A Mouse Cytoplasmic Exoribonuclease (mXRN1p) with Preference for G4 Tetraplex Substrates

A comprehensive set of sequence analysis programs for the VAX

1984 • 14,824 citations

Methods in yeast genetics

1979 • 7,824 citations

A bacteriophage T7 RNA polymerase/promoter system for controlled exclusive expression of specific genes.

1985 • 3,185 citations

Structural features in eukaryotic mRNAs that modulate the initiation of translation.

1991 • 1,849 citations

Formation of parallel four-stranded complexes by guanine-rich motifs in DNA and its implications for meiosis

1988 • 1,734 citations

mRNA stability in mammalian cells

1995 • 1,258 citations

Factor required for mammalian spliceosome assembly is localized to discrete regions in the nucleus

1990 • 723 citations

[40] Immunofluorescence methods for yeast

1991 • 705 citations

G-Quartet Structures in Telomeric DNA

1994 • 694 citations

A turnover pathway for both stable and unstable mRNAs in yeast: evidence for a requirement for deadenylation.

1993 • 660 citations

INTERRELATIONSHIPS OF THE PATHWAYS OF mRNA DECAY AND TRANSLATION IN EUKARYOTIC CELLS

1996 • 653 citations

Degradation of mRNA in eukaryotes

1995 • 648 citations

Macromolecular Domains within the Cell Nucleus

1993 • 611 citations

The intracellular localization of messenger RNAs

1995 • 534 citations

Deadenylation of the unstable mRNA encoded by the yeast MFA2 gene leads to decapping followed by 5'-->3' digestion of the transcript.

1994 • 511 citations

Carbohydrate Metabolism During Ascospore Development in Yeast

1974 • 425 citations

Premature translational termination triggers mRNA decapping

1994 • 399 citations

Control of Messenger RNA Stability

1993 • 394 citations

Yeast cells lacking 5'-->3' exoribonuclease 1 contain mRNA species that are poly(A) deficient and partially lack the 5' cap structure.

1993 • 378 citations

Isolation and characterization of RAT1: an essential gene of Saccharomyces cerevisiae required for the efficient nucleocytoplasmic trafficking of mRNA.

1992 • 370 citations

Turnover Mechanisms of the Stable Yeast PGK1 mRNA

1995 • 341 citations

X-ray fiber diffraction and model-building study of polyguanylic acid and polyinosinic acid

1975 • 339 citations

An essential component of the decapping enzyme required for normal rates of mRNA turnover

1996 • 328 citations

Control of messenger RNA stability in higher eukaryotes

1996 • 315 citations

The 5′ end of yeast 5.8S rRNA is generated by exonucleases from an upstream cleavage site.

1994 • 308 citations

Solution structure of an unusually stable RNA tetraplex containing G- and U-quartet structures

1992 • 261 citations

Double-stranded RNA viruses of Saccharomyces cerevisiae

1996 • 252 citations

[15] Preparation of extracts from higher eukaryotes

1990 • 252 citations

Mechanisms and control of mRNA turnover in Saccharomyces cerevisiae

1996 • 246 citations

Evidence for interstrand quadruplex formation in the dimerization of human immunodeficiency virus 1 genomic RNA.

1993 • 243 citations

Processing of pre‐ribosomal RNA in Saccharomyces cerevisiae

1995 • 210 citations

Processing of Eukaryotic Ribosomal RNA

1994 • 200 citations

Replication occurs at discrete foci spaced throughout nuclei replicating in vitro

1989 • 192 citations

Yeast Cells Lacking 5'→3' Exoribonuclease 1 Contain mRNA Species That are Poly(A) Deficient and Partially Lack the 5' Cap Structure

1993 • 190 citations

Purification and characterization of a Saccharomyces cerevisiae exoribonuclease which yields 5'-mononucleotides by a 5' leads to 3' mode of hydrolysis.

1980 • 188 citations

The yeast telomere-binding protein RAP1 binds to and promotes the formation of DNA quadruplexes in telomeric DNA.

1994 • 176 citations

Poly(A) RNA codistribution with microfilaments: evaluation by in situ hybridization and quantitative digital imaging microscopy.

1992 • 154 citations

Disruption of the gene XRN1, coding for a 5′→3′ exoribonuclease, restricts yeast cell growth

1990 • 152 citations

Tetramerization of an RNA oligonucleotide containing a GGGG sequence

1991 • 144 citations

The yeast KEM1 gene encodes a nuclease specific for G4 tetraplex DNA: Implication of in vivo functions for this novel DNA structure

1994 • 140 citations

Purification and characterization of an activity from Saccharomyces cerevisiae that catalyzes homologous pairing and strand exchange.

1987 • 132 citations

Fragments of the internal transcribed spacer 1 of pre-rRNA accumulate in Saccharomyces cerevisiae lacking 5'----3' exoribonuclease 1

1991 • 128 citations

kem mutations affect nuclear fusion in Saccharomyces cerevisiae.

1990 • 117 citations

Strand exchange protein 1 from Saccharomyces cerevisiae. A novel multifunctional protein that contains DNA strand exchange and exonuclease activities

1991 • 112 citations

An essential yeast gene with homology to the exonuclease-encoding XRN1/KEM1 gene also encodes a protein with exoribonuclease activity.

1993 • 112 citations

Molecular and genetic analysis of the gene encoding the Saccharomyces cerevisiae strand exchange protein Sep1.

1991 • 104 citations

A Yeast Gene Product, G4p2, with a Specific Affinity for Quadruplex Nucleic Acids

1995 • 100 citations

The rate-limiting step in yeast PGK1 mRNA degradation is an endonucleolytic cleavage in the 3'-terminal part of the coding region.

1992 • 96 citations

Cloning and characterization of DST2, the gene for DNA strand transfer protein beta from Saccharomyces cerevisiae.

1991 • 95 citations

Regulation and Intracellular Localization of Saccharomyces cerevisiae Strand Exchange Protein 1 (Sep1/Xrn1/Kem1), a Multifunctional Exonuclease

1995 • 88 citations

rarmutations which increase artificial chromosome stability inSaccharomyces cerevisiaeidentify transcription and recombination proteins

1991 • 76 citations

Gene disruption of a G4-DNA-dependent nuclease in yeast leads to cellular senescence and telomere shortening.

1995 • 71 citations

An exoribonuclease from saccharomyces cerevisiae: Effect of modifications of 5′ end groups on the hydrolysis of substrates to 5′ mononucleotides

1978 • 69 citations

Localisation of splicing snRNPs in mammalian cells

1993 • 67 citations

DNA strand transfer protein beta from yeast mitotic cells differs from strand transfer protein alpha from meiotic cells.

1990 • 64 citations

A role of Sep1 (= Kem1, Xrn1) as a microtubule-associated protein in Saccharomyces cerevisiae.

1995 • 62 citations

The search for the right partner: Homologous pairing and DNA strand exchange proteins in eukaryotes

1994 • 60 citations

Purification of a human polyribosome-associated 3‘ to 5‘ exoribonuclease.

1994 • 57 citations

Long-Range RNA Interaction of Two Sequence Elements Required for Endonucleolytic Cleavage of Human Insulin-Like Growth Factor II mRNAs

1995 • 55 citations

The sep1 mutant of Saccharomyces cerevisiae arrests in pachytene and is deficient in meiotic recombination.

1995 • 51 citations

Recombination and RNA processing: a common strand?

1991 • 47 citations

A 5′ exoribonuclease from cytoplasmic extracts of mouse sarcoma 180 ascites cells

1993 • 39 citations

Molecular and Genetic Analysis of the Gene Encoding the Saccharomyces cerevisiae Strand Exchange Protein Sep1

1991 • 36 citations

An Essential Yeast Gene with Homology to the Exonuclease-Encoding XRN1/KEM1 Gene Also Encodes a Protein with Exoribonuclease Activity

1993 • 35 citations

Requirement of S. pombe exonuclease II, a homologue of S. cerevisiae Sep1, for normal mitotic growth and viability

1996 • 34 citations

Molecular analysis of the dhp1 + gene of Schizosaccharomyces pombe: an essential gene that has homology to the DST 2 and RAT 1 genes of Saccharomyces cerevisiae

1994 • 32 citations

Characterization of cDNA encoding mouse homolog of fission yeastdhp1⁺gene: structural and functional conservation

1995 • 32 citations

mRNA Degradation in Eukaryotic Cells: An Overview

1993 • 31 citations

Saccharomyces cerevisiae cells lacking the homologous pairing protein p175 SEP1 arrest at pachytene during meiotic prophase

1994 • 30 citations

The Rate-Limiting Step in Yeast PGK1 mRNA Degradation Is an Endonucleolytic Cleavage in the 3′-Terminal Part of the Coding Region

1992 • 28 citations

Cloning and Characterization of DST2, the Gene for DNA Strand Transfer Protein β from Saccharomyces cerevisiae

1991 • 24 citations

A single-stranded DNA exonuclease from Schizosaccharomyces pombe

1992 • 24 citations

Control of Poly(A) Length

1993 • 24 citations

A multifunctional exonuclease from vegetative Schizosaccharomyces pombe cells exhibiting in vitro strand exchange activity.

1994 • 22 citations

Identification of functional domains in the Sep1 protein (= Kem1, Xrn1), which is required for transition through meiotic prophase in Saccharomyces cerevisiae

1995 • 20 citations

Eukaryotic Nucleases and mRNA Turnover

1993 • 19 citations

Okadaic acid co‐induces vimentin expression and cell cycle arrest in MPC‐11 mouse plasmacytoma cells

1995 • 15 citations

The activity of the Saccharomyces cerevisiae strand exchange protein 1 intrinsic exonuclease during joint molecule formation.

1994 • 14 citations

Use of Monoclonal Antibodies in the Functional Characterization of the Saccharomyces Cerevisiae Sepl Protein

1995 • 10 citations

Use of Monoclonal Antibodies in the Functional Characterization of the Saccharomyces Cerevisiae Sepl Protein

1995 • 8 citations