P bodies: at the crossroads of post-transcriptional pathways

MicroRNAs

2004 • 33,206 citations

Control of translation and mRNA degradation by miRNAs and siRNAs: Table 1.

2006 • 1,957 citations

Zebrafish MiR-430 Promotes Deadenylation and Clearance of Maternal mRNAs

2006 • 1,582 citations

Inhibition of Translational Initiation by Let-7 MicroRNA in Human Cells

2005 • 1,408 citations

Stress granules and processing bodies are dynamically linked sites of mRNP remodeling

2005 • 1,403 citations

Decapping and Decay of Messenger RNA Occur in Cytoplasmic Processing Bodies

2003 • 1,323 citations

Regulation by let-7 and lin-4 miRNAs Results in Target mRNA Degradation

2005 • 1,311 citations

Relief of microRNA-Mediated Translational Repression in Human Cells Subjected to Stress

2006 • 1,285 citations

MicroRNA-dependent localization of targeted mRNAs to mammalian P-bodies

2005 • 1,210 citations

RNA-Binding Proteins Tia-1 and Tiar Link the Phosphorylation of Eif-2α to the Assembly of Mammalian Stress Granules

1999 • 1,169 citations

MicroRNAs direct rapid deadenylation of mRNA

2006 • 1,114 citations

mRNA degradation by miRNAs and GW182 requires both CCR4:NOT deadenylase and DCP1:DCP2 decapping complexes

2006 • 1,006 citations

AU-rich elements and associated factors: are there unifying principles?

2005 • 976 citations

RNA granules

2006 • 946 citations

AU Binding Proteins Recruit the Exosome to Degrade ARE-Containing mRNAs

2001 • 859 citations

Involvement of MicroRNA in AU-Rich Element-Mediated mRNA Instability

2005 • 848 citations

The enzymes and control of eukaryotic mRNA turnover

2004 • 793 citations

Movement of Eukaryotic mRNAs Between Polysomes and Cytoplasmic Processing Bodies

2005 • 754 citations

Processing bodies require RNA for assembly and contain nontranslating mRNAs

2005 • 696 citations

A role for the P-body component GW182 in microRNA function

2005 • 670 citations

Cytoplasmic foci are sites of mRNA decay in human cells

2004 • 644 citations

Argonaute 2/RISC resides in sites of mammalian mRNA decay known as cytoplasmic bodies

2005 • 631 citations

General Translational Repression by Activators of mRNA Decapping

2005 • 630 citations

RNA-quality control by the exosome

2006 • 628 citations

staufen, a gene required to localize maternal RNAs in the Drosophila egg

1991 • 612 citations

Identification of Novel Argonaute-Associated Proteins

2005 • 533 citations

Moving messages: the intracellular localization of mRNAs

2005 • 531 citations

Neuronal RNA Granules

2001 • 518 citations

Deadenylation of the unstable mRNA encoded by the yeast MFA2 gene leads to decapping followed by 5'-->3' digestion of the transcript.

1994 • 511 citations

Translation Repression in Human Cells by MicroRNA-Induced Gene Silencing Requires RCK/p54

2006 • 505 citations

A crucial role for GW182 and the DCP1:DCP2 decapping complex in miRNA-mediated gene silencing

2005 • 491 citations

MK2-induced tristetraprolin:14-3-3 complexes prevent stress granule association and ARE-mRNA decay

2004 • 488 citations

Disruption of GW bodies impairs mammalian RNA interference

2005 • 487 citations

RNAi: The Nuts and Bolts of the RISC Machine

2005 • 474 citations

Recruitment and activation of mRNA decay enzymes by two ARE-mediated decay activation domains in the proteins TTP and BRF-1

2005 • 468 citations

Human Dcp2: a catalytically active mRNA decapping enzyme located in specific cytoplasmic structures

2002 • 464 citations

Nonsense-mediated mRNA decay: molecular insights and mechanistic variations across species

2005 • 456 citations

Multiple Processing Body Factors and the ARE Binding Protein TTP Activate mRNA Decapping

2005 • 454 citations

A KH Domain RNA Binding Protein, KSRP, Promotes ARE-Directed mRNA Turnover by Recruiting the Degradation Machinery

2004 • 440 citations

Yeast Sm-like proteins function in mRNA decapping and decay

2000 • 434 citations

Mechanistic links between nonsense-mediated mRNA decay and pre-mRNA splicing in mammalian cells

2005 • 402 citations

A Sm-like protein complex that participates in mRNA degradation

2000 • 390 citations

A role for eIF4E and eIF4E-transporter in targeting mRNPs to mammalian processing bodies

2005 • 389 citations

The human LSm1-7 proteins colocalize with the mRNA-degrading enzymes Dcp1/2 and Xrn1 in distinct cytoplasmic foci

2002 • 387 citations

Posterior localization of vasa protein correlates with, but is not sufficient for, pole cell development.

1990 • 374 citations

AtXRN4 Degrades mRNA in Arabidopsis and Its Substrates Include Selected miRNA Targets

2004 • 372 citations

The mammalian exosome mediates the efficient degradation of mRNAs that contain AU-rich elements

2002 • 369 citations

A Phosphorylated Cytoplasmic Autoantigen, GW182, Associates with a Unique Population of Human mRNAs within Novel Cytoplasmic Speckles

2002 • 365 citations

Nonsense-Mediated mRNA Decay in Mammalian Cells Involves Decapping, Deadenylating, and Exonucleolytic Activities

2003 • 365 citations

Trapping of messenger RNA by Fragile X Mental Retardation protein into cytoplasmic granules induces translation repression

2002 • 356 citations

Identification of a Human Decapping Complex Associated with hUpf Proteins in Nonsense-Mediated Decay

2002 • 355 citations

A Mouse Cytoplasmic Exoribonuclease (mXRN1p) with Preference for G4 Tetraplex Substrates

1997 • 341 citations

Decay of mRNAs targeted by RISC requires XRN1, the Ski complex, and the exosome

2005 • 337 citations

The chromatoid body of male germ cells: Similarity with processing bodies and presence of Dicer and microRNA pathway components

2006 • 333 citations

Phosphorylation of hUPF1 Induces Formation of mRNA Surveillance Complexes Containing hSMG-5 and hSMG-7

2003 • 331 citations

Localization of vasa protein to the Drosophila pole plasm is independent of its RNA-binding and helicase activities

1994 • 328 citations

Me31B silences translation of oocyte-localizing RNAs through the formation of cytoplasmic RNP complex duringDrosophilaoogenesis

2001 • 327 citations

aubergineencodes aDrosophilapolar granule component required for pole cell formation and related to eIF2C

2001 • 321 citations

Microtubule-dependent Recruitment of Staufen-Green Fluorescent Protein into Large RNA-containing Granules and Subsequent Dendritic Transport in Living Hippocampal Neurons

1999 • 301 citations

The translational regulator CPEB1 provides a link between dcp1 bodies and stress granules

2005 • 293 citations

SMG7 Acts as a Molecular Link between mRNA Surveillance and mRNA Decay

2004 • 286 citations

Targeting of Aberrant mRNAs to Cytoplasmic Processing Bodies

2006 • 284 citations

Nonsense-mediated mRNA decay in Drosophila:at the intersection of the yeast and mammalian pathways

2003 • 284 citations

Early nonsense: mRNA decay solves a translational problem

2006 • 280 citations

Bringing the role of mRNA decay in the control of gene expression into focus

2004 • 268 citations

The Developmental Timing Regulator AIN-1 Interacts with miRISCs and May Target the Argonaute Protein ALG-1 to Cytoplasmic P Bodies in C. elegans

2005 • 268 citations

Mammalian stress granules represent sites of accumulation of stalled translation initiation complexes

2003 • 268 citations

Facilitation of dendritic mRNA transport by CPEB

2003 • 256 citations

MicroRNAs Silence Gene Expression by Repressing Protein Expression and/or by Promoting mRNA Decay

2006 • 251 citations

A role for the eIF4E-binding protein 4E-T in P-body formation and mRNA decay

2005 • 247 citations

A complex containing the Sm protein CAR-1 and the RNA helicase CGH-1 is required for embryonic cytokinesis in Caenorhabditis elegans

2005 • 242 citations

Nonsense-mediated messenger RNA decay is initiated by endonucleolytic cleavage in Drosophila

2004 • 241 citations

ARE‐mRNA degradation requires the 5′–3′ decay pathway

2005 • 241 citations

Maelstrom, aDrosophila spindle-class gene, encodes a protein that colocalizes with Vasa and RDE1/AGO1 homolog, Aubergine, in nuage

2003 • 233 citations

Targeting an mRNA for Decapping

2001 • 233 citations

SMG7 Is a 14-3-3-like Adaptor in the Nonsense-Mediated mRNA Decay Pathway

2005 • 225 citations

Oskar protein interaction with Vasa represents an essential step in polar granule assembly.

1996 • 222 citations

An NMD Pathway in Yeast Involving Accelerated Deadenylation and Exosome-Mediated 3′→5′ Degradation

2003 • 212 citations

GW182 is critical for the stability of GW bodies expressed during the cell cycle and cell proliferation

2004 • 205 citations

Structures of the PIN domains of SMG6 and SMG5 reveal a nuclease within the mRNA surveillance complex

2006 • 195 citations

Human Retroviral Host Restriction Factors APOBEC3G and APOBEC3F Localize to mRNA Processing Bodies

2006 • 194 citations

Ge-1 is a central component of the mammalian cytoplasmic mRNA processing body

2005 • 192 citations

Isolation and characterization of Staufen-containing ribonucleoprotein particles from rat brain

2003 • 163 citations

A conserved RNA-protein complex component involved in physiological germline apoptosis regulation inC. elegans

2005 • 162 citations

RNA-associated protein 55 (RAP55) localizes to mRNA processing bodies and stress granules

2006 • 159 citations

Identification of Edc3p as an Enhancer of mRNA Decapping inSaccharomyces cerevisiae

2004 • 156 citations

Computational Modeling and Experimental Analysis of Nonsense-Mediated Decay in Yeast

2003 • 151 citations

The insulin-like growth factor mRNA binding-protein IMP-1 and the Ras-regulatory protein G3BP associate with tau mRNA and HuD protein in differentiated P19 neuronal cells

2004 • 145 citations

Staufen Recruitment into Stress Granules Does Not Affect Early mRNA Transport in Oligodendrocytes

2004 • 145 citations

A conserved role of a DEAD box helicase in mRNA masking

2001 • 143 citations

Isolation of a Ribonucleoprotein Complex Involved in mRNA Localization in Drosophila Oocytes

2000 • 141 citations

The Two Proteins Pat1p (Mrt1p) and Spb8p Interact In Vivo, Are Required for mRNA Decay, and Are Functionally Linked to Pab1p

2000 • 140 citations

The RNA polymerase II subunit Rpb4p mediates decay of a specific class of mRNAs

2005 • 139 citations

Distribution of tudor protein in the Drosophila embryo suggests separation of functions based on site of localization

1993 • 136 citations

SMG-5, required for C.elegans nonsense-mediated mRNA decay, associates with SMG-2 and protein phosphatase 2A

2003 • 135 citations

Rapid Deadenylation Triggered by a Nonsense Codon Precedes Decay of the RNA Body in a Mammalian Cytoplasmic Nonsense-Mediated Decay Pathway

2003 • 135 citations

Process or perish: quality control in mRNA biogenesis

2005 • 133 citations

Regulated ARE-Mediated mRNA Decay in Saccharomyces cerevisiae

2001 • 132 citations

XenopusStaufen is a component of a ribonucleoprotein complex containing Vg1 RNA and kinesin

2004 • 131 citations

A Sponge-like Structure Involved in the Association and Transport of Maternal Products during Drosophila Oogenesis

1997 • 125 citations

Formation of GW bodies is a consequence of microRNA genesis

2006 • 123 citations

The active form of Xp54 RNA helicase in translational repression is an RNA-mediated oligomer

2004 • 122 citations

An isoform of eIF4E is a component of germ granules and is required for spermatogenesis inC. elegans

2001 • 120 citations

Live imaging of nuage and polar granules: evidence against a precursor-product relationship and a novel role for Oskar in stabilization of polar granule components

2004 • 111 citations

Upf1p, Nmd2p, and Upf3p Regulate the Decapping and Exonucleolytic Degradation of both Nonsense-Containing mRNAs and Wild-Type mRNAs

2001 • 101 citations

Drosophila tudor is essential for polar granule assembly and pole cell specification, but not for posterior patterning

2004 • 97 citations

Vertebrate GLD2 poly(A) polymerases in the germline and the brain

2005 • 97 citations

Drosophila Decapping Protein 1, dDcp1, Is a Component of the oskar mRNP Complex and Directs Its Posterior Localization in the Oocyte

2006 • 96 citations

BDNF induces translocation of initiation factor 4E to mRNA granules: Evidence for a role of synaptic microfilaments and integrins

2003 • 96 citations

Novel modes of protein–RNA recognition in the RNAi pathway

2005 • 92 citations

Novel Sm‐like proteins with long C‐terminal tails and associated methyltransferases

2004 • 86 citations

Novel conserved domains in proteins with predicted roles in eukaryotic cell-cycle regulation, decapping and RNA stability

2004 • 76 citations

Premature termination codons enhance mRNA decapping in human cells

2004 • 71 citations

Fragile X Mental Retardation Protein Shifts between Polyribosomes and Stress Granules after Neuronal Injury by Arsenite Stress orIn VivoHippocampal Electrode Insertion

2006 • 68 citations

Caenorhabditis elegansDecapping Proteins: Localization and Functional Analysis of Dcp1, Dcp2, and DcpS during Embryogenesis

2005 • 67 citations

Sbp1p Affects Translational Repression and Decapping in Saccharomyces cerevisiae

2006 • 63 citations

Mutations in the Saccharomyces cerevisiae LSM1 Gene That Affect mRNA Decapping and 3′ End Protection

2005 • 62 citations

Quantitative Proteomics Identifies Gemin5, A Scaffolding Protein Involved in Ribonucleoprotein Assembly, as a Novel Partner for Eukaryotic Initiation Factor 4E

2006 • 46 citations

Dcs2, a Novel Stress-induced Modulator of m7GpppX Pyrophosphatase Activity that Locates to P Bodies

2006 • 42 citations

Requirement for P granules and meiosis for accumulation of the germline RNA helicase CGH-1

2005 • 34 citations

Determinants of Rbp1p Localization in Specific Cytoplasmic mRNA-processing Foci, P-bodies

2006 • 15 citations