In vitro evidence that UV-induced frameshift and substitution mutations at T tracts are the result of misalignment-mediated replication past a specific thymine dimer

DNA sequence analysis with a modified bacteriophage T7 DNA polymerase.

1987 • 2,266 citations

Frameshift Mutations and the Genetic Code

1966 • 1,400 citations

The structure of an oligo(dA)·oligo(dT) tract and its biological implications

1987 • 975 citations

SEQUENCE-DIRECTED CURVATURE OF DNA

1990 • 490 citations

Intrinsically bent DNA.

1990 • 428 citations

Escherichia coli thioredoxin confers processivity on the DNA polymerase activity of the gene 5 protein of bacteriophage T7.

1987 • 399 citations

UV-induced mutation hotspots occur at DNA damage hotspots

1982 • 397 citations

MOLECULAR MECHANISMS OF ULTRAVIOLET RADIATION CARCINOGENESIS

1990 • 385 citations

Genetic and Crystallographic Studies of the 3′,5′-Exonucleolytic Site of DNA Polymerase I

1988 • 344 citations

Cocrystal structure of an editing complex of Klenow fragment with DNA.

1988 • 324 citations

Misalignment-mediated DNA synthesis errors

1990 • 306 citations

The base substitution fidelity of eucaryotic DNA polymerases. Mispairing frequencies, site preferences, insertion preferences, and base substitution by dislocation.

1986 • 301 citations

MECHANISMS OF SPONTANEOUS AND INDUCED FRAMESHIFT MUTATION IN BACTERIOPHAGE T4

1985 • 292 citations

Mutagenic specificity of ultraviolet light

1985 • 282 citations

Selective Inactivation of the Exonuclease Activity of Bacteriophage T7 DNA Polymerase by in Vitro Mutagenesis

1989 • 258 citations

Photoproduct frequency is not the major determinant of UV base substitution hot spots or cold spots in human cells.

1987 • 242 citations

FRAMESHIFT MUTATION: DETERMINANTS OF SPECIFICITY

1990 • 238 citations

Escherichia coli thioredoxin stabilizes complexes of bacteriophage T7 DNA polymerase and primed templates.

1987 • 207 citations

Mutational specificity of a conditional Escherichia coli mutator, mutD5

1974 • 200 citations

Frequency and spectrum of mutations produced by a single cis-syn thymine-thymine cyclobutane dimer in a single-stranded vector.

1988 • 189 citations

The fidelity of DNA synthesis catalyzed by derivatives of Escherichia coli DNA polymerase I.

1990 • 169 citations

THE ACCOMMODATION OF NONCOMPLEMENTARY BASES IN HELICAL POLYRIBONUCLEOTIDES AND DEOXYRIBONUCLEIC ACIDS

1960 • 158 citations

Novel blunt-end addition reactions catalyzed by DNA polymerase I of Escherichia coli

1987 • 151 citations

Changes in DNA base sequence induced by targeted mutagenesis of lambda phage by ultraviolet light

1984 • 141 citations

Capacity of RecA protein to bind preferentially to UV lesions and inhibit the editing subunit (epsilon) of DNA polymerase III: a possible mechanism for SOS-induced targeted mutagenesis.

1986 • 137 citations

Frameshift errors initiated by nucleotide misincorporation.

1990 • 136 citations

Mechanisms of ultraviolet-induced mutation

1987 • 130 citations

Differential extension of 3′ mispairs is a major contribution to the high fidelity of calf thymus DNA polymerase-α

1989 • 129 citations

How DNA Travels between the Separate Polymerase and 3′-5′-Exonuclease Sites of DNA Polymerase I (Klenow Fragment)

1989 • 129 citations

Physical studies of DNA premelting equilibria in duplexes with and without homo dA.cntdot.dT tracts: correlations with DNA bending

1990 • 119 citations

Proton NMR assignment and melting temperature study of cis-syn and trans-syn thymine dimer containing duplexes of d(CGTATTATGC).cntdot.d(GCATAATACG)

1990 • 116 citations

Mutation induced by DNA damage: a many protein affair

1990 • 114 citations

¹H NMR study of the exchangeable protons of the duplex d(GCGTTGCG).d(CGCAACGC) containing a thymine photodimer containing a thymine photodimer

1987 • 113 citations

Site-specific effect of thymine dimer formation on dAn.dTn tract bending and its biological implications.

1991 • 107 citations

The three-dimensional structure of a DNA duplex containing looped-out bases

1988 • 99 citations

Sequence analysis of ultraviolet-induced mutations in M13lacZ hybrid phage DNA

1984 • 96 citations

Extrahelical adenosine stacks into right-handed DNA: solution conformation of the d(C-G-C-A-G-A-G-C-T-C-G-C-G) duplex deduced from distance geometry analysis of nuclear Overhauser effect spectra

1986 • 94 citations

The two-step model of bacterial UV mutagenesis

1985 • 92 citations

A domain of the klenow fragment of Escherichia coli DNA polymerase I has polymerase but no exonuclease activity

1986 • 90 citations

DNA bending by the bulge defect

1989 • 88 citations

Unpaired cytosine in the deoxyoligonucleotide duplex dCA3CA3G.cntdot.dCT6G is outside of the helix

1983 • 85 citations

Structural model for an oligonucleotide containing a bulged guanosine by NMR and energy minimization

1988 • 80 citations

Non-targeted mutagenesis of unirradiated lambda phage in Escherichia coli host cells irradiated with ultraviolet light

1984 • 79 citations

A building block for the sequence-specific introduction of cis-syn thymine dimers into oligonucleotides. Solid-phase synthesis of TpT[c,s]pTpT

1987 • 74 citations

Cis-syn thymine dimers are not absolute blocks to replication by DNA polymerase I of Escherichia coli in vitro

1990 • 70 citations

Comparison of ultraviolet irradiation-induced mutagenesis of the lacI gene in Escherichia coli and in human 293 cells

1989 • 69 citations

A REVIEW OF SOME TOPICS CONCERNING MUTAGENESIS BY ULTRAVIOLET LIGHT

1987 • 60 citations

DNA, sunlight, and skin cancer

1990 • 54 citations

N-Acetoxy-N-acetyl-2-aminofluorene-induced mutagenesis in the lacI gene of Escherichia coli

1990 • 54 citations

Ultraviolet-induced dimerization of non-adjacent pyrimidines

1988 • 35 citations

Mechanisms of frameshift mutagenesis by aflatoxin B1-2,3-dichloride

1987 • 35 citations

Ultraviolet light-induced mutagenesis in the Escherichia coli chromosome

1987 • 28 citations

Mutation induced in vitro on a C-8 guanine aminofluorene containing template by a modified T7 DNA polymerase

1989 • 16 citations