 • 202 citations

Crystal Structure of a DinB Lesion Bypass DNA Polymerase Catalytic Fragment Reveals a Classic Polymerase Catalytic Domain

2001 • 199 citations

Evidence for a second function forSaccharomyces cerevisiaeRev1p

2000 • 197 citations

Preferential Incorporation of G Opposite Template T by the Low-Fidelity Human DNA Polymerase ι

2000 • 195 citations

Archaeal DNA Replication: Identifying the Pieces to Solve a Puzzle

1999 • 195 citations

Interaction with PCNA Is Essential for Yeast DNA Polymerase η Function

2001 • 195 citations

Human and mouse homologs of Escherichia coli DinB (DNA polymerase IV), members of the UmuC/DinB superfamily

1999 • 189 citations

Targeting of human DNA polymerase ι to the replication machinery via interaction with PCNA

2001 • 184 citations

Novel Human and Mouse Homologs of Saccharomyces cerevisiae DNA Polymerase η

1999 • 183 citations

The human DINB1 gene encodes the DNA polymerase Polθ

2000 • 182 citations

Crystal structure of a DinB family error-prone DNA polymerase from Sulfolobus solfataricus.

2001 • 176 citations

Stimulation of DNA Synthesis Activity of Human DNA Polymerase κ by PCNA

2002 • 173 citations

The β clamp targets DNA polymerase IV to DNA and strongly increases its processivity

2000 • 170 citations

Molecular analysis of mutations in DNA polymerase η in xeroderma pigmentosum-variant patients

2002 • 166 citations

Regulation of SOS mutagenesis by proteolysis.

1996 • 165 citations

Escherichia coli DNA Polymerase IV Mutator Activity: Genetic Requirements and Mutational Specificity

2000 • 161 citations

The REV1 gene of Saccharomyces cerevisiae: isolation, sequence, and functional analysis

1989 • 145 citations

Structural analysis of the umu operon required for inducible mutagenesis in Escherichia coli.

1985 • 138 citations

Deletion of the Saccharomyces cerevisiae gene RAD30 encoding an Escherichia coli DinB homolog confers UV radiation sensitivity and altered mutability

1998 • 134 citations

A model for SOS-lesion-targeted mutations in Escherichia coli

2001 • 128 citations

The appearance of the UmuD'C protein complex in Escherichia coli switches repair from homologous recombination to SOS mutagenesis

1993 • 127 citations

Unique misinsertion specificity of poliota may decrease the mutagenic potential of deaminated cytosines

2001 • 117 citations

Purification and Characterization of polκ, a DNA Polymerase Encoded by the Human DINB1 Gene

2001 • 117 citations

The processivity factor β controls DNA polymerase IV traffic during spontaneous mutagenesis and translesion synthesis in vivo

2002 • 115 citations

Specific RecA amino acid changes affect RecA–UmuD′C interaction

1998 • 113 citations

Purification of a Soluble UmuD′C Complex from Escherichia coli

1996 • 105 citations

Clamp loader structure predicts the architecture of DNA polymerase III holoenzyme and RFC

2001 • 101 citations

The two-step model of bacterial UV mutagenesis

1985 • 92 citations

Identification of a DinB/UmuC homolog in the archeon Sulfolobus solfataricus

1996 • 92 citations

A rapid method for cloning mutagenic DNA repair genes: isolation of umu-complementing genes from multidrug resistance plasmids R391, R446b, and R471a

1993 • 89 citations

Salmonella typhimurium has two homologous but different umuDC operons: cloning of a new umuDC-like operon (samAB) present in a 60-megadalton cryptic plasmid of S. typhimurium

1991 • 84 citations

Proofreading of DNA Polymerase η-dependent Replication Errors

2001 • 74 citations

dinP, a new gene in Escherichia coli, whose product shows similarities to UmuC and its homologues

1995 • 71 citations

Characterization of the umu-complementing operon from R391

1995 • 70 citations

Resistance to ultraviolet light in Pseudomonas syringae: sequence and functional analysis of the plasmid-encoded rulAB genes

1996 • 70 citations

Quantitation of the inhibition of hfr x F− recombination by the mutagenesis complex UmuD′C

1997 • 66 citations

Sequence analysis and mapping of the Salmonella typhimurium LT2 umuDC operon

1990 • 63 citations

Genomic structure, chromosomal localization and identification of mutations in the xeroderma pigmentosum variant (XPV) gene

2000 • 60 citations

Synthetic Activity of Sso DNA Polymerase Y1, an Archaeal DinB-like DNA Polymerase, Is Stimulated by Processivity Factors Proliferating Cell Nuclear Antigen and Replication Factor C

2001 • 56 citations

Mutations in human DNA polymerase eta motif II alter bypass of DNA lesions

2001 • 55 citations

Modulation of RecA Nucleoprotein Function by the Mutagenic UmuD′C Protein Complex

1998 • 54 citations

Mechanisms of dCMP Transferase Reactions Catalyzed by Mouse Rev1 Protein

2002 • 53 citations

umuDC -Mediated Cold Sensitivity Is a Manifestation of Functions of the UmuD ₂ C Complex Involved in a DNA Damage Checkpoint Control

2001 • 52 citations

In vivo stability of the Umu mutagenesis proteins: a major role for RecA

1996 • 50 citations

Structural characterization of the Salmonella typhimurium LT2 umu operon

1990 • 50 citations

Human DNA Polymerase ι Promiscuous Mismatch Extension

2001 • 49 citations

Lesion Bypass by the Escherichia coli DNA Polymerase V Requires Assembly of a RecA Nucleoprotein Filament

2001 • 47 citations

Acidic Residues Critical for the Activity and Biological Function of Yeast DNA Polymerase η

2001 • 47 citations

Three Proliferating Cell Nuclear Antigen-Like Proteins Found in the Hyperthermophilic Archaeon Aeropyrum pernix : Interactions with the Two DNA Polymerases

2002 • 44 citations

Visualization of two binding sites for the Escherichia coli UmuD′2C complex (DNA pol V) on RecA-ssDNA filaments

2000 • 42 citations

Isolation and characterization of novel plasmid-encoded umuC mutants

1994 • 41 citations

Escherichia coli umuDC mutants: DNA sequence alterations and UmuD cleavage

1992 • 38 citations

Specific amino acid changes enhance the anti‐recombination activity of the UmuD′C complex

2000 • 18 citations

Mutagenic DNA repair in Escherichia coli, XX. Overproduction of UmuD′ protein results in suppression of the umuC36 mutation in excision defective bacteria

1991 • 18 citations